(Q28560922)

English

Rabphilin 3A

mammalian protein found in Rattus norvegicus

rabphilin 3A homolog
exophilin-1
Rph3a
rabphilin-3A

In more languages

Statements

1 reference

17 November 2021

UniProt protein ID

Zinc finger, FYVE/PHD-type

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/P47709

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/P47709

Zinc finger, RING/FYVE/PHD-type

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/P47709

C2 domain superfamily

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/P47709

membrane protein

1 reference

based on heuristic

inferred from GOA cell component → membrane

C2 domain, protein family

1 reference

based on heuristic

inferred from protein domain or family

Zinc finger, FYVE-related, protein family

1 reference

based on heuristic

inferred from protein domain or family

1 reference

based on heuristic

inferred from protein domain or family

Rab-binding domain, protein family

1 reference

based on heuristic

inferred from protein domain or family

1 reference

17 November 2021

UniProt protein ID

1 reference

17 November 2021

UniProt protein ID

molecular function

calcium ion binding

determination method

3 references

9 May 2019

Synaptic targeting of rabphilin-3A, a synaptic vesicle Ca2+/phospholipid-binding protein, depends on rab3A/3C

Rat genome database

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P47709

determination method

9 May 2019

The C2A-C2B linker defines the high affinity Ca(2+) binding mode of rabphilin-3A

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P47709

determination method

9 May 2019

Structural determinants for Ca2+ and phosphatidylinositol 4,5-bisphosphate binding by the C2A domain of rabphilin-3A

Rat genome database

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P47709

determination method

protein binding

determination method

7 references

9 May 2019

Rabphilin 3A retains NMDA receptors at synaptic sites through interaction with GluN2A/PSD-95 complex

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P47709

determination method

9 May 2019

Rab3 reversibly recruits rabphilin to synaptic vesicles by a mechanism analogous to raf recruitment by ras

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P47709

determination method

9 May 2019

Structural basis of Rab effector specificity: crystal structure of the small G protein Rab3A complexed with the effector domain of rabphilin-3A

Rat genome database

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P47709

determination method

9 May 2019

Identification of a rabphilin-3A-interacting protein as GTP cyclohydrolase I in PC12 cells

Rat genome database

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P47709

determination method

9 May 2019

Identification of a novel protein complex containing annexin A4, rabphilin and synaptotagmin

Rat genome database

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P47709

determination method

9 May 2019

Structural basis of Rab effector specificity: crystal structure of the small G protein Rab3A complexed with the effector domain of rabphilin-3A

IntAct protein interaction database

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P47709

determination method

9 May 2019

Rabphilin regulates SNARE-dependent re-priming of synaptic vesicles for fusion

IntAct protein interaction database

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P47709

determination method

phospholipid binding

determination method

1 reference

9 May 2019

Synaptic targeting of rabphilin-3A, a synaptic vesicle Ca2+/phospholipid-binding protein, depends on rab3A/3C

Rat genome database

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P47709

determination method

calcium-dependent phospholipid binding

determination method

1 reference

9 May 2019

The C2A-C2B linker defines the high affinity Ca(2+) binding mode of rabphilin-3A

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P47709

determination method

phosphatidylinositol-4,5-bisphosphate binding

determination method

1 reference

9 May 2019

Structural determinants for Ca2+ and phosphatidylinositol 4,5-bisphosphate binding by the C2A domain of rabphilin-3A

Rat genome database

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P47709

determination method

zinc ion binding

determination method

1 reference

9 May 2019

Structural basis of Rab effector specificity: crystal structure of the small G protein Rab3A complexed with the effector domain of rabphilin-3A

Rat genome database

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P47709

determination method

determination method

1 reference

9 May 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P47709

determination method

selenium binding

determination method

1 reference

9 May 2019

Structural basis of Rab effector specificity: crystal structure of the small G protein Rab3A complexed with the effector domain of rabphilin-3A

Rat genome database

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P47709

determination method

phosphate ion binding

determination method

1 reference

9 May 2019

Characterization of rabphilin phosphorylation using phospho-specific antibodies

Rat genome database

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P47709

determination method

protein-containing complex binding

determination method

1 reference

9 May 2019

Identification of a novel protein complex containing annexin A4, rabphilin and synaptotagmin

Rat genome database

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P47709

determination method

metal ion binding

determination method

1 reference

9 May 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P47709

determination method

inositol 1,4,5 trisphosphate binding

determination method

1 reference

9 May 2019

Structural determinants for Ca2+ and phosphatidylinositol 4,5-bisphosphate binding by the C2A domain of rabphilin-3A

Rat genome database

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P47709

determination method

Golgi apparatus

determination method

1 reference

9 May 2019

Novel localization of Rab3D in rat intestinal goblet cells and Brunner's gland acinar cells suggests a role in early Golgi trafficking

Rat genome database

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P47709

determination method

determination method

1 reference

9 May 2019

The Rab27 effector Rabphilin, unlike Granuphilin and Noc2, rapidly exchanges between secretory granules and cytosol in PC12 cells

Rat genome database

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P47709

determination method

synaptic vesicle

determination method

3 references

9 May 2019

Rab3 reversibly recruits rabphilin to synaptic vesicles by a mechanism analogous to raf recruitment by ras

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P47709

determination method

9 May 2019

Identification of a novel protein complex containing annexin A4, rabphilin and synaptotagmin

Rat genome database

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P47709

determination method

9 May 2019

Developmental regulation and specific brain distribution of phosphorabphilin

Rat genome database

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P47709

determination method

extrinsic component of membrane

determination method

1 reference

9 May 2019

Synaptic targeting of rabphilin-3A, a synaptic vesicle Ca2+/phospholipid-binding protein, depends on rab3A/3C

Rat genome database

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P47709

determination method

determination method

1 reference

9 May 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P47709

determination method

secretory granule

determination method

1 reference

9 May 2019

The Rab27 effector Rabphilin, unlike Granuphilin and Noc2, rapidly exchanges between secretory granules and cytosol in PC12 cells

Rat genome database

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P47709

determination method

synaptic vesicle membrane

determination method

1 reference

8 April 2019

Synaptic targeting of rabphilin-3A, a synaptic vesicle Ca2+/phospholipid-binding protein, depends on rab3A/3C

Rat genome database

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P47709

determination method

neuromuscular junction

determination method

1 reference

9 May 2019

Localization of Rabphilin-3A on the synaptic vesicle

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P47709

determination method

protein-containing complex

determination method

1 reference

9 May 2019

Identification of a novel protein complex containing annexin A4, rabphilin and synaptotagmin

Rat genome database

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P47709

determination method

neuron projection

determination method

1 reference

9 May 2019

Identification of a novel protein complex containing annexin A4, rabphilin and synaptotagmin

Rat genome database

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P47709

determination method

extrinsic component of synaptic vesicle membrane

determination method

3 references

cholinergic synapse

determination method

1 reference

9 May 2019

Localization of Rabphilin-3A on the synaptic vesicle

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P47709

determination method

dendritic spine

determination method

1 reference

8 April 2019

Rabphilin 3A retains NMDA receptors at synaptic sites through interaction with GluN2A/PSD-95 complex

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P47709

determination method

postsynaptic membrane

determination method

1 reference

8 April 2019

Rabphilin 3A retains NMDA receptors at synaptic sites through interaction with GluN2A/PSD-95 complex

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P47709

determination method

plasma membrane

determination method

1 reference

9 May 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P47709

determination method

cytoplasmic vesicle

determination method

1 reference

9 May 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P47709

determination method

cell projection

determination method

1 reference

9 May 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P47709

determination method

biological process

intracellular protein transport

determination method

1 reference

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P47709

determination method

brain development

determination method

1 reference

9 May 2019

Developmental regulation and specific brain distribution of phosphorabphilin

Rat genome database

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P47709

determination method

protein transport

determination method

1 reference

9 May 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P47709

determination method

dendritic spine organization

determination method

1 reference

9 May 2019

Rabphilin 3A retains NMDA receptors at synaptic sites through interaction with GluN2A/PSD-95 complex

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P47709

determination method

regulation of NMDA receptor activity

determination method

1 reference

9 May 2019

Rabphilin 3A retains NMDA receptors at synaptic sites through interaction with GluN2A/PSD-95 complex

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P47709

determination method

Identifiers

RefSeq protein ID

1 reference

7 September 2021

1 reference

7 September 2021

1 reference

7 September 2021

1 reference

7 September 2021

1 reference

7 September 2021

1 reference

7 September 2021

UniProt protein ID

1 reference

17 November 2021

UniProt protein ID

Ensembl protein ID

ENSRNOP00000001844

1 reference

ensembl Release 104

Ensembl protein ID

ENSRNOP00000001844

Sitelinks

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Multilingual sites(0 entries)

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