(Q14907140)

Death-like domain superfamily

1 reference

stated in

Death domain, protein family

1 reference

based on heuristic

inferred from protein domain or family

Death effector domain, protein family

1 reference

based on heuristic

inferred from protein domain or family

1 reference

25 May 2022

1 reference

25 May 2022

15 references

9 May 2019

Inhibition of both the extrinsic and intrinsic death pathways through nonhomotypic death-fold interactions

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q61160

9 May 2019

Caspase-8 and caspase-10 activate NF-kappaB through RIP, NIK and IKKalpha kinases

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q61160

9 May 2019

The mouse cell surface protein TOSO regulates Fas/Fas ligand-induced apoptosis through its binding to Fas-associated death domain

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q61160

9 May 2019

Apoptosis caused by p53-induced protein with death domain (PIDD) depends on the death adapter protein RAIDD.

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q61160

9 May 2019

FADD and caspase-8 control the outcome of autophagic signaling in proliferating T cells

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q61160

9 May 2019

The E3 ubiquitin ligase itch couples JNK activation to TNFalpha-induced cell death by inducing c-FLIP(L) turnover

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q61160

9 May 2019

cIAP1 and TAK1 protect cells from TNF-induced necrosis by preventing RIP1/RIP3-dependent reactive oxygen species production

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q61160

9 May 2019

Palmitoylation is required for efficient Fas cell death signaling

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q61160

9 May 2019

Activity of protein kinase RIPK3 determines whether cells die by necroptosis or apoptosis

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q61160

9 May 2019

TIPE2, a negative regulator of innate and adaptive immunity that maintains immune homeostasis

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q61160

9 May 2019

NEMO Prevents Steatohepatitis and Hepatocellular Carcinoma by Inhibiting RIPK1 Kinase Activity-Mediated Hepatocyte Apoptosis

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q61160

9 May 2019

Catalytic activity of the caspase-8-FLIP(L) complex inhibits RIPK3-dependent necrosis

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q61160

9 May 2019

Phosphorylation and linear ubiquitin direct A20 inhibition of inflammation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q61160

9 May 2019

Caveolin-1 mediates Fas-BID signaling in hyperoxia-induced apoptosis

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q61160

9 May 2019

Phosphorylation-driven assembly of the RIP1-RIP3 complex regulates programmed necrosis and virus-induced inflammation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q61160

CD95 death-inducing signaling complex

IPI

death receptor binding

regulation of apoptotic process

1 reference

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q61160

positive regulation of extrinsic apoptotic signaling pathway via death domain receptors

1 reference

14 February 2019

Apoptosis caused by p53-induced protein with death domain (PIDD) depends on the death adapter protein RAIDD.

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q61160

positive regulation of CD8-positive, alpha-beta cytotoxic T cell extravasation

IGI

1 reference

9 May 2019

Complementary roles of Fas-associated death domain (FADD) and receptor interacting protein kinase-3 (RIPK3) in T-cell homeostasis and antiviral immunity

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q61160

T cell differentiation in thymus

1 reference

9 May 2019

Complementary roles of Fas-associated death domain (FADD) and receptor interacting protein kinase-3 (RIPK3) in T-cell homeostasis and antiviral immunity

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q61160

positive regulation of adaptive immune response

1 reference

9 May 2019

Complementary roles of Fas-associated death domain (FADD) and receptor interacting protein kinase-3 (RIPK3) in T-cell homeostasis and antiviral immunity

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q61160

extrinsic apoptotic signaling pathway

3 references

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q61160

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q61160

14 February 2019

The phosphoprotein protein PEA-15 inhibits Fas- but increases TNF-R1-mediated caspase-8 activity and apoptosis

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q61160

cardiac muscle tissue development

IDA

1 reference

9 May 2019

No death without life: vital functions of apoptotic effectors

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q61160

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q61160

TAS

immune system process

1 reference

9 May 2019

1 reference

9 May 2019

Complementary roles of Fas-associated death domain (FADD) and receptor interacting protein kinase-3 (RIPK3) in T-cell homeostasis and antiviral immunity

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q61160

negative regulation of activation-induced cell death of T cells

IGI

1 reference

9 May 2019

Complementary roles of Fas-associated death domain (FADD) and receptor interacting protein kinase-3 (RIPK3) in T-cell homeostasis and antiviral immunity

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q61160

positive regulation of T cell mediated cytotoxicity

1 reference

9 May 2019

Complementary roles of Fas-associated death domain (FADD) and receptor interacting protein kinase-3 (RIPK3) in T-cell homeostasis and antiviral immunity

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q61160

positive regulation of interferon-gamma production

1 reference

9 May 2019

Complementary roles of Fas-associated death domain (FADD) and receptor interacting protein kinase-3 (RIPK3) in T-cell homeostasis and antiviral immunity

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q61160

1 reference

9 May 2019

Complementary roles of Fas-associated death domain (FADD) and receptor interacting protein kinase-3 (RIPK3) in T-cell homeostasis and antiviral immunity

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q61160

1 reference

9 May 2019

Complementary roles of Fas-associated death domain (FADD) and receptor interacting protein kinase-3 (RIPK3) in T-cell homeostasis and antiviral immunity

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q61160

cellular response to mechanical stimulus

1 reference

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q61160

No death without life: vital functions of apoptotic effectors

T cell differentiation

1 reference

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q61160

extrinsic apoptotic signaling pathway in absence of ligand

TAS

1 reference

9 May 2019

Fas/tumor necrosis factor receptor death signaling is required for axotomy-induced death of motoneurons in vivo

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q61160

positive regulation of extrinsic apoptotic signaling pathway

positive regulation of I-kappaB kinase/NF-kappaB signaling

1 reference

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q61160

motor neuron apoptotic process

1 reference

9 May 2019

Fas/tumor necrosis factor receptor death signaling is required for axotomy-induced death of motoneurons in vivo

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q61160

Complementary roles of Fas-associated death domain (FADD) and receptor interacting protein kinase-3 (RIPK3) in T-cell homeostasis and antiviral immunity

lymph node development

1 reference

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q61160

1 reference

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q61160

positive regulation of activated T cell proliferation

1 reference

9 May 2019

Complementary roles of Fas-associated death domain (FADD) and receptor interacting protein kinase-3 (RIPK3) in T-cell homeostasis and antiviral immunity

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q61160

4 references

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q61160

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q61160

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q61160

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q61160

1 reference

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q61160

behavioral response to cocaine

1 reference

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q61160

1 reference

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q61160

extrinsic apoptotic signaling pathway

4 references

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q61160

9 May 2019

Apoptosis caused by p53-induced protein with death domain (PIDD) depends on the death adapter protein RAIDD.

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q61160

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q61160

9 May 2019

The phosphoprotein protein PEA-15 inhibits Fas- but increases TNF-R1-mediated caspase-8 activity and apoptosis

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q61160

TRAIL-activated apoptotic signaling pathway

IDA

positive regulation of extrinsic apoptotic signaling pathway

4 references

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q61160

9 May 2019

Survival function of the FADD-CASPASE-8-cFLIP(L) complex

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q61160

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q61160

9 May 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q61160

IBA

has part(s)

Death effector domain

1 reference

stated in

Death domain

1 reference

stated in