(Q27646556)

1

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Andrew L Faber

2

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Candice Horn

3

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Gregory P Donoho

4

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Stephen L Briggs

5

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Christiane M Robbins

6

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Galen Hostetter

7

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Sophie Boguslawski

8

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Tracy Y Moses

9

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Stephanie Savage

10

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Mark Uhlik

11

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Aimin Lin

12

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Jian Du

13

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Yue-Wei Qian

14

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Douglas J Zeckner

15

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Jeffrey Touchman

17

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Ketan Patel

18

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Spyro Mousses

19

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Michael Bittner

20

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Richard Schevitz

21

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Mei-Huei T Lai

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Kerry L Blanchard

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James E Thomas

AKT1/PKBalpha kinase is frequently elevated in human cancers and its constitutive activation is required for oncogenic transformation in NIH3T3 cells

24

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language of work or name

English

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publication date

26 July 2007

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published in

Nature

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volume

448

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issue

7152

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page(s)

439-44

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cites work

1 reference

https://api.crossref.org/works/10.1038%2FNATURE05933

A specific product of phosphatidylinositol 3-kinase directly activates the protein kinase Akt through its pleckstrin homology domain.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNATURE05933

The phosphatidylinositol 3-Kinase AKT pathway in human cancer

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNATURE05933

7 January 2021

The PIK3CA gene is mutated with high frequency in human breast cancers.

1 reference

https://api.crossref.org/works/10.1038%2FNATURE05933

7 January 2021

Mutation of the PIK3CA gene in ovarian and breast cancer

1 reference

https://api.crossref.org/works/10.1038%2FNATURE05933

7 January 2021

PIK3CA gene is frequently mutated in breast carcinomas and hepatocellular carcinomas.

1 reference

https://api.crossref.org/works/10.1038%2FNATURE05933

7 January 2021

Frequent mutation of the PIK3CA gene in ovarian and breast cancers.

1 reference

https://api.crossref.org/works/10.1038%2FNATURE05933

7 January 2021

PIK3CA mutations correlate with hormone receptors, node metastasis, and ERBB2, and are mutually exclusive with PTEN loss in human breast carcinoma

1 reference

https://api.crossref.org/works/10.1038%2FNATURE05933

7 January 2021

High frequency of mutations of the PIK3CA gene in human cancers

1 reference

https://api.crossref.org/works/10.1038%2FNATURE05933

7 January 2021

New insights into tumor suppression: PTEN suppresses tumor formation by restraining the phosphoinositide 3-kinase/AKT pathway

1 reference

https://api.crossref.org/works/10.1038%2FNATURE05933

7 January 2021

PTEN promoter is methylated in a proportion of invasive breast cancers

1 reference

https://api.crossref.org/works/10.1038%2FNATURE05933

7 January 2021

The phosphoinositide 3-kinase pathway

1 reference

https://api.crossref.org/works/10.1038%2FNATURE05933

7 January 2021

Living with lethal PIP3 levels: viability of flies lacking PTEN restored by a PH domain mutation in Akt/PKB.

1 reference

https://api.crossref.org/works/10.1038%2FNATURE05933

7 January 2021

Mutation of the pleckstrin homology domain of Bruton's tyrosine kinase in immunodeficiency impaired inositol 1,3,4,5-tetrakisphosphate binding capacity

1 reference

https://api.crossref.org/works/10.1038%2FNATURE05933

7 January 2021

The protein kinase encoded by the Akt proto-oncogene is a target of the PDGF-activated phosphatidylinositol 3-kinase

1 reference

https://api.crossref.org/works/10.1038%2FNATURE05933

7 January 2021

Transformation potential of Ras isoforms correlates with activation of phosphatidylinositol 3-kinase but not ERK.

1 reference

https://api.crossref.org/works/10.1038%2FNATURE05933

7 January 2021

Role of translocation in the activation and function of protein kinase B

1 reference

https://api.crossref.org/works/10.1038%2FNATURE05933

7 January 2021

The consensus coding sequences of human breast and colorectal cancers

1 reference

https://api.crossref.org/works/10.1038%2FNATURE05933

7 January 2021

Binding of phosphatidylinositol 3,4,5-trisphosphate to the pleckstrin homology domain of protein kinase B induces a conformational change

1 reference

https://api.crossref.org/works/10.1038%2FNATURE05933

7 January 2021

High-resolution structure of the pleckstrin homology domain of protein kinase b/akt bound to phosphatidylinositol (3,4,5)-trisphosphate

1 reference

https://api.crossref.org/works/10.1038%2FNATURE05933

7 January 2021

Structural insights into the regulation of PDK1 by phosphoinositides and inositol phosphates.

1 reference

https://api.crossref.org/works/10.1038%2FNATURE05933

7 January 2021

Direct regulation of the Akt proto-oncogene product by phosphatidylinositol-3,4-bisphosphate

1 reference

https://api.crossref.org/works/10.1038%2FNATURE05933

7 January 2021

Protein kinase B kinases that mediate phosphatidylinositol 3,4,5-trisphosphate-dependent activation of protein kinase B

1 reference

https://api.crossref.org/works/10.1038%2FNATURE05933

7 January 2021

Identification and characterization of pleckstrin-homology-domain-dependent and isoenzyme-specific Akt inhibitors

1 reference

https://api.crossref.org/works/10.1038%2FNATURE05933

7 January 2021

Akt/PKB localisation and 3' phosphoinositide generation at sites of epithelial cell-matrix and cell-cell interaction

1 reference

https://api.crossref.org/works/10.1038%2FNATURE05933

7 January 2021

Multiple phosphoinositide 3-kinase-dependent steps in activation of protein kinase B

1 reference

https://api.crossref.org/works/10.1038%2FNATURE05933

7 January 2021

The c-myc oncogene driven by immunoglobulin enhancers induces lymphoid malignancy in transgenic mice

1 reference

https://api.crossref.org/works/10.1038%2FNATURE05933

7 January 2021

Survival signalling by Akt and eIF4E in oncogenesis and cancer therapy

1 reference

https://api.crossref.org/works/10.1038%2FNATURE05933

7 January 2021

Perturbations of the AKT signaling pathway in human cancer

1 reference

https://api.crossref.org/works/10.1038%2FNATURE05933

7 January 2021

Colorectal cancer: mutations in a signalling pathway

1 reference

https://api.crossref.org/works/10.1038%2FNATURE05933

7 January 2021

Molecular cloning of the akt oncogene and its human homologues AKT1 and AKT2: amplification of AKT1 in a primary human gastric adenocarcinoma

1 reference

https://api.crossref.org/works/10.1038%2FNATURE05933

7 January 2021

Genetic alterations and aberrant expression of genes related to the phosphatidyl-inositol-3'-kinase/protein kinase B (Akt) signal transduction pathway in glioblastomas.

1 reference

https://api.crossref.org/works/10.1038%2FNATURE05933

7 January 2021

Mutational analysis of AKT1, AKT2 and AKT3 genes in common human carcinomas

1 reference

https://api.crossref.org/works/10.1038%2FNATURE05933

7 January 2021

Identifiers

DOI

10.1038/NATURE05933

1 reference

Consolidated OpenCitations Corpus – April 2017

Dimensions Publication ID

1572546

1023428666

0 references

1572546

1 reference

Consolidated OpenCitations Corpus – April 2017

Consolidated OpenCitations Corpus – April 2017

1 reference