(Q21163357)

English

GHRL

protein-coding gene in the species Homo sapiens

ghrelin
Ghrelin
ghrelin and obestatin prepropeptide
MTLRP

In more languages

Statements

1 reference

ensembl Release 106

Ensembl gene ID

ENSG00000157017

protein-coding gene

1 reference

Ensembl Release 87

Ensembl gene ID

ENSG00000157017

Synthesis, secretion, and deacylation of Ghrelin

0 references

1 reference

ensembl Release 106

Ensembl gene ID

ENSG00000157017

1 reference

6 July 2017

UniProt protein ID

Ghrelin and obestatin prepropeptide

0 references

0 references

0 references

human chromosome 3

genomic assembly

genome assembly GRCh38

Genome assembly GRCh37

1 reference

ensembl Release 106

Ensembl gene ID

ENSG00000157017

strand orientation

genomic assembly

genome assembly GRCh38

Genome assembly GRCh37

1 reference

ensembl Release 106

Ensembl gene ID

ENSG00000157017

10327359

human chromosome 3

genomic assembly

Genome assembly GRCh37

1 reference

ensembl Release 106

Ensembl gene ID

ENSG00000157017

10285666

human chromosome 3

genomic assembly

genome assembly GRCh38

1 reference

ensembl Release 106

Ensembl gene ID

ENSG00000157017

10292947

human chromosome 3

genomic assembly

genome assembly GRCh38

1 reference

ensembl Release 106

Ensembl gene ID

ENSG00000157017

10334631

human chromosome 3

genomic assembly

Genome assembly GRCh37

1 reference

ensembl Release 106

Ensembl gene ID

ENSG00000157017

cytogenetic location

3p25.3

1 reference

15 May 2022

biological process

G protein-coupled receptor signaling pathway

determination method

4 references

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9UBU3

determination method

8 April 2019

Loss of constitutive activity of the growth hormone secretagogue receptor in familial short stature

HUGO Gene Nomenclature Committee

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9UBU3

determination method

8 April 2019

Ghrelin is a growth-hormone-releasing acylated peptide from stomach

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9UBU3

determination method

8 April 2019

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9UBU3

determination method

positive regulation of cortisol secretion

determination method

positive regulation of growth hormone receptor signaling pathway

determination method

1 reference

8 April 2019

Ghrelin is no longer able to stimulate growth hormone secretion in patients with Cushing's syndrome but instead induces exaggerated corticotropin and cortisol responses

British Heart Foundation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9UBU3

determination method

negative regulation of insulin secretion

determination method

1 reference

8 April 2019

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9UBU3

determination method

positive regulation of corticotropin secretion

determination method

1 reference

8 April 2019

Ghrelin is no longer able to stimulate growth hormone secretion in patients with Cushing's syndrome but instead induces exaggerated corticotropin and cortisol responses

British Heart Foundation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9UBU3

determination method

negative regulation of locomotion

determination method

1 reference

8 April 2019

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9UBU3

determination method

cortisol secretion

determination method

1 reference

8 April 2019

Ghrelin does not regulate the GH response to insulin-induced hypoglycaemia in children but could be involved in the regulation of cortisol secretion

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9UBU3

determination method

response to estrogen

determination method

1 reference

8 April 2019

Effects of estrogen and recombinant human insulin-like growth factor-I on ghrelin secretion in severe undernutrition

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9UBU3

determination method

negative regulation of endothelial cell proliferation

determination method

1 reference

8 April 2019

Ghrelin inhibits FGF-2-mediated angiogenesis in vitro and in vivo

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9UBU3

determination method

positive regulation of circadian sleep/wake cycle, non-REM sleep

determination method

1 reference

8 April 2019

Ghrelin alone or co-administered with GHRH or CRH increases non-REM sleep and decreases REM sleep in young males

British Heart Foundation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9UBU3

determination method

cartilage development

determination method

1 reference

8 April 2019

The endogenous growth hormone secretagogue (ghrelin) is synthesized and secreted by chondrocytes

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9UBU3

determination method

decidualization

determination method

1 reference

8 April 2019

Facilitation of decidualization by locally produced ghrelin in the human endometrium

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9UBU3

determination method

regulation of cell population proliferation

determination method

2 references

8 April 2019

Ghrelin is produced by the human erythroleukemic HEL cell line and involved in an autocrine pathway leading to cell proliferation

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9UBU3

determination method

8 April 2019

Ghrelin and unacylated ghrelin stimulate human osteoblast growth via mitogen-activated protein kinase (MAPK)/phosphoinositide 3-kinase (PI3K) pathways in the absence of GHS-R1a

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9UBU3

determination method

growth hormone secretion

determination method

1 reference

8 April 2019

Loss of constitutive activity of the growth hormone secretagogue receptor in familial short stature

HUGO Gene Nomenclature Committee

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9UBU3

determination method

positive regulation of growth hormone secretion

determination method

3 references

27 March 2018

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q9UBU3&geneProductId=UniProtKB:Q9UBU3

determination method

27 March 2018

Ghrelin alone or co-administered with GHRH or CRH increases non-REM sleep and decreases REM sleep in young males

British Heart Foundation

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q9UBU3&geneProductId=UniProtKB:Q9UBU3

determination method

27 March 2018

Ghrelin is no longer able to stimulate growth hormone secretion in patients with Cushing's syndrome but instead induces exaggerated corticotropin and cortisol responses

British Heart Foundation

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q9UBU3&geneProductId=UniProtKB:Q9UBU3

determination method

excitatory postsynaptic potential

determination method

1 reference

8 April 2019

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9UBU3

determination method

hormone-mediated signaling pathway

determination method

1 reference

8 April 2019

Loss of constitutive activity of the growth hormone secretagogue receptor in familial short stature

HUGO Gene Nomenclature Committee

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9UBU3

determination method

glucose metabolic process

determination method

1 reference

8 April 2019

Plasma levels of acylated ghrelin during an oral glucose tolerance test in obese children

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9UBU3

determination method

positive regulation of multicellular organism growth

determination method

1 reference

8 April 2019

Loss of constitutive activity of the growth hormone secretagogue receptor in familial short stature

HUGO Gene Nomenclature Committee

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9UBU3

determination method

negative regulation of angiogenesis

determination method

1 reference

8 April 2019

Ghrelin inhibits FGF-2-mediated angiogenesis in vitro and in vivo

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9UBU3

determination method

response to hormone

determination method

1 reference

8 April 2019

Ghrelin inhibits leptin- and activation-induced proinflammatory cytokine expression by human monocytes and T cells

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9UBU3

determination method

actin polymerization or depolymerization

determination method

1 reference

8 April 2019

Ghrelin inhibits leptin- and activation-induced proinflammatory cytokine expression by human monocytes and T cells

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9UBU3

determination method

positive regulation of response to food

determination method

1 reference

8 April 2019

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9UBU3

determination method

negative regulation of circadian sleep/wake cycle, REM sleep

determination method

1 reference

8 April 2019

Ghrelin alone or co-administered with GHRH or CRH increases non-REM sleep and decreases REM sleep in young males

British Heart Foundation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9UBU3

determination method

negative regulation of inflammatory response

determination method

1 reference

27 March 2018

Ghrelin inhibits leptin- and activation-induced proinflammatory cytokine expression by human monocytes and T cells

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q9UBU3&geneProductId=UniProtKB:Q9UBU3

determination method

positive regulation of protein tyrosine kinase activity

determination method

1 reference

8 April 2019

Gene Ontology Consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9UBU3

determination method

adult feeding behavior

determination method

1 reference

8 April 2019

HUGO Gene Nomenclature Committee

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9UBU3

determination method

response to nutrient levels

determination method

1 reference

8 April 2019

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9UBU3

determination method

positive regulation of eating behavior

determination method

1 reference

8 April 2019

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9UBU3

determination method

gastric emptying

determination method

1 reference

8 April 2019

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9UBU3

determination method

positive regulation of insulin secretion involved in cellular response to glucose stimulus

determination method

1 reference

8 April 2019

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9UBU3

determination method

positive regulation of growth

determination method

1 reference

8 April 2019

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9UBU3

determination method

response to electrical stimulus

determination method

1 reference

8 April 2019

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9UBU3

determination method

regulation of transmission of nerve impulse

determination method

1 reference

8 April 2019

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9UBU3

determination method

positive regulation of bone development

determination method

1 reference

8 April 2019

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9UBU3

determination method

positive regulation of sprouting angiogenesis

determination method

1 reference

8 April 2019

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9UBU3

determination method

positive regulation of gastro-intestinal system smooth muscle contraction

determination method

1 reference

8 April 2019

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9UBU3

determination method

positive regulation of small intestine smooth muscle contraction

determination method

1 reference

8 April 2019

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9UBU3

determination method

regulation of gastric motility

determination method

1 reference

8 April 2019

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9UBU3

determination method

positive regulation of vascular endothelial cell proliferation

determination method

1 reference

8 April 2019

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9UBU3

determination method

positive regulation of growth rate

determination method

1 reference

8 April 2019

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9UBU3

determination method

positive regulation of small intestinal transit

determination method

1 reference

8 April 2019

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9UBU3

determination method

positive regulation of gastric mucosal blood circulation

determination method

1 reference

8 April 2019

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9UBU3

determination method

positive regulation of feeding behavior

determination method

1 reference

8 April 2019

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9UBU3

determination method

regulation of signaling receptor activity

determination method

1 reference

8 April 2019

Gene Ontology Consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9UBU3

determination method

energy homeostasis

determination method

1 reference

27 March 2018

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q9UBU3&geneProductId=UniProtKB:Q9UBU3

determination method

negative regulation of inflammatory response

determination method

positive regulation of growth hormone secretion

determination method

4 references

8 April 2019

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9UBU3

determination method

8 April 2019

Ghrelin alone or co-administered with GHRH or CRH increases non-REM sleep and decreases REM sleep in young males

British Heart Foundation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9UBU3

determination method

8 April 2019

Ghrelin is no longer able to stimulate growth hormone secretion in patients with Cushing's syndrome but instead induces exaggerated corticotropin and cortisol responses

British Heart Foundation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9UBU3

determination method

8 April 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9UBU3

determination method

postsynaptic modulation of chemical synaptic transmission

determination method

1 reference

8 April 2019

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9UBU3

determination method

regulation of postsynapse organization

determination method

1 reference

8 April 2019

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9UBU3

determination method

9487

1 reference

15 May 2022

2 references

HomoloGene build68

9487

Orthologous MAtrix

https://omabrowser.org/oma/vps/Q9UBU3/

2 references

HomoloGene build68

9487

Orthologous MAtrix

https://omabrowser.org/oma/vps/Q9UBU3/

1

1 reference

20 April 2022

https://bgee.org/bgee15_0/gene/ENSG00000157017

body of stomach

2

1 reference

20 April 2022

https://bgee.org/bgee15_0/gene/ENSG00000157017

pancreatic epithelial cell

3

1 reference

20 April 2022

https://bgee.org/bgee15_0/gene/ENSG00000157017

4

1 reference

20 April 2022

https://bgee.org/bgee15_0/gene/ENSG00000157017

bone marrow cells

5

1 reference

20 April 2022

https://bgee.org/bgee15_0/gene/ENSG00000157017

pancreatic ductal cell

6

1 reference

20 April 2022

https://bgee.org/bgee15_0/gene/ENSG00000157017

islet of Langerhans

7

1 reference

20 April 2022

https://bgee.org/bgee15_0/gene/ENSG00000157017

8

1 reference

20 April 2022

https://bgee.org/bgee15_0/gene/ENSG00000157017

9

1 reference

20 April 2022

https://bgee.org/bgee15_0/gene/ENSG00000157017

10

1 reference

20 April 2022

https://bgee.org/bgee15_0/gene/ENSG00000157017

http://identifiers.org/ncbigene/51738

1 reference

Identifiers.org

http://www.ebi.ac.uk/miriam/main/collections/MIR:00000069

Identifiers

1 reference

15 May 2022

1 reference

15 May 2022

1 reference

15 May 2022

1 reference

15 May 2022

1 reference

15 May 2022

1 reference

15 May 2022

1 reference

15 May 2022

1 reference

15 May 2022

1 reference

15 May 2022

1 reference

15 May 2022

1 reference

15 May 2022

1 reference

15 May 2022

Encyclopædia Universalis ID

0 references

Ensembl gene ID

ENSG00000157017

1 reference

ensembl Release 106

Ensembl gene ID

ENSG00000157017

Ensembl transcript ID

ENST00000287656

1 reference

ensembl Release 106

Ensembl gene ID

ENSG00000157017

ENST00000335542

1 reference

ensembl Release 106

Ensembl gene ID

ENSG00000157017

ENST00000422159

1 reference

ensembl Release 106

Ensembl gene ID

ENSG00000157017

ENST00000425479

1 reference

ensembl Release 106

Ensembl gene ID

ENSG00000157017

ENST00000429122

1 reference

ensembl Release 106

Ensembl gene ID

ENSG00000157017

ENST00000430179

1 reference

ensembl Release 106

Ensembl gene ID

ENSG00000157017

ENST00000437422

1 reference

ensembl Release 106

Ensembl gene ID

ENSG00000157017

ENST00000439975

1 reference

ensembl Release 106

Ensembl gene ID

ENSG00000157017

ENST00000446937

1 reference

ensembl Release 106

Ensembl gene ID

ENSG00000157017

ENST00000449238

1 reference

ensembl Release 106

Ensembl gene ID

ENSG00000157017

ENST00000457360

1 reference

ensembl Release 106

Ensembl gene ID

ENSG00000157017

ENST00000475759

1 reference

ensembl Release 106

Ensembl gene ID

ENSG00000157017

ENST00000476283

1 reference

ensembl Release 106

Ensembl gene ID

ENSG00000157017

ENST00000481287

1 reference

ensembl Release 106

Ensembl gene ID

ENSG00000157017

ENST00000491589

1 reference

ensembl Release 106

Ensembl gene ID

ENSG00000157017

HGNC gene symbol

1 reference

15 May 2022

1 reference

15 May 2022

Microsoft Academic ID

0 references

0 references

1 reference

based on heuristic

inferred by common HGNC mappings on source and on Wikidata

15 June 2023

Sitelinks

Wikipedia(1 entry)

enwiki GHRL

Wikibooks(0 entries)

Wikinews(0 entries)

Wikiquote(0 entries)

Wikisource(0 entries)

Wikiversity(0 entries)

Wikivoyage(0 entries)

Wiktionary(0 entries)

Multilingual sites(0 entries)

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