(Q21115385)

http://www.ebi.ac.uk/interpro/protein/Q03135

auxiliary protein involved in transmembrane transport

1 reference

Transporter Classification Database ID

8.A.26.1.1

retrieved

2 October 2019

based on heuristic

hierarchical database ID heuristic

Caveolin, conserved site, protein family

1 reference

based on heuristic

inferred from protein domain or family

1 reference

13 November 2019

1 reference

13 November 2019

protein-macromolecule adaptor activity

1 reference

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q03135

transmembrane transporter binding

1 reference

31 October 2017

The regulation of the cardiac potassium channel (HERG) by caveolin-1

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q03135&geneProductId=UniProtKB:Q03135

structural molecule activity

1 reference

31 October 2017

Identification and characterization of a novel human plant pathogenesis-related protein that localizes to lipid-enriched microdomains in the Golgi complex

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q03135&geneProductId=UniProtKB:Q03135

signaling receptor binding

1 reference

9 May 2019

Caveolin is necessary for Wnt-3a-dependent internalization of LRP6 and accumulation of beta-catenin

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q03135

1 reference

9 May 2019

The sonic hedgehog receptor patched associates with caveolin-1 in cholesterol-rich microdomains of the plasma membrane

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q03135

1 reference

9 May 2019

The role of prostacyclin synthase and thromboxane synthase signaling in the development and progression of cancer

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q03135

40 references

9 May 2019

Syntenin regulates TGF-β1-induced Smad activation and the epithelial-to-mesenchymal transition by inhibiting caveolin-mediated TGF-β type I receptor internalization

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q03135

9 May 2019

Cavin3 interacts with cavin1 and caveolin1 to increase surface dynamics of caveolae.

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q03135

9 May 2019

Interaction of deleted in liver cancer 1 with tensin2 in caveolae and implications in tumor suppression

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q03135

9 May 2019

MLC1 trafficking and membrane expression in astrocytes: role of caveolin-1 and phosphorylation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q03135

9 May 2019

Endolysosomal sorting of ubiquitylated caveolin-1 is regulated by VCP and UBXD1 and impaired by VCP disease mutations

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q03135

9 May 2019

Caveolin-1 triggers T-cell activation via CD26 in association with CARMA1

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q03135

9 May 2019

Caveolin-1 interacts with Derlin-1 and promotes ubiquitination and degradation of cyclooxygenase-2 via collaboration with p97 complex

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q03135

9 May 2019

Caveolin is necessary for Wnt-3a-dependent internalization of LRP6 and accumulation of beta-catenin

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q03135

9 May 2019

Caveolin-1 mediates Fas-BID signaling in hyperoxia-induced apoptosis

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q03135

9 May 2019

Some protein tyrosine phosphatases target in part to lipid rafts and interact with caveolin-1

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q03135

9 May 2019

Molecular composition and ultrastructure of the caveolar coat complex

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q03135

9 May 2019

Activation of TRPC1 by STIM1 in ER-PM microdomains involves release of the channel from its scaffold caveolin-1.

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q03135

9 May 2019

Inhibition of thioredoxin reductase 1 by caveolin 1 promotes stress-induced premature senescence

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q03135

9 May 2019

SRBC/cavin-3 is a caveolin adapter protein that regulates caveolae function

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q03135

9 May 2019

The regulation of the cardiac potassium channel (HERG) by caveolin-1

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q03135

9 May 2019

The Niemann-Pick C1 and caveolin-1 proteins interact to modulate efflux of low density lipoprotein-derived cholesterol from late endocytic compartments

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q03135

9 May 2019

Caveolin-1 mediates Salmonella invasion via the regulation of SopE-dependent Rac1 activation and actin reorganization

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q03135

9 May 2019

TLR4-mediated expulsion of bacteria from infected bladder epithelial cells

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q03135

9 May 2019

Phosphotyrosine signaling networks in epidermal growth factor receptor overexpressing squamous carcinoma cells

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q03135

9 May 2019

Dynamic profiling of the post-translational modifications and interaction partners of epidermal growth factor receptor signaling after stimulation by epidermal growth factor using Extended Range Proteomic Analysis (ERPA)

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q03135

9 May 2019

Caveolin-1 regulates Mcl-1 stability and anoikis in lung carcinoma cells

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q03135

9 May 2019

Identification of a novel inhibitor of differentiation-1 (ID-1) binding partner, caveolin-1, and its role in epithelial-mesenchymal transition and resistance to apoptosis in prostate cancer cells

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q03135

9 May 2019

Hypoxia promotes ligand-independent EGF receptor signaling via hypoxia-inducible factor-mediated upregulation of caveolin-1

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q03135

9 May 2019

Autophagy protein microtubule-associated protein 1 light chain-3B (LC3B) activates extrinsic apoptosis during cigarette smoke-induced emphysema

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q03135

9 May 2019

Identification of phosphocaveolin-1 as a novel protein tyrosine phosphatase 1B substrate

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q03135

9 May 2019

Tyrosine-phosphorylated caveolin-1 blocks bacterial uptake by inducing Vav2-RhoA-mediated cytoskeletal rearrangements

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q03135

9 May 2019

The mammalian-membrane two-hybrid assay (MaMTH) for probing membrane-protein interactions in human cells

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q03135

9 May 2019

Flotillins/cavatellins are differentially expressed in cells and tissues and form a hetero-oligomeric complex with caveolins in vivo. Characterization and epitope-mapping of a novel flotillin-1 monoclonal antibody probe

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q03135

9 May 2019

Membrane glucocorticoid receptor activation induces proteomic changes aligning with classical glucocorticoid effects

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q03135

9 May 2019

Tyrosine phosphorylation of caveolin-2 at residue 27: differences in the spatial and temporal behavior of phospho-Cav-2 (pY19 and pY27).

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q03135

9 May 2019

Constitutive and growth factor-regulated phosphorylation of caveolin-1 occurs at the same site (Tyr-14) in vivo: identification of a c-Src/Cav-1/Grb7 signaling cassette

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q03135

9 May 2019

Sterol carrier protein-2 directly interacts with caveolin-1 in vitro and in vivo

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q03135

9 May 2019

New host factors important for respiratory syncytial virus (RSV) replication revealed by a novel microfluidics screen for interactors of matrix (M) protein

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q03135

9 May 2019

Factor X/Xa elicits protective signaling responses in endothelial cells directly via PAR-2 and indirectly via endothelial protein C receptor-dependent recruitment of PAR-1

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q03135

9 May 2019

BENE, a novel raft-associated protein of the MAL proteolipid family, interacts with caveolin-1 in human endothelial-like ECV304 cells

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q03135

9 May 2019

Maxi-K channels localize to caveolae in human myometrium: a role for an actin-channel-caveolin complex in the regulation of myometrial smooth muscle K+ current

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q03135

9 May 2019

Caveolin-1 scaffold domain interacts with TRPC1 and IP3R3 to regulate Ca2+ store release-induced Ca2+ entry in endothelial cells

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q03135

9 May 2019

Tissue factor induction by protease-activated receptor 1 requires intact caveolin-enriched membrane microdomains in human endothelial cells

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q03135

9 May 2019

New host factors important for respiratory syncytial virus (RSV) replication revealed by a novel microfluidics screen for interactors of matrix (M) protein

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q03135

9 May 2019

Caveolin-1 mediates Salmonella invasion via the regulation of SopE-dependent Rac1 activation and actin reorganization

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q03135

molecular adaptor activity

4 references

31 October 2017

Caveolin-1 scaffold domain interacts with TRPC1 and IP3R3 to regulate Ca2+ store release-induced Ca2+ entry in endothelial cells

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q03135&geneProductId=UniProtKB:Q03135

31 October 2017

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q03135&geneProductId=UniProtKB:Q03135

9 May 2019

Caveolin-1 scaffold domain interacts with TRPC1 and IP3R3 to regulate Ca2+ store release-induced Ca2+ entry in endothelial cells

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q03135

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q03135

1 reference

9 May 2019

Caveolin-1 interacts with Derlin-1 and promotes ubiquitination and degradation of cyclooxygenase-2 via collaboration with p97 complex

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q03135

1 reference

9 May 2019

BENE, a novel raft-associated protein of the MAL proteolipid family, interacts with caveolin-1 in human endothelial-like ECV304 cells

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q03135

inward rectifier potassium channel inhibitor activity

1 reference

9 May 2019

The regulation of the cardiac potassium channel (HERG) by caveolin-1

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q03135

identical protein binding

1 reference

9 May 2019

Nitrosation-dependent caveolin 1 phosphorylation, ubiquitination, and degradation and its association with idiopathic pulmonary arterial hypertension

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q03135

protein heterodimerization activity

1 reference

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q03135

structural molecule activity

Nitrosation-dependent caveolin 1 phosphorylation, ubiquitination, and degradation and its association with idiopathic pulmonary arterial hypertension

protein kinase binding

3 references

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q03135

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q03135

9 May 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q03135

molecular adaptor activity

6 references

1 January 2018

Caveolin-1 scaffold domain interacts with TRPC1 and IP3R3 to regulate Ca2+ store release-induced Ca2+ entry in endothelial cells

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q03135

1 January 2018

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q03135

1 January 2018

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q03135

8 April 2019

Caveolin-1 scaffold domain interacts with TRPC1 and IP3R3 to regulate Ca2+ store release-induced Ca2+ entry in endothelial cells

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q03135

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q03135

8 April 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q03135

structural molecule activity

1 reference

9 May 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q03135

protein-containing complex binding

1 reference

9 May 2019

Caveolin-1 interacts with Derlin-1 and promotes ubiquitination and degradation of cyclooxygenase-2 via collaboration with p97 complex

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q03135

endocytic vesicle membrane

cell component

1 reference

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q03135

1 reference

9 May 2019

A protein interaction network for Ecm29 links the 26 S proteasome to molecular motors and endosomal components

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q03135

3 references

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q03135

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q03135

9 May 2019

Caveolin-1 mediates Salmonella invasion via the regulation of SopE-dependent Rac1 activation and actin reorganization

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q03135

3 references

31 October 2017

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q03135&geneProductId=UniProtKB:Q03135

31 October 2017

Analysis of the myosin-II-responsive focal adhesion proteome reveals a role for β-Pix in negative regulation of focal adhesion maturation

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q03135&geneProductId=UniProtKB:Q03135

31 October 2017

Src-induced phosphorylation of caveolin-2 on tyrosine 19. Phospho-caveolin-2 (Tyr(P)19) is localized near focal adhesions, remains associated with lipid rafts/caveolae, but no longer forms a high molecular mass hetero-oligomer with caveolin-1

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q03135&geneProductId=UniProtKB:Q03135

VCP-NPL4-UFD1 AAA ATPase complex

1 reference

8 April 2019

Caveolin-1 interacts with Derlin-1 and promotes ubiquitination and degradation of cyclooxygenase-2 via collaboration with p97 complex

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q03135

perinuclear region of cytoplasm

3 references

31 October 2017

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q03135&geneProductId=UniProtKB:Q03135

31 October 2017

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q03135&geneProductId=UniProtKB:Q03135

31 October 2017

MLC1 trafficking and membrane expression in astrocytes: role of caveolin-1 and phosphorylation

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q03135&geneProductId=UniProtKB:Q03135

11 references

31 October 2017

Dynamics and interaction of caveolin-1 isoforms with BMP-receptors

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q03135&geneProductId=UniProtKB:Q03135

31 October 2017

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q03135&geneProductId=UniProtKB:Q03135

31 October 2017

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q03135&geneProductId=UniProtKB:Q03135

31 October 2017

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q03135&geneProductId=UniProtKB:Q03135

31 October 2017

SDPR induces membrane curvature and functions in the formation of caveolae

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q03135&geneProductId=UniProtKB:Q03135

31 October 2017

N-terminal processing and modifications of caveolin-1 in caveolae from human adipocytes

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q03135&geneProductId=UniProtKB:Q03135

31 October 2017

Caveolin-1 and caveolin-3 form heterooligomeric complexes in atrial cardiac myocytes that are required for doxorubicin-induced apoptosis

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q03135&geneProductId=UniProtKB:Q03135

31 October 2017

Molecular composition and ultrastructure of the caveolar coat complex

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q03135&geneProductId=UniProtKB:Q03135

31 October 2017

Maxi-K channels localize to caveolae in human myometrium: a role for an actin-channel-caveolin complex in the regulation of myometrial smooth muscle K+ current

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q03135&geneProductId=UniProtKB:Q03135

31 October 2017

Serine 23 and 36 phosphorylation of caveolin-2 is differentially regulated by targeting to lipid raft/caveolae and in mitotic endothelial cells

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q03135&geneProductId=UniProtKB:Q03135

31 October 2017

New host factors important for respiratory syncytial virus (RSV) replication revealed by a novel microfluidics screen for interactors of matrix (M) protein

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q03135&geneProductId=UniProtKB:Q03135

1 reference

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q03135

Caveolin-1 and -2 in airway epithelium: expression and in situ association as detected by FRET-CLSM

apical plasma membrane

1 reference

31 October 2017

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q03135&geneProductId=UniProtKB:Q03135

9 references

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q03135

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q03135

9 May 2019

Caveolin-1 mediates Fas-BID signaling in hyperoxia-induced apoptosis

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q03135

9 May 2019

Flotillin-1 facilitates toll-like receptor 3 signaling in human endothelial cells

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q03135

9 May 2019

Syntenin regulates TGF-β1-induced Smad activation and the epithelial-to-mesenchymal transition by inhibiting caveolin-mediated TGF-β type I receptor internalization

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q03135

9 May 2019

The myosin motor Myo1c is required for VEGFR2 delivery to the cell surface and for angiogenic signaling

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q03135

9 May 2019

BENE, a novel raft-associated protein of the MAL proteolipid family, interacts with caveolin-1 in human endothelial-like ECV304 cells

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q03135

9 May 2019

Association of the calpain/calpastatin network with subcellular organelles

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q03135

9 May 2019

The shedding activity of ADAM17 is sequestered in lipid rafts

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q03135

integral component of membrane

1 reference

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q03135

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q03135

early endosome membrane

1 reference

9 May 2019

5 references

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q03135

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q03135

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q03135

9 May 2019

The myosin motor Myo1c is required for VEGFR2 delivery to the cell surface and for angiogenic signaling

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q03135

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q03135

intracellular anatomical structure

1 reference

31 October 2017

Maxi-K channels localize to caveolae in human myometrium: a role for an actin-channel-caveolin complex in the regulation of myometrial smooth muscle K+ current

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q03135&geneProductId=UniProtKB:Q03135

1 reference

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q03135

endoplasmic reticulum membrane

1 reference

9 May 2019

Caveolin-1 interacts with Derlin-1 and promotes ubiquitination and degradation of cyclooxygenase-2 via collaboration with p97 complex

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q03135

3 references

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q03135

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q03135

9 May 2019

BENE, a novel raft-associated protein of the MAL proteolipid family, interacts with caveolin-1 in human endothelial-like ECV304 cells

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q03135

integral component of plasma membrane

1 reference

31 October 2017

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q03135&geneProductId=UniProtKB:Q03135

1 reference

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q03135

basolateral plasma membrane

1 reference

31 October 2017

Caveolin-1 and -2 in airway epithelium: expression and in situ association as detected by FRET-CLSM

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q03135&geneProductId=UniProtKB:Q03135

1 reference

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q03135

1 reference

9 May 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q03135

3 references

11 references

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q03135

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q03135

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q03135

9 May 2019

SDPR induces membrane curvature and functions in the formation of caveolae

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q03135

9 May 2019

N-terminal processing and modifications of caveolin-1 in caveolae from human adipocytes

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q03135

9 May 2019

Molecular composition and ultrastructure of the caveolar coat complex

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q03135

9 May 2019

Caveolin-1 and caveolin-3 form heterooligomeric complexes in atrial cardiac myocytes that are required for doxorubicin-induced apoptosis

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q03135

9 May 2019

Maxi-K channels localize to caveolae in human myometrium: a role for an actin-channel-caveolin complex in the regulation of myometrial smooth muscle K+ current

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q03135

9 May 2019

Serine 23 and 36 phosphorylation of caveolin-2 is differentially regulated by targeting to lipid raft/caveolae and in mitotic endothelial cells

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q03135

9 May 2019

New host factors important for respiratory syncytial virus (RSV) replication revealed by a novel microfluidics screen for interactors of matrix (M) protein

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q03135

9 May 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q03135

4 references

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q03135

9 May 2019

Src-induced phosphorylation of caveolin-2 on tyrosine 19. Phospho-caveolin-2 (Tyr(P)19) is localized near focal adhesions, remains associated with lipid rafts/caveolae, but no longer forms a high molecular mass hetero-oligomer with caveolin-1

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q03135

9 May 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q03135

9 May 2019

Analysis of the myosin-II-responsive focal adhesion proteome reveals a role for β-Pix in negative regulation of focal adhesion maturation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q03135

3 references

9 May 2019

MLC1 trafficking and membrane expression in astrocytes: role of caveolin-1 and phosphorylation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q03135

9 May 2019

The E3-ubiquitin ligase TRIM50 interacts with HDAC6 and p62, and promotes the sequestration and clearance of ubiquitinated proteins into the aggresome

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q03135

9 May 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q03135

protein-containing complex

4 references

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q03135

9 May 2019

Endolysosomal sorting of ubiquitylated caveolin-1 is regulated by VCP and UBXD1 and impaired by VCP disease mutations

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q03135

9 May 2019

Molecular composition and ultrastructure of the caveolar coat complex

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q03135

9 May 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q03135

1 reference

9 May 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q03135

perinuclear region of cytoplasm

4 references

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q03135

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q03135

9 May 2019

MLC1 trafficking and membrane expression in astrocytes: role of caveolin-1 and phosphorylation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q03135

9 May 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q03135

caveolin-mediated endocytosis

biological process

1 reference

9 May 2019

MLC1 trafficking and membrane expression in astrocytes: role of caveolin-1 and phosphorylation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q03135

1 reference

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q03135

Caveolin-1-deficient mice show accelerated mammary gland development during pregnancy, premature lactation, and hyperactivation of the Jak-2/STAT5a signaling cascade.

response to progesterone

1 reference

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q03135

negative regulation of protein binding

1 reference

9 May 2019

Caveolin is necessary for Wnt-3a-dependent internalization of LRP6 and accumulation of beta-catenin

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q03135

protein localization to plasma membrane raft

1 reference

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q03135

negative regulation of pinocytosis

1 reference

9 May 2019

Prominin-2 expression increases protrusions, decreases caveolae and inhibits Cdc42 dependent fluid phase endocytosis

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q03135

1 reference

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q03135

1 reference

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q03135

apoptotic signaling pathway

1 reference

9 May 2019

Caveolin-1 mediates Fas-BID signaling in hyperoxia-induced apoptosis

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q03135

positive regulation of extrinsic apoptotic signaling pathway

1 reference

9 May 2019

Caveolin-1 mediates Fas-BID signaling in hyperoxia-induced apoptosis

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q03135

BENE, a novel raft-associated protein of the MAL proteolipid family, interacts with caveolin-1 in human endothelial-like ECV304 cells

cholesterol homeostasis

3 references

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q03135

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q03135

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q03135

negative regulation of cell population proliferation

1 reference

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q03135

cellular response to transforming growth factor beta stimulus

1 reference

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q03135

positive regulation of toll-like receptor 3 signaling pathway

1 reference

9 May 2019

Flotillin-1 facilitates toll-like receptor 3 signaling in human endothelial cells

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q03135

regulation of cytosolic calcium ion concentration

1 reference

9 May 2019

Caveolin-1 scaffold domain interacts with TRPC1 and IP3R3 to regulate Ca2+ store release-induced Ca2+ entry in endothelial cells

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q03135

1 reference

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q03135

regulation of cardiac muscle cell action potential involved in regulation of contraction

1 reference

9 May 2019

The regulation of the cardiac potassium channel (HERG) by caveolin-1

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q03135

negative regulation of transforming growth factor beta receptor signaling pathway

IC

1 reference

9 May 2019

Syntenin regulates TGF-β1-induced Smad activation and the epithelial-to-mesenchymal transition by inhibiting caveolin-mediated TGF-β type I receptor internalization

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q03135

protein localization to basolateral plasma membrane

1 reference

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q03135

receptor internalization involved in canonical Wnt signaling pathway

1 reference

9 May 2019

Caveolin is necessary for Wnt-3a-dependent internalization of LRP6 and accumulation of beta-catenin

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q03135

regulation of membrane repolarization during action potential

1 reference

9 May 2019

The regulation of the cardiac potassium channel (HERG) by caveolin-1

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q03135

positive regulation of peptidyl-serine phosphorylation

1 reference

9 May 2019

Serine 23 and 36 phosphorylation of caveolin-2 is differentially regulated by targeting to lipid raft/caveolae and in mitotic endothelial cells

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q03135

regulation of entry of bacterium into host cell

1 reference

9 May 2019

Caveolin-1 mediates Salmonella invasion via the regulation of SopE-dependent Rac1 activation and actin reorganization

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q03135

negative regulation of MAP kinase activity

1 reference

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q03135

negative regulation of potassium ion transmembrane transport

1 reference

9 May 2019

The regulation of the cardiac potassium channel (HERG) by caveolin-1

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q03135

1 reference

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q03135

receptor-mediated endocytosis of virus by host cell

1 reference

9 May 2019

The Tyro3 receptor kinase Axl enhances macropinocytosis of Zaire ebolavirus

Community Assessment of Community Annotation with Ontologies

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q03135

regulation of blood coagulation

IGI

1 reference

9 May 2019

Tissue factor induction by protease-activated receptor 1 requires intact caveolin-enriched membrane microdomains in human endothelial cells

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q03135

1 reference

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q03135

positive regulation of intrinsic apoptotic signaling pathway

1 reference

9 May 2019

Caveolin-1 mediates Fas-BID signaling in hyperoxia-induced apoptosis

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q03135

negative regulation of necroptotic process

1 reference

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q03135

regulation of the force of heart contraction

1 reference

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q03135

negative regulation of cytokine-mediated signaling pathway

1 reference

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q03135

cellular response to exogenous dsRNA

1 reference

9 May 2019

Flotillin-1 facilitates toll-like receptor 3 signaling in human endothelial cells

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q03135

regulation of ruffle assembly

1 reference

9 May 2019

Caveolin-1 mediates Salmonella invasion via the regulation of SopE-dependent Rac1 activation and actin reorganization

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q03135

positive regulation of protein binding

1 reference

9 May 2019

Caveolin-1 interacts with Derlin-1 and promotes ubiquitination and degradation of cyclooxygenase-2 via collaboration with p97 complex

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q03135

positive regulation of protein ubiquitination

1 reference

9 May 2019

Caveolin-1 interacts with Derlin-1 and promotes ubiquitination and degradation of cyclooxygenase-2 via collaboration with p97 complex

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q03135

1 reference

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q03135

positive regulation of cell adhesion molecule production

1 reference

9 May 2019

Flotillin-1 facilitates toll-like receptor 3 signaling in human endothelial cells

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q03135

negative regulation of nitric-oxide synthase activity

1 reference

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q03135

Caveolin-1 mediates Salmonella invasion via the regulation of SopE-dependent Rac1 activation and actin reorganization

response to bacterium

1 reference

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q03135

5 references

31 October 2017

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q03135&geneProductId=UniProtKB:Q03135

31 October 2017

Involvement of caveolin-2 in caveolar biogenesis in MDCK cells

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q03135&geneProductId=UniProtKB:Q03135

31 October 2017

Nitrosation-dependent caveolin 1 phosphorylation, ubiquitination, and degradation and its association with idiopathic pulmonary arterial hypertension

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q03135&geneProductId=UniProtKB:Q03135

31 October 2017

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q03135&geneProductId=UniProtKB:Q03135

31 October 2017

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q03135&geneProductId=UniProtKB:Q03135

cellular response to hyperoxia

1 reference

9 May 2019

Caveolin-1 mediates Fas-BID signaling in hyperoxia-induced apoptosis

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q03135

BENE, a novel raft-associated protein of the MAL proteolipid family, interacts with caveolin-1 in human endothelial-like ECV304 cells

cholesterol transport

1 reference

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q03135

cellular response to starvation

1 reference

31 October 2017

Dynamics and interaction of caveolin-1 isoforms with BMP-receptors

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q03135&geneProductId=UniProtKB:Q03135

1 reference

9 May 2019

Caveolin-1 triggers T-cell activation via CD26 in association with CARMA1

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q03135

regulation of nitric-oxide synthase activity

1 reference

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q03135

Syntenin regulates TGF-β1-induced Smad activation and the epithelial-to-mesenchymal transition by inhibiting caveolin-mediated TGF-β type I receptor internalization

receptor internalization

1 reference

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q03135

positive regulation of peptidase activity

1 reference

9 May 2019

Gene Ontology Consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q03135

positive regulation of ER-associated ubiquitin-dependent protein catabolic process

1 reference

9 May 2019

Caveolin-1 interacts with Derlin-1 and promotes ubiquitination and degradation of cyclooxygenase-2 via collaboration with p97 complex

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q03135

negative regulation of BMP signaling pathway

IC

1 reference

31 October 2017

Dynamics and interaction of caveolin-1 isoforms with BMP-receptors

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q03135&geneProductId=UniProtKB:Q03135

positive regulation of gene expression

1 reference

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q03135

protein complex oligomerization

1 reference

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q03135

negative regulation of peptidyl-serine phosphorylation

1 reference

9 May 2019

Serine 23 and 36 phosphorylation of caveolin-2 is differentially regulated by targeting to lipid raft/caveolae and in mitotic endothelial cells

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q03135

posttranscriptional regulation of gene expression

1 reference

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q03135

maintenance of protein location in cell

1 reference

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q03135

negative regulation of signal transduction

1 reference

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q03135

regulation of the force of heart contraction by chemical signal

1 reference

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q03135

beta-catenin destruction complex disassembly

1 reference

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q03135

positive regulation of canonical Wnt signaling pathway

1 reference

9 May 2019

Caveolin is necessary for Wnt-3a-dependent internalization of LRP6 and accumulation of beta-catenin

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q03135

negative regulation of tyrosine phosphorylation of STAT protein

1 reference

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q03135

negative regulation of inward rectifier potassium channel activity

1 reference

9 May 2019

The regulation of the cardiac potassium channel (HERG) by caveolin-1

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q03135

negative regulation of endothelial cell proliferation

cellular calcium ion homeostasis

1 reference

9 May 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q03135

positive regulation of cell migration

1 reference

9 May 2019

Caveolin-1 mediates tumor cell migration and invasion and its regulation by miR-133a in head and neck squamous cell carcinoma

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q03135

negative regulation of protein tyrosine kinase activity

3 references

9 May 2019

Nitrosation-dependent caveolin 1 phosphorylation, ubiquitination, and degradation and its association with idiopathic pulmonary arterial hypertension

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q03135

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q03135

9 May 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q03135

6 references

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q03135

9 May 2019

Involvement of caveolin-2 in caveolar biogenesis in MDCK cells

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q03135

9 May 2019

Nitrosation-dependent caveolin 1 phosphorylation, ubiquitination, and degradation and its association with idiopathic pulmonary arterial hypertension

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q03135

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q03135

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q03135

9 May 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q03135

positive regulation of NF-kappaB transcription factor activity

1 reference

9 May 2019

Downregulation of miR-138 sustains NF-κB activation and promotes lipid raft formation in esophageal squamous cell carcinoma.

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q03135

has part(s)

Caveolin, conserved site

1 reference

stated in

InterPro Release 71.0