(Q21113312)

hierarchical database ID heuristic

Transporter Classification Database ID

1.A.9.5.4

Neurotransmitter-gated ion-channel ligand-binding domain superfamily

1 October 2019

part of

1 reference

Gamma-aminobutyric-acid A receptor, beta subunit

1 reference

Neurotransmitter-gated ion-channel transmembrane domain superfamily

1 reference

Transporter Classification Database ID

GABAA receptor

1 reference

1.A.9.5.4

2 October 2019

hierarchical database ID heuristic

Neurotransmitter-gated ion-channel transmembrane domain, protein family

1 reference

inferred from protein domain or family

Neurotransmitter-gated ion-channel ligand-binding domain, protein family

1 reference

inferred from protein domain or family

Neurotransmitter-gated ion-channel, conserved site, protein family

1 reference

inferred from protein domain or family

1 reference

13 November 2019

1 reference

13 November 2019

GABA-A receptor activity

4 references

31 January 2018

The GABAA receptor beta 3 subunit gene: characterization of a human cDNA from chromosome 15q11q13 and mapping to a region of conserved synteny on mouse chromosome 7

http://www.ebi.ac.uk/QuickGO/annotations?protein=P28472&geneProductId=UniProtKB:P28472

31 January 2018

GABRB3 mutation, G32R, associated with childhood absence epilepsy alters α1β3γ2L γ-aminobutyric acid type A (GABAA) receptor expression and channel gating

http://www.ebi.ac.uk/QuickGO/annotations?protein=P28472&geneProductId=UniProtKB:P28472

31 January 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=P28472&geneProductId=UniProtKB:P28472

31 January 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=P28472&geneProductId=UniProtKB:P28472

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P28472

chloride channel activity

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P28472

extracellular ligand-gated ion channel activity

1 reference

31 January 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=P28472&geneProductId=UniProtKB:P28472

GABA-gated chloride ion channel activity

5 references

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P28472

8 April 2019

Epileptic encephalopathy de novo GABRB mutations impair GABAA receptor function

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P28472

8 April 2019

GABRB3 mutation, G32R, associated with childhood absence epilepsy alters α1β3γ2L γ-aminobutyric acid type A (GABAA) receptor expression and channel gating

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P28472

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P28472

8 April 2019

Insensitivity to anaesthetic agents conferred by a class of GABA(A) receptor subunit

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P28472

transmembrane signaling receptor activity

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P28472

The GABAA receptor beta 3 subunit gene: characterization of a human cDNA from chromosome 15q11q13 and mapping to a region of conserved synteny on mouse chromosome 7

GABA-A receptor activity

5 references

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P28472

8 April 2019

GABRB3 mutation, G32R, associated with childhood absence epilepsy alters α1β3γ2L γ-aminobutyric acid type A (GABAA) receptor expression and channel gating

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P28472

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P28472

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P28472

8 April 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P28472

transmitter-gated ion channel activity involved in regulation of postsynaptic membrane potential

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P28472

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P28472

cell component

postsynaptic membrane

1 reference

8 April 2019

2 references

1 reference

31 January 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=P28472&geneProductId=UniProtKB:P28472

integral component of plasma membrane

2 references

31 January 2018

The GABAA receptor beta 3 subunit gene: characterization of a human cDNA from chromosome 15q11q13 and mapping to a region of conserved synteny on mouse chromosome 7

http://www.ebi.ac.uk/QuickGO/annotations?protein=P28472&geneProductId=UniProtKB:P28472

31 January 2018

GABRB3 mutation, G32R, associated with childhood absence epilepsy alters α1β3γ2L γ-aminobutyric acid type A (GABAA) receptor expression and channel gating

http://www.ebi.ac.uk/QuickGO/annotations?protein=P28472&geneProductId=UniProtKB:P28472

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P28472

IMP

chloride channel complex

1 reference

8 April 2019

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P28472

http://www.ebi.ac.uk/QuickGO/annotations?protein=P28472&geneProductId=UniProtKB:P28472

GABA-A receptor complex

5 references

31 January 2018

31 January 2018

GABRB3 mutation, G32R, associated with childhood absence epilepsy alters α1β3γ2L γ-aminobutyric acid type A (GABAA) receptor expression and channel gating

http://www.ebi.ac.uk/QuickGO/annotations?protein=P28472&geneProductId=UniProtKB:P28472

31 January 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=P28472&geneProductId=UniProtKB:P28472

31 January 2018

Epileptic encephalopathy de novo GABRB mutations impair GABAA receptor function

http://www.ebi.ac.uk/QuickGO/annotations?protein=P28472&geneProductId=UniProtKB:P28472

31 January 2018

Insensitivity to anaesthetic agents conferred by a class of GABA(A) receptor subunit

http://www.ebi.ac.uk/QuickGO/annotations?protein=P28472&geneProductId=UniProtKB:P28472

4 references

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P28472

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P28472

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P28472

8 April 2019

Epileptic encephalopathy de novo GABRB mutations impair GABAA receptor function

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P28472

cytoplasmic vesicle membrane

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P28472

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P28472

integral component of plasma membrane

3 references

8 April 2019

The GABAA receptor beta 3 subunit gene: characterization of a human cDNA from chromosome 15q11q13 and mapping to a region of conserved synteny on mouse chromosome 7

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P28472

8 April 2019

GABRB3 mutation, G32R, associated with childhood absence epilepsy alters α1β3γ2L γ-aminobutyric acid type A (GABAA) receptor expression and channel gating

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P28472

8 April 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P28472

1 reference

8 April 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P28472

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P28472

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P28472

GABA-A receptor complex

6 references

8 April 2019

8 April 2019

GABRB3 mutation, G32R, associated with childhood absence epilepsy alters α1β3γ2L γ-aminobutyric acid type A (GABAA) receptor expression and channel gating

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P28472

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P28472

8 April 2019

Epileptic encephalopathy de novo GABRB mutations impair GABAA receptor function

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P28472

8 April 2019

Insensitivity to anaesthetic agents conferred by a class of GABA(A) receptor subunit

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P28472

8 April 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P28472

negative regulation of neuron apoptotic process

biological process

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P28472

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P28472

inhibitory postsynaptic potential

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P28472

regulation of neuron apoptotic process

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P28472

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P28472

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P28472

inner ear receptor cell development

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P28472

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P28472

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P28472

1 reference

31 January 2018

The GABAA receptor beta 3 subunit gene: characterization of a human cDNA from chromosome 15q11q13 and mapping to a region of conserved synteny on mouse chromosome 7

http://www.ebi.ac.uk/QuickGO/annotations?protein=P28472&geneProductId=UniProtKB:P28472

negative regulation of neuron death

TAS

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P28472

cellular response to histamine

1 reference

8 April 2019

Histamine action on vertebrate GABAA receptors: direct channel gating and potentiation of GABA responses

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P28472

chloride transmembrane transport

4 references

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P28472

8 April 2019

GABRB3 mutation, G32R, associated with childhood absence epilepsy alters α1β3γ2L γ-aminobutyric acid type A (GABAA) receptor expression and channel gating

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P28472

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P28472

8 April 2019

Insensitivity to anaesthetic agents conferred by a class of GABA(A) receptor subunit

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P28472

gamma-aminobutyric acid signaling pathway

1 reference

8 April 2019

Epileptic encephalopathy de novo GABRB mutations impair GABAA receptor function

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P28472

ion transmembrane transport

IMP

1 reference

31 January 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=P28472&geneProductId=UniProtKB:P28472

chemical synaptic transmission

1 reference

8 April 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P28472

regulation of membrane potential

1 reference

8 April 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P28472

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

nervous system process

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P28472

physically interacts with

1 reference

IUPHAR/BPS Guide to PHARMACOLOGY

Guide to Pharmacology Ligand ID

7336

language of work or name

17 August 2016

1 reference

IUPHAR/BPS Guide to PHARMACOLOGY

Guide to Pharmacology Ligand ID

4051

language of work or name

17 August 2016

1 reference

14 August 2023

https://platform.opentargets.org/drug/CHEMBL450

1 reference

14 August 2023

https://platform.opentargets.org/drug/CHEMBL1201317

butalbital

1 reference

14 August 2023

https://platform.opentargets.org/drug/CHEMBL454

chlordiazepoxide

1 reference

14 August 2023

https://platform.opentargets.org/drug/CHEMBL451

diazepam

1 reference

14 August 2023

https://platform.opentargets.org/drug/CHEMBL12

prazepam

1 reference

14 August 2023

https://platform.opentargets.org/drug/CHEMBL969

zopiclone

1 reference

14 August 2023

https://platform.opentargets.org/drug/CHEMBL135400

1 reference

14 August 2023

https://platform.opentargets.org/drug/CHEMBL220492

clotiazepam

1 reference

14 August 2023

https://platform.opentargets.org/drug/CHEMBL1697737

allopregnanolone

1 reference

14 August 2023

https://platform.opentargets.org/drug/CHEMBL38856

chlordiazepoxide hydrochloride

1 reference

14 August 2023

https://platform.opentargets.org/drug/CHEMBL1200703

clorazepate dipotassium

1 reference

14 August 2023

https://platform.opentargets.org/drug/CHEMBL2096631

methohexital sodium

1 reference

14 August 2023

https://platform.opentargets.org/drug/CHEMBL30219

pentobarbital sodium

1 reference

14 August 2023

https://platform.opentargets.org/drug/CHEMBL971

has part(s)

Neurotransmitter-gated ion-channel transmembrane domain

1 reference

Neurotransmitter-gated ion-channel ligand-binding domain

1 reference

Neurotransmitter-gated ion-channel, conserved site

1 reference

Transporter Classification Database ID

Identifiers

1 reference

30 May 2020

1 reference

30 May 2020

1 reference

30 May 2020

1 reference

30 May 2020

1 reference

30 May 2020

1 reference

30 May 2020

1 reference

13 November 2019

1 reference

1 reference

1 reference

1 reference

1 reference

1 reference

1 reference

1 reference

1 reference

1 reference

1 reference

1 reference

1 reference

1 reference

4 August 2016

language of work or name

English

1.A.9.5.4

2 references

Transporter Classification database

13 March 2020

Transporter Classification database