(Q21134471)

English

Profilin 1

mammalian protein found in Homo sapiens

epididymis tissue protein Li 184a
profilin I
profilin-1
PFN1

In more languages

Statements

1 reference

13 November 2019

UniProt protein ID

Profilin superfamily

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/P07737

Profilin1/2/3, vertebrate

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/P07737

membrane protein

1 reference

based on heuristic

inferred from GOA cell component → membrane

Profilin conserved site, protein family

1 reference

based on heuristic

inferred from protein domain or family

1 reference

13 November 2019

UniProt protein ID

1 reference

13 November 2019

UniProt protein ID

molecular function

actin monomer binding

determination method

1 reference

8 April 2019

Phosphorylation of profilin by ROCK1 regulates polyglutamine aggregation

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P07737

determination method

protein binding

determination method

10 references

8 April 2019

Differential remodeling of actin cytoskeleton architecture by profilin isoforms leads to distinct effects on cell migration and invasion

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P07737

determination method

8 April 2019

The association of cortactin with profilin-1 is critical for smooth muscle contraction

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P07737

determination method

8 April 2019

Phosphorylation of profilin by ROCK1 regulates polyglutamine aggregation

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P07737

determination method

8 April 2019

WAVE, a novel WASP-family protein involved in actin reorganization induced by Rac

IntAct protein interaction database

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P07737

determination method

8 April 2019

Three-dimensional structure of cofilin bound to monomeric actin derived by structural mass spectrometry data

IntAct protein interaction database

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P07737

determination method

8 April 2019

The essential role of profilin in the assembly of actin for microspike formation

IntAct protein interaction database

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P07737

determination method

8 April 2019

The structural basis of actin interaction with multiple WH2/beta-thymosin motif-containing proteins.

IntAct protein interaction database

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P07737

determination method

8 April 2019

Structural basis for parasite-specific functions of the divergent profilin of Plasmodium falciparum

IntAct protein interaction database

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P07737

determination method

8 April 2019

Modulation of actin structure and function by phosphorylation of Tyr-53 and profilin binding

IntAct protein interaction database

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P07737

determination method

8 April 2019

Streamline proteomic approach for characterizing protein-protein interaction network in a RAD52 protein complex

IntAct protein interaction database

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P07737

determination method

adenyl-nucleotide exchange factor activity

determination method

1 reference

8 April 2019

Distinct biochemical characteristics of the two human profilin isoforms

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P07737

determination method

determination method

4 references

17 October 2017

Structural basis for the recruitment of profilin-actin complexes during filament elongation by Ena/VASP.

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?protein=P07737&geneProductId=UniProtKB:P07737

determination method

17 October 2017

Distinct biochemical characteristics of the two human profilin isoforms

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?protein=P07737&geneProductId=UniProtKB:P07737

determination method

17 October 2017

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?protein=P07737&geneProductId=UniProtKB:P07737

determination method

17 October 2017

http://www.ebi.ac.uk/QuickGO/annotations?protein=P07737&geneProductId=UniProtKB:P07737

determination method

proline-rich region binding

determination method

1 reference

8 April 2019

Structural basis for the recruitment of profilin-actin complexes during filament elongation by Ena/VASP.

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P07737

determination method

determination method

1 reference

17 October 2017

The mRNA-bound proteome and its global occupancy profile on protein-coding transcripts

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?protein=P07737&geneProductId=UniProtKB:P07737

determination method

cadherin binding

determination method

1 reference

17 October 2017

E-cadherin interactome complexity and robustness resolved by quantitative proteomics

British Heart Foundation

http://www.ebi.ac.uk/QuickGO/annotations?protein=P07737&geneProductId=UniProtKB:P07737

determination method

signaling receptor binding

determination method

1 reference

17 October 2017

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?protein=P07737&geneProductId=UniProtKB:P07737

determination method

determination method

1 reference

8 April 2019

The mRNA-bound proteome and its global occupancy profile on protein-coding transcripts

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P07737

determination method

determination method

5 references

8 April 2019

Structural basis for the recruitment of profilin-actin complexes during filament elongation by Ena/VASP.

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P07737

determination method

8 April 2019

Distinct biochemical characteristics of the two human profilin isoforms

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P07737

determination method

8 April 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P07737

determination method

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P07737

determination method

8 April 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P07737

determination method

phosphatidylinositol-4,5-bisphosphate binding

determination method

1 reference

8 April 2019

Distinct biochemical characteristics of the two human profilin isoforms

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P07737

determination method

cadherin binding

determination method

1 reference

8 April 2019

E-cadherin interactome complexity and robustness resolved by quantitative proteomics

British Heart Foundation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P07737

determination method

determination method

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P07737

determination method

blood microparticle

determination method

1 reference

17 October 2017

Proteomic analysis of microvesicles from plasma of healthy donors reveals high individual variability

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?protein=P07737&geneProductId=UniProtKB:P07737

determination method

determination method

1 reference

17 October 2017

Defining the membrane proteome of NK cells

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?protein=P07737&geneProductId=UniProtKB:P07737

determination method

determination method

1 reference

17 October 2017

Analysis of the myosin-II-responsive focal adhesion proteome reveals a role for β-Pix in negative regulation of focal adhesion maturation

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?protein=P07737&geneProductId=UniProtKB:P07737

determination method

determination method

1 reference

8 April 2019

The association of cortactin with profilin-1 is critical for smooth muscle contraction

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P07737

determination method

extracellular exosome

determination method

4 references

17 October 2017

Large-scale proteomics and phosphoproteomics of urinary exosomes

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?protein=P07737&geneProductId=UniProtKB:P07737

determination method

17 October 2017

MHC class II-associated proteins in B-cell exosomes and potential functional implications for exosome biogenesis

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?protein=P07737&geneProductId=UniProtKB:P07737

determination method

17 October 2017

In-depth proteomic analyses of exosomes isolated from expressed prostatic secretions in urine

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?protein=P07737&geneProductId=UniProtKB:P07737

determination method

17 October 2017

Proteomic analysis of podocyte exosome-enriched fraction from normal human urine

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?protein=P07737&geneProductId=UniProtKB:P07737

determination method

determination method

1 reference

8 April 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P07737

determination method

determination method

3 references

17 October 2017

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?protein=P07737&geneProductId=UniProtKB:P07737

determination method

17 October 2017

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?protein=P07737&geneProductId=UniProtKB:P07737

determination method

17 October 2017

The association of cortactin with profilin-1 is critical for smooth muscle contraction

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?protein=P07737&geneProductId=UniProtKB:P07737

determination method

extracellular space

determination method

1 reference

17 October 2017

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?protein=P07737&geneProductId=UniProtKB:P07737

determination method

neuron projection

determination method

1 reference

17 October 2017

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?protein=P07737&geneProductId=UniProtKB:P07737

determination method

determination method

1 reference

17 October 2017

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?protein=P07737&geneProductId=UniProtKB:P07737

determination method

determination method

4 references

8 April 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P07737

determination method

8 April 2019

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P07737

determination method

8 April 2019

The association of cortactin with profilin-1 is critical for smooth muscle contraction

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P07737

determination method

8 April 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P07737

determination method

determination method

1 reference

8 April 2019

Analysis of the myosin-II-responsive focal adhesion proteome reveals a role for β-Pix in negative regulation of focal adhesion maturation

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P07737

determination method

determination method

1 reference

8 April 2019

Defining the membrane proteome of NK cells

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P07737

determination method

extracellular exosome

determination method

3 references

8 April 2019

MHC class II-associated proteins in B-cell exosomes and potential functional implications for exosome biogenesis

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P07737

determination method

8 April 2019

Large-scale proteomics and phosphoproteomics of urinary exosomes

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P07737

determination method

8 April 2019

In-depth proteomic analyses of exosomes isolated from expressed prostatic secretions in urine

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P07737

determination method

blood microparticle

determination method

1 reference

8 April 2019

Proteomic analysis of microvesicles from plasma of healthy donors reveals high individual variability

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P07737

determination method

glutamatergic synapse

determination method

1 reference

8 April 2019

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P07737

determination method

biological process

positive regulation of actin filament polymerization

determination method

1 reference

8 April 2019

Differential remodeling of actin cytoskeleton architecture by profilin isoforms leads to distinct effects on cell migration and invasion

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P07737

determination method

positive regulation of ATP-dependent activity

determination method

1 reference

8 April 2019

Distinct biochemical characteristics of the two human profilin isoforms

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P07737

determination method

negative regulation of actin filament polymerization

determination method

1 reference

8 April 2019

Distinct biochemical characteristics of the two human profilin isoforms

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P07737

determination method

positive regulation of ruffle assembly

determination method

1 reference

8 April 2019

Differential remodeling of actin cytoskeleton architecture by profilin isoforms leads to distinct effects on cell migration and invasion

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P07737

determination method

regulation of transcription by RNA polymerase II

determination method

1 reference

8 April 2019

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P07737

determination method

protein stabilization

determination method

1 reference

8 April 2019

Phosphorylation of profilin by ROCK1 regulates polyglutamine aggregation

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P07737

determination method

positive regulation of epithelial cell migration

determination method

1 reference

8 April 2019

Differential remodeling of actin cytoskeleton architecture by profilin isoforms leads to distinct effects on cell migration and invasion

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P07737

determination method

negative regulation of actin filament bundle assembly

determination method

1 reference

8 April 2019

Differential remodeling of actin cytoskeleton architecture by profilin isoforms leads to distinct effects on cell migration and invasion

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P07737

determination method

neural tube closure

determination method

1 reference

8 April 2019

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P07737

determination method

positive regulation of actin filament bundle assembly

determination method

1 reference

8 April 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P07737

determination method

negative regulation of stress fiber assembly

determination method

1 reference

8 April 2019

Differential remodeling of actin cytoskeleton architecture by profilin isoforms leads to distinct effects on cell migration and invasion

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P07737

determination method

actin cytoskeleton organization

determination method

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P07737

determination method

Wnt signaling pathway, planar cell polarity pathway

determination method

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P07737

determination method

response to organic substance

determination method

1 reference

17 October 2017

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?protein=P07737&geneProductId=UniProtKB:P07737

determination method

positive regulation of transcription by RNA polymerase II

determination method

1 reference

17 October 2017

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?protein=P07737&geneProductId=UniProtKB:P07737

determination method

positive regulation of viral transcription

determination method

1 reference

17 October 2017

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?protein=P07737&geneProductId=UniProtKB:P07737

determination method

positive regulation of DNA metabolic process

determination method

1 reference

17 October 2017

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?protein=P07737&geneProductId=UniProtKB:P07737

determination method

positive regulation of stress fiber assembly

determination method

1 reference

17 October 2017

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?protein=P07737&geneProductId=UniProtKB:P07737

determination method

cellular response to growth factor stimulus

determination method

1 reference

17 October 2017

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?protein=P07737&geneProductId=UniProtKB:P07737

determination method

regulation of actin filament polymerization

determination method

1 reference

8 April 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P07737

determination method

synapse maturation

determination method

1 reference

8 April 2019

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P07737

determination method

modification of postsynaptic actin cytoskeleton

determination method

1 reference

8 April 2019

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P07737

determination method

Profilin conserved site

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/P07737

Identifiers

RefSeq protein ID

1 reference

30 May 2020

1 reference

30 May 2020

UniProt protein ID

1 reference

13 November 2019

UniProt protein ID

Ensembl protein ID

ENSP00000460363

1 reference

Ensembl Release 99

Ensembl protein ID

ENSP00000460363

ENSP00000225655

1 reference

Ensembl Release 99

Ensembl protein ID

ENSP00000225655

ENSP00000465019

1 reference

Ensembl Release 99

Ensembl protein ID

ENSP00000465019

PDB structure ID

1 reference

UniProt protein ID

30 June 2016

language of work or name

1 reference

UniProt protein ID

30 June 2016

language of work or name

1 reference

UniProt protein ID

30 June 2016

language of work or name

1 reference

UniProt protein ID

30 June 2016

language of work or name

1 reference

UniProt protein ID

30 June 2016

language of work or name

1 reference

UniProt protein ID

30 June 2016

language of work or name

1 reference

UniProt protein ID

30 June 2016

language of work or name

1 reference

UniProt protein ID

30 June 2016

language of work or name

1 reference

UniProt protein ID

30 June 2016

language of work or name

1 reference

UniProt protein ID

30 June 2016

language of work or name

1 reference

UniProt protein ID

30 June 2016

language of work or name

1 reference

UniProt protein ID

30 June 2016

language of work or name

Sitelinks

Wikipedia(0 entries)

Wikibooks(0 entries)

Wikinews(0 entries)

Wikiquote(0 entries)

Wikisource(0 entries)

Wikiversity(0 entries)

Wikivoyage(0 entries)

Wiktionary(0 entries)

Multilingual sites(0 entries)

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