(Q15996701)

http://www.ebi.ac.uk/interpro/protein/Q5VWK5

Immunoglobulin-like fold

1 reference

stated in

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/Q5VWK5

Fibronectin type III, protein family

1 reference

based on heuristic

inferred from protein domain or family

1 reference

13 November 2019

1 reference

13 November 2019

interleukin-23 receptor activity

1 reference

8 April 2019

A receptor for the heterodimeric cytokine IL-23 is composed of IL-12Rbeta1 and a novel cytokine receptor subunit, IL-23R

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q5VWK5

interleukin-12 receptor binding

1 reference

31 January 2018

A receptor for the heterodimeric cytokine IL-23 is composed of IL-12Rbeta1 and a novel cytokine receptor subunit, IL-23R

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q5VWK5&geneProductId=UniProtKB:Q5VWK5

A receptor for the heterodimeric cytokine IL-23 is composed of IL-12Rbeta1 and a novel cytokine receptor subunit, IL-23R

IPI

interleukin-23 binding

1 reference

31 January 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q5VWK5&geneProductId=UniProtKB:Q5VWK5

cytokine receptor activity

IPI

1 reference

8 April 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q5VWK5

1 reference

8 April 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q5VWK5

integral component of membrane

IBA

cell component

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q5VWK5

interleukin-23 receptor complex

1 reference

31 January 2018

A receptor for the heterodimeric cytokine IL-23 is composed of IL-12Rbeta1 and a novel cytokine receptor subunit, IL-23R

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q5VWK5&geneProductId=UniProtKB:Q5VWK5

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q5VWK5

1 reference

31 January 2018

Structural basis for endosomal trafficking of diverse transmembrane cargos by PX-FERM proteins

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q5VWK5&geneProductId=UniProtKB:Q5VWK5

2 references

external side of plasma membrane

1 reference

8 April 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q5VWK5

negative regulation of interleukin-10 production

IBA

biological process

1 reference

8 April 2019

IL-23 is increased in dendritic cells in multiple sclerosis and down-regulation of IL-23 by antisense oligos increases dendritic cell IL-10 production

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q5VWK5

response to interferon-gamma

IMP

1 reference

8 April 2019

A receptor for the heterodimeric cytokine IL-23 is composed of IL-12Rbeta1 and a novel cytokine receptor subunit, IL-23R

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q5VWK5

positive regulation of interleukin-12 production

1 reference

8 April 2019

Salmonella induced IL-23 and IL-1beta allow for IL-12 production by monocytes and Mphi1 through induction of IFN-gamma in CD56 NK/NK-like T cells

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q5VWK5

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q5VWK5

immune system process

1 reference

8 April 2019

positive regulation of T cell mediated cytotoxicity

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q5VWK5

positive regulation of interferon-gamma production

3 references

8 April 2019

IL-23 modulates CD56+/CD3- NK cell and CD56+/CD3+ NK-like T cell function differentially from IL-12

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q5VWK5

8 April 2019

Novel p19 protein engages IL-12p40 to form a cytokine, IL-23, with biological activities similar as well as distinct from IL-12

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q5VWK5

8 April 2019

Salmonella induced IL-23 and IL-1beta allow for IL-12 production by monocytes and Mphi1 through induction of IFN-gamma in CD56 NK/NK-like T cells

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q5VWK5

positive regulation of osteoclast differentiation

1 reference

8 April 2019

IL-23 induces human osteoclastogenesis via IL-17 in vitro, and anti-IL-23 antibody attenuates collagen-induced arthritis in rats

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q5VWK5

positive regulation of T-helper 17 cell lineage commitment

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q5VWK5

positive regulation of NK T cell activation

1 reference

8 April 2019

IL-23 modulates CD56+/CD3- NK cell and CD56+/CD3+ NK-like T cell function differentially from IL-12

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q5VWK5

positive regulation of natural killer cell proliferation

1 reference

8 April 2019

IL-23 modulates CD56+/CD3- NK cell and CD56+/CD3+ NK-like T cell function differentially from IL-12

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q5VWK5

response to lipopolysaccharide

1 reference

8 April 2019

A receptor for the heterodimeric cytokine IL-23 is composed of IL-12Rbeta1 and a novel cytokine receptor subunit, IL-23R

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q5VWK5

positive regulation of T-helper 17 type immune response

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q5VWK5

positive regulation of granulocyte macrophage colony-stimulating factor production

1 reference

8 April 2019

Salmonella induced IL-23 and IL-1beta allow for IL-12 production by monocytes and Mphi1 through induction of IFN-gamma in CD56 NK/NK-like T cells

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q5VWK5

defense response to Gram-negative bacterium

1 reference

8 April 2019

Commensal Gram-negative bacteria prime human dendritic cells for enhanced IL-23 and IL-27 expression and enhanced Th1 development

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q5VWK5

positive regulation of T cell proliferation

1 reference

8 April 2019

A receptor for the heterodimeric cytokine IL-23 is composed of IL-12Rbeta1 and a novel cytokine receptor subunit, IL-23R

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q5VWK5

positive regulation of memory T cell differentiation

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q5VWK5

positive regulation of interleukin-17 production

1 reference

8 April 2019

IL-23 induces human osteoclastogenesis via IL-17 in vitro, and anti-IL-23 antibody attenuates collagen-induced arthritis in rats

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q5VWK5

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q5VWK5

innate immune response

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q5VWK5

inflammatory response

1 reference

8 April 2019

positive regulation of activated T cell proliferation

1 reference

8 April 2019

Novel p19 protein engages IL-12p40 to form a cytokine, IL-23, with biological activities similar as well as distinct from IL-12

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q5VWK5

positive regulation of activation of Janus kinase activity

1 reference

8 April 2019

A receptor for the heterodimeric cytokine IL-23 is composed of IL-12Rbeta1 and a novel cytokine receptor subunit, IL-23R

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q5VWK5

regulation of tyrosine phosphorylation of STAT protein

1 reference

8 April 2019

A receptor for the heterodimeric cytokine IL-23 is composed of IL-12Rbeta1 and a novel cytokine receptor subunit, IL-23R

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q5VWK5

positive regulation of tyrosine phosphorylation of STAT protein

cytokine-mediated signaling pathway

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q5VWK5

interleukin-23-mediated signaling pathway

TAS

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q5VWK5

1 reference

InterPro Release 71.0