(Q21114780)

http://www.ebi.ac.uk/interpro/protein/Q96AZ6

Ribonuclease H-like superfamily

1 reference

stated in

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/Q96AZ6

Exonuclease, RNase T/DNA polymerase III family

1 reference

based on heuristic

inferred from protein domain or family

1 reference

13 November 2019

1 reference

13 November 2019

3'-5'-exoribonuclease activity

1 reference

9 May 2019

The human interferon- and estrogen-regulated ISG20/HEM45 gene product degrades single-stranded RNA and DNA in vitro

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q96AZ6

single-stranded DNA 3'-5' exodeoxyribonuclease activity

1 reference

9 May 2019

The human interferon- and estrogen-regulated ISG20/HEM45 gene product degrades single-stranded RNA and DNA in vitro

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q96AZ6

exoribonuclease II activity

1 reference

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q96AZ6

1 reference

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q96AZ6

1 reference

9 May 2019

The exonuclease ISG20 mainly localizes in the nucleolus and the Cajal (Coiled) bodies and is associated with nuclear SMN protein-containing complexes

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q96AZ6

1 reference

9 May 2019

The exonuclease ISG20 mainly localizes in the nucleolus and the Cajal (Coiled) bodies and is associated with nuclear SMN protein-containing complexes

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q96AZ6

1 reference

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q96AZ6

1 reference

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q96AZ6

1 reference

9 May 2019

The exonuclease ISG20 mainly localizes in the nucleolus and the Cajal (Coiled) bodies and is associated with nuclear SMN protein-containing complexes

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q96AZ6

1 reference

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q96AZ6

1 reference

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q96AZ6

3 references

9 May 2019

Antiviral activities of ISG20 in positive-strand RNA virus infections

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q96AZ6

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q96AZ6

9 May 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q96AZ6

3 references

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q96AZ6

9 May 2019

Antiviral activities of ISG20 in positive-strand RNA virus infections

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q96AZ6

9 May 2019

The exonuclease ISG20 mainly localizes in the nucleolus and the Cajal (Coiled) bodies and is associated with nuclear SMN protein-containing complexes

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q96AZ6

1 reference

9 May 2019

Molecular cloning of a new interferon-induced PML nuclear body-associated protein

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q96AZ6

3 references

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q96AZ6

9 May 2019

Antiviral activities of ISG20 in positive-strand RNA virus infections

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q96AZ6

9 May 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q96AZ6

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q96AZ6

IBA

biological process

immune system process

1 reference

9 May 2019

1 reference

9 May 2019

ISG20, a new interferon-induced RNase specific for single-stranded RNA, defines an alternative antiviral pathway against RNA genomic viruses

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q96AZ6

The human interferon- and estrogen-regulated ISG20/HEM45 gene product degrades single-stranded RNA and DNA in vitro

RNA catabolic process

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q96AZ6

negative regulation of viral genome replication

1 reference

8 April 2019

Antiviral activities of ISG20 in positive-strand RNA virus infections

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q96AZ6

DNA catabolic process, exonucleolytic

IMP

1 reference

8 April 2019

The human interferon- and estrogen-regulated ISG20/HEM45 gene product degrades single-stranded RNA and DNA in vitro

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q96AZ6

type I interferon signaling pathway

1 reference

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q96AZ6

1 reference

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q96AZ6

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q96AZ6

IEA

innate immune response

1 reference

9 May 2019

cell population proliferation

IEA

1 reference

1 January 2018

Expression and estrogen regulation of the HEM45 MRNA in human tumor lines and in the rat uterus

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q96AZ6

RNA phosphodiester bond hydrolysis, exonucleolytic

TAS

1 reference

9 May 2019

Gene Ontology Consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q96AZ6

defense response to virus

IEA

3 references

9 May 2019

Antiviral activities of ISG20 in positive-strand RNA virus infections

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q96AZ6

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q96AZ6

9 May 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q96AZ6

Exonuclease, RNase T/DNA polymerase III

IBA

has part(s)

1 reference

stated in

InterPro Release 71.0