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Regulation and roles of PI3Kβ, a major actor in platelet signaling and functions
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stated in
Europe PubMed Central
PubMed publication ID
21035500
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:21035500%20AND%20SRC:MED&resulttype=core&format=json
retrieved
15 January 2020
title
Regulation and roles of PI3Kβ, a major actor in platelet signaling and functions
(English)
1 reference
stated in
Europe PubMed Central
PubMed publication ID
21035500
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:21035500%20AND%20SRC:MED&resulttype=core&format=json
retrieved
15 January 2020
main subject
Phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit beta
1 reference
stated in
GOA release 2020-03-11
Phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit gamma
1 reference
stated in
GOA release 2020-03-11
Phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha
1 reference
stated in
GOA release 2020-03-11
platelet aggregation
1 reference
stated in
GOA release 2020-03-11
author
Marie-Pierre Gratacap
series ordinal
1
1 reference
stated in
Europe PubMed Central
PubMed publication ID
21035500
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:21035500%20AND%20SRC:MED&resulttype=core&format=json
retrieved
15 January 2020
Julie Guillermet-Guibert
series ordinal
2
1 reference
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Europe PubMed Central
PubMed publication ID
21035500
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:21035500%20AND%20SRC:MED&resulttype=core&format=json
retrieved
15 January 2020
Gaetan Chicanne
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4
1 reference
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Europe PubMed Central
PubMed publication ID
21035500
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:21035500%20AND%20SRC:MED&resulttype=core&format=json
retrieved
15 January 2020
Fréderique Gaits-Iacovoni
series ordinal
6
1 reference
stated in
Europe PubMed Central
PubMed publication ID
21035500
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:21035500%20AND%20SRC:MED&resulttype=core&format=json
retrieved
15 January 2020
author name string
Valérie Martin
series ordinal
3
1 reference
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Europe PubMed Central
PubMed publication ID
21035500
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:21035500%20AND%20SRC:MED&resulttype=core&format=json
retrieved
15 January 2020
Hélène Tronchère
series ordinal
5
1 reference
stated in
Europe PubMed Central
PubMed publication ID
21035500
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:21035500%20AND%20SRC:MED&resulttype=core&format=json
retrieved
15 January 2020
Bernard Payrastre
series ordinal
7
1 reference
stated in
Europe PubMed Central
PubMed publication ID
21035500
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:21035500%20AND%20SRC:MED&resulttype=core&format=json
retrieved
15 January 2020
language of work or name
English
0 references
publication date
28 October 2010
1 reference
stated in
Europe PubMed Central
PubMed publication ID
21035500
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:21035500%20AND%20SRC:MED&resulttype=core&format=json
retrieved
15 January 2020
published in
Advances in Enzyme Regulation
1 reference
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Europe PubMed Central
PubMed publication ID
21035500
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:21035500%20AND%20SRC:MED&resulttype=core&format=json
retrieved
15 January 2020
volume
51
1 reference
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Europe PubMed Central
PubMed publication ID
21035500
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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:21035500%20AND%20SRC:MED&resulttype=core&format=json
retrieved
15 January 2020
issue
1
1 reference
stated in
Europe PubMed Central
PubMed publication ID
21035500
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:21035500%20AND%20SRC:MED&resulttype=core&format=json
retrieved
15 January 2020
page(s)
106-116
1 reference
stated in
Europe PubMed Central
PubMed publication ID
21035500
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:21035500%20AND%20SRC:MED&resulttype=core&format=json
retrieved
15 January 2020
cites work
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Different roles of SHIP1 according to the cell context: the example of blood platelets.
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7 January 2021
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Should individual PI3 kinase isoforms be targeted in cancer?
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https://api.crossref.org/works/10.1016%2FJ.ADVENZREG.2010.09.011
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7 January 2021
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A pharmacological map of the PI3-K family defines a role for p110alpha in insulin signaling
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7 January 2021
based on heuristic
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Dominant role of the p110beta isoform of PI3K over p110alpha in energy homeostasis regulation by POMC and AgRP neurons
1 reference
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reference URL
https://api.crossref.org/works/10.1016%2FJ.ADVENZREG.2010.09.011
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7 January 2021
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Mammalian phosphoinositide kinases and phosphatases
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reference URL
https://api.crossref.org/works/10.1016%2FJ.ADVENZREG.2010.09.011
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Twice upon a time: PI3K's secret double life exposed
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Phosphoinositide signaling disorders in human diseases
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Crossref
reference URL
https://api.crossref.org/works/10.1016%2FJ.ADVENZREG.2010.09.011
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7 January 2021
based on heuristic
inferred from DOI database lookup
Activation of PI 3-kinase by G protein betagamma subunits
1 reference
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Crossref
reference URL
https://api.crossref.org/works/10.1016%2FJ.ADVENZREG.2010.09.011
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7 January 2021
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inferred from DOI database lookup
Phosphoinositides: key players in cell signalling, in time and space.
1 reference
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reference URL
https://api.crossref.org/works/10.1016%2FJ.ADVENZREG.2010.09.011
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inferred from DOI database lookup
Phosphoinositide recognition domains
1 reference
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Crossref
reference URL
https://api.crossref.org/works/10.1016%2FJ.ADVENZREG.2010.09.011
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7 January 2021
based on heuristic
inferred from DOI database lookup
Phosphatidylinositol-3-OH kinases are Rab5 effectors.
1 reference
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Crossref
reference URL
https://api.crossref.org/works/10.1016%2FJ.ADVENZREG.2010.09.011
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inferred from DOI database lookup
Phosphoinositides in cell regulation and membrane dynamics
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https://api.crossref.org/works/10.1016%2FJ.ADVENZREG.2010.09.011
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inferred from DOI database lookup
Angiogenesis selectively requires the p110alpha isoform of PI3K to control endothelial cell migration.
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https://api.crossref.org/works/10.1016%2FJ.ADVENZREG.2010.09.011
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Essential roles of PI(3)K-p110beta in cell growth, metabolism and tumorigenesis
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https://api.crossref.org/works/10.1016%2FJ.ADVENZREG.2010.09.011
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The PtdIns(3,4)P(2) phosphatase INPP4A is a suppressor of excitotoxic neuronal death
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https://api.crossref.org/works/10.1016%2FJ.ADVENZREG.2010.09.011
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7 January 2021
based on heuristic
inferred from DOI database lookup
PI 3-kinase p110beta: a new target for antithrombotic therapy
1 reference
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Crossref
reference URL
https://api.crossref.org/works/10.1016%2FJ.ADVENZREG.2010.09.011
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7 January 2021
based on heuristic
inferred from DOI database lookup
Effective use of PI3K and MEK inhibitors to treat mutant Kras G12D and PIK3CA H1047R murine lung cancers
1 reference
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reference URL
https://api.crossref.org/works/10.1016%2FJ.ADVENZREG.2010.09.011
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7 January 2021
based on heuristic
inferred from DOI database lookup
The emerging mechanisms of isoform-specific PI3K signalling
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Crossref
reference URL
https://api.crossref.org/works/10.1016%2FJ.ADVENZREG.2010.09.011
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7 January 2021
based on heuristic
inferred from DOI database lookup
Phosphoinositide 3-OH kinase p85alpha and p110beta are essential for androgen receptor transactivation and tumor progression in prostate cancers
1 reference
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Crossref
reference URL
https://api.crossref.org/works/10.1016%2FJ.ADVENZREG.2010.09.011
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7 January 2021
based on heuristic
inferred from DOI database lookup
A collagen-related peptide regulates phospholipase Cgamma2 via phosphatidylinositol 3-kinase in human platelets
1 reference
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Crossref
reference URL
https://api.crossref.org/works/10.1016%2FJ.ADVENZREG.2010.09.011
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7 January 2021
based on heuristic
inferred from DOI database lookup
Specific role for p85/p110beta in GTP-binding-protein-mediated activation of Akt.
1 reference
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Crossref
reference URL
https://api.crossref.org/works/10.1016%2FJ.ADVENZREG.2010.09.011
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7 January 2021
based on heuristic
inferred from DOI database lookup
A chemical screen in diverse breast cancer cell lines reveals genetic enhancers and suppressors of sensitivity to PI3K isoform-selective inhibition.
1 reference
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Crossref
reference URL
https://api.crossref.org/works/10.1016%2FJ.ADVENZREG.2010.09.011
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7 January 2021
based on heuristic
inferred from DOI database lookup
Role of phosphoinositide 3-kinase beta in platelet aggregation and thromboxane A2 generation mediated by Gi signalling pathways
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FJ.ADVENZREG.2010.09.011
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7 January 2021
based on heuristic
inferred from DOI database lookup
Signalling through Class I PI3Ks in mammalian cells
1 reference
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Crossref
reference URL
https://api.crossref.org/works/10.1016%2FJ.ADVENZREG.2010.09.011
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7 January 2021
based on heuristic
inferred from DOI database lookup
Oncogenic transformation induced by the p110beta, -gamma, and -delta isoforms of class I phosphoinositide 3-kinase
1 reference
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Crossref
reference URL
https://api.crossref.org/works/10.1016%2FJ.ADVENZREG.2010.09.011
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7 January 2021
based on heuristic
inferred from DOI database lookup
The p110beta isoform of phosphoinositide 3-kinase signals downstream of G protein-coupled receptors and is functionally redundant with p110gamma.
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FJ.ADVENZREG.2010.09.011
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7 January 2021
based on heuristic
inferred from DOI database lookup
Activity of any class IA PI3K isoform can sustain cell proliferation and survival.
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FJ.ADVENZREG.2010.09.011
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7 January 2021
based on heuristic
inferred from DOI database lookup
A constitutively activated form of the p110beta isoform of PI3-kinase induces prostatic intraepithelial neoplasia in mice
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FJ.ADVENZREG.2010.09.011
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7 January 2021
based on heuristic
inferred from DOI database lookup
Phosphoinositide 3-kinase inhibition spares actin assembly in activating platelets but reverses platelet aggregation
1 reference
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Crossref
reference URL
https://api.crossref.org/works/10.1016%2FJ.ADVENZREG.2010.09.011
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7 January 2021
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inferred from DOI database lookup
Purification and characterization of Gbetagamma-responsive phosphoinositide 3-kinases from pig platelet cytosol
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The role of phosphoinositide 3-kinase lipid products in cell function
1 reference
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Crossref
reference URL
https://api.crossref.org/works/10.1016%2FJ.ADVENZREG.2010.09.011
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7 January 2021
based on heuristic
inferred from DOI database lookup
Roles of non-catalytic subunits in gbetagamma-induced activation of class I phosphoinositide 3-kinase isoforms beta and gamma
1 reference
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Crossref
reference URL
https://api.crossref.org/works/10.1016%2FJ.ADVENZREG.2010.09.011
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7 January 2021
based on heuristic
inferred from DOI database lookup
Phosphoinositide 3-kinase p110 beta regulates integrin alpha IIb beta 3 avidity and the cellular transmission of contractile forces.
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FJ.ADVENZREG.2010.09.011
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Non-redundant roles of phosphoinositide 3-kinase isoforms alpha and beta in glycoprotein VI-induced platelet signaling and thrombus formation.
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FJ.ADVENZREG.2010.09.011
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Role of phosphoinositide 3-kinase beta in glycoprotein VI-mediated Akt activation in platelets
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FJ.ADVENZREG.2010.09.011
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Phosphoinositide 3-kinase pathway activation in phosphate and tensin homolog (PTEN)-deficient prostate cancer cells is independent of receptor tyrosine kinases and mediated by the p110beta and p110delta catalytic subunits
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FJ.ADVENZREG.2010.09.011
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Akt Activation in Platelets Depends on Gi Signaling Pathways
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FJ.ADVENZREG.2010.09.011
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Integrin alpha IIb beta 3-dependent calcium signals regulate platelet-fibrinogen interactions under flow. Involvement of phospholipase C gamma 2
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FJ.ADVENZREG.2010.09.011
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
SHIP1 and Lyn Kinase Negatively Regulate Integrin alpha IIb beta 3 signaling in platelets.
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FJ.ADVENZREG.2010.09.011
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
A phosphoinositide 3-kinase-AKT-nitric oxide-cGMP signaling pathway in stimulating platelet secretion and aggregation
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FJ.ADVENZREG.2010.09.011
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Essential role of the p110beta subunit of phosphoinositide 3-OH kinase in male fertility.
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FJ.ADVENZREG.2010.09.011
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Overlapping and distinct roles for PI3Kbeta and gamma isoforms in S1P-induced migration of human and mouse endothelial cells
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FJ.ADVENZREG.2010.09.011
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Association of phosphatidylinositol 3-kinase composed of p110beta-catalytic and p85-regulatory subunits with the small GTPase Rab5.
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FJ.ADVENZREG.2010.09.011
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Resistance to thromboembolism in PI3Kgamma-deficient mice.
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FJ.ADVENZREG.2010.09.011
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Integrins in platelet activation
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FJ.ADVENZREG.2010.09.011
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Dual P2Y 12 receptor signaling in thrombin-stimulated platelets--involvement of phosphoinositide 3-kinase beta but not gamma isoform in Ca2+ mobilization and procoagulant activity.
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FJ.ADVENZREG.2010.09.011
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
High frequency of mutations of the PIK3CA gene in human cancers
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FJ.ADVENZREG.2010.09.011
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
The phosphoinositide 3-kinase pathway
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FJ.ADVENZREG.2010.09.011
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Phosphoinositide 3-kinase p110beta activity: key role in metabolism and mammary gland cancer but not development
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FJ.ADVENZREG.2010.09.011
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Phosphoinositide 3-kinases p110alpha and p110beta regulate cell cycle entry, exhibiting distinct activation kinetics in G1 phase
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FJ.ADVENZREG.2010.09.011
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Synthesis and function of 3-phosphorylated inositol lipids
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FJ.ADVENZREG.2010.09.011
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Mutations in phosphoinositide metabolizing enzymes and human disease
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FJ.ADVENZREG.2010.09.011
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
PIK3CA and PIK3CB inhibition produce synthetic lethality when combined with estrogen deprivation in estrogen receptor-positive breast cancer
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FJ.ADVENZREG.2010.09.011
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
PI3K pathway activation mediates resistance to MEK inhibitors in KRAS mutant cancers
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FJ.ADVENZREG.2010.09.011
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Isoform-specific phosphoinositide 3-kinase inhibitors exert distinct effects in solid tumors
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FJ.ADVENZREG.2010.09.011
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Interaction between von Willebrand factor and glycoprotein Ib activates Src kinase in human platelets: role of phosphoinositide 3-kinase
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FJ.ADVENZREG.2010.09.011
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Signaling through GP Ib-IX-V activates alpha IIb beta 3 independently of other receptors.
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FJ.ADVENZREG.2010.09.011
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Sequential activation of p38 and ERK pathways by cGMP-dependent protein kinase leading to activation of the platelet integrin alphaIIb beta3
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FJ.ADVENZREG.2010.09.011
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Roles of the C-terminal tyrosine residues of LAT in GPVI-induced platelet activation: insights into the mechanism of PLC gamma 2 activation
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FJ.ADVENZREG.2010.09.011
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
The role of Akt in the signaling pathway of the glycoprotein Ib-IX induced platelet activation
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FJ.ADVENZREG.2010.09.011
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Genetic evidence for a predominant role of PI3Kbeta catalytic activity in ITAM- and integrin-mediated signaling in platelets.
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FJ.ADVENZREG.2010.09.011
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Deletion of the p110 isoform of phosphoinositide 3-kinase in platelets reveals its central role in Akt activation and thrombus formation in vitro and in vivo
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FJ.ADVENZREG.2010.09.011
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Essential role for phosphoinositide 3-kinase in shear-dependent signaling between platelet glycoprotein Ib/V/IX and integrin alpha(IIb)beta(3).
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FJ.ADVENZREG.2010.09.011
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Identifiers
DOI
10.1016/J.ADVENZREG.2010.09.011
1 reference
stated in
Europe PubMed Central
PubMed publication ID
21035500
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:21035500%20AND%20SRC:MED&resulttype=core&format=json
retrieved
15 January 2020
PubMed publication ID
21035500
1 reference
stated in
Europe PubMed Central
PubMed publication ID
21035500
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:21035500%20AND%20SRC:MED&resulttype=core&format=json
retrieved
15 January 2020
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