Wikidata

(Q21170314)

English

DEAD-box helicase 5

mammalian protein found in Homo sapiens

  • DEAD box-5
  • DDX5
  • probable ATP-dependent RNA helicase DDX5
  • DEAD box protein 5
  • DEAD (Asp-Glu-Ala-Asp) box polypeptide 5
  • DEAD/H (Asp-Glu-Ala-Asp/His) box polypeptide 5 (RNA helicase, 68kD)
  • DEAD (Asp-Glu-Ala-Asp) box helicase 5
  • ATP-dependent RNA helicase DDX5
  • RNA helicase p68
  • Ddx5 protein, human
In more languages

Statements

molecular function
protein binding
determination method
IPI
31 references
retrieved
8 April 2019
stated in
Transcription-dependent nucleolar cap localization and possible nuclear function of DExH RNA helicase RHAU.
GOA
curator
UniProt
UniProt protein ID
P17844
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P17844
determination method
IPI
retrieved
8 April 2019
stated in
The RNA helicase Ddx5/p68 binds to hUpf3 and enhances NMD of Ddx17/p72 and Smg5 mRNA
GOA
curator
UniProt
UniProt protein ID
P17844
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P17844
determination method
IPI
retrieved
8 April 2019
stated in
RNA helicase p68 (DDX5) regulates tau exon 10 splicing by modulating a stem-loop structure at the 5' splice site
GOA
curator
UniProt
UniProt protein ID
P17844
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P17844
determination method
IPI
retrieved
8 April 2019
stated in
Proteomic and functional analysis of Argonaute-containing mRNA-protein complexes in human cells
GOA
curator
UniProt
UniProt protein ID
P17844
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P17844
determination method
IPI
retrieved
8 April 2019
stated in
RNA helicases DDX5 and DDX17 dynamically orchestrate transcription, miRNA, and splicing programs in cell differentiation
GOA
curator
UniProt
UniProt protein ID
P17844
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P17844
determination method
IPI
retrieved
8 April 2019
stated in
p68 (Ddx5) interacts with Runx2 and regulates osteoblast differentiation
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P17844
determination method
IPI
retrieved
8 April 2019
stated in
Dual role of the ddx5/ddx17 RNA helicases in the control of the pro-migratory NFAT5 transcription factor
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P17844
determination method
IPI
retrieved
8 April 2019
stated in
The nuclear DEAD box RNA helicase p68 interacts with the nucleolar protein fibrillarin and colocalizes specifically in nascent nucleoli during telophase
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P17844
determination method
IPI
retrieved
8 April 2019
stated in
Dynamic protein-protein interaction wiring of the human spliceosome
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P17844
determination method
IPI
retrieved
8 April 2019
stated in
A physical interaction network of dengue virus and human proteins
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P17844
determination method
IPI
retrieved
8 April 2019
stated in
The p68 and p72 DEAD box RNA helicases interact with HDAC1 and repress transcription in a promoter-specific manner
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P17844
determination method
IPI
retrieved
8 April 2019
stated in
The RNA helicase DDX5/p68 is a key factor promoting c-fos expression at different levels from transcription to mRNA export
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P17844
determination method
IPI
retrieved
8 April 2019
stated in
Synergism between p68 RNA helicase and the transcriptional coactivators CBP and p300
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P17844
determination method
IPI
retrieved
8 April 2019
stated in
Generation and comprehensive analysis of an influenza virus polymerase cellular interaction network
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P17844
determination method
IPI
retrieved
8 April 2019
stated in
Modulation of microRNA processing by p53
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P17844
determination method
IPI
retrieved
8 April 2019
stated in
Mammalian splicing factor SF1 interacts with SURP domains of U2 snRNP-associated proteins
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P17844
determination method
IPI
retrieved
8 April 2019
stated in
Acetylation of p53 stimulates miRNA processing and determines cell survival following genotoxic stress
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P17844
determination method
IPI
retrieved
8 April 2019
stated in
The RNA helicases p68/p72 and the noncoding RNA SRA are coregulators of MyoD and skeletal muscle differentiation
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P17844
determination method
IPI
retrieved
8 April 2019
stated in
SMAD proteins control DROSHA-mediated microRNA maturation
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P17844
determination method
IPI
retrieved
8 April 2019
stated in
Identification of intracellular proteins associated with the EBV-encoded nuclear antigen 5 using an efficient TAP procedure and FT-ICR mass spectrometry
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P17844
determination method
IPI
retrieved
8 April 2019
stated in
The DEAD box protein p68: a novel transcriptional coactivator of the p53 tumour suppressor
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P17844
determination method
IPI
retrieved
8 April 2019
stated in
Phosphorylated p68 RNA helicase activates Snail1 transcription by promoting HDAC1 dissociation from the Snail1 promoter
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P17844
determination method
IPI
retrieved
8 April 2019
stated in
Hippo signaling regulates microprocessor and links cell-density-dependent miRNA biogenesis to cancer
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P17844
determination method
IPI
retrieved
8 April 2019
stated in
The variable N-terminal region of DDX5 contains structural elements and auto-inhibits its interaction with NS5B of hepatitis C virus
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P17844
determination method
IPI
retrieved
8 April 2019
stated in
Histone deacetylase 1 enhances microRNA processing via deacetylation of DGCR8
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P17844
determination method
IPI
retrieved
8 April 2019
stated in
The RNA helicase p68 modulates expression and function of the Δ133 isoform(s) of p53, and is inversely associated with Δ133p53 expression in breast cancer
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P17844
determination method
IPI
retrieved
8 April 2019
stated in
Cellular RNA helicase p68 relocalization and interaction with the hepatitis C virus (HCV) NS5B protein and the potential role of p68 in HCV RNA replication
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P17844
determination method
IPI
retrieved
8 April 2019
stated in
DDX5 facilitates HIV-1 replication as a cellular co-factor of Rev.
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P17844
determination method
IPI
retrieved
8 April 2019
stated in
SMAD proteins control DROSHA-mediated microRNA maturation
GOA
curator
British Heart Foundation
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P17844
determination method
IPI
retrieved
8 April 2019
stated in
Host factors that interact with the pestivirus N-terminal protease, Npro, are components of the ribonucleoprotein complex
GOA
curator
AgBase
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P17844
determination method
IPI
retrieved
8 April 2019
stated in
Proteomic profiling of cellular proteins interacting with the hepatitis C virus core protein
GOA
curator
AgBase
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P17844
determination method
IPI
cell component
biological process

Identifiers

MeSH descriptor ID
C506749
subject named as
Ddx5 protein, human
0 references
Ensembl protein ID
 
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