(Q24314705)

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Interaction of the ubiquitin carboxyl terminal esterase L1 with alpha(2)-adrenergic receptors inhibits agonist-mediated p44/42 MAP kinase activation

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Interaction of the ubiquitin carboxyl terminal esterase L1 with alpha(2)-adrenergic receptors inhibits agonist-mediated p44/42 MAP kinase activation (English)

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Adrenoceptor alpha 2B

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GOA release 2020-03-11

Ubiquitin C-terminal hydrolase L1

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GOA release 2020-03-11

Adrenoceptor alpha 2C

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GOA release 2020-03-11

Adrenoceptor alpha 2A

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GOA release 2020-03-11

negative regulation of norepinephrine secretion

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GOA release 2020-03-11

author name string

Bernd Weber

1

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Christian Schaper

2

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Yi Wang

3

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Jens Scholz

4

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Berthold Bein

5

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language of work or name

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publication date

October 2009

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Cellular Signalling

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21

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10

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1513-21

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Silencing of the UCHL1 gene in human colorectal and ovarian cancers.

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Activity profiling of deubiquitinating enzymes in cervical carcinoma biopsies and cell lines.

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The analgesic action of dexmedetomidine--a novel alpha 2-adrenoceptor agonist--in healthy volunteers.

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Ubiquitin hydrolase Uch-L1 rescues beta-amyloid-induced decreases in synaptic function and contextual memory

1 reference

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Dopaminergic neuronal loss in transgenic mice expressing the Parkinson's disease-associated UCH-L1 I93M mutant.

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The UCH-L1 gene encodes two opposing enzymatic activities that affect alpha-synuclein degradation and Parkinson's disease susceptibility

1 reference

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Substrate specificity of deubiquitinating enzymes: ubiquitin C-terminal hydrolases

1 reference

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Intragenic deletion in the gene encoding ubiquitin carboxy-terminal hydrolase in gad mice

1 reference

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Interaction and colocalization of PGP9.5 with JAB1 and p27(Kip1)

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Beta-arrestin-dependent signaling and trafficking of 7-transmembrane receptors is reciprocally regulated by the deubiquitinase USP33 and the E3 ligase Mdm2

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Substitution of a mutant alpha2a-adrenergic receptor via "hit and run" gene targeting reveals the role of this subtype in sedative, analgesic, and anesthetic-sparing responses in vivo

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Interaction of arrestins with intracellular domains of muscarinic and alpha2-adrenergic receptors.

1 reference

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Stimulation of mitogen-activated protein kinase by G protein-coupled alpha(2)-adrenergic receptors does not require agonist-elicited endocytosis

1 reference

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Agonist-regulated Interaction between alpha2-adrenergic receptors and spinophilin

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The third intracellular loop of alpha 2-adrenergic receptors determines subtype specificity of arrestin interaction

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Regulated interactions of the alpha 2A adrenergic receptor with spinophilin, 14-3-3zeta, and arrestin 3.

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Oxidative modifications and down-regulation of ubiquitin carboxyl-terminal hydrolase L1 associated with idiopathic Parkinson's and Alzheimer's diseases

1 reference

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Ubiquitin carboxy-terminal hydrolase L1 binds to and stabilizes monoubiquitin in neuron

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Perioperative Sympatholysis

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Effect of mivazerol on perioperative cardiac complications during non-cardiac surgery in patients with coronary heart disease: the European Mivazerol Trial (EMIT).

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Outcome and prognostic factors in critically ill cancer patients admitted to the intensive care unit

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Isolation of PGP 9.5, a new human neurone-specific protein detected by high-resolution two-dimensional electrophoresis

1 reference

https://api.crossref.org/works/10.1016%2FJ.CELLSIG.2009.05.011

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Alpha 2-adrenergic agonist enrichment of spinophilin at the cell surface involves beta gamma subunits of Gi proteins and is preferentially induced by the alpha 2A-subtype.

1 reference

https://api.crossref.org/works/10.1016%2FJ.CELLSIG.2009.05.011

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based on heuristic

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Spinophilin blocks arrestin actions in vitro and in vivo at G protein-coupled receptors

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https://api.crossref.org/works/10.1016%2FJ.CELLSIG.2009.05.011

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beta-Arrestin: a protein that regulates beta-adrenergic receptor function

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Adrenergic receptors as models for G protein-coupled receptors

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The role of receptor kinases and arrestins in G protein-coupled receptor regulation

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Alpha 2-adrenergic receptors increase cell migration and decrease F-actin labeling in rat aortic smooth muscle cells

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10.1016/J.CELLSIG.2009.05.011

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