(Q21113470)

English

Junctophilin 2

mammalian protein found in Homo sapiens

JPH2
junctophilin-2
junctophilin type 2

In more languages

Statements

1 reference

13 November 2019

UniProt protein ID

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/Q9BR39

1 reference

13 November 2019

UniProt protein ID

1 reference

13 November 2019

UniProt protein ID

molecular function

phosphatidic acid binding

determination method

1 reference

8 April 2019

Human junctophilin-2 undergoes a structural rearrangement upon binding PtdIns(3,4,5)P3 and the S101R mutation identified in hypertrophic cardiomyopathy obviates this response

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9BR39

determination method

phosphatidylinositol-4-phosphate binding

determination method

1 reference

8 April 2019

Human junctophilin-2 undergoes a structural rearrangement upon binding PtdIns(3,4,5)P3 and the S101R mutation identified in hypertrophic cardiomyopathy obviates this response

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9BR39

determination method

phosphatidylinositol-5-phosphate binding

determination method

1 reference

8 April 2019

Human junctophilin-2 undergoes a structural rearrangement upon binding PtdIns(3,4,5)P3 and the S101R mutation identified in hypertrophic cardiomyopathy obviates this response

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9BR39

determination method

phosphatidylserine binding

determination method

1 reference

8 April 2019

Human junctophilin-2 undergoes a structural rearrangement upon binding PtdIns(3,4,5)P3 and the S101R mutation identified in hypertrophic cardiomyopathy obviates this response

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9BR39

determination method

phosphatidylinositol-3,4,5-trisphosphate binding

determination method

1 reference

8 April 2019

Human junctophilin-2 undergoes a structural rearrangement upon binding PtdIns(3,4,5)P3 and the S101R mutation identified in hypertrophic cardiomyopathy obviates this response

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9BR39

determination method

protein binding

determination method

1 reference

8 April 2019

S165F mutation of junctophilin 2 affects Ca2+ signalling in skeletal muscle

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9BR39

determination method

phosphatidylinositol-3,5-bisphosphate binding

determination method

1 reference

8 April 2019

Human junctophilin-2 undergoes a structural rearrangement upon binding PtdIns(3,4,5)P3 and the S101R mutation identified in hypertrophic cardiomyopathy obviates this response

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9BR39

determination method

phosphatidylinositol-4,5-bisphosphate binding

determination method

1 reference

8 April 2019

Human junctophilin-2 undergoes a structural rearrangement upon binding PtdIns(3,4,5)P3 and the S101R mutation identified in hypertrophic cardiomyopathy obviates this response

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9BR39

determination method

phosphatidylinositol-3-phosphate binding

determination method

1 reference

8 April 2019

Human junctophilin-2 undergoes a structural rearrangement upon binding PtdIns(3,4,5)P3 and the S101R mutation identified in hypertrophic cardiomyopathy obviates this response

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9BR39

determination method

calcium-release channel activity

determination method

3 references

10 September 2018

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q9BR39&geneProductId=UniProtKB:Q9BR39

determination method

10 September 2018

S165F mutation of junctophilin 2 affects Ca2+ signalling in skeletal muscle

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q9BR39&geneProductId=UniProtKB:Q9BR39

determination method

10 September 2018

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q9BR39&geneProductId=UniProtKB:Q9BR39

determination method

determination method

1 reference

8 April 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9BR39

determination method

integral component of membrane

determination method

1 reference

8 April 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9BR39

determination method

sarcoplasmic reticulum membrane

determination method

1 reference

8 April 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9BR39

determination method

endoplasmic reticulum

determination method

1 reference

27 March 2018

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q9BR39&geneProductId=UniProtKB:Q9BR39

determination method

plasma membrane

determination method

1 reference

27 March 2018

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q9BR39&geneProductId=UniProtKB:Q9BR39

determination method

junctional sarcoplasmic reticulum membrane

determination method

1 reference

8 April 2019

New molecular components supporting ryanodine receptor-mediated Ca(2+) release: roles of junctophilin and TRIC channel in embryonic cardiomyocytes

British Heart Foundation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9BR39

determination method

determination method

1 reference

8 April 2019

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9BR39

determination method

endoplasmic reticulum membrane

determination method

1 reference

27 March 2018

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q9BR39&geneProductId=UniProtKB:Q9BR39

determination method

sarcoplasmic reticulum

determination method

3 references

junctional membrane complex

determination method

determination method

1 reference

8 April 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9BR39

determination method

biological process

regulation of cardiac muscle tissue development

determination method

1 reference

8 April 2019

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9BR39

determination method

calcium ion transport into cytosol

determination method

1 reference

8 April 2019

New molecular components supporting ryanodine receptor-mediated Ca(2+) release: roles of junctophilin and TRIC channel in embryonic cardiomyocytes

British Heart Foundation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9BR39

determination method

positive regulation of cytosolic calcium ion concentration

determination method

1 reference

8 April 2019

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9BR39

determination method

positive regulation of ryanodine-sensitive calcium-release channel activity

determination method

1 reference

8 April 2019

S165F mutation of junctophilin 2 affects Ca2+ signalling in skeletal muscle

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9BR39

determination method

calcium ion homeostasis

determination method

1 reference

8 April 2019

S165F mutation of junctophilin 2 affects Ca2+ signalling in skeletal muscle

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9BR39

determination method

regulation of ryanodine-sensitive calcium-release channel activity

determination method

1 reference

8 April 2019

New molecular components supporting ryanodine receptor-mediated Ca(2+) release: roles of junctophilin and TRIC channel in embryonic cardiomyocytes

British Heart Foundation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9BR39

determination method

release of sequestered calcium ion into cytosol

determination method

1 reference

8 April 2019

Gene Ontology Consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9BR39

determination method

multicellular organism development

determination method

1 reference

8 April 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9BR39

determination method

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/Q9BR39

Identifiers

RefSeq protein ID

1 reference

30 May 2020

1 reference

30 May 2020

1 reference

30 May 2020

UniProt protein ID

1 reference

13 November 2019

UniProt protein ID

Ensembl protein ID

ENSP00000344590

1 reference

Ensembl Release 99

Ensembl protein ID

ENSP00000344590

ENSP00000362071

1 reference

Ensembl Release 99

Ensembl protein ID

ENSP00000362071

Sitelinks

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Wikinews(0 entries)

Wikiquote(0 entries)

Wikisource(0 entries)

Wikiversity(0 entries)

Wikivoyage(0 entries)

Wiktionary(0 entries)

Multilingual sites(0 entries)

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