(Q21127191)

http://www.ebi.ac.uk/interpro/protein/O43623

Zinc finger C2H2-type, protein family

1 reference

based on heuristic

inferred from protein domain or family

1 reference

13 November 2019

1 reference

13 November 2019

1 reference

5 June 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=O43623&geneProductId=UniProtKB:O43623

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O43623

1 reference

8 April 2019

A proteome-scale map of the human interactome network

IntAct protein interaction database

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O43623

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O43623

DNA-binding transcription factor activity, RNA polymerase II-specific

2 references

10 September 2018

A census of human transcription factors: function, expression and evolution

Norwegian University of Science and Technology, Systems Biology team

http://www.ebi.ac.uk/QuickGO/annotations?protein=O43623&geneProductId=UniProtKB:O43623

10 September 2018

Norwegian University of Science and Technology, Systems Biology team

http://www.ebi.ac.uk/QuickGO/annotations?protein=O43623&geneProductId=UniProtKB:O43623

DNA-binding transcription repressor activity, RNA polymerase II-specific

ISA

5 references

5 June 2018

Slug is a direct Notch target required for initiation of cardiac cushion cellularization

http://www.ebi.ac.uk/QuickGO/annotations?protein=O43623&geneProductId=UniProtKB:O43623

5 June 2018

Slug regulates integrin expression and cell proliferation in human epidermal keratinocytes

http://www.ebi.ac.uk/QuickGO/annotations?protein=O43623&geneProductId=UniProtKB:O43623

5 June 2018

The SLUG zinc-finger protein represses E-cadherin in breast cancer

http://www.ebi.ac.uk/QuickGO/annotations?protein=O43623&geneProductId=UniProtKB:O43623

5 June 2018

Human Slug is a repressor that localizes to sites of active transcription

http://www.ebi.ac.uk/QuickGO/annotations?protein=O43623&geneProductId=UniProtKB:O43623

10 September 2018

The SLUG zinc-finger protein represses E-cadherin in breast cancer

http://www.ebi.ac.uk/QuickGO/annotations?protein=O43623&geneProductId=UniProtKB:O43623

RNA polymerase II transcription regulatory region sequence-specific DNA binding

1 reference

8 April 2019

The SLUG zinc-finger protein represses E-cadherin in breast cancer

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O43623

DNA-binding transcription repressor activity, RNA polymerase II-specific

9 references

10 September 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=O43623&geneProductId=UniProtKB:O43623

10 September 2018

Human Slug is a repressor that localizes to sites of active transcription

http://www.ebi.ac.uk/QuickGO/annotations?protein=O43623&geneProductId=UniProtKB:O43623

10 September 2018

Slug is a direct Notch target required for initiation of cardiac cushion cellularization

http://www.ebi.ac.uk/QuickGO/annotations?protein=O43623&geneProductId=UniProtKB:O43623

10 September 2018

Slug regulates integrin expression and cell proliferation in human epidermal keratinocytes

http://www.ebi.ac.uk/QuickGO/annotations?protein=O43623&geneProductId=UniProtKB:O43623

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O43623

8 April 2019

Slug regulates integrin expression and cell proliferation in human epidermal keratinocytes

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O43623

8 April 2019

Slug is a direct Notch target required for initiation of cardiac cushion cellularization

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O43623

8 April 2019

The SLUG zinc-finger protein represses E-cadherin in breast cancer

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O43623

8 April 2019

Human Slug is a repressor that localizes to sites of active transcription

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O43623

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O43623

DNA-binding transcription factor activity

1 reference

8 April 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O43623

transcription factor activity, RNA polymerase II distal enhancer sequence-specific binding

IBA

1 reference

10 September 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=O43623&geneProductId=UniProtKB:O43623

1 reference

8 April 2019

The SLUG zinc-finger protein represses E-cadherin in breast cancer

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O43623

DNA-binding transcription factor activity, RNA polymerase II-specific

3 references

8 April 2019

A census of human transcription factors: function, expression and evolution

Norwegian University of Science and Technology, Systems Biology team

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O43623

8 April 2019

Norwegian University of Science and Technology, Systems Biology team

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O43623

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O43623

3 references

5 June 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=O43623&geneProductId=UniProtKB:O43623

5 June 2018

Syntenin regulates TGF-β1-induced Smad activation and the epithelial-to-mesenchymal transition by inhibiting caveolin-mediated TGF-β type I receptor internalization

http://www.ebi.ac.uk/QuickGO/annotations?protein=O43623&geneProductId=UniProtKB:O43623

5 June 2018

Human Slug is a repressor that localizes to sites of active transcription

http://www.ebi.ac.uk/QuickGO/annotations?protein=O43623&geneProductId=UniProtKB:O43623

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O43623

5 references

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O43623

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O43623

8 April 2019

Syntenin regulates TGF-β1-induced Smad activation and the epithelial-to-mesenchymal transition by inhibiting caveolin-mediated TGF-β type I receptor internalization

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O43623

8 April 2019

Human Slug is a repressor that localizes to sites of active transcription

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O43623

8 April 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O43623

Slug is a direct Notch target required for initiation of cardiac cushion cellularization

IBA

biological process

Notch signaling pathway

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O43623

negative regulation of vitamin D receptor signaling pathway

1 reference

8 April 2019

Snail2 cooperates with Snail1 in the repression of vitamin D receptor in colon cancer

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O43623

regulation of transcription, DNA-templated

1 reference

5 June 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=O43623&geneProductId=UniProtKB:O43623

neural crest cell development

1 reference

8 April 2019

SLUG (SNAI2) deletions in patients with Waardenburg disease

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O43623

negative regulation of keratinocyte proliferation

1 reference

8 April 2019

Slug regulates integrin expression and cell proliferation in human epidermal keratinocytes

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O43623

regulation of bicellular tight junction assembly

1 reference

8 April 2019

Aberrant expression of the transcription factors snail and slug alters the response to genotoxic stress

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O43623

positive regulation of cell migration

1 reference

8 April 2019

Aberrant expression of the transcription factors snail and slug alters the response to genotoxic stress

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O43623

negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage

1 reference

8 April 2019

Aberrant expression of the transcription factors snail and slug alters the response to genotoxic stress

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O43623

transcription, DNA-templated

1 reference

5 June 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=O43623&geneProductId=UniProtKB:O43623

cellular response to epidermal growth factor stimulus

1 reference

8 April 2019

Erk5 controls Slug expression and keratinocyte activation during wound healing

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O43623

regulation of chemokine production

1 reference

8 April 2019

Slug contributes to the regulation of CXCL12 expression in human osteoblasts

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O43623

multicellular organism development

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O43623

negative regulation of chondrocyte differentiation

1 reference

8 April 2019

Slug gene expression supports human osteoblast maturation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O43623

negative regulation of DNA damage response, signal transduction by p53 class mediator

1 reference

8 April 2019

Aberrant expression of the transcription factors snail and slug alters the response to genotoxic stress

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O43623

osteoblast differentiation

1 reference

8 April 2019

SLUG: a new target of lymphoid enhancer factor-1 in human osteoblasts

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O43623

canonical Wnt signaling pathway

IEP

1 reference

5 June 2018

SLUG: a new target of lymphoid enhancer factor-1 in human osteoblasts

http://www.ebi.ac.uk/QuickGO/annotations?protein=O43623&geneProductId=UniProtKB:O43623

negative regulation of cell adhesion mediated by integrin

1 reference

8 April 2019

Slug regulates integrin expression and cell proliferation in human epidermal keratinocytes

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O43623

negative regulation of anoikis

IC

1 reference

8 April 2019

Jagged1-mediated Notch activation induces epithelial-to-mesenchymal transition through Slug-induced repression of E-cadherin

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O43623

negative regulation of transcription by RNA polymerase II

3 references

5 June 2018

Slug is a direct Notch target required for initiation of cardiac cushion cellularization

http://www.ebi.ac.uk/QuickGO/annotations?protein=O43623&geneProductId=UniProtKB:O43623

5 June 2018

The SLUG zinc-finger protein represses E-cadherin in breast cancer

http://www.ebi.ac.uk/QuickGO/annotations?protein=O43623&geneProductId=UniProtKB:O43623

5 June 2018

Human Slug is a repressor that localizes to sites of active transcription

http://www.ebi.ac.uk/QuickGO/annotations?protein=O43623&geneProductId=UniProtKB:O43623

epithelial to mesenchymal transition

2 references

5 June 2018

The zinc-finger protein slug causes desmosome dissociation, an initial and necessary step for growth factor-induced epithelial-mesenchymal transition

http://www.ebi.ac.uk/QuickGO/annotations?protein=O43623&geneProductId=UniProtKB:O43623

5 June 2018

Jagged1-mediated Notch activation induces epithelial-to-mesenchymal transition through Slug-induced repression of E-cadherin

http://www.ebi.ac.uk/QuickGO/annotations?protein=O43623&geneProductId=UniProtKB:O43623

epithelial to mesenchymal transition involved in endocardial cushion formation

1 reference

27 March 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=O43623&geneProductId=UniProtKB:O43623

cell migration involved in endocardial cushion formation

1 reference

5 June 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=O43623&geneProductId=UniProtKB:O43623

sensory perception of sound

1 reference

5 June 2018

SLUG (SNAI2) deletions in patients with Waardenburg disease

http://www.ebi.ac.uk/QuickGO/annotations?protein=O43623&geneProductId=UniProtKB:O43623

The zinc-finger protein slug causes desmosome dissociation, an initial and necessary step for growth factor-induced epithelial-mesenchymal transition

desmosome disassembly

1 reference

5 June 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=O43623&geneProductId=UniProtKB:O43623

1 reference

5 June 2018

SLUG (SNAI2) deletions in patients with Waardenburg disease

http://www.ebi.ac.uk/QuickGO/annotations?protein=O43623&geneProductId=UniProtKB:O43623

Erk5 controls Slug expression and keratinocyte activation during wound healing

epithelium development

1 reference

5 June 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=O43623&geneProductId=UniProtKB:O43623

negative regulation of extrinsic apoptotic signaling pathway in absence of ligand

1 reference

5 June 2018

SLUG, a ces-1-related zinc finger transcription factor gene with antiapoptotic activity, is a downstream target of the E2A-HLF oncoprotein

http://www.ebi.ac.uk/QuickGO/annotations?protein=O43623&geneProductId=UniProtKB:O43623

negative regulation of transcription by RNA polymerase II

4 references

8 April 2019

Slug is a direct Notch target required for initiation of cardiac cushion cellularization

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O43623

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O43623

8 April 2019

The SLUG zinc-finger protein represses E-cadherin in breast cancer

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O43623

8 April 2019

Human Slug is a repressor that localizes to sites of active transcription

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O43623

epithelial to mesenchymal transition

3 references

8 April 2019

Jagged1-mediated Notch activation induces epithelial-to-mesenchymal transition through Slug-induced repression of E-cadherin

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O43623

8 April 2019

The zinc-finger protein slug causes desmosome dissociation, an initial and necessary step for growth factor-induced epithelial-mesenchymal transition

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O43623

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O43623

aortic valve morphogenesis

1 reference

8 April 2019

NOTCH1 missense alleles associated with left ventricular outflow tract defects exhibit impaired receptor processing and defective EMT.

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O43623

epithelial to mesenchymal transition involved in endocardial cushion formation

TAS

3 references

8 April 2019

NOTCH1 missense alleles associated with left ventricular outflow tract defects exhibit impaired receptor processing and defective EMT.

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O43623

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O43623

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O43623

regulation of transcription, DNA-templated

1 reference

8 April 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O43623

negative regulation of cell adhesion involved in substrate-bound cell migration

IBA

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O43623

response to radiation

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O43623

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O43623

positive regulation of histone acetylation

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O43623

negative regulation of apoptotic process

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O43623

positive regulation of fat cell differentiation

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O43623

white fat cell differentiation

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O43623

roof of mouth development

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O43623

cartilage morphogenesis

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O43623

regulation of branching involved in salivary gland morphogenesis

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O43623

cellular response to ionizing radiation

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O43623

negative regulation of stem cell proliferation

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O43623

Notch signaling involved in heart development

1 reference

8 April 2019

NOTCH1 missense alleles associated with left ventricular outflow tract defects exhibit impaired receptor processing and defective EMT.

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O43623

TAS

has part(s)

Zinc finger C2H2-type

1 reference

stated in

InterPro Release 71.0