(Q21498822)

http://www.ebi.ac.uk/interpro/protein/O35598

disintegrin domain superfamily

1 reference

stated in

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/O35598

Metallopeptidase, catalytic domain superfamily

1 reference

stated in

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/O35598

membrane protein

1 reference

inferred from GOA cell component → membrane

Peptidase M12B, ADAM/reprolysin, protein family

1 reference

ADAM10/ADAM17 catalytic domain, protein family

1 reference

Disintegrin domain, protein family

1 reference

Peptidase M12B, propeptide family

1 reference

protein homodimerization activity

1 reference

25 May 2022

1 reference

25 May 2022

1 reference

9 May 2019

MADM, a novel adaptor protein that mediates phosphorylation of the 14-3-3 binding site of myeloid leukemia factor 1

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O35598

1 reference

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O35598

The Notch ligand Delta1 is sequentially cleaved by an ADAM protease and gamma-secretase

endopeptidase activity

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O35598

1 reference

9 May 2019

MADM, a novel adaptor protein that mediates phosphorylation of the 14-3-3 binding site of myeloid leukemia factor 1

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O35598

1 reference

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O35598

1 reference

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O35598

1 reference

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O35598

metallopeptidase activity

6 references

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O35598

9 May 2019

The disintegrin/metalloprotease ADAM 10 is essential for Notch signalling but not for alpha-secretase activity in fibroblasts

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O35598

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O35598

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O35598

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O35598

9 May 2019

Ectodomain shedding of the neural recognition molecule CHL1 by the metalloprotease-disintegrin ADAM8 promotes neurite outgrowth and suppresses neuronal cell death

British Heart Foundation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O35598

MADM, a novel adaptor protein that mediates phosphorylation of the 14-3-3 binding site of myeloid leukemia factor 1

protein kinase binding

1 reference

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O35598

metalloendopeptidase activity

5 references

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O35598

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O35598

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O35598

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O35598

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O35598

endopeptidase activity

3 references

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O35598

8 April 2019

Metalloproteases regulate T-cell proliferation and effector function via LAG-3

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O35598

8 April 2019

The Notch ligand Delta1 is sequentially cleaved by an ADAM protease and gamma-secretase

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O35598

endopeptidase activity

4 references

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O35598

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O35598

9 May 2019

Metalloproteases regulate T-cell proliferation and effector function via LAG-3

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O35598

9 May 2019

The Notch ligand Delta1 is sequentially cleaved by an ADAM protease and gamma-secretase

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O35598

1 reference

9 May 2019

MADM, a novel adaptor protein that mediates phosphorylation of the 14-3-3 binding site of myeloid leukemia factor 1

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O35598

integral component of membrane

1 reference

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O35598

4 references

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O35598

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O35598

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O35598

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O35598

1 reference

9 May 2019

Synapse-associated protein-97 mediates alpha-secretase ADAM10 trafficking and promotes its activity

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O35598

MADM, a novel adaptor protein that mediates phosphorylation of the 14-3-3 binding site of myeloid leukemia factor 1

Golgi-associated vesicle

1 reference

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O35598

1 reference

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O35598

1 reference

31 January 2018

Extracellular matrix secretion by cardiac fibroblasts: role of microRNA-29b and microRNA-30c

British Heart Foundation

http://www.ebi.ac.uk/QuickGO/annotations?protein=O35598&geneProductId=UniProtKB:O35598

1 reference

31 January 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=O35598&geneProductId=UniProtKB:O35598

1 reference

9 May 2019

Extracellular matrix secretion by cardiac fibroblasts: role of microRNA-29b and microRNA-30c

British Heart Foundation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O35598

collagen-containing extracellular matrix

HDA

HDA

glutamatergic synapse

4 references

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O35598

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O35598

9 May 2019

Synaptic localization and activity of ADAM10 regulate excitatory synapses through N-cadherin cleavage

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O35598

9 May 2019

Synaptic localization and activity of ADAM10 regulate excitatory synapses through N-cadherin cleavage

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O35598

negative regulation of cell adhesion

EXP

biological process

1 reference

9 May 2019

Ectodomains of the LDL receptor-related proteins LRP1b and LRP4 have anchorage independent functions in vivo

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O35598

in utero embryonic development

1 reference

9 May 2019

The disintegrin/metalloprotease ADAM 10 is essential for Notch signalling but not for alpha-secretase activity in fibroblasts

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O35598

MADM, a novel adaptor protein that mediates phosphorylation of the 14-3-3 binding site of myeloid leukemia factor 1

IMP

protein phosphorylation

1 reference

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O35598

membrane protein ectodomain proteolysis

4 references

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O35598

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O35598

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O35598

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O35598

nucleocytoplasmic transport

1 reference

9 May 2019

MADM, a novel adaptor protein that mediates phosphorylation of the 14-3-3 binding site of myeloid leukemia factor 1

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O35598

The disintegrin/metalloprotease ADAM 10 is essential for Notch signalling but not for alpha-secretase activity in fibroblasts

NAS

Notch signaling pathway

3 references

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O35598

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O35598

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O35598

Notch receptor processing

1 reference

9 May 2019

The disintegrin/metalloprotease ADAM 10 is essential for Notch signalling but not for alpha-secretase activity in fibroblasts

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O35598

1 reference

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O35598

response to antineoplastic agent

1 reference

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O35598

membrane protein ectodomain proteolysis

5 references

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O35598

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O35598

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O35598

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O35598

9 May 2019

Metalloproteases regulate T-cell proliferation and effector function via LAG-3

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O35598