(Q21109261)

Rap/Ran-GAP superfamily

1 reference

Armadillo-type fold

1 reference

Tuberin-type domain, protein family

1 reference

inferred from protein domain or family

Rap GTPase activating protein domain family

1 reference

inferred from protein domain or family

Tuberin, N-terminal domain, protein family

1 reference

inferred from protein domain or family

1 reference

13 November 2019

1 reference

13 November 2019

1 reference

8 April 2019

Docking motif-guided mapping of the interactome of protein phosphatase-1

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P49815

protein homodimerization activity

IDA

1 reference

8 April 2019

Characterization of the cytosolic tuberin-hamartin complex. Tuberin is a cytosolic chaperone for hamartin

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P49815

GTPase activator activity

IPI

3 references

5 June 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=P49815&geneProductId=UniProtKB:P49815

5 June 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=P49815&geneProductId=UniProtKB:P49815

5 June 2018

The tuberous sclerosis 2 gene product, tuberin, functions as a Rab5 GTPase activating protein (GAP) in modulating endocytosis

http://www.ebi.ac.uk/QuickGO/annotations?protein=P49815&geneProductId=UniProtKB:P49815

1 reference

8 April 2019

The ubiquitination of rag A GTPase by RNF152 negatively regulates mTORC1 activation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P49815

21 references

8 April 2019

WD40 protein FBW5 promotes ubiquitination of tumor suppressor TSC2 by DDB1-CUL4-ROC1 ligase

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P49815

8 April 2019

Interaction between hamartin and tuberin, the TSC1 and TSC2 gene products

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P49815

8 April 2019

p53 target genes sestrin1 and sestrin2 connect genotoxic stress and mTOR signaling

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P49815

8 April 2019

Regulation of TSC2 by 14-3-3 binding

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P49815

8 April 2019

Characterization of the cytosolic tuberin-hamartin complex. Tuberin is a cytosolic chaperone for hamartin

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P49815

8 April 2019

Identification and characterization of the interaction between tuberin and 14-3-3zeta

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P49815

8 April 2019

Proteomic and biochemical analysis of 14-3-3-binding proteins during C2-ceramide-induced apoptosis

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P49815

8 April 2019

Hamartin, the product of the tuberous sclerosis 1 (TSC1) gene, interacts with tuberin and appears to be localized to cytoplasmic vesicles

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P49815

8 April 2019

IKK beta suppression of TSC1 links inflammation and tumor angiogenesis via the mTOR pathway

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P49815

8 April 2019

Protein interaction network of the mammalian Hippo pathway reveals mechanisms of kinase-phosphatase interactions

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P49815

8 April 2019

PDK1-SGK1 Signaling Sustains AKT-Independent mTORC1 Activation and Confers Resistance to PI3Kα Inhibition

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P49815

8 April 2019

Insulin like growth factor-1-induced phosphorylation and altered distribution of tuberous sclerosis complex (TSC)1/TSC2 in C2C12 myotubes

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P49815

8 April 2019

SIRT1 negatively regulates the mammalian target of rapamycin

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P49815

8 April 2019

Comprehensive proteomic analysis of interphase and mitotic 14-3-3-binding proteins

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P49815

8 April 2019

Interaction between hamartin and tuberin, the TSC1 and TSC2 gene products

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P49815

8 April 2019

Docking motif-guided mapping of the interactome of protein phosphatase-1

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P49815

8 April 2019

Tuberous sclerosis-2 (TSC2) regulates the stability of death-associated protein kinase-1 (DAPK) through a lysosome-dependent degradation pathway

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P49815

8 April 2019

The p38 and MK2 kinase cascade phosphorylates tuberin, the tuberous sclerosis 2 gene product, and enhances its interaction with 14-3-3

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P49815

8 April 2019

Carboxy terminal tail of polycystin-1 regulates localization of TSC2 to repress mTOR

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P49815

8 April 2019

Activity of TSC2 is inhibited by AKT-mediated phosphorylation and membrane partitioning

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P49815

8 April 2019

The Sestrins interact with GATOR2 to negatively regulate the amino-acid-sensing pathway upstream of mTORC1

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P49815

Tumor suppressor Tsc1 is a new Hsp90 co-chaperone that facilitates folding of kinase and non-kinase clients.

IPI

Hsp90 protein binding

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P49815

GTPase activator activity

IPI

4 references

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P49815

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P49815

8 April 2019

The tuberous sclerosis 2 gene product, tuberin, functions as a Rab5 GTPase activating protein (GAP) in modulating endocytosis

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P49815

8 April 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P49815

4 references

5 June 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=P49815&geneProductId=UniProtKB:P49815

5 June 2018

Tuberin nuclear localization can be regulated by phosphorylation of its carboxyl terminus

http://www.ebi.ac.uk/QuickGO/annotations?protein=P49815&geneProductId=UniProtKB:P49815

5 June 2018

Activity of TSC2 is inhibited by AKT-mediated phosphorylation and membrane partitioning

http://www.ebi.ac.uk/QuickGO/annotations?protein=P49815&geneProductId=UniProtKB:P49815

5 June 2018

Interaction between hamartin and tuberin, the TSC1 and TSC2 gene products

http://www.ebi.ac.uk/QuickGO/annotations?protein=P49815&geneProductId=UniProtKB:P49815

3 references

perinuclear region of cytoplasm

1 reference

8 April 2019

Co-localization of the TSC2 product tuberin with its target Rap1 in the Golgi apparatus

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P49815

1 reference

8 April 2019

The ubiquitination of rag A GTPase by RNF152 negatively regulates mTORC1 activation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P49815

5 references

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P49815

8 April 2019

Activity of TSC2 is inhibited by AKT-mediated phosphorylation and membrane partitioning

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P49815

8 April 2019

Interaction between hamartin and tuberin, the TSC1 and TSC2 gene products

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P49815

8 April 2019

Tuberin nuclear localization can be regulated by phosphorylation of its carboxyl terminus

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P49815

8 April 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P49815

3 references

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P49815

8 April 2019

Interaction between hamartin and tuberin, the TSC1 and TSC2 gene products

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P49815

8 April 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P49815

regulation of endocytosis

IBA

biological process

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P49815

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P49815

insulin-like growth factor receptor signaling pathway

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P49815

1 reference

8 April 2019

The tuberous sclerosis 2 gene product, tuberin, functions as a Rab5 GTPase activating protein (GAP) in modulating endocytosis

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P49815

protein import into nucleus

TAS

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P49815

negative regulation of protein kinase activity

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P49815

negative regulation of Wnt signaling pathway

1 reference

8 April 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P49815

negative regulation of phosphatidylinositol 3-kinase signaling

IBA

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P49815

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

regulation of cell cycle

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P49815

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P49815

positive regulation of GTPase activity

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P49815

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P49815

negative regulation of insulin receptor signaling pathway

1 reference

8 April 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P49815

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P49815

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P49815

regulation of small GTPase mediated signal transduction

IEA

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P49815

vesicle-mediated transport

IEA

1 reference

8 April 2019

The tuberous sclerosis 2 gene product, tuberin, functions as a Rab5 GTPase activating protein (GAP) in modulating endocytosis

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P49815

negative regulation of cell population proliferation

TAS

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P49815

regulation of insulin receptor signaling pathway

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P49815

positive regulation of macroautophagy

1 reference

8 April 2019

IκB kinase complex (IKK) triggers detachment-induced autophagy in mammary epithelial cells independently of the PI3K-AKT-MTORC1 pathway

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P49815

1 reference

8 April 2019

IκB kinase complex (IKK) triggers detachment-induced autophagy in mammary epithelial cells independently of the PI3K-AKT-MTORC1 pathway

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P49815

negative regulation of mitophagy

IGI

1 reference

8 April 2019

Epigenetic regulation of autophagy by the methyltransferase EZH2 through an MTOR-dependent pathway

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P49815

protein kinase B signaling

NAS

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P49815

negative regulation of TOR signaling

3 references

8 April 2019

IκB kinase complex (IKK) triggers detachment-induced autophagy in mammary epithelial cells independently of the PI3K-AKT-MTORC1 pathway

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P49815

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P49815

8 April 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P49815

Rap GTPase activating protein domain

IBA

has part(s)

1 reference

Tuberin-type domain

1 reference

Tuberin, N-terminal

1 reference

https://docs.openalex.org/download-snapshot/snapshot-data-format

Identifiers

MeSH descriptor ID

D000077005

subject named as

Tuberous Sclerosis Complex 2 Protein

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1 reference

30 May 2020

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30 May 2020

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30 May 2020

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30 May 2020

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30 May 2020

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30 May 2020

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30 May 2020

1 reference

30 May 2020

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30 May 2020

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30 May 2020

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30 May 2020

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30 May 2020

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30 May 2020

1 reference

30 May 2020

1 reference

30 May 2020

1 reference

30 May 2020

1 reference

30 May 2020

1 reference

30 May 2020

1 reference

30 May 2020

1 reference

13 November 2019

1 reference

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1 reference

1 reference

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1 reference

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1 reference

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1 reference

1 reference

1 reference

0 references

Microsoft Academic ID

0 references

1 reference

26 January 2022

UMLS CUI

C0291147

1 reference

inferred by common MeSH mappings on source and on Wikidata