(Q24337242)

1

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Anhco Nguyen

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Daniel Lim

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Mary Q Stewart

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Andrew E H Elia

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Michael B Yaffe

Identification of novel phosphorylation sites required for activation of MAPKAP kinase-2

6

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language of work or name

English

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publication date

7 January 2005

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published in

Molecular Cell

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volume

17

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page(s)

37-48

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issue

1

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cites work

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7 January 2021

Structural superposition of proteins with unknown alignment and detection of topological similarity using a six-dimensional search algorithm

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A novel kinase cascade triggered by stress and heat shock that stimulates MAPKAP kinase-2 and phosphorylation of the small heat shock proteins

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The structural basis for 14-3-3:phosphopeptide binding specificity

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The 1.7 A crystal structure of human cell cycle checkpoint kinase Chk1: implications for Chk1 regulation

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Molecular recognitions in the MAP kinase cascades

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Nuclear export of the stress-activated protein kinase p38 mediated by its substrate MAPKAP kinase-2

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Catalytically active MAP KAP kinase 2 structures in complex with staurosporine and ADP reveal differences with the autoinhibited enzyme

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Chk1 and Chk2 kinases in checkpoint control and cancer

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A conserved docking motif in MAP kinases common to substrates, activators and regulators

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The DNA damage response: putting checkpoints in perspective

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Initiation of a G2/M checkpoint after ultraviolet radiation requires p38 kinase

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A motif-based profile scanning approach for genome-wide prediction of signaling pathways

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Phosphoproteome analysis by mass spectrometry and its application to Saccharomyces cerevisiae

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Crystal structure of an activated Akt/protein kinase B ternary complex with GSK3-peptide and AMP-PNP

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Structure and mechanism of BRCA1 BRCT domain recognition of phosphorylated BACH1 with implications for cancer

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Regulating mammalian checkpoints through Cdc25 inactivation

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Cdc25-dependent activation of cyclin A/cdk2 is blocked in G2 phase arrested cells independently of ATM/ATR.

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Role of MAP kinases in UVB-induced phosphorylation of p53 at serine 20.

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Cdc25A phosphatase: combinatorial phosphorylation, ubiquitylation and proteolysis

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The substrate specificity and structure of mitogen-activated protein (MAP) kinase-activated protein kinase-2

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Disruption of the checkpoint kinase 1/cell division cycle 25A pathway abrogates ionizing radiation-induced S and G2 checkpoints

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Pro-inflammatory cytokines and environmental stress cause p38 mitogen-activated protein kinase activation by dual phosphorylation on tyrosine and threonine

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Phosphorylation of the respiratory burst oxidase subunit p47phox as determined by two-dimensional phosphopeptide mapping. Phosphorylation by protein kinase C, protein kinase A, and a mitogen-activated protein kinase

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Identification of mitogen-activated protein (MAP) kinase-activated protein kinase-3, a novel substrate of CSBP p38 MAP kinase

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LSP1 is the major substrate for mitogen-activated protein kinase-activated protein kinase 2 in human neutrophils

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Determination of the specific substrate sequence motifs of protein kinase C isozymes

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MAPKAP kinase 2 phosphorylates serum response factor in vitro and in vivo

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Determination of substrate motifs for human Chk1 and hCds1/Chk2 by the oriented peptide library approach.

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Arachidonic acid promotes phosphorylation of 5-lipoxygenase at Ser-271 by MAPK-activated protein kinase 2 (MK2).

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14-3-3 acts as an intramolecular bridge to regulate cdc25B localization and activity

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DNA damage-induced replication arrest in Xenopus egg extracts

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Topoisomerase II and histone deacetylase inhibitors delay the G2/M transition by triggering the p38 MAPK checkpoint pathway

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Regulation of G(2)/M events by Cdc25A through phosphorylation-dependent modulation of its stability

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Feedback control of the protein kinase TAK1 by SAPK2a/p38

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MAP kinase pathways activated by stress: the p38 MAPK pathway

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Binding of 14-3-3 proteins and nuclear export control the intracellular localization of the mitotic inducer Cdc25.

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Requirement for Atr in phosphorylation of Chk1 and cell cycle regulation in response to DNA replication blocks and UV-damaged DNA in Xenopus egg extracts

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Cell cycle checkpoint signaling through the ATM and ATR kinases

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Stress-induced phosphorylation and activation of the transcription factor CHOP (GADD153) by p38 MAP Kinase

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Cdc25 Mitotic Inducer Targeted by Chk1 DNA Damage Checkpoint Kinase

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Mitotic and G2 checkpoint control: regulation of 14-3-3 protein binding by phosphorylation of Cdc25C on serine-216

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CDC25 phosphatases as potential human oncogenes

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Targeting of p38 mitogen-activated protein kinases to MEF2 transcription factors

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Absence of apparent phenotype in mice lacking Cdc25C protein phosphatase

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Distinct cellular functions of MK2.

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The p38 Mitogen-Activated Protein Kinase Pathway Links the DNA Mismatch Repair System to the G2 Checkpoint and to Resistance to Chemotherapeutic DNA-Methylating Agents

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ERK and p38 MAPK-activated protein kinases: a family of protein kinases with diverse biological functions

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Cooperative function of Chk1 and p38 pathways in activating G2 arrest following exposure to temozolomide

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7 January 2021