(Q24290107)

English

An asn to lys polymorphism in the third intracellular loop of the human alpha 2A-adrenergic receptor imparts enhanced agonist-promoted Gi coupling

scientific article

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scholarly article

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An asn to lys polymorphism in the third intracellular loop of the human alpha 2A-adrenergic receptor imparts enhanced agonist-promoted Gi coupling (English)

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Adrenoceptor alpha 2A

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GOA release 2020-03-11

phospholipase C-activating adrenergic receptor signaling pathway

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GOA release 2020-03-11

author name string

K M Small

1

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S L Forbes

2

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K M Brown

3

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S B Liggett

4

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language of work or name

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publication date

8 December 2000

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Journal of Biological Chemistry

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275

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49

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38518-23

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Pharmacologic and therapeutic applications of alpha 2-adrenoceptor subtypes

1 reference

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Two functionally distinct alpha2-adrenergic receptors regulate sympathetic neurotransmission

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Substitution of a mutant alpha2a-adrenergic receptor via "hit and run" gene targeting reveals the role of this subtype in sedative, analgesic, and anesthetic-sparing responses in vivo

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Guanabenz. A review of its pharmacodynamic properties and therapeutic efficacy in hypertension

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Expression of altered alpha2-adrenergic phenotypic traits in normotensive humans at genetic risk of hereditary (essential) hypertension

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Alpha 2-adrenergic receptor gene polymorphism and hypertension in blacks

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Pharmacogenetics of relevant targets in asthma.

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Genetic markers at the leptin (OB) locus are not significantly linked to hypertension in African Americans

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High level transient gene expression in human lymphoid cells by SV40 large T antigen boost

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Four consecutive serines in the third intracellular loop are the sites for beta-adrenergic receptor kinase-mediated phosphorylation and desensitization of the alpha 2A-adrenergic receptor

1 reference

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21 January 2018

The palmitoylated cysteine of the cytoplasmic tail of alpha 2A-adrenergic receptors confers subtype-specific agonist-promoted downregulation

1 reference

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Measurement of protein using bicinchoninic acid

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Regulation of phosphoinositide phospholipases by hormones, neurotransmitters, and other agonists linked to G proteins

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Sympathoinhibitory function of the alpha(2A)-adrenergic receptor subtype.

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Defects in G protein-coupled signal transduction in human disease

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Essential hypertension in African Caribbeans associates with a variant of the beta2-adrenoceptor.

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The Ile164 beta2-adrenergic receptor polymorphism adversely affects the outcome of congestive heart failure

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A constitutively activating mutation of the luteinizing hormone receptor in familial male precocious puberty

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Association between β2-adrenoceptor polymorphism and susceptibility to bronchodilator desensitisation in moderately severe stable asthmatics

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Regulation of mitogen-activated protein kinase pathways by catecholamine receptors

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based on heuristic

inferred from DOI database lookup

Agonist-mediated downregulation of G alpha i via the alpha 2-adrenergic receptor is targeted by receptor-Gi interaction and is independent of receptor signaling and regulation

1 reference

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7 January 2021

based on heuristic

inferred from DOI database lookup

G protein-coupled receptor kinase specificity for phosphorylation and desensitization of alpha2-adrenergic receptor subtypes

1 reference

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7 January 2021

based on heuristic

inferred from DOI database lookup

Abnormal regulation of the sympathetic nervous system in alpha2A-adrenergic receptor knockout mice.

1 reference

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7 January 2021

based on heuristic

inferred from DOI database lookup

Visual pigment gene structure and the severity of color vision defects

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Association of hypertension with beta2- and alpha2c10-adrenergic receptor genotype

1 reference

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based on heuristic

inferred from DOI database lookup

Identifiers

10.1074/JBC.M004550200

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