(Q24292770)

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Delayed transactivation of the receptor for nerve growth factor is required for sustained signaling and differentiation by alpha2-adrenergic receptors in transfected PC12 cells

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Delayed transactivation of the receptor for nerve growth factor is required for sustained signaling and differentiation by alpha2-adrenergic receptors in transfected PC12 cells (English)

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Adrenoceptor alpha 2B

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GOA release 2020-03-11

Adrenoceptor alpha 2C

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GOA release 2020-03-11

Adrenoceptor alpha 2A

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GOA release 2020-03-11

adrenergic receptor signaling pathway

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GOA release 2020-03-11

author name string

Georgios Karkoulias

1

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Christodoulos Flordellis

2

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language of work or name

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publication date

May 2007

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Cellular Signalling

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19

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5

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945-57

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Neuronal differentiation signals are controlled by nerve growth factor receptor/Trk binding sites for SHC and PLC gamma.

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Different mechanisms for inhibition of cell proliferation via cell cycle proteins in PC12 cells by nerve growth factor and staurosporine

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A radioactive binding assay for inhibitors of trkA kinase

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WAF1, a potential mediator of p53 tumor suppression

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A novel phosphoinositide 3 kinase activity in myeloid-derived cells is activated by G protein beta gamma subunits

1 reference

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Trk receptors use redundant signal transduction pathways involving SHC and PLC-gamma 1 to mediate NGF responses

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alpha(2)-Adrenergic receptors activate MAPK and Akt through a pathway involving arachidonic acid metabolism by cytochrome P450-dependent epoxygenase, matrix metalloproteinase activation and subtype-specific transactivation of EGFR.

1 reference

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Localization and trafficking of alpha2-adrenergic receptor subtypes in cells and tissues

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Central adenosine A(2A) receptors: an overview

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Two alpha(2)-adrenergic receptor subtypes, alpha(2A) and alpha(2C), inhibit transmitter release in the brain of gene-targeted mice

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D-amphetamine and L-5-hydroxytryptophan-induced behaviours in mice with genetically-altered expression of the alpha2C-adrenergic receptor subtype.

1 reference

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EGF triggers neuronal differentiation of PC12 cells that overexpress the EGF receptor

1 reference

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Ras-dependent activation of MAP kinase pathway mediated by G-protein beta gamma subunits.

1 reference

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Role of transactivation of the EGF receptor in signalling by G-protein-coupled receptors

1 reference

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EGF receptor transactivation by G-protein-coupled receptors requires metalloproteinase cleavage of proHB-EGF

1 reference

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Alpha2A-adrenoceptors are important modulators of the effects of D-amphetamine on startle reactivity and brain monoamines

1 reference

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Sustained activation of the mitogen-activated protein (MAP) kinase cascade may be required for differentiation of PC12 cells. Comparison of the effects of nerve growth factor and epidermal growth factor

1 reference

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Activation of Trk neurotrophin receptors in the absence of neurotrophins

1 reference

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Cell cycle arrest mediated by the MEK/mitogen-activated protein kinase pathway

1 reference

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Constitutive overexpression of CDK2 inhibits neuronal differentiation of rat pheochromocytoma PC12 cells

1 reference

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Discovery of a novel, potent, and Src family-selective tyrosine kinase inhibitor. Study of Lck- and FynT-dependent T cell activation

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Gbetagamma subunits mediate Src-dependent phosphorylation of the epidermal growth factor receptor. A scaffold for G protein-coupled receptor-mediated Ras activation

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Differential coupling of alpha1-, alpha2-, and beta-adrenergic receptors to mitogen-activated protein kinase pathways and differentiation in transfected PC12 cells

1 reference

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Activation of Trk neurotrophin receptor signaling by pituitary adenylate cyclase-activating polypeptides

1 reference

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Cyclic AMP induces transactivation of the receptors for epidermal growth factor and nerve growth factor, thereby modulating activation of MAP kinase, Akt, and neurite outgrowth in PC12 cells

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Differential kinetic and spatial patterns of beta-arrestin and G protein-mediated ERK activation by the angiotensin II receptor

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Angiotensin II Induces Transactivation of Two Different Populations of the Platelet-derived Growth Factor β Receptor

1 reference

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Subtype-specific neuronal differentiation of PC12 cells transfected with alpha2-adrenergic receptors

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alpha2-Adrenoceptor agonists: shedding light on neuroprotection?

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Signal characteristics of G protein-transactivated EGF receptor

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Targeted in vivo expression of the cyclin-dependent kinase inhibitor p21 halts hepatocyte cell-cycle progression, postnatal liver development and regeneration

1 reference

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Relationship Between the Nerve Growth Factor-Regulated Clone 73 Gene Product and the 58-Kilodalton Neuronal Intermediate Filament Protein (Peripherin)

1 reference

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Activation of extracellular-regulated kinase by 5-hydroxytryptamine(2A) receptors in PC12 cells is protein kinase C-independent and requires calmodulin and tyrosine kinases

1 reference

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Kappa-opioid receptor signals through Src and focal adhesion kinase to stimulate c-Jun N-terminal kinases in transfected COS-7 cells and human monocytic THP-1 cells

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Genetic alteration of alpha 2C-adrenoceptor expression in mice: influence on locomotor, hypothermic, and neurochemical effects of dexmedetomidine, a subtype-nonselective alpha 2-adrenoceptor agonist.

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Type-specific regulation of adenylyl cyclase by G protein beta gamma subunits

1 reference

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Central hypotensive effects of the alpha2a-adrenergic receptor subtype.

1 reference

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Cardiovascular regulation in mice lacking alpha2-adrenergic receptor subtypes b and c.

1 reference

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Mitogen-activated protein kinase activation is insufficient for growth factor receptor-mediated PC12 cell differentiation

1 reference

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MyoD-induced expression of p21 inhibits cyclin-dependent kinase activity upon myocyte terminal differentiation

1 reference

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Effects of p21(Cip1/Waf1) at both the G1/S and the G2/M cell cycle transitions: pRb is a critical determinant in blocking DNA replication and in preventing endoreduplication

1 reference

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Physiological significance of alpha(2)-adrenergic receptor subtype diversity: one receptor is not enough

1 reference

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Diverse tissue expression of rat alpha 2-adrenergic receptor genes.

1 reference

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Role of the α 2B -Adrenergic Receptor in the Development of Salt-Induced Hypertension

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Transactivation of the insulin-like growth factor-I receptor by angiotensin II mediates downstream signaling from the angiotensin II type 1 receptor to phosphatidylinositol 3-kinase

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1 reference

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based on heuristic

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Nerve growth factor-treated, neurite-bearing PC12 cells continue to synthesize DNA

1 reference

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7 January 2021

based on heuristic

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K-252a: a specific inhibitor of the action of nerve growth factor on PC 12 cells

1 reference

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based on heuristic

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NGF regulates the PC12 cell cycle machinery through specific inhibition of the Cdk kinases and induction of cyclin D1

1 reference

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1 reference

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p21--negative regulator of the cell cycle

1 reference

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10.1016/J.CELLSIG.2006.11.003

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