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Structure-function of the G protein-coupled receptor superfamily
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scholarly article
1 reference
stated in
Europe PubMed Central
PMCID
3540149
retrieved
3 November 2017
title
Structure-function of the G protein-coupled receptor superfamily
(English)
1 reference
stated in
Europe PubMed Central
PMCID
3540149
retrieved
3 November 2017
main subject
G protein-coupled receptor
0 references
author
Vsevolod Katritch
series ordinal
1
1 reference
stated in
Europe PubMed Central
PubMed ID
23140243
retrieved
25 June 2017
Raymond C. Stevens
series ordinal
3
1 reference
stated in
Europe PubMed Central
PubMed ID
23140243
retrieved
25 June 2017
Vadim Cherezov
series ordinal
2
object named as
Vadim Cherezov
1 reference
stated in
Europe PubMed Central
PMCID
3540149
retrieved
3 November 2017
publication date
8 November 2012
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stated in
Europe PubMed Central
PMCID
3540149
retrieved
3 November 2017
published in
Annual Review of Pharmacology and Toxicology
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stated in
Europe PubMed Central
PMCID
3540149
retrieved
3 November 2017
volume
53
1 reference
stated in
Europe PubMed Central
PMCID
3540149
retrieved
3 November 2017
page(s)
531-556
1 reference
stated in
Europe PubMed Central
PMCID
3540149
retrieved
3 November 2017
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Conformational changes in the g protein-coupled receptor rhodopsin revealed by histidine hydrogen-deuterium exchange
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Conserved Binding Mode of Human β 2 Adrenergic Receptor Inverse Agonists and Antagonist Revealed by X-ray Crystallography
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20 June 2018
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Dopamine D2 receptors form higher order oligomers at physiological expression levels
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Structure of a beta1-adrenergic G-protein-coupled receptor
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A Specific Cholesterol Binding Site Is Established by the 2.8 Å Structure of the Human β2-Adrenergic Receptor
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PubMed Central
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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3540149
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20 June 2018
An ion-responsive motif in the second transmembrane segment of rhodopsin-like receptors
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PubMed Central
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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3540149
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20 June 2018
Mutations affecting the oligomerization interface of G-protein-coupled receptors revealed by a novel de novo protein design framework
1 reference
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PubMed Central
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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3540149
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20 June 2018
High-resolution crystal structure of an engineered human beta2-adrenergic G protein-coupled receptor
1 reference
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PubMed Central
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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3540149
retrieved
20 June 2018
GPCR engineering yields high-resolution structural insights into beta2-adrenergic receptor function
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3540149
retrieved
20 June 2018
Crystal structure of the human beta2 adrenergic G-protein-coupled receptor
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3540149
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20 June 2018
Activation of G protein-coupled receptors: beyond two-state models and tertiary conformational changes.
1 reference
stated in
PubMed Central
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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3540149
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20 June 2018
Conformational complexity of G-protein-coupled receptors
1 reference
stated in
PubMed Central
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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3540149
retrieved
20 June 2018
The alpha1b-adrenoceptor exists as a higher-order oligomer: effective oligomerization is required for receptor maturation, surface delivery, and function
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3540149
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20 June 2018
G protein coupled receptor structure and activation
1 reference
stated in
PubMed Central
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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3540149
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20 June 2018
How many drug targets are there?
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PubMed Central
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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3540149
retrieved
20 June 2018
Crystal structure of a photoactivated deprotonated intermediate of rhodopsin
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3540149
retrieved
20 June 2018
Oligomeric structure of the alpha1b-adrenoceptor: comparisons with rhodopsin
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3540149
retrieved
20 June 2018
Local peptide movement in the photoreaction intermediate of rhodopsin
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3540149
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20 June 2018
GPCR agonists and antagonists in the clinic
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stated in
PubMed Central
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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3540149
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20 June 2018
Keynote review: allosterism in membrane receptors
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PubMed Central
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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3540149
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20 June 2018
Molecular mechanism of 7TM receptor activation--a global toggle switch model
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PubMed Central
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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3540149
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20 June 2018
Crosstalk in G protein-coupled receptors: changes at the transmembrane homodimer interface determine activation
1 reference
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PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3540149
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20 June 2018
The supramolecular structure of the GPCR rhodopsin in solution and native disc membranes
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3540149
retrieved
20 June 2018
Random mutagenesis of the M3 muscarinic acetylcholine receptor expressed in yeast: identification of second-site mutations that restore function to a coupling-deficient mutant M3 receptor.
1 reference
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PubMed Central
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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3540149
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20 June 2018
Structure of bovine rhodopsin in a trigonal crystal form.
1 reference
stated in
PubMed Central
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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3540149
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20 June 2018
The G protein-coupled receptor rhodopsin in the native membrane
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3540149
retrieved
20 June 2018
Identification of amino acid residues crucial for chemokine receptor dimerization.
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3540149
retrieved
20 June 2018
The G-protein-coupled receptors in the human genome form five main families. Phylogenetic analysis, paralogon groups, and fingerprints
1 reference
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PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3540149
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20 June 2018
Constitutive activity of G-protein-coupled receptors: cause of disease and common property of wild-type receptors
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3540149
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20 June 2018
Beta2 adrenergic receptor activation. Modulation of the proline kink in transmembrane 6 by a rotamer toggle switch
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3540149
retrieved
20 June 2018
The binding site of aminergic G protein-coupled receptors: the transmembrane segments and second extracellular loop
1 reference
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PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3540149
retrieved
20 June 2018
Crystal structure of rhodopsin: A G protein-coupled receptor
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3540149
retrieved
20 June 2018
A conserved tyrosine residue (Y601) in transmembrane domain 5 of the human thyrotropin receptor serves as a molecular switch to determine G-protein coupling.
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3540149
retrieved
20 June 2018
Mutagenesis reveals structure-activity parallels between human A2A adenosine receptors and biogenic amine G protein-coupled receptors
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3540149
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20 June 2018
Opiate agonists and antagonists discriminated by receptor binding in brain.
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3540149
retrieved
20 June 2018
Distinct phosphorylation sites on the β(2)-adrenergic receptor establish a barcode that encodes differential functions of β-arrestin.
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3540149
retrieved
26 November 2018
Observation of "ionic lock" formation in molecular dynamics simulations of wild-type beta 1 and beta 2 adrenergic receptors
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3540149
retrieved
26 November 2018
Monitoring the interaction of a single G-protein key binding site with rhodopsin disk membranes upon light activation.
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3540149
retrieved
26 November 2018
Development and crystallization of a minimal thermostabilised G protein-coupled receptor.
1 reference
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PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3540149
retrieved
26 November 2018
Functional role of the "ionic lock"--an interhelical hydrogen-bond network in family A heptahelical receptors.
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3540149
retrieved
26 November 2018
The repertoire of G-protein-coupled receptors in fully sequenced genomes
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3540149
retrieved
26 November 2018
The retinal conformation and its environment in rhodopsin in light of a new 2.2 A crystal structure
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3540149
retrieved
26 November 2018
C5a receptor oligomerization. I. Disulfide trapping reveals oligomers and potential contact surfaces in a G protein-coupled receptor
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3540149
retrieved
26 November 2018
Functionally different agonists induce distinct conformations in the G protein coupling domain of the beta 2 adrenergic receptor
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3540149
retrieved
26 November 2018
Fluorescent labeling of purified beta 2 adrenergic receptor. Evidence for ligand-specific conformational changes
1 reference
stated in
PubMed
reference URL
https://pubmed.ncbi.nlm.nih.gov/23140243
retrieved
12 December 2020
based on heuristic
inferred from PubMed ID database lookup
Identifiers
DOI
10.1146/ANNUREV-PHARMTOX-032112-135923
1 reference
stated in
Europe PubMed Central
PMCID
3540149
retrieved
3 November 2017
PMCID
3540149
1 reference
stated in
Europe PubMed Central
PMCID
3540149
retrieved
3 November 2017
PubMed ID
23140243
1 reference
stated in
Europe PubMed Central
PMCID
3540149
retrieved
3 November 2017
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