(Q2657109)

http://www.ebi.ac.uk/interpro/protein/Q14116

Interleukin-18

1 reference

stated in

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/Q14116

1 reference

13 November 2019

1 reference

13 November 2019

8 references

8 April 2019

Interleukin-18 induces rheumatoid arthritis synovial fibroblast CXC chemokine production through NFkappaB activation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q14116

8 April 2019

Cloning of the cDNA for human IFN-gamma-inducing factor, expression in Escherichia coli, and studies on the biologic activities of the protein

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q14116

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q14116

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q14116

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q14116

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q14116

8 April 2019

The structure and binding mode of interleukin-18

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q14116

8 April 2019

The structural basis for receptor recognition of human interleukin-18

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q14116

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q14116

3 references

8 April 2019

Interleukin-18 induces rheumatoid arthritis synovial fibroblast CXC chemokine production through NFkappaB activation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q14116

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q14116

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q14116

4 references

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q14116

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q14116

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q14116

8 April 2019

Pro/anti-inflammatory cytokines in the pathogenesis of premature coronary artery disease

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q14116

positive regulation of inflammatory response

biological process

1 reference

8 April 2019

Divergent effects of IL-12 and IL-23 on the production of IL-17 by human T cells

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q14116

1 reference

8 April 2019

Cloning of a novel receptor subunit, AcPL, required for interleukin-18 signaling

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q14116

cellular response to organic cyclic compound

TAS

1 reference

8 April 2019

Inhibitory effects of honokiol on lipopolysaccharide-induced cellular responses and signaling events in human renal mesangial cells

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q14116

Regulation of Th1 and Th2 immune responses by IL-18

type 2 immune response

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q14116

1 reference

8 April 2019

Inhibitory effects of honokiol on lipopolysaccharide-induced cellular responses and signaling events in human renal mesangial cells

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q14116

positive regulation of natural killer cell proliferation

IMP

1 reference

8 April 2019

IL-23 modulates CD56+/CD3- NK cell and CD56+/CD3+ NK-like T cell function differentially from IL-12

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q14116

1 reference

8 April 2019

Interleukin-18 promotes sleep in rabbits and rats

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q14116

regulation of cell adhesion

ISS

1 reference

8 April 2019

A novel role for interleukin-18 in adhesion molecule induction through NF kappa B and phosphatidylinositol (PI) 3-kinase-dependent signal transduction pathways

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q14116

positive regulation of NK T cell proliferation

1 reference

8 April 2019

IL-23 modulates CD56+/CD3- NK cell and CD56+/CD3+ NK-like T cell function differentially from IL-12

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q14116

positive regulation of granulocyte macrophage colony-stimulating factor production

1 reference

8 April 2019

Salmonella induced IL-23 and IL-1beta allow for IL-12 production by monocytes and Mphi1 through induction of IFN-gamma in CD56 NK/NK-like T cells

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q14116

positive regulation of tissue remodeling

1 reference

8 April 2019

Divergent effects of IL-12 and IL-23 on the production of IL-17 by human T cells

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q14116

1 reference

8 April 2019

Evidence of IL-18 as a novel angiogenic mediator

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q14116

T-helper 1 type immune response

1 reference

8 April 2019

Interferon-gamma-inducing factor enhances T helper 1 cytokine production by stimulated human T cells: synergism with interleukin-12 for interferon-gamma production

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q14116

positive regulation of interleukin-17 production

1 reference

8 April 2019

Divergent effects of IL-12 and IL-23 on the production of IL-17 by human T cells

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q14116

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q14116

inflammatory response

4 references

8 April 2019

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q14116

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q14116

8 April 2019

Inhibitory effects of honokiol on lipopolysaccharide-induced cellular responses and signaling events in human renal mesangial cells

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q14116

lipopolysaccharide-mediated signaling pathway

1 reference

8 April 2019

Inhibitory effects of honokiol on lipopolysaccharide-induced cellular responses and signaling events in human renal mesangial cells

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q14116

positive regulation of activated T cell proliferation

1 reference

8 April 2019

Interferon-gamma-inducing factor enhances T helper 1 cytokine production by stimulated human T cells: synergism with interleukin-12 for interferon-gamma production

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q14116

positive regulation of protein kinase B signaling

1 reference

8 April 2019

Interleukin-18/WNT1-inducible signaling pathway protein-1 signaling mediates human saphenous vein smooth muscle cell proliferation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q14116

positive regulation of phosphatidylinositol 3-kinase signaling

1 reference

8 April 2019

Interleukin-18/WNT1-inducible signaling pathway protein-1 signaling mediates human saphenous vein smooth muscle cell proliferation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q14116

positive regulation of smooth muscle cell proliferation

1 reference

8 April 2019

Interleukin-18/WNT1-inducible signaling pathway protein-1 signaling mediates human saphenous vein smooth muscle cell proliferation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q14116

activation of protein kinase B activity

1 reference

8 April 2019

Interleukin-18/WNT1-inducible signaling pathway protein-1 signaling mediates human saphenous vein smooth muscle cell proliferation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q14116

positive regulation of transcription by RNA polymerase II

1 reference

8 April 2019

Interleukin-18 may lead to benign prostatic hyperplasia via thrombospondin-1 production in prostatic smooth muscle cells

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q14116

positive regulation of tyrosine phosphorylation of STAT protein

1 reference

8 April 2019

IL-18 activates STAT3 in the natural killer cell line 92, augments cytotoxic activity, and mediates IFN-gamma production by the stress kinase p38 and by the extracellular regulated kinases p44erk-1 and p42erk-21

Community Assessment of Community Annotation with Ontologies

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q14116

positive regulation of gene expression

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q14116

natural killer cell activation

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q14116

positive regulation of interferon-gamma production

5 references

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q14116

8 April 2019

The structure and binding mode of interleukin-18

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q14116

8 April 2019

IL-12 synergizes with IL-18 or IL-1beta for IFN-gamma production from human T cells

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q14116

8 April 2019

IL-23 modulates CD56+/CD3- NK cell and CD56+/CD3+ NK-like T cell function differentially from IL-12

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q14116

8 April 2019

Salmonella induced IL-23 and IL-1beta allow for IL-12 production by monocytes and Mphi1 through induction of IFN-gamma in CD56 NK/NK-like T cells

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q14116

negative regulation of myoblast differentiation

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q14116

cell population proliferation

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q14116

regulation of signaling receptor activity

1 reference

8 April 2019

Gene Ontology Consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q14116

interleukin-6 production

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q14116

T-helper 1 cell cytokine production

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q14116

neutrophil activation

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q14116

natural killer cell mediated cytotoxicity

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q14116

cytokine-mediated signaling pathway

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q14116

interleukin-18-mediated signaling pathway

TAS

4 references

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q14116

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q14116

8 April 2019

The structural basis for receptor recognition of human interleukin-18

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q14116

8 April 2019

Interleukin-18/WNT1-inducible signaling pathway protein-1 signaling mediates human saphenous vein smooth muscle cell proliferation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q14116

positive regulation of NIK/NF-kappaB signaling

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q14116

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q14116

positive regulation of NF-kappaB transcription factor activity

1 reference

8 April 2019

The structural basis for receptor recognition of human interleukin-18

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q14116

positive regulation of T-helper 1 cell cytokine production

1 reference

8 April 2019

IL-12 synergizes with IL-18 or IL-1beta for IFN-gamma production from human T cells

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q14116

positive regulation of neuroinflammatory response

1 reference

8 April 2019

Role of TNF in mast cell neuroinflammation and pain

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q14116

TAS

Gene Atlas image

PBB GE IL18 206295 at fs.png
732 × 530; 12 KB

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Identifiers

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1 reference

30 May 2020

1 reference

30 May 2020

1 reference

30 May 2020

1 reference

30 May 2020

1 reference

13 November 2019

1 reference

1 reference

1 reference

1 reference

28 October 2013

1 reference

9 August 2016

1 reference

9 August 2016

1 reference

9 August 2016

1 reference

9 August 2016

1 reference

9 August 2016

1 reference

9 August 2016

1 reference

9 August 2016

1 reference

9 August 2016

1 reference

9 August 2016

1 reference

9 August 2016

1 reference

9 August 2016

1 reference

9 August 2016

1 reference

9 August 2016