(Q21171815)

English

Synaptotagmin 1

mammalian protein found in Homo sapiens

synaptotagmin-1
sytI
SYT1
p65
synaptotagmin I

In more languages

Statements

1 reference

13 November 2019

UniProt protein ID

C2 domain superfamily

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/P21579

Synaptotagmin 1/2

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/P21579

synaptosomal vesicle fusion pore

1 reference

Transporter Classification Database ID

2 October 2019

based on heuristic

hierarchical database ID heuristic

membrane protein

1 reference

based on heuristic

inferred from GOA cell component → membrane

C2 domain, protein family

1 reference

based on heuristic

inferred from protein domain or family

1 reference

based on heuristic

inferred from protein domain or family

1 reference

13 November 2019

UniProt protein ID

1 reference

13 November 2019

UniProt protein ID

molecular function

protein C-terminus binding

determination method

1 reference

8 April 2019

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P21579

determination method

metal ion binding

determination method

1 reference

8 April 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P21579

determination method

identical protein binding

determination method

1 reference

8 April 2019

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P21579

determination method

calcium-dependent protein binding

determination method

1 reference

8 April 2019

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P21579

determination method

phospholipid binding

determination method

1 reference

8 April 2019

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P21579

determination method

calmodulin binding

determination method

1 reference

8 April 2019

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P21579

determination method

1-phosphatidylinositol binding

determination method

1 reference

8 April 2019

Direct interaction of the Rab3 effector RIM with Ca2+ channels, SNAP-25, and synaptotagmin

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P21579

determination method

phosphatidylserine binding

determination method

1 reference

26 September 2017

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?protein=P21579&geneProductId=UniProtKB:P21579

determination method

low-density lipoprotein particle receptor binding

determination method

1 reference

8 April 2019

Normal development and fertility of knockout mice lacking the tumor suppressor gene LRP1b suggest functional compensation by LRP1

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P21579

determination method

syntaxin binding

determination method

1 reference

26 September 2017

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?protein=P21579&geneProductId=UniProtKB:P21579

determination method

protein binding

determination method

6 references

8 April 2019

Human SCAMP5, a novel secretory carrier membrane protein, facilitates calcium-triggered cytokine secretion by interaction with SNARE machinery

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P21579

determination method

8 April 2019

Direct interaction of the Rab3 effector RIM with Ca2+ channels, SNAP-25, and synaptotagmin

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P21579

determination method

8 April 2019

S100A13-C2A binary complex structure-a key component in the acidic fibroblast growth factor for the non-classical pathway

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P21579

determination method

8 April 2019

Systematic protein-protein interaction mapping for clinically relevant human GPCRs

IntAct protein interaction database

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P21579

determination method

8 April 2019

Expanding the substantial interactome of NEMO using protein microarrays

IntAct protein interaction database

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P21579

determination method

8 April 2019

Alternative splicing of the voltage-gated Ca2+ channel beta4 subunit creates a uniquely folded N-terminal protein binding domain with cell-specific expression in the cerebellar cortex

IntAct protein interaction database

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P21579

determination method

syntaxin-1 binding

determination method

3 references

8 April 2019

Direct interaction of the Rab3 effector RIM with Ca2+ channels, SNAP-25, and synaptotagmin

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P21579

determination method

8 April 2019

Parkinsons Disease Gene Ontology Initiative

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P21579

determination method

8 April 2019

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P21579

determination method

calcium-dependent phospholipid binding

determination method

4 references

26 September 2017

Sr2+ binding to the Ca2+ binding site of the synaptotagmin 1 C2B domain triggers fast exocytosis without stimulating SNARE interactions

Parkinsons Disease Gene Ontology Initiative

http://www.ebi.ac.uk/QuickGO/annotations?protein=P21579&geneProductId=UniProtKB:P21579

determination method

26 September 2017

Parkinsons Disease Gene Ontology Initiative

http://www.ebi.ac.uk/QuickGO/annotations?protein=P21579&geneProductId=UniProtKB:P21579

determination method

26 September 2017

http://www.ebi.ac.uk/QuickGO/annotations?protein=P21579&geneProductId=UniProtKB:P21579

determination method

26 September 2017

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?protein=P21579&geneProductId=UniProtKB:P21579

determination method

syntaxin-3 binding

determination method

1 reference

8 April 2019

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P21579

determination method

protein heterodimerization activity

determination method

1 reference

8 April 2019

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P21579

determination method

determination method

3 references

calcium-dependent phospholipid binding

determination method

5 references

8 April 2019

Sr2+ binding to the Ca2+ binding site of the synaptotagmin 1 C2B domain triggers fast exocytosis without stimulating SNARE interactions

Parkinsons Disease Gene Ontology Initiative

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P21579

determination method

8 April 2019

Parkinsons Disease Gene Ontology Initiative

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P21579

determination method

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P21579

determination method

8 April 2019

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P21579

determination method

8 April 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P21579

determination method

phosphatidylinositol-4,5-bisphosphate binding

determination method

1 reference

8 April 2019

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P21579

determination method

calcium ion sensor activity

determination method

1 reference

8 April 2019

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P21579

determination method

terminal bouton

determination method

1 reference

26 September 2017

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?protein=P21579&geneProductId=UniProtKB:P21579

determination method

determination method

1 reference

8 April 2019

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P21579

determination method

clathrin-sculpted glutamate transport vesicle membrane

determination method

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P21579

determination method

intracellular organelle

determination method

1 reference

8 April 2019

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P21579

determination method

transport vesicle membrane

determination method

1 reference

8 April 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P21579

determination method

determination method

1 reference

8 April 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P21579

determination method

integral component of membrane

determination method

1 reference

8 April 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P21579

determination method

Golgi apparatus

determination method

1 reference

8 April 2019

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P21579

determination method

determination method

1 reference

8 April 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P21579

determination method

clathrin-sculpted gamma-aminobutyric acid transport vesicle membrane

determination method

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P21579

determination method

presynaptic membrane

determination method

1 reference

8 April 2019

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P21579

determination method

dense core granule

determination method

1 reference

26 September 2017

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?protein=P21579&geneProductId=UniProtKB:P21579

determination method

clathrin-sculpted monoamine transport vesicle membrane

determination method

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P21579

determination method

chromaffin granule membrane

determination method

1 reference

8 April 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P21579

determination method

determination method

2 references

excitatory synapse

determination method

1 reference

8 April 2019

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P21579

determination method

synaptic vesicle

determination method

3 references

secretory granule

determination method

1 reference

8 April 2019

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P21579

determination method

clathrin-sculpted acetylcholine transport vesicle membrane

determination method

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P21579

determination method

cytoplasmic vesicle

determination method

1 reference

8 April 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P21579

determination method

synaptic vesicle membrane

determination method

4 references

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P21579

determination method

8 April 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P21579

determination method

8 April 2019

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P21579

determination method

8 April 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P21579

determination method

plasma membrane

determination method

integral component of synaptic vesicle membrane

determination method

1 reference

8 April 2019

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P21579

determination method

determination method

1 reference

26 September 2017

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?protein=P21579&geneProductId=UniProtKB:P21579

determination method

clathrin-coated vesicle membrane

determination method

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P21579

determination method

neuron projection terminus

determination method

1 reference

8 April 2019

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P21579

determination method

determination method

3 references

8 April 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P21579

determination method

8 April 2019

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P21579

determination method

8 April 2019

Intracellular distribution of differentially phosphorylated dual-specificity tyrosine phosphorylation-regulated kinase 1A (DYRK1A).

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P21579

determination method

exocytic vesicle

determination method

1 reference

8 April 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P21579

determination method

hippocampal mossy fiber to CA3 synapse

determination method

1 reference

8 April 2019

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P21579

determination method

glutamatergic synapse

determination method

1 reference

8 April 2019

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P21579

determination method

biological process

positive regulation of vesicle fusion

determination method

1 reference

8 April 2019

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P21579

determination method

chemical synaptic transmission

determination method

1 reference

8 April 2019

Structural and functional conservation of synaptotagmin (p65) in Drosophila and humans

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P21579

determination method

synaptic vesicle exocytosis

determination method

1 reference

26 September 2017

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?protein=P21579&geneProductId=UniProtKB:P21579

determination method

positive regulation of calcium ion-dependent exocytosis

determination method

1 reference

8 April 2019

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P21579

determination method

response to calcium ion

determination method

1 reference

8 April 2019

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P21579

determination method

brain development

determination method

1 reference

8 April 2019

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P21579

determination method

glutamate secretion

determination method

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P21579

determination method

positive regulation of dendrite extension

determination method

1 reference

8 April 2019

SYT14L, especially its C2 domain, is involved in regulating melanocyte differentiation

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P21579

determination method

regulation of exocytosis

determination method

1 reference

8 April 2019

Direct interaction of the Rab3 effector RIM with Ca2+ channels, SNAP-25, and synaptotagmin

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P21579

determination method

synaptic vesicle endocytosis

determination method

1 reference

8 April 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P21579

determination method

vesicle docking

determination method

1 reference

8 April 2019

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P21579

determination method

cell differentiation

determination method

1 reference

8 April 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P21579

determination method

neurotransmitter secretion

determination method

4 references

8 April 2019

Direct interaction of the Rab3 effector RIM with Ca2+ channels, SNAP-25, and synaptotagmin

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P21579

determination method

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P21579

determination method

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P21579

determination method

8 April 2019

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P21579

determination method

determination method

1 reference

26 September 2017

http://www.ebi.ac.uk/QuickGO/annotations?protein=P21579&geneProductId=UniProtKB:P21579

determination method

calcium ion-regulated exocytosis of neurotransmitter

determination method

1 reference

14 January 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?protein=P21579&geneProductId=UniProtKB:P21579

determination method

regulation of dopamine secretion

determination method

1 reference

26 September 2017

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?protein=P21579&geneProductId=UniProtKB:P21579

determination method

protein heterooligomerization

determination method

1 reference

8 April 2019

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P21579

determination method

membrane organization

determination method

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P21579

determination method

vesicle-mediated transport

determination method

1 reference

8 April 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P21579

determination method

calcium-ion regulated exocytosis

determination method

1 reference

8 April 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P21579

determination method

cellular response to calcium ion

determination method

3 references

calcium-dependent activation of synaptic vesicle fusion

determination method

1 reference

8 April 2019

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P21579

determination method

spontaneous neurotransmitter secretion

determination method

1 reference

8 April 2019

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P21579

determination method

synchronous neurotransmitter secretion

determination method

1 reference

8 April 2019

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P21579

determination method

regulation of synaptic vesicle exocytosis

determination method

1 reference

8 April 2019

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P21579

determination method

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/P21579

Synaptotagmin domain

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/P21579

Identifiers

MeSH descriptor ID

subject named as

Synaptotagmin I

0 references

D12.776.157.125.825.249

0 references

D12.776.543.990.850.249

0 references

RefSeq protein ID

1 reference

30 May 2020

1 reference

30 May 2020

1 reference

30 May 2020

1 reference

30 May 2020

1 reference

30 May 2020

1 reference

30 May 2020

1 reference

30 May 2020

UniProt protein ID

1 reference

13 November 2019

UniProt protein ID

Ensembl protein ID

ENSP00000261205

1 reference

Ensembl Release 99

Ensembl protein ID

ENSP00000261205

ENSP00000376932

1 reference

Ensembl Release 99

Ensembl protein ID

ENSP00000376932

ENSP00000447575

1 reference

Ensembl Release 99

Ensembl protein ID

ENSP00000447575

ENSP00000391056

1 reference

Ensembl Release 99

Ensembl protein ID

ENSP00000391056

ENSP00000401559

1 reference

Ensembl Release 99

Ensembl protein ID

ENSP00000401559

ENSP00000447035

1 reference

Ensembl Release 99

Ensembl protein ID

ENSP00000447035

ENSP00000447656

1 reference

Ensembl Release 99

Ensembl protein ID

ENSP00000447656

ENSP00000448861

1 reference

Ensembl Release 99

Ensembl protein ID

ENSP00000448861

ENSP00000448964

1 reference

Ensembl Release 99

Ensembl protein ID

ENSP00000448964

ENSP00000450321

1 reference

Ensembl Release 99

Ensembl protein ID

ENSP00000450321

PDB structure ID

1 reference

UniProt protein ID

4 August 2016

language of work or name

1 reference

UniProt protein ID

4 August 2016

language of work or name

1 reference

UniProt protein ID

4 August 2016

language of work or name

1 reference

UniProt protein ID

4 August 2016

language of work or name

1 reference

UniProt protein ID

4 August 2016

language of work or name

1 reference

UniProt protein ID

4 August 2016

language of work or name

1 reference

UniProt protein ID

4 August 2016

language of work or name

1 reference

UniProt protein ID

4 August 2016

language of work or name

1 reference

UniProt protein ID

4 August 2016

language of work or name

1 reference

UniProt protein ID

4 August 2016

language of work or name

1 reference

UniProt protein ID

4 August 2016

language of work or name

1 reference

UniProt protein ID

4 August 2016

language of work or name

1 reference

UniProt protein ID

4 August 2016

language of work or name

Transporter Classification Database ID

2 references

Transporter Classification database

13 March 2020

Transporter Classification database

29 April 2020

1 reference

based on heuristic

inferred by common MeSH mappings on source and on Wikidata

25 May 2023

Sitelinks

Wikipedia(0 entries)

Wikibooks(0 entries)

Wikinews(0 entries)

Wikiquote(0 entries)

Wikisource(0 entries)

Wikiversity(0 entries)

Wikivoyage(0 entries)

Wiktionary(0 entries)

Multilingual sites(0 entries)

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