(Q27640112)

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X-ray structure of the hRORalpha LBD at 1.63 A: structural and functional data that cholesterol or a cholesterol derivative is the natural ligand of RORalpha

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X-ray structure of the hRORalpha LBD at 1.63 A: structural and functional data that cholesterol or a cholesterol derivative is the natural ligand of RORalpha (English)

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author name string

Joerg A Kallen

1

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Jean-Marc Schlaeppi

2

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Francis Bitsch

3

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Sabine Geisse

4

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Martin Geiser

5

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Isabelle Delhon

6

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Brigitte Fournier

7

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publication date

December 2002

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10

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12

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1697-707

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The ROR nuclear orphan receptor subfamily: critical regulators of multiple biological processes

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Disruption of retinoid-related orphan receptor beta changes circadian behavior, causes retinal degeneration and leads to vacillans phenotype in mice

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Retinoid-related orphan receptor gamma (RORgamma) is essential for lymphoid organogenesis and controls apoptosis during thymopoiesis

1 reference

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Isoform-specific amino-terminal domains dictate DNA-binding properties of ROR alpha, a novel family of orphan hormone nuclear receptors

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The nonconserved hinge region and distinct amino-terminal domains of the ROR alpha orphan nuclear receptor isoforms are required for proper DNA bending and ROR alpha-DNA interactions

1 reference

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Transcriptional regulation of apolipoprotein A-I gene expression by the nuclear receptor RORalpha

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Transcriptional regulation of apolipoprotein C-III gene expression by the orphan nuclear receptor RORalpha

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Identification of a novel peroxisome proliferator-activated receptor (PPAR) gamma promoter in man and transactivation by the nuclear receptor RORalpha1

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Disruption of the nuclear hormone receptor RORalpha in staggerer mice

1 reference

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staggerer phenotype in retinoid-related orphan receptor alpha-deficient mice.

1 reference

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An orphan nuclear receptor, mROR alpha, and its spatial expression in adult mouse brain

1 reference

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Defective development of the thymus and immunological abnormalities in the neurological mouse mutation "staggerer".

1 reference

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The orphan nuclear receptor ROR alpha is a negative regulator of the inflammatory response

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Severe atherosclerosis and hypoalphalipoproteinemia in the staggerer mouse, a mutant of the nuclear receptor RORalpha

1 reference

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In vitro and in vivo evidence for orphan nuclear receptor RORalpha function in bone metabolism

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Age-related phenotypes in the staggerer mouse expand the RORalpha nuclear receptor's role beyond the cerebellum

1 reference

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Transcriptional activation of the nuclear receptor RZR alpha by the pineal gland hormone melatonin and identification of CGP 52608 as a synthetic ligand

1 reference

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Exogenous expression of a dominant negative RORalpha1 vector in muscle cells impairs differentiation: RORalpha1 directly interacts with p300 and myoD

1 reference

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Structural studies on nuclear receptors.

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Structural and functional evidence for ligand-independent transcriptional activation by the estrogen-related receptor 3

1 reference

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7 January 2021

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X-ray structure of the orphan nuclear receptor RORbeta ligand-binding domain in the active conformation.

1 reference

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7 January 2021

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Nuclear receptors and lipid physiology: opening the X-files

1 reference

https://api.crossref.org/works/10.1016%2FS0969-2126%2802%2900912-7

7 January 2021

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The role of orphan nuclear receptors in the regulation of cholesterol homeostasis

1 reference

https://api.crossref.org/works/10.1016%2FS0969-2126%2802%2900912-7

7 January 2021

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PROCHECK: a program to check the stereochemical quality of protein structures

1 reference

https://api.crossref.org/works/10.1016%2FS0969-2126%2802%2900912-7

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Crystal structure of the ligand-binding domain of the human nuclear receptor RXR-alpha

1 reference

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7 January 2021

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A canonical structure for the ligand-binding domain of nuclear receptors

1 reference

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Ligand binding and co-activator assembly of the peroxisome proliferator-activated receptor-gamma

1 reference

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Improved methods for building protein models in electron density maps and the location of errors in these models

1 reference

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Natural ligands of nuclear receptors have conserved volumes

1 reference

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7 January 2021

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A unique PPARgamma ligand with potent insulin-sensitizing yet weak adipogenic activity

1 reference

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Characterization of crystal content by ESI-MS and MALDI-MS.

1 reference

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7 January 2021

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Crystal structure of a heterodimeric complex of RAR and RXR ligand-binding domains

1 reference

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7 January 2021

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Crystal structure of the ligand-binding domain of the ultraspiracle protein USP, the ortholog of retinoid X receptors in insects

1 reference

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Hepatocyte nuclear factor 4 is a transcription factor that constitutively binds fatty acids

1 reference

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Regulation of the mevalonate pathway

1 reference

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A proteolytic pathway that controls the cholesterol content of membranes, cells, and blood

1 reference

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Lipid lowering: statins and the future

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Crystal structure of the HNF4 alpha ligand binding domain in complex with endogenous fatty acid ligand

1 reference

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7 January 2021

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Genetic disorders of cholesterol biosynthesis in mice and humans.

1 reference

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Arterial inflammation and atherosclerosis

1 reference

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Detection, delineation, measurement and display of cavities in macromolecular structures

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Identifiers

10.1016/S0969-2126(02)00912-7

1 reference

Consolidated OpenCitations Corpus – April 2017

OpenCitations bibliographic resource ID

OpenCitations bibliographic resource ID

1 reference

Consolidated OpenCitations Corpus – April 2017

OpenCitations bibliographic resource ID

1 reference

Consolidated OpenCitations Corpus – April 2017

OpenCitations bibliographic resource ID

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