(Q21116057)

Immunoglobulin-like domain superfamily

1 reference

Immunoglobulin-like fold

1 reference

Fibronectin type III, protein family

1 reference

Immunoglobulin subtype, protein family

1 reference

Type I cytokine receptor, cytokine-binding domain, protein family

1 reference

Immunoglobulin subtype 2, protein family

1 reference

immunoglobulin-like domain, protein family

1 reference

Immunoglobulin domain, protein family

1 reference

Long hematopoietin receptor, soluble alpha chain, conserved site, protein family

1 reference

ciliary neurotrophic factor receptor activity

1 reference

13 November 2019

1 reference

13 November 2019

1 reference

8 April 2019

Signaling of human ciliary neurotrophic factor (CNTF) revisited. The interleukin-6 receptor can serve as an alpha-receptor for CTNF

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P08887

protein homodimerization activity

1 reference

8 April 2019

The human interleukin-6 (IL-6) receptor exists as a preformed dimer in the plasma membrane

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P08887

interleukin-6 receptor binding

1 reference

8 April 2019

Hexameric structure and assembly of the interleukin-6/IL-6 alpha-receptor/gp130 complex

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P08887

4 references

8 April 2019

Hexameric structure and assembly of the interleukin-6/IL-6 alpha-receptor/gp130 complex

IntAct protein interaction database

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P08887

8 April 2019

Structural Organization of a Full-Length gp130/LIF-R Cytokine Receptor Transmembrane Complex

IntAct protein interaction database

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P08887

8 April 2019

Detection of direct binding of human herpesvirus 8-encoded interleukin-6 (vIL-6) to both gp130 and IL-6 receptor (IL-6R) and identification of amino acid residues of vIL-6 important for IL-6R-dependent and -independent signaling

IntAct protein interaction database

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P08887

8 April 2019

Bacterial induction of TNF-alpha converting enzyme expression and IL-6 receptor alpha shedding regulates airway inflammatory signaling

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P08887

cytokine receptor activity

1 reference

27 March 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=P08887&geneProductId=UniProtKB:P08887

1 reference

8 April 2019

An Aminopeptidase, ARTS-1, Is Required for Interleukin-6 Receptor Shedding

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P08887

ciliary neurotrophic factor binding

1 reference

8 April 2019

Signaling of human ciliary neurotrophic factor (CNTF) revisited. The interleukin-6 receptor can serve as an alpha-receptor for CTNF

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P08887

interleukin-12 receptor binding

1 reference

8 April 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P08887

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

growth factor activity

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P08887

1 reference

8 April 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P08887

Hexameric structure and assembly of the interleukin-6/IL-6 alpha-receptor/gp130 complex

interleukin-6 binding

3 references

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P08887

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P08887

8 April 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P08887

interleukin-12 alpha subunit binding

1 reference

8 April 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P08887

interleukin-23 receptor binding

1 reference

8 April 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P08887

integral component of membrane

cell component

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P08887

2 references

2 references

3 references

basolateral plasma membrane

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P08887

Bacterial induction of TNF-alpha converting enzyme expression and IL-6 receptor alpha shedding regulates airway inflammatory signaling

apical plasma membrane

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P08887

ciliary neurotrophic factor receptor complex

1 reference

8 April 2019

Signaling of human ciliary neurotrophic factor (CNTF) revisited. The interleukin-6 receptor can serve as an alpha-receptor for CTNF

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P08887

3 references

27 March 2018

Bacterial induction of TNF-alpha converting enzyme expression and IL-6 receptor alpha shedding regulates airway inflammatory signaling

http://www.ebi.ac.uk/QuickGO/annotations?protein=P08887&geneProductId=UniProtKB:P08887

27 March 2018

JAK/STAT but not ERK1/ERK2 pathway mediates interleukin (IL)-6/soluble IL-6R down-regulation of Type II collagen, aggrecan core, and link protein transcription in articular chondrocytes. Association with a down-regulation of SOX9 expression

http://www.ebi.ac.uk/QuickGO/annotations?protein=P08887&geneProductId=UniProtKB:P08887

27 March 2018

Normal platelets possess the soluble form of IL-6 receptor

http://www.ebi.ac.uk/QuickGO/annotations?protein=P08887&geneProductId=UniProtKB:P08887

1 reference

27 March 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=P08887&geneProductId=UniProtKB:P08887

interleukin-6 receptor complex

3 references

8 April 2019

Molecular cloning and expression of an IL-6 signal transducer, gp130

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P08887

8 April 2019

Hexameric structure and assembly of the interleukin-6/IL-6 alpha-receptor/gp130 complex

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P08887

8 April 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P08887

external side of plasma membrane

1 reference

8 April 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P08887

1 reference

8 April 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P08887

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

interleukin-12 complex

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P08887

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

interleukin-23 complex

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P08887

positive regulation of activation of Janus kinase activity

biological process

1 reference

27 March 2018

JAK/STAT but not ERK1/ERK2 pathway mediates interleukin (IL)-6/soluble IL-6R down-regulation of Type II collagen, aggrecan core, and link protein transcription in articular chondrocytes. Association with a down-regulation of SOX9 expression

http://www.ebi.ac.uk/QuickGO/annotations?protein=P08887&geneProductId=UniProtKB:P08887

1 reference

8 April 2019

Molecular cloning and expression of an IL-6 signal transducer, gp130

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P08887

Cellular cholesterol depletion triggers shedding of the human interleukin-6 receptor by ADAM10 and ADAM17 (TACE)

hepatic immune response

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P08887

extrinsic apoptotic signaling pathway

1 reference

8 April 2019

Differential regulation of neutrophil-activating chemokines by IL-6 and its soluble receptor isoforms

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P08887

1 reference

8 April 2019

Novel path to activation of vascular smooth muscle cells: up-regulation of gp130 creates an autocrine activation loop by IL-6 and its soluble receptor

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P08887

ciliary neurotrophic factor-mediated signaling pathway

IC

1 reference

8 April 2019

Signaling of human ciliary neurotrophic factor (CNTF) revisited. The interleukin-6 receptor can serve as an alpha-receptor for CTNF

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P08887

positive regulation of leukocyte chemotaxis

1 reference

8 April 2019

Differential regulation of neutrophil-activating chemokines by IL-6 and its soluble receptor isoforms

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P08887

negative regulation of interleukin-8 production

1 reference

27 March 2018

Bacterial induction of TNF-alpha converting enzyme expression and IL-6 receptor alpha shedding regulates airway inflammatory signaling

http://www.ebi.ac.uk/QuickGO/annotations?protein=P08887&geneProductId=UniProtKB:P08887

positive regulation of osteoblast differentiation

NAS

1 reference

8 April 2019

Gp130 activation by soluble interleukin-6 receptor/interleukin-6 enhances osteoblastic differentiation of human bone marrow-derived mesenchymal stem cells

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P08887

defense response to Gram-negative bacterium

1 reference

8 April 2019

Bacterial induction of TNF-alpha converting enzyme expression and IL-6 receptor alpha shedding regulates airway inflammatory signaling

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P08887

1 reference

8 April 2019

Cellular cholesterol depletion triggers shedding of the human interleukin-6 receptor by ADAM10 and ADAM17 (TACE)

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P08887

positive regulation of NF-kappaB transcription factor activity

1 reference

27 March 2018

JAK/STAT but not ERK1/ERK2 pathway mediates interleukin (IL)-6/soluble IL-6R down-regulation of Type II collagen, aggrecan core, and link protein transcription in articular chondrocytes. Association with a down-regulation of SOX9 expression

http://www.ebi.ac.uk/QuickGO/annotations?protein=P08887&geneProductId=UniProtKB:P08887

positive regulation of interleukin-6 production

1 reference

8 April 2019

Novel path to activation of vascular smooth muscle cells: up-regulation of gp130 creates an autocrine activation loop by IL-6 and its soluble receptor

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P08887

positive regulation of peptidyl-tyrosine phosphorylation

1 reference

8 April 2019

Shedding of the interleukin-6 (IL-6) receptor (gp80) determines the ability of IL-6 to induce gp130 phosphorylation in human osteoblasts

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P08887

positive regulation of chemokine production

1 reference

8 April 2019

Novel path to activation of vascular smooth muscle cells: up-regulation of gp130 creates an autocrine activation loop by IL-6 and its soluble receptor

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P08887

neutrophil mediated immunity

1 reference

27 March 2018

Bacterial induction of TNF-alpha converting enzyme expression and IL-6 receptor alpha shedding regulates airway inflammatory signaling

http://www.ebi.ac.uk/QuickGO/annotations?protein=P08887&geneProductId=UniProtKB:P08887

negative regulation of collagen biosynthetic process

1 reference

27 March 2018

JAK/STAT but not ERK1/ERK2 pathway mediates interleukin (IL)-6/soluble IL-6R down-regulation of Type II collagen, aggrecan core, and link protein transcription in articular chondrocytes. Association with a down-regulation of SOX9 expression

http://www.ebi.ac.uk/QuickGO/annotations?protein=P08887&geneProductId=UniProtKB:P08887

positive regulation of MAPK cascade

1 reference

27 March 2018

JAK/STAT but not ERK1/ERK2 pathway mediates interleukin (IL)-6/soluble IL-6R down-regulation of Type II collagen, aggrecan core, and link protein transcription in articular chondrocytes. Association with a down-regulation of SOX9 expression

http://www.ebi.ac.uk/QuickGO/annotations?protein=P08887&geneProductId=UniProtKB:P08887

positive regulation of smooth muscle cell proliferation

1 reference

8 April 2019

Novel path to activation of vascular smooth muscle cells: up-regulation of gp130 creates an autocrine activation loop by IL-6 and its soluble receptor

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P08887

defense response to Gram-positive bacterium

1 reference

27 March 2018

Bacterial induction of TNF-alpha converting enzyme expression and IL-6 receptor alpha shedding regulates airway inflammatory signaling

http://www.ebi.ac.uk/QuickGO/annotations?protein=P08887&geneProductId=UniProtKB:P08887

positive regulation of tyrosine phosphorylation of STAT protein

NAS

1 reference

27 March 2018

Signaling of human ciliary neurotrophic factor (CNTF) revisited. The interleukin-6 receptor can serve as an alpha-receptor for CTNF

http://www.ebi.ac.uk/QuickGO/annotations?protein=P08887&geneProductId=UniProtKB:P08887

interleukin-6-mediated signaling pathway

3 references

10 September 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=P08887&geneProductId=UniProtKB:P08887

10 September 2018

Signaling of human ciliary neurotrophic factor (CNTF) revisited. The interleukin-6 receptor can serve as an alpha-receptor for CTNF

http://www.ebi.ac.uk/QuickGO/annotations?protein=P08887&geneProductId=UniProtKB:P08887

10 September 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=P08887&geneProductId=UniProtKB:P08887

positive regulation of T-helper 1 type immune response

1 reference

8 April 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P08887

regulation of signaling receptor activity

1 reference

8 April 2019

Gene Ontology Consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P08887

positive regulation of activation of Janus kinase activity

1 reference

8 April 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P08887

positive regulation of interferon-gamma production

1 reference

8 April 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P08887

positive regulation of natural killer cell activation

1 reference

8 April 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P08887

positive regulation of activated T cell proliferation

1 reference

8 April 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P08887

positive regulation of tyrosine phosphorylation of STAT protein

positive regulation of lymphocyte proliferation

1 reference

8 April 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P08887

positive regulation of NK T cell activation

1 reference

8 April 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P08887

interleukin-6-mediated signaling pathway

4 references

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P08887

8 April 2019

Signaling of human ciliary neurotrophic factor (CNTF) revisited. The interleukin-6 receptor can serve as an alpha-receptor for CTNF

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P08887

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P08887

8 April 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P08887

positive regulation of glomerular mesangial cell proliferation

1 reference

8 April 2019

Rs12976445 Polymorphism is Associated with Risk of Diabetic Nephropathy Through Modulating Expression of MicroRNA-125 and Interleukin-6R.

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P08887

has part(s)

immunoglobulin domain

1 reference

immunoglobulin subtype 2

1 reference

fibronectin type III

1 reference

immunoglobulin-like domain

1 reference

Type I cytokine receptor, cytokine-binding domain

1 reference

Long hematopoietin receptor, soluble alpha chain, conserved site

1 reference

immunoglobulin subtype

1 reference

D12.776.543.750.705.852.420.400

Identifiers

MeSH descriptor ID

D019947

subject named as

Receptors, Interleukin-6

0 references

MeSH tree code

0 references

1 reference

30 May 2020

1 reference

30 May 2020

1 reference

30 May 2020

1 reference

30 May 2020

1 reference

30 May 2020

1 reference

30 May 2020

1 reference

30 May 2020

1 reference

30 May 2020

1 reference

30 May 2020

1 reference

30 May 2020

1 reference

30 May 2020

1 reference

30 May 2020

1 reference

30 May 2020

1 reference

13 November 2019

1 reference

1 reference

1 reference

1 reference

1 reference

1 reference

1 reference

20 March 2016

language of work or name

1 reference

20 March 2016

language of work or name

1 reference

20 March 2016

language of work or name

1 reference

inferred by common MeSH mappings on source and on Wikidata