(Q21096365)

http://www.ebi.ac.uk/interpro/protein/O95863

Zinc finger C2H2-type, protein family

1 reference

based on heuristic

inferred from protein domain or family

image

SNAI1.png
1,920 × 975; 605 KB

0 references

1 reference

13 November 2019

1 reference

13 November 2019

sequence-specific DNA binding

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O95863

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O95863

RNA polymerase II transcription regulatory region sequence-specific DNA binding

1 reference

5 June 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=O95863&geneProductId=UniProtKB:O95863

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O95863

1 reference

8 April 2019

Dual regulation of Snail by GSK-3beta-mediated phosphorylation in control of epithelial-mesenchymal transition

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O95863

14 references

8 April 2019

A molecular role for lysyl oxidase-like 2 enzyme in snail regulation and tumor progression

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O95863

8 April 2019

eEF1A mediates the nuclear export of SNAG-containing proteins via the Exportin5-aminoacyl-tRNA complex

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O95863

8 April 2019

The hypoxia-controlled FBXL14 ubiquitin ligase targets SNAIL1 for proteasome degradation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O95863

8 April 2019

Dual regulation of Snail by GSK-3beta-mediated phosphorylation in control of epithelial-mesenchymal transition

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O95863

8 April 2019

Ajuba LIM proteins are snail/slug corepressors required for neural crest development in Xenopus

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O95863

8 April 2019

PKD1 phosphorylation-dependent degradation of SNAIL by SCF-FBXO11 regulates epithelial-mesenchymal transition and metastasis

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O95863

8 April 2019

Stabilization of snail by NF-kappaB is required for inflammation-induced cell migration and invasion

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O95863

8 April 2019

The collagen receptor discoidin domain receptor 2 stabilizes SNAIL1 to facilitate breast cancer metastasis

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O95863

8 April 2019

Acetylation of snail modulates the cytokinome of cancer cells to enhance the recruitment of macrophages

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O95863

8 April 2019

p53 inhibits tumor cell invasion via the degradation of snail protein in hepatocellular carcinoma

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O95863

8 April 2019

A proteome-scale map of the human interactome network

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O95863

8 April 2019

Poly(ADP-ribose)-dependent regulation of Snail1 protein stability

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O95863

8 April 2019

Requirement of the histone demethylase LSD1 in Snai1-mediated transcriptional repression during epithelial-mesenchymal transition

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O95863

8 April 2019

The SNAG domain of Snail1 functions as a molecular hook for recruiting lysine-specific demethylase 1

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O95863

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O95863

DNA-binding transcription repressor activity, RNA polymerase II-specific

4 references

5 June 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=O95863&geneProductId=UniProtKB:O95863

5 June 2018

The SLUG zinc-finger protein represses E-cadherin in breast cancer

http://www.ebi.ac.uk/QuickGO/annotations?protein=O95863&geneProductId=UniProtKB:O95863

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O95863

8 April 2019

The SLUG zinc-finger protein represses E-cadherin in breast cancer

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O95863

1 reference

8 April 2019

The SLUG zinc-finger protein represses E-cadherin in breast cancer

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O95863

9 references

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O95863

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O95863

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O95863

8 April 2019

Syntenin regulates TGF-β1-induced Smad activation and the epithelial-to-mesenchymal transition by inhibiting caveolin-mediated TGF-β type I receptor internalization

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O95863

8 April 2019

eEF1A mediates the nuclear export of SNAG-containing proteins via the Exportin5-aminoacyl-tRNA complex

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O95863

8 April 2019

The hypoxia-controlled FBXL14 ubiquitin ligase targets SNAIL1 for proteasome degradation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O95863

8 April 2019

Dual regulation of Snail by GSK-3beta-mediated phosphorylation in control of epithelial-mesenchymal transition

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O95863

8 April 2019

ALX1 induces snail expression to promote epithelial-to-mesenchymal transition and invasion of ovarian cancer cells

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O95863

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O95863

6 references

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O95863

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O95863

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O95863

8 April 2019

eEF1A mediates the nuclear export of SNAG-containing proteins via the Exportin5-aminoacyl-tRNA complex

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O95863

8 April 2019

The hypoxia-controlled FBXL14 ubiquitin ligase targets SNAIL1 for proteasome degradation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O95863

8 April 2019

Dual regulation of Snail by GSK-3beta-mediated phosphorylation in control of epithelial-mesenchymal transition

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O95863

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O95863

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O95863

trophoblast giant cell differentiation

biological process

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O95863

roof of mouth development

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O95863

regulation of bicellular tight junction assembly

1 reference

8 April 2019

Aberrant expression of the transcription factors snail and slug alters the response to genotoxic stress

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O95863

positive regulation of cell migration

IMP

3 references

8 April 2019

Type I collagen promotes epithelial-mesenchymal transition through ILK-dependent activation of NF-kappaB and LEF-1

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O95863

8 April 2019

Aberrant expression of the transcription factors snail and slug alters the response to genotoxic stress

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O95863

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O95863

regulation of transcription by RNA polymerase II

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O95863

epithelial to mesenchymal transition involved in endocardial cushion formation

1 reference

27 March 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=O95863&geneProductId=UniProtKB:O95863

negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage

1 reference

8 April 2019

Aberrant expression of the transcription factors snail and slug alters the response to genotoxic stress

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O95863

multicellular organism development

IMP

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O95863

negative regulation of vitamin D biosynthetic process

1 reference

8 April 2019

Snail2 cooperates with Snail1 in the repression of vitamin D receptor in colon cancer

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O95863

negative regulation of DNA damage response, signal transduction by p53 class mediator

1 reference

8 April 2019

Aberrant expression of the transcription factors snail and slug alters the response to genotoxic stress

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O95863

osteoblast differentiation

IMP

1 reference

8 April 2019

SLUG: a new target of lymphoid enhancer factor-1 in human osteoblasts

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O95863

negative regulation of cell differentiation involved in embryonic placenta development

IEP

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O95863

cartilage morphogenesis

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O95863

hair follicle morphogenesis

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O95863

left/right pattern formation

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O95863

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O95863

negative regulation of transcription, DNA-templated

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O95863

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O95863

negative regulation of transcription by RNA polymerase II

4 references

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O95863

8 April 2019

Aberrant expression of the transcription factors snail and slug alters the response to genotoxic stress

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O95863

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O95863

8 April 2019

The SLUG zinc-finger protein represses E-cadherin in breast cancer

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O95863

epithelial to mesenchymal transition

3 references

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O95863

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O95863

8 April 2019

A molecular role for lysyl oxidase-like 2 enzyme in snail regulation and tumor progression

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O95863

positive regulation of epithelial to mesenchymal transition

5 references

8 April 2019

A Wnt-Axin2-GSK3beta cascade regulates Snail1 activity in breast cancer cells

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O95863

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O95863

8 April 2019

Type I collagen promotes epithelial-mesenchymal transition through ILK-dependent activation of NF-kappaB and LEF-1

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O95863

8 April 2019

ALX1 induces snail expression to promote epithelial-to-mesenchymal transition and invasion of ovarian cancer cells

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O95863

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O95863

aortic valve morphogenesis

1 reference

8 April 2019

NOTCH1 missense alleles associated with left ventricular outflow tract defects exhibit impaired receptor processing and defective EMT.

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O95863

epithelial to mesenchymal transition involved in endocardial cushion formation

TAS

3 references

8 April 2019

NOTCH1 missense alleles associated with left ventricular outflow tract defects exhibit impaired receptor processing and defective EMT.

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O95863

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O95863

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O95863

Notch signaling involved in heart development

3 references

8 April 2019

NOTCH1 missense alleles associated with left ventricular outflow tract defects exhibit impaired receptor processing and defective EMT.

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O95863

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O95863

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O95863

has part(s)

Zinc finger C2H2-type

1 reference

stated in

InterPro Release 71.0