(Q21105326)

Metallopeptidase, catalytic domain superfamily

1 reference

ADAMTS/ADAMTS-like

1 reference

Peptidase M12B, ADAM/reprolysin, protein family

1 reference

ADAM-TS Spacer 1, protein family

1 reference

PLAC, protein family

1 reference

Thrombospondin type-1 (TSP1) repeat, protein family

1 reference

Peptidase M12B, propeptide family

1 reference

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P58397

1 reference

13 November 2019

1 reference

13 November 2019

1 reference

8 April 2019

5 references

8 April 2019

A proteome-scale map of the human interactome network

IntAct protein interaction database

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P58397

8 April 2019

ADAMTS-12 associates with and degrades cartilage oligomeric matrix protein

IntAct protein interaction database

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P58397

8 April 2019

Inhibition of ADAMTS-7 and ADAMTS-12 degradation of cartilage oligomeric matrix protein by alpha-2-macroglobulin

IntAct protein interaction database

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P58397

8 April 2019

ADAMTS-12 associates with and degrades cartilage oligomeric matrix protein

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P58397

8 April 2019

Inhibition of ADAMTS-7 and ADAMTS-12 degradation of cartilage oligomeric matrix protein by alpha-2-macroglobulin

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P58397

metalloendopeptidase activity

IPI

4 references

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P58397

8 April 2019

The ADAMTS12 metalloproteinase exhibits anti-tumorigenic properties through modulation of the Ras-dependent ERK signalling pathway

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P58397

8 April 2019

ADAMTS-12 associates with and degrades cartilage oligomeric matrix protein

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P58397

8 April 2019

Inhibition of ADAMTS-7 and ADAMTS-12 degradation of cartilage oligomeric matrix protein by alpha-2-macroglobulin

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P58397

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P58397

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P58397

1 reference

24 April 2018

Identification, characterization, and intracellular processing of ADAM-TS12, a novel human disintegrin with a complex structural organization involving multiple thrombospondin-1 repeats

http://www.ebi.ac.uk/QuickGO/annotations?protein=P58397&geneProductId=UniProtKB:P58397

collagen-containing extracellular matrix

1 reference

1 January 2018

Identification, characterization, and intracellular processing of ADAM-TS12, a novel human disintegrin with a complex structural organization involving multiple thrombospondin-1 repeats

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P58397

regulation of endothelial tube morphogenesis

biological process

1 reference

8 April 2019

The ADAMTS12 metalloproteinase exhibits anti-tumorigenic properties through modulation of the Ras-dependent ERK signalling pathway

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P58397

proteoglycan catabolic process

1 reference

8 April 2019

The ADAMTS12 metalloproteinase exhibits anti-tumorigenic properties through modulation of the Ras-dependent ERK signalling pathway

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P58397

negative regulation of hepatocyte growth factor receptor signaling pathway

1 reference

8 April 2019

The ADAMTS12 metalloproteinase exhibits anti-tumorigenic properties through modulation of the Ras-dependent ERK signalling pathway

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P58397

negative regulation of cellular response to vascular endothelial growth factor stimulus

1 reference

8 April 2019

The ADAMTS12 metalloproteinase exhibits anti-tumorigenic properties through modulation of the Ras-dependent ERK signalling pathway

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P58397

cellular response to tumor necrosis factor

1 reference

8 April 2019

Inhibition of ADAMTS-7 and ADAMTS-12 degradation of cartilage oligomeric matrix protein by alpha-2-macroglobulin

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P58397

cellular response to BMP stimulus

IMP

1 reference

8 April 2019

Negative effects of ADAMTS-7 and ADAMTS-12 on endplate cartilage differentiation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P58397

negative regulation of cellular response to hepatocyte growth factor stimulus

1 reference

8 April 2019

The ADAMTS12 metalloproteinase exhibits anti-tumorigenic properties through modulation of the Ras-dependent ERK signalling pathway

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P58397

2 references

negative regulation of chondrocyte differentiation

1 reference

8 April 2019

Negative effects of ADAMTS-7 and ADAMTS-12 on endplate cartilage differentiation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P58397

cellular response to interleukin-1

1 reference

8 April 2019

Inhibition of ADAMTS-7 and ADAMTS-12 degradation of cartilage oligomeric matrix protein by alpha-2-macroglobulin

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P58397

regulation of inflammatory response

IMP

1 reference

8 April 2019

ADAMTS-12 metalloprotease is necessary for normal inflammatory response

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P58397

1 reference

8 April 2019

Regulated expression of ADAMTS-12 in human trophoblastic cells: a role for ADAMTS-12 in epithelial cell invasion?

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P58397

1 reference

8 April 2019

Regulated expression of ADAMTS-12 in human trophoblastic cells: a role for ADAMTS-12 in epithelial cell invasion?

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P58397

Thrombospondin type-1 (TSP1) repeat

IMP

has part(s)

1 reference

PLAC

1 reference

Peptidase M12B, ADAM/reprolysin

1 reference

ADAM-TS Spacer 1

1 reference

Peptidase M12B, propeptide

1 reference