(Q34535632)

2 August 2017

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title

Telomerase in the human organism (English)

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2 August 2017

Kathleen Collins

1

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2 August 2017

James R Mitchell

series ordinal

2

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2 August 2017

language of work or name

English

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publication date

1 January 2002

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2 August 2017

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2 August 2017

21

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2 August 2017

4

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2 August 2017

564-579

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https://scigraph.springernature.com/pub.10.1038/sj.onc.1205083

2 August 2017

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cites work

Euplotes telomerase contains an La motif protein produced by apparent translational frameshifting

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1205083

N-terminal domains of the human telomerase catalytic subunit required for enzyme activity in vivo

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1205083

Mice without telomerase: what can they teach us about human cancer?

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1205083

The RNA world of the nucleolus: two major families of small RNAs defined by different box elements with related functions

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1205083

Reconstitution of human telomerase activity in vitro

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1205083

Telomerase is not an epidermal stem cell marker and is downregulated by calcium

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1205083

Telomere shortening and tumor formation by mouse cells lacking telomerase RNA

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1205083

Mechanism of telomerase induction during T cell activation

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1205083

Telomerase activity in normal and malignant hematopoietic cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1205083

Modeling chromosomal instability and epithelial carcinogenesis in the telomerase-deficient mouse

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1205083

Secondary structure of vertebrate telomerase RNA

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1205083

Differential expression of telomerase activity in hematopoietic progenitors from adult human bone marrow

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1205083

Telomere maintenance mechanisms and cellular immortalization.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1205083

The hTERTalpha splice variant is a dominant negative inhibitor of telomerase activity

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1205083

The reverse transcriptase component of the Tetrahymena telomerase ribonucleoprotein complex

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1205083

Dissociation among in vitro telomerase activity, telomere maintenance, and cellular immortalization

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1205083

Stable expression in yeast of the mature form of human telomerase RNA depends on its association with the box H/ACA small nucleolar RNP proteins Cbf5p, Nhp2p and Nop10p

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1205083

Dyskeratosis congenita: an inherited bone marrow failure syndrome

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1205083

Dyskeratosis congenita in all its forms

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1205083

In vitro assembly of human H/ACA small nucleolar RNPs reveals unique features of U17 and telomerase RNAs

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1205083

Telomeres and HIV disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1205083

Coordinate regulation of G- and C strand length during new telomere synthesis

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1205083

Yeast snoRNA accumulation relies on a cleavage-dependent/polyadenylation-independent 3'-processing apparatus

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1205083

hnRNP A1 may interact simultaneously with telomeric DNA and the human telomerase RNA in vitro

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1205083

Heterogeneous nuclear ribonucleoproteins C1 and C2 associate with the RNA component of human telomerase

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1205083

The La antigen associates with the human telomerase ribonucleoprotein and influences telomere length in vivo

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1205083

The rate of telomere sequence loss in human leukocytes varies with age.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1205083

The family of box ACA small nucleolar RNAs is defined by an evolutionarily conserved secondary structure and ubiquitous sequence elements essential for RNA accumulation

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1205083

Hematopoietic stem cells and aging

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1205083

Expression of mouse telomerase reverse transcriptase during development, differentiation and proliferation

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1205083

A telomeric sequence in the RNA of Tetrahymena telomerase required for telomere repeat synthesis

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1205083

Mammalian telomeres end in a large duplex loop

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1205083

Activation of a cAMP pathway and induction of melanogenesis correlate with association of p16(INK4) and p27(KIP1) to CDKs, loss of E2F-binding activity, and premature senescence of human melanocytes.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1205083

Telomere length dynamics and chromosomal instability in cells derived from telomerase null mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1205083

Telomerase activity in the regenerative basal layer of the epidermis inhuman skin and in immortal and carcinoma-derived skin keratinocytes

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1205083

A mammalian telomerase-associated protein

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1205083

Dyskerin localizes to the nucleolus and its mislocalization is unlikely to play a role in the pathogenesis of dyskeratosis congenita

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1205083

X-linked dyskeratosis congenita is caused by mutations in a highly conserved gene with putative nucleolar functions

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1205083

Nhp2p and Nop10p are essential for the function of H/ACA snoRNPs

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1205083

The mouse telomerase RNA 5"-end lies just upstream of the telomerase template sequence

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1205083

Position within the host intron is critical for efficient processing of box C/D snoRNAs in mammalian cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1205083

Immunohistochemical detection of telomerase (hTERT) protein in human cancer tissues and a subset of cells in normal tissues

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1205083

Functional requirement of p23 and Hsp90 in telomerase complexes

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1205083

Immortalization of human CD8+ T cell clones by ectopic expression of telomerase reverse transcriptase

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1205083

Telomere shortening is proportional to the size of the G-rich telomeric 3'-overhang

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1205083

A comprehensive two-hybrid analysis to explore the yeast protein interactome

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1205083

Isolation of a candidate human telomerase catalytic subunit gene, which reveals complex splicing patterns in different cell types.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1205083

Specific association of human telomerase activity with immortal cells and cancer

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1205083

Small nucleolar RNA-guided post-transcriptional modification of cellular RNAs

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1205083

Dyskeratosis Congenita (DC) Registry: identification of new features of DC.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1205083

Unexplained aplastic anaemia, immunodeficiency, and cerebellar hypoplasia (Hoyeraal-Hreidarsson syndrome) due to mutations in the dyskeratosis congenita gene, DKC1

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1205083

Identification of novel DKC1 mutations in patients with dyskeratosis congenita: implications for pathophysiology and diagnosis

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1205083

Expression of TERT in early premalignant lesions and a subset of cells in normal tissues.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1205083

Pseudouridine synthases: four families of enzymes containing a putative uridine-binding motif also conserved in dUTPases and dCTP deaminases

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1205083

Precursors to the U3 small nucleolar RNA lack small nucleolar RNP proteins but are stabilized by La binding.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1205083

Telomere elongation by hnRNP A1 and a derivative that interacts with telomeric repeats and telomerase

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1205083

The box H + ACA snoRNAs carry Cbf5p, the putative rRNA pseudouridine synthase

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1205083

RNA binding domain of telomerase reverse transcriptase

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1205083

Identification of two RNA-binding proteins associated with human telomerase RNA

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1205083

Telomere end-replication problem and cell aging

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1205083

Telomerase RNA function in recombinant Tetrahymena telomerase

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1205083

Reverse transcriptase motifs in the catalytic subunit of telomerase

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1205083

Constitutive and regulated expression of telomerase reverse transcriptase (hTERT) in human lymphocytes

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1205083

The telomerase reverse transcriptase is limiting and necessary for telomerase function in vivo.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1205083

Mass cultured human fibroblasts overexpressing hTERT encounter a growth crisis following an extended period of proliferation.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1205083

Dyskeratosis congenita, telomeres and human ageing

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1205083

Telomeres and their control

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1205083

Accelerated telomere shortening in ataxia telangiectasia

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1205083

hEST2, the putative human telomerase catalytic subunit gene, is up-regulated in tumor cells and during immortalization

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1205083

A box H/ACA small nucleolar RNA-like domain at the human telomerase RNA 3' end

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1205083

Human telomerase activation requires two independent interactions between telomerase RNA and telomerase reverse transcriptase

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1205083

A telomerase component is defective in the human disease dyskeratosis congenita

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1205083

Reversing time: origin of telomerase

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1205083

TLP1: a gene encoding a protein component of mammalian telomerase is a novel member of WD repeats family

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1205083

Severe growth defect in mouse cells lacking the telomerase RNA component.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1205083

In vivo telomere dynamics of human hematopoietic stem cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1205083

Telomerase activity does not always imply telomere maintenance

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1205083

Human H/ACA small nucleolar RNPs and telomerase share evolutionarily conserved proteins NHP2 and NOP10

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1205083

Normal human mammary epithelial cells spontaneously escape senescence and acquire genomic changes

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1205083

Telomere fluorescence measurements in granulocytes and T lymphocyte subsets point to a high turnover of hematopoietic stem cells and memory T cells in early childhood.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1205083

Transfer of the human telomerase reverse transcriptase (TERT) gene into T lymphocytes results in extension of replicative potential.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1205083

One-step affinity purification protocol for human telomerase

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1205083

Saccharomyces cerevisiae telomerase is an Sm small nuclear ribonucleoprotein particle

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1205083

A survey of telomerase activity in human cancer

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1205083

The frequency of immortalization of human fibroblasts and mammary epithelial cells transfected with SV40 large T-antigen

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1205083

RNA-binding protein Nrd1 directs poly(A)-independent 3'-end formation of RNA polymerase II transcripts

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1205083

Telomerase and human tumorigenesis

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1205083

The human papillomavirus type 16 E6 and E7 oncoproteins dissociate cellular telomerase activity from the maintenance of telomere length

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1205083

Expression of telomerase activity in human endometrium is localized to epithelial glandular cells and regulated in a menstrual phase-dependent manner correlated with cell proliferation

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1205083

Detection of telomerase activity in malignant and nonmalignant skin conditions

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1205083

Two inactive fragments of the integral RNA cooperate to assemble active telomerase with the human protein catalytic subunit (hTERT) in vitro

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1205083

Developmental regulation of telomerase activity in human fetal tissues during gestation.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1205083

Evidence for a mitotic clock in human hematopoietic stem cells: loss of telomeric DNA with age.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1205083

Very short telomeres in the peripheral blood of patients with X-linked and autosomal dyskeratosis congenita

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1205083

The RNA component of telomerase is mutated in autosomal dominant dyskeratosis congenita

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1205083

Cbf5p, a potential pseudouridine synthase, and Nhp2p, a putative RNA-binding protein, are present together with Gar1p in all H BOX/ACA-motif snoRNPs and constitute a common bipartite structure.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1205083

Reconstitution of human telomerase with the template RNA component hTR and the catalytic protein subunit hTRT

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1205083

Telomere lengthening and telomerase activation during human B cell differentiation

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1205083

Human telomerase contains two cooperating telomerase RNA molecules

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1205083

Telomere dynamics in cancer progression and prevention: fundamental differences in human and mouse telomere biology

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1205083

Overlap of dyskeratosis congenita with the Hoyeraal-Hreidarsson syndrome

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1205083

Both transcriptional and posttranscriptional mechanisms regulate human telomerase template RNA levels

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1205083

An alternate splicing variant of the human telomerase catalytic subunit inhibits telomerase activity

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1205083

In vivo alteration of telomere sequences and senescence caused by mutated Tetrahymena telomerase RNAs

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1205083

Point mutations in yeast CBF5 can abolish in vivo pseudouridylation of rRNA

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1205083

Functional reconstitution of human telomerase expressed in Saccharomyces cerevisiae

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1205083

7 January 2021

Telomerase is active in normal gastrointestinal mucosa and not up-regulated in precancerous lesions

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1205083

7 January 2021

Chromosomal breakage analysis in dyskeratosis congenita peripheral blood lymphocytes

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1205083

7 January 2021

Telomerase-mediated telomere addition in vivo requires DNA primase and DNA polymerases alpha and delta.

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1205083

7 January 2021

Up-regulation of telomerase in human B lymphocytes occurs independently of cellular proliferation and with expression of the telomerase catalytic subunit

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1205083

7 January 2021

Accelerated telomere shortening and telomerase activation in Fanconi's anaemia

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1205083

7 January 2021

Cutting edge: telomerase activation in human T lymphocytes does not require increase in telomerase reverse transcriptase (hTERT) protein but is associated with hTERT phosphorylation and nuclear translocation

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1205083

7 January 2021

Dyskeratosis and ribosomal rebellion

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1205083

7 January 2021

Identification of Functional Domains and Dominant Negative Mutations in Vertebrate Telomerase RNA Using anin VivoReconstitution System

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1205083

7 January 2021

Telomerase activity reconstituted in vitro with purified human telomerase reverse transcriptase and human telomerase RNA component.

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1205083

7 January 2021

NAP57, a mammalian nucleolar protein with a putative homolog in yeast and bacteria

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1205083

7 January 2021

Telomerase activity concentrates in the mitotically active segments of human hair follicles

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1205083

7 January 2021

Tissue-specific alternate splicing of human telomerase reverse transcriptase (hTERT) influences telomere lengths during human development

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1205083

7 January 2021

Identifiers

DOI

10.1038/SJ.ONC.1205083

1 reference

Dimensions Publication ID

2 August 2017

0 references

1 reference