(Q33522555)

27 July 2017

ATR activation and replication fork restart are defective in FANCM-deficient cells (English)

1 reference

27 July 2017

Wojciech Niedzwiedz

3

0 references

author name string

Rebekka A Schwab

series ordinal

1

1 reference

27 July 2017

Andrew N Blackford

series ordinal

2

1 reference

27 July 2017

language of work or name

English

0 references

publication date

7 January 2010

1 reference

27 July 2017

1 reference

27 July 2017

29

1 reference

27 July 2017

4

1 reference

27 July 2017

806-818

1 reference

describes a project that uses

27 July 2017

ImageJ

1 reference

11 June 2022

https://www.ebi.ac.uk/europepmc/webservices/rest/PMC2829160/fullTextXML

based on heuristic

inferred from PubMed Central ID database lookup

cites work

The Walker B motif in avian FANCM is required to limit sister chromatid exchanges but is dispensable for DNA crosslink repair

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2829160

Impaired FANCD2 monoubiquitination and hypersensitivity to camptothecin uniquely characterize Fanconi anemia complementation group M.

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2829160

Single-stranded DNA orchestrates an ATM-to-ATR switch at DNA breaks

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2829160

Identification and analysis of new proteins involved in the DNA damage response network of Fanconi anemia and Bloom syndrome.

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2829160

ATR and Rad17 collaborate in modulating Rad9 localisation at sites of DNA damage.

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2829160

FANCM and FAAP24 function in ATR-mediated checkpoint signaling independently of the Fanconi anemia core complex

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2829160

Fanconi anemia proteins stabilize replication forks

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2829160

ATR: an essential regulator of genome integrity

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2829160

Excess MCM proteins protect human cells from replicative stress by licensing backup origins of replication.

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2829160

TopBP1 activates ATR through ATRIP and a PIKK regulatory domain

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2829160

Claspin promotes normal replication fork rates in human cells

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2829160

Plx1 is required for chromosomal DNA replication under stressful conditions

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2829160

The Fanconi anemia protein FANCM can promote branch migration of Holliday junctions and replication forks

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2829160

Tel2 regulates the stability of PI3K-related protein kinases

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2829160

Dormant origins licensed by excess Mcm2-7 are required for human cells to survive replicative stress.

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2829160

The mammalian DNA replication elongation checkpoint: implication of Chk1 and relationship with origin firing as determined by single DNA molecule and single cell analyses

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2829160

Emergence of a DNA-damage response network consisting of Fanconi anaemia and BRCA proteins

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2829160

The intra-S-phase checkpoint affects both DNA replication initiation and elongation: single-cell and -DNA fiber analyses

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2829160

Chk1 regulates the density of active replication origins during the vertebrate S phase.

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2829160

Loss of FANCC function is associated with failure to inhibit late firing replication origins after DNA cross-linking

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2829160

HCLK2 is essential for the mammalian S-phase checkpoint and impacts on Chk1 stability

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2829160

In vitro biological activity of a novel small-molecule inhibitor of polo-like kinase 1.

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2829160

Claspin operates downstream of TopBP1 to direct ATR signaling towards Chk1 activation

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2829160

Chk1 requirement for high global rates of replication fork progression during normal vertebrate S phase

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2829160

TopBP1 activates the ATR-ATRIP complex

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2829160

The vertebrate Hef ortholog is a component of the Fanconi anemia tumor-suppressor pathway.

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2829160

Histone H2A phosphorylation in DNA double-strand break repair

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2829160

Saccharomyces cerevisiae MPH1 gene, required for homologous recombination-mediated mutation avoidance, encodes a 3' to 5' DNA helicase

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2829160

Chk1-dependent S-M checkpoint delay in vertebrate cells is linked to maintenance of viable replication structures.

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2829160

ATR and ATM regulate the timing of DNA replication origin firing

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2829160

Chk1-deficient tumour cells are viable but exhibit multiple checkpoint and survival defects

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2829160

ORC and the intra-S-phase checkpoint: a threshold regulates Rad53p activation in S phase

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2829160

DNA replication is required for the checkpoint response to damaged DNA in Xenopus egg extracts

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2829160

Fork reversal and ssDNA accumulation at stalled replication forks owing to checkpoint defects

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2829160

Maintenance of genome stability in Saccharomyces cerevisiae

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2829160

Regulation of ATR substrate selection by Rad17-dependent loading of Rad9 complexes onto chromatin

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2829160

ATR and ATRIP: partners in checkpoint signaling

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2829160

Cell cycle checkpoint signaling through the ATM and ATR kinases

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2829160

ATR-mediated checkpoint pathways regulate phosphorylation and activation of human Chk1

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2829160

The Chk1 protein kinase and the Cdc25C regulatory pathways are targets of the anticancer agent UCN-01

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2829160

Replicon clusters are stable units of chromosome structure: evidence that nuclear organization contributes to the efficient activation and propagation of S phase in human cells

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2829160

Fancm-deficient mice reveal unique features of Fanconi anemia complementation group M.

28 July 2018

1 reference

https://api.crossref.org/works/10.1038%2FEMBOJ.2009.385

Identification of FAAP24, a Fanconi anemia core complex protein that interacts with FANCM.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FEMBOJ.2009.385

HCLK2 is required for activity of the DNA damage response kinase ATR.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FEMBOJ.2009.385

The Rad9-Hus1-Rad1 (9-1-1) clamp activates checkpoint signaling via TopBP1.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FEMBOJ.2009.385

Activation of mammalian Chk1 during DNA replication arrest: a role for Chk1 in the intra-S phase checkpoint monitoring replication origin firing

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FEMBOJ.2009.385

The structure-specific endonuclease Mus81 contributes to replication restart by generating double-strand DNA breaks

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FEMBOJ.2009.385

The Fanconi anemia pathway is required for the DNA replication stress response and for the regulation of common fragile site stability

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FEMBOJ.2009.385

Cell cycle-dependent chromatin loading of the Fanconi anemia core complex by FANCM/FAAP24.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FEMBOJ.2009.385

Cooperation of the N-terminal Helicase and C-terminal endonuclease activities of Archaeal Hef protein in processing stalled replication forks

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FEMBOJ.2009.385

Characterization of a novel ATR-dependent, Chk1-independent, intra-S-phase checkpoint that suppresses initiation of replication in Xenopus

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FEMBOJ.2009.385

A human ortholog of archaeal DNA repair protein Hef is defective in Fanconi anemia complementation group M

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FEMBOJ.2009.385

Fanconi anemia and DNA replication repair

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FEMBOJ.2009.385

Spontaneous homologous recombination is induced by collapsed replication forks that are caused by endogenous DNA single-strand breaks

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FEMBOJ.2009.385

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FEMBOJ.2009.385

Selective accumulation of virus-specific CD8+ T cells within the peripheral blood stem cell compartment.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FEMBOJ.2009.385

The FANCM ortholog Fml1 promotes recombination at stalled replication forks and limits crossing over during DNA double-strand break repair

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FEMBOJ.2009.385

TopBP1 and DNA polymerase-alpha directly recruit the 9-1-1 complex to stalled DNA replication forks.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FEMBOJ.2009.385

Ataxia-telangiectasia mutated (ATM)-dependent activation of ATR occurs through phosphorylation of TopBP1 by ATM.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FEMBOJ.2009.385

Sensing DNA damage through ATRIP recognition of RPA-ssDNA complexes

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FEMBOJ.2009.385

Gross Chromosomal Rearrangements and Elevated Recombination at an Inducible Site-Specific Replication Fork Barrier

21 January 2018

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/20057355

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Identifiers

DOI

10.1038/EMBOJ.2009.385

1 reference

27 July 2017

1 reference

27 July 2017

1 reference