(Q3054016)

English

endoglin

mammalian protein found in Homo sapiens

ENG
ORW1
END
CD105 antigen
HHT1
Endoglin

In more languages

Statements

1 reference

13 November 2019

UniProt protein ID

Zona pellucida domain, protein family

1 reference

based on heuristic

inferred from protein domain or family

1 reference

13 November 2019

UniProt protein ID

1 reference

13 November 2019

UniProt protein ID

molecular function

type I transforming growth factor beta receptor binding

determination method

activin binding

determination method

1 reference

8 April 2019

Endoglin: An accessory component of the TGF-beta-binding receptor-complex with diagnostic, prognostic, and bioimmunotherapeutic potential in human malignancies

British Heart Foundation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P17813

determination method

transforming growth factor beta-activated receptor activity

determination method

1 reference

17 October 2017

Endoglin expression in metastatic breast cancer cells enhances their invasive phenotype

British Heart Foundation

http://www.ebi.ac.uk/QuickGO/annotations?protein=P17813&geneProductId=UniProtKB:P17813

determination method

galactose binding

determination method

1 reference

8 April 2019

Biochemical characterization of the 44G4 antigen from the HOON pre-B leukemic cell line

British Heart Foundation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P17813

determination method

determination method

1 reference

8 April 2019

Endoglin is an accessory protein that interacts with the signaling receptor complex of multiple members of the transforming growth factor-beta superfamily

British Heart Foundation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P17813

determination method

protein binding

determination method

6 references

8 April 2019

Structural Basis of the Human Endoglin-BMP9 Interaction: Insights into BMP Signaling and HHT1

IntAct protein interaction database

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P17813

determination method

8 April 2019

Endoglin mediates fibronectin/α5β1 integrin and TGF-β pathway crosstalk in endothelial cells

IntAct protein interaction database

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P17813

determination method

8 April 2019

Critical role of endoglin in tumor cell plasticity of Ewing sarcoma and melanoma

IntAct protein interaction database

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P17813

determination method

8 April 2019

Endoglin is an accessory protein that interacts with the signaling receptor complex of multiple members of the transforming growth factor-beta superfamily

HUGO Gene Nomenclature Committee

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P17813

determination method

8 April 2019

Interaction and functional interplay between endoglin and ALK-1, two components of the endothelial transforming growth factor-beta receptor complex

HUGO Gene Nomenclature Committee

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P17813

determination method

8 April 2019

Endoglin is an accessory protein that interacts with the signaling receptor complex of multiple members of the transforming growth factor-beta superfamily

British Heart Foundation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P17813

determination method

transforming growth factor beta binding

determination method

3 references

8 April 2019

Endoglin is a component of the transforming growth factor-beta receptor system in human endothelial cells

British Heart Foundation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P17813

determination method

8 April 2019

Endoglin is an accessory protein that interacts with the signaling receptor complex of multiple members of the transforming growth factor-beta superfamily

British Heart Foundation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P17813

determination method

8 April 2019

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P17813

determination method

transmembrane signaling receptor activity

determination method

1 reference

8 April 2019

S-endoglin expression is induced in senescent endothelial cells and contributes to vascular pathology

British Heart Foundation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P17813

determination method

type II transforming growth factor beta receptor binding

determination method

3 references

8 April 2019

Endoglin forms a heteromeric complex with the signaling receptors for transforming growth factor-beta

British Heart Foundation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P17813

determination method

8 April 2019

Extracellular and cytoplasmic domains of endoglin interact with the transforming growth factor-beta receptors I and II

British Heart Foundation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P17813

determination method

8 April 2019

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P17813

determination method

identical protein binding

determination method

1 reference

8 April 2019

Structural Basis of the Human Endoglin-BMP9 Interaction: Insights into BMP Signaling and HHT1

IntAct protein interaction database

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P17813

determination method

protein homodimerization activity

determination method

1 reference

8 April 2019

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P17813

determination method

integral component of membrane

determination method

1 reference

8 April 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P17813

determination method

determination method

1 reference

8 April 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P17813

determination method

determination method

1 reference

17 October 2017

Analysis of the myosin-II-responsive focal adhesion proteome reveals a role for β-Pix in negative regulation of focal adhesion maturation

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?protein=P17813&geneProductId=UniProtKB:P17813

determination method

receptor complex

determination method

1 reference

8 April 2019

Endoglin is an accessory protein that interacts with the signaling receptor complex of multiple members of the transforming growth factor-beta superfamily

British Heart Foundation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P17813

determination method

endothelial microparticle

determination method

1 reference

8 April 2019

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P17813

determination method

external side of plasma membrane

determination method

1 reference

8 April 2019

Regulated expression on human macrophages of endoglin, an Arg-Gly-Asp-containing surface antigen

British Heart Foundation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P17813

determination method

plasma membrane

determination method

1 reference

8 April 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P17813

determination method

determination method

1 reference

8 April 2019

Analysis of the myosin-II-responsive focal adhesion proteome reveals a role for β-Pix in negative regulation of focal adhesion maturation

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P17813

determination method

determination method

1 reference

8 April 2019

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P17813

determination method

biological process

cell migration involved in endocardial cushion formation

determination method

1 reference

8 April 2019

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P17813

determination method

response to hypoxia

determination method

1 reference

17 October 2017

Severe intrauterine growth restriction pregnancies have increased placental endoglin levels: hypoxic regulation via transforming growth factor-beta 3

British Heart Foundation

http://www.ebi.ac.uk/QuickGO/annotations?protein=P17813&geneProductId=UniProtKB:P17813

determination method

regulation of transcription, DNA-templated

determination method

1 reference

8 April 2019

Interaction and functional interplay between endoglin and ALK-1, two components of the endothelial transforming growth factor-beta receptor complex

HUGO Gene Nomenclature Committee

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P17813

determination method

negative regulation of nitric-oxide synthase activity

determination method

1 reference

17 October 2017

S-endoglin expression is induced in senescent endothelial cells and contributes to vascular pathology

British Heart Foundation

http://www.ebi.ac.uk/QuickGO/annotations?protein=P17813&geneProductId=UniProtKB:P17813

determination method

negative regulation of protein autophosphorylation

determination method

1 reference

8 April 2019

Extracellular and cytoplasmic domains of endoglin interact with the transforming growth factor-beta receptors I and II

British Heart Foundation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P17813

determination method

determination method

1 reference

17 October 2017

Endoglin expression in metastatic breast cancer cells enhances their invasive phenotype

British Heart Foundation

http://www.ebi.ac.uk/QuickGO/annotations?protein=P17813&geneProductId=UniProtKB:P17813

determination method

positive regulation of pathway-restricted SMAD protein phosphorylation

determination method

regulation of phosphorylation

determination method

1 reference

17 October 2017

Endoglin: An accessory component of the TGF-beta-binding receptor-complex with diagnostic, prognostic, and bioimmunotherapeutic potential in human malignancies

British Heart Foundation

http://www.ebi.ac.uk/QuickGO/annotations?protein=P17813&geneProductId=UniProtKB:P17813

determination method

extracellular matrix disassembly

determination method

1 reference

17 October 2017

Endoglin expression in metastatic breast cancer cells enhances their invasive phenotype

British Heart Foundation

http://www.ebi.ac.uk/QuickGO/annotations?protein=P17813&geneProductId=UniProtKB:P17813

determination method

positive regulation of systemic arterial blood pressure

determination method

1 reference

17 October 2017

S-endoglin expression is induced in senescent endothelial cells and contributes to vascular pathology

British Heart Foundation

http://www.ebi.ac.uk/QuickGO/annotations?protein=P17813&geneProductId=UniProtKB:P17813

determination method

determination method

1 reference

17 October 2017

Endoglin expression in metastatic breast cancer cells enhances their invasive phenotype

British Heart Foundation

http://www.ebi.ac.uk/QuickGO/annotations?protein=P17813&geneProductId=UniProtKB:P17813

determination method

negative regulation of transcription by RNA polymerase II

determination method

1 reference

17 October 2017

S-endoglin expression is induced in senescent endothelial cells and contributes to vascular pathology

British Heart Foundation

http://www.ebi.ac.uk/QuickGO/annotations?protein=P17813&geneProductId=UniProtKB:P17813

determination method

negative regulation of transforming growth factor beta receptor signaling pathway

determination method

1 reference

17 October 2017

Endoglin: An accessory component of the TGF-beta-binding receptor-complex with diagnostic, prognostic, and bioimmunotherapeutic potential in human malignancies

British Heart Foundation

http://www.ebi.ac.uk/QuickGO/annotations?protein=P17813&geneProductId=UniProtKB:P17813

determination method

BMP signaling pathway

determination method

1 reference

8 April 2019

Endoglin: An accessory component of the TGF-beta-binding receptor-complex with diagnostic, prognostic, and bioimmunotherapeutic potential in human malignancies

British Heart Foundation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P17813

determination method

negative regulation of pathway-restricted SMAD protein phosphorylation

determination method

1 reference

17 October 2017

S-endoglin expression is induced in senescent endothelial cells and contributes to vascular pathology

British Heart Foundation

http://www.ebi.ac.uk/QuickGO/annotations?protein=P17813&geneProductId=UniProtKB:P17813

determination method

positive regulation of angiogenesis

determination method

1 reference

8 April 2019

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P17813

determination method

negative regulation of endothelial cell proliferation

determination method

1 reference

17 October 2017

S-endoglin expression is induced in senescent endothelial cells and contributes to vascular pathology

British Heart Foundation

http://www.ebi.ac.uk/QuickGO/annotations?protein=P17813&geneProductId=UniProtKB:P17813

determination method

heart development

determination method

1 reference

8 April 2019

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P17813

determination method

regulation of cell adhesion

determination method

1 reference

17 October 2017

Endoglin: An accessory component of the TGF-beta-binding receptor-complex with diagnostic, prognostic, and bioimmunotherapeutic potential in human malignancies

British Heart Foundation

http://www.ebi.ac.uk/QuickGO/annotations?protein=P17813&geneProductId=UniProtKB:P17813

determination method

determination method

1 reference

8 April 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P17813

determination method

negative regulation of cell migration

determination method

1 reference

8 April 2019

Endoglin phosphorylation by ALK2 contributes to the regulation of prostate cancer cell migration

British Heart Foundation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P17813

determination method

regulation of cell population proliferation

determination method

1 reference

17 October 2017

Endoglin: An accessory component of the TGF-beta-binding receptor-complex with diagnostic, prognostic, and bioimmunotherapeutic potential in human malignancies

British Heart Foundation

http://www.ebi.ac.uk/QuickGO/annotations?protein=P17813&geneProductId=UniProtKB:P17813

determination method

central nervous system vasculogenesis

determination method

1 reference

8 April 2019

Endoglin, a TGF-beta binding protein of endothelial cells, is the gene for hereditary haemorrhagic telangiectasia type 1

British Heart Foundation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P17813

determination method

positive regulation of BMP signaling pathway

determination method

1 reference

8 April 2019

Identification of BMP9 and BMP10 as functional activators of the orphan activin receptor-like kinase 1 (ALK1) in endothelial cells

British Heart Foundation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P17813

determination method

cell chemotaxis

determination method

1 reference

17 October 2017

Endoglin expression in metastatic breast cancer cells enhances their invasive phenotype

British Heart Foundation

http://www.ebi.ac.uk/QuickGO/annotations?protein=P17813&geneProductId=UniProtKB:P17813

determination method

transforming growth factor beta receptor signaling pathway

determination method

1 reference

17 October 2017

Endoglin expression in metastatic breast cancer cells enhances their invasive phenotype

British Heart Foundation

http://www.ebi.ac.uk/QuickGO/annotations?protein=P17813&geneProductId=UniProtKB:P17813

determination method

determination method

1 reference

17 October 2017

Endoglin expression in metastatic breast cancer cells enhances their invasive phenotype

British Heart Foundation

http://www.ebi.ac.uk/QuickGO/annotations?protein=P17813&geneProductId=UniProtKB:P17813

determination method

detection of hypoxia

determination method

1 reference

17 October 2017

Severe intrauterine growth restriction pregnancies have increased placental endoglin levels: hypoxic regulation via transforming growth factor-beta 3

British Heart Foundation

http://www.ebi.ac.uk/QuickGO/annotations?protein=P17813&geneProductId=UniProtKB:P17813

determination method

positive regulation of gene expression

determination method

1 reference

8 April 2019

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P17813

determination method

regulation of cardiac muscle cell apoptotic process

determination method

1 reference

8 April 2019

British Heart Foundation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P17813

determination method

bone development

determination method

1 reference

8 April 2019

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P17813

determination method

endocardial cushion to mesenchymal transition

determination method

1 reference

8 April 2019

British Heart Foundation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P17813

determination method

sprouting angiogenesis

determination method

1 reference

8 April 2019

British Heart Foundation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P17813

determination method

response to corticosteroid

determination method

1 reference

8 April 2019

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P17813

determination method

extracellular matrix constituent secretion

determination method

1 reference

8 April 2019

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P17813

determination method

regulation of cell proliferation involved in heart morphogenesis

determination method

1 reference

8 April 2019

British Heart Foundation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P17813

determination method

response to transforming growth factor beta

determination method

1 reference

8 April 2019

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P17813

determination method

positive regulation of collagen biosynthetic process

determination method

1 reference

8 April 2019

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P17813

determination method

cellular response to mechanical stimulus

determination method

1 reference

8 April 2019

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P17813

determination method

positive regulation of transcription by RNA polymerase II

determination method

3 references

17 October 2017

British Heart Foundation

http://www.ebi.ac.uk/QuickGO/annotations?protein=P17813&geneProductId=UniProtKB:P17813

determination method

17 October 2017

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?protein=P17813&geneProductId=UniProtKB:P17813

determination method

17 October 2017

S-endoglin expression is induced in senescent endothelial cells and contributes to vascular pathology

British Heart Foundation

http://www.ebi.ac.uk/QuickGO/annotations?protein=P17813&geneProductId=UniProtKB:P17813

determination method

regulation of cardiac neural crest cell migration involved in outflow tract morphogenesis

determination method

1 reference

8 April 2019

British Heart Foundation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P17813

determination method

positive regulation of pathway-restricted SMAD protein phosphorylation

determination method

1 reference

8 April 2019

Extracellular and cytoplasmic domains of endoglin interact with the transforming growth factor-beta receptors I and II

British Heart Foundation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P17813

determination method

positive regulation of protein kinase B signaling

determination method

1 reference

8 April 2019

miR-342-5p Is a Notch Downstream Molecule and Regulates Multiple Angiogenic Pathways Including Notch, Vascular Endothelial Growth Factor and Transforming Growth Factor β Signaling

British Heart Foundation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P17813

determination method

Gene Atlas image

PBB GE ENG 201809 s at fs.png
732 × 530; 12 KB

0 references

Zona pellucida domain

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/P17813

Identifiers

MeSH descriptor ID

subject named as

Endoglin

0 references

D12.776.543.750.250

0 references

RefSeq protein ID

1 reference

30 May 2020

1 reference

30 May 2020

1 reference

30 May 2020

UniProt protein ID

1 reference

13 November 2019

UniProt protein ID

Ensembl protein ID

ENSP00000362299

1 reference

Ensembl Release 99

Ensembl protein ID

ENSP00000362299

ENSP00000341917

1 reference

Ensembl Release 99

Ensembl protein ID

ENSP00000341917

ENSP00000479015

1 reference

Ensembl Release 99

Ensembl protein ID

ENSP00000479015

1 reference

based on heuristic

inferred by common MeSH mappings on source and on Wikidata

25 May 2023

Sitelinks

Wikipedia(0 entries)

Wikibooks(0 entries)

Wikinews(0 entries)

Wikiquote(0 entries)

Wikisource(0 entries)

Wikiversity(0 entries)

Wikivoyage(0 entries)

Wiktionary(0 entries)

Multilingual sites(0 entries)

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