(Q34713446)

4 August 2017

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title

TGFbeta-SMAD signal transduction: molecular specificity and functional flexibility (English)

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4 August 2017

Bernhard Schmierer

1

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Caroline S. Hill

object named as

Caroline S Hill

series ordinal

2

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publication date

1 December 2007

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Nature Reviews Molecular Cell Biology

4 August 2017

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4 August 2017

8

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4 August 2017

970-982

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4 August 2017

12

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https://scigraph.springernature.com/pub.10.1038/nrm2297

4 August 2017

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cites work

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Specificity and versatility in tgf-beta signaling through Smads

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Smads orchestrate specific histone modifications and chromatin remodeling to activate transcription

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Regulation of the polarity protein Par6 by TGFbeta receptors controls epithelial cell plasticity

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TGF-beta activates Erk MAP kinase signalling through direct phosphorylation of ShcA

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Negative regulation of TGF-beta receptor/Smad signal transduction.

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Smad7 binds to Smurf2 to form an E3 ubiquitin ligase that targets the TGF beta receptor for degradation

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Smurf1 interacts with transforming growth factor-beta type I receptor through Smad7 and induces receptor degradation

31 March 2020

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Regulation of Smurf2 ubiquitin ligase activity by anchoring the E2 to the HECT domain

31 March 2020

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GADD34-PP1c recruited by Smad7 dephosphorylates TGFbeta type I receptor

31 March 2020

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Smad7 antagonizes transforming growth factor beta signaling in the nucleus by interfering with functional Smad-DNA complex formation

31 March 2020

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Specific activation of Smad1 signaling pathways by the BMP7 type I receptor, ALK2

31 March 2020

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31 March 2020

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The BMP7/ActRII extracellular domain complex provides new insights into the cooperative nature of receptor assembly

31 March 2020

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Myostatin Signals through a Transforming Growth Factor β-Like Signaling Pathway To Block Adipogenesis

31 March 2020

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Activin type IIA and IIB receptors mediate Gdf11 signaling in axial vertebral patterning

31 March 2020

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31 March 2020

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31 March 2020

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31 March 2020

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The structure of the follistatin:activin complex reveals antagonism of both type I and type II receptor binding

31 March 2020

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Nodal Signaling in Vertebrate Development

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Lefty blocks a subset of TGFbeta signals by antagonizing EGF-CFC coreceptors

31 March 2020

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31 March 2020

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Two major Smad pathways in TGF-beta superfamily signalling.

31 March 2020

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Lateral signaling enhances TGF-beta response complexity

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31 March 2020

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Endofin acts as a Smad anchor for receptor activation in BMP signaling

31 March 2020

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Endofin, a FYVE domain protein, interacts with Smad4 and facilitates transforming growth factor-beta signaling

31 March 2020

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Smad transcription factors

31 March 2020

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Direct binding of Smad3 and Smad4 to critical TGF beta-inducible elements in the promoter of human plasminogen activator inhibitor-type 1 gene

31 March 2020

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Human Smad3 and Smad4 are sequence-specific transcription activators

31 March 2020

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Crystal structure of a Smad MH1 domain bound to DNA: insights on DNA binding in TGF-beta signaling

31 March 2020

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Drosophila Mad binds to DNA and directly mediates activation of vestigial by Decapentaplegic

31 March 2020

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Dpp-responsive silencers are bound by a trimeric Mad-Medea complex

31 March 2020

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A simple molecular complex mediates widespread BMP-induced repression during Drosophila development.

31 March 2020

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Schnurri transcription factors from Drosophila and vertebrates can mediate Bmp signaling through a phylogenetically conserved mechanism

31 March 2020

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Identification and functional characterization of distinct critically important bone morphogenetic protein-specific response elements in the Id1 promoter

31 March 2020

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Negative feedback regulation of TGF-beta signaling by the SnoN oncoprotein

31 March 2020

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Arkadia activates Smad3/Smad4-dependent transcription by triggering signal-induced SnoN degradation

31 March 2020

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Arkadia induces degradation of SnoN and c-Ski to enhance transforming growth factor-beta signaling

31 March 2020

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A transcriptional partner for MAD proteins in TGF-beta signalling

31 March 2020

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Smad4 and FAST-1 in the assembly of activin-responsive factor

31 March 2020

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Mixer/Bon and FoxH1/Sur have overlapping and divergent roles in Nodal signaling and mesendoderm induction

31 March 2020

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Different Smad2 partners bind a common hydrophobic pocket in Smad2 via a defined proline-rich motif

31 March 2020

1 reference

A self-enabling TGFbeta response coupled to stress signaling: Smad engages stress response factor ATF3 for Id1 repression in epithelial cells.

31 March 2020

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Integration of TGF-beta and Ras/MAPK signaling through p53 phosphorylation.

31 March 2020

1 reference

Hematopoiesis controlled by distinct TIF1gamma and Smad4 branches of the TGFbeta pathway

31 March 2020

1 reference

Germ-layer specification and control of cell growth by Ectodermin, a Smad4 ubiquitin ligase

31 March 2020

1 reference

Cells’ Perception of Position in a Concentration Gradient

31 March 2020

1 reference

Graded changes in dose of a Xenopus activin A homologue elicit stepwise transitions in embryonic cell fate

31 March 2020

1 reference

The interpretation of position in a morphogen gradient as revealed by occupancy of activin receptors

31 March 2020

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SB-431542 is a potent and specific inhibitor of transforming growth factor-beta superfamily type I activin receptor-like kinase (ALK) receptors ALK4, ALK5, and ALK7

31 March 2020

1 reference

Morphogen gradient interpretation by a regulated trafficking step during ligand-receptor transduction

31 March 2020

1 reference

Gradients and thresholds: BMP response gradients unveiled in Drosophila embryos

31 March 2020

1 reference

Distinct endocytic pathways regulate TGF-β receptor signalling and turnover

31 March 2020

1 reference

Clathrin- and non-clathrin-mediated endocytic regulation of cell signalling

31 March 2020

1 reference

Nucleocytoplasmic shuttling of Smads 2, 3, and 4 permits sensing of TGF-beta receptor activity

31 March 2020

1 reference

Analysis of Smad nucleocytoplasmic shuttling in living cells.

31 March 2020

1 reference

Kinetic analysis of Smad nucleocytoplasmic shuttling reveals a mechanism for transforming growth factor beta-dependent nuclear accumulation of Smads

31 March 2020

1 reference

Ubiquitin-dependent degradation of TGF-beta-activated smad2.

31 March 2020

1 reference

Nucleocytoplasmic shuttling of signal transducers.

31 March 2020

1 reference

Identification of phosphatases for Smad in the BMP/DPP pathway

31 March 2020

1 reference

PPM1A functions as a Smad phosphatase to terminate TGFbeta signaling

31 March 2020

1 reference

Protein serine/threonine phosphatase PPM1A dephosphorylates Smad1 in the bone morphogenetic protein signaling pathway

31 March 2020

1 reference

Protein phosphatase-2C alpha as a positive regulator of insulin sensitivity through direct activation of phosphatidylinositol 3-kinase in 3T3-L1 adipocytes

31 March 2020

1 reference

Protein phosphatase 2Calpha dephosphorylates axin and activates LEF-1-dependent transcription

31 March 2020

1 reference

Dephosphorylation of human cyclin-dependent kinases by protein phosphatase type 2C alpha and beta 2 isoforms

31 March 2020

1 reference

Transforming growth factor beta-independent shuttling of Smad4 between the cytoplasm and nucleus.

31 March 2020

1 reference

Smad2 nucleocytoplasmic shuttling by nucleoporins CAN/Nup214 and Nup153 feeds TGFbeta signaling complexes in the cytoplasm and nucleus

31 March 2020

1 reference

Postsynaptic mad signaling at the Drosophila neuromuscular junction.

31 March 2020

1 reference

Nuclear targeting of transforming growth factor-beta-activated Smad complexes

31 March 2020

1 reference

Meaningful relationships: the regulation of the Ras/Raf/MEK/ERK pathway by protein interactions

31 March 2020

1 reference

Computational modeling of the dynamics of the MAP kinase cascade activated by surface and internalized EGF receptors

31 March 2020

1 reference

The DSmurf ubiquitin-protein ligase restricts BMP signaling spatially and temporally during Drosophila embryogenesis.

31 March 2020

1 reference

The chemical basis of morphogenesis

31 March 2020

1 reference

Cleavage of Chordin by Xolloid metalloprotease suggests a role for proteolytic processing in the regulation of Spemann organizer activity

31 March 2020

1 reference

The bone morphogenetic protein 1/Tolloid-like metalloproteinases

31 March 2020

1 reference

Embryonic dorsal-ventral signaling: secreted frizzled-related proteins as inhibitors of tolloid proteinases

31 March 2020

1 reference

Sizzled controls dorso-ventral polarity by repressing cleavage of the Chordin protein

31 March 2020

1 reference

Quantitative models of developmental pattern formation

31 March 2020

1 reference

Shaping morphogen gradients

31 March 2020

1 reference

Regulatory principles of developmental signaling

31 March 2020

1 reference

Morpheus unbound: reimagining the morphogen gradient

31 March 2020

1 reference

Decapentaplegic acts as a morphogen to organize dorsal-ventral pattern in the Drosophila embryo.

31 March 2020

1 reference

Direct and long-range action of a DPP morphogen gradient.

31 March 2020

1 reference

The screw gene encodes a ubiquitously expressed member of the TGF-beta family required for specification of dorsal cell fates in the Drosophila embryo

31 March 2020

1 reference

Spatially restricted activation of the SAX receptor by SCW modulates DPP/TKV signaling in Drosophila dorsal-ventral patterning.

31 March 2020

1 reference

Stepwise formation of a SMAD activity gradient during dorsal-ventral patterning of the Drosophila embryo.

31 March 2020

1 reference

Spatial bistability of Dpp-receptor interactions during Drosophila dorsal-ventral patterning.

31 March 2020

1 reference

Cleavage of the BMP-4 antagonist chordin by zebrafish tolloid

31 March 2020

1 reference

Production of a DPP activity gradient in the early Drosophila embryo through the opposing actions of the SOG and TLD proteins

31 March 2020

1 reference

Holy Tolloido: Tolloid cleaves SOG/Chordin to free DPP/BMPs.

31 March 2020

1 reference

Distinct domain utilization by Smad3 and Smad4 for nucleoporin interaction and nuclear import.

31 March 2020

1 reference

Transforming growth factor-beta induces nuclear import of Smad3 in an importin-beta1 and Ran-dependent manner

31 March 2020

1 reference

Importin beta mediates nuclear translocation of Smad 3

31 March 2020

1 reference

Nucleocytoplasmic shuttling of Smad1 conferred by its nuclear localization and nuclear export signals

31 March 2020

1 reference

An extended bipartite nuclear localization signal in Smad4 is required for its nuclear import and transcriptional activity

31 March 2020

1 reference

Msk is required for nuclear import of TGF-{beta}/BMP-activated Smads

31 March 2020

1 reference

Regulation of intracellular dynamics of Smad4 by its leucine-rich nuclear export signal

31 March 2020

1 reference

Identification of two Smad4 proteins in Xenopus. Their common and distinct properties.

31 March 2020

1 reference

The mechanism of nuclear export of Smad3 involves exportin 4 and Ran

31 March 2020

1 reference

The interpretation of morphogen gradients

31 March 2020

1 reference

Recognition of phosphorylated-Smad2-containing complexes by a novel Smad interaction motif

31 March 2020

1 reference

Smad affinity can direct distinct readouts of the embryonic extracellular Dpp gradient in Drosophila

31 March 2020

1 reference

A mechanism for the sharp transition of morphogen gradient interpretation in Xenopus

31 March 2020

1 reference

The Xenopus Brachyury promoter is activated by FGF and low concentrations of activin and suppressed by high concentrations of activin and by paired-type homeodomain proteins

31 March 2020

1 reference

Responses of embryonic Xenopus cells to activin and FGF are separated by multiple dose thresholds and correspond to distinct axes of the mesoderm.

31 March 2020

1 reference

DNA-binding specificity and embryological function of Xom (Xvent-2).

31 March 2020

1 reference

Functional specificity of the Xenopus T-domain protein Brachyury is conferred by its ability to interact with Smad1.

31 March 2020

1 reference

Interaction of goosecoid and brachyury in Xenopus mesoderm patterning

31 March 2020

1 reference

The Drosophila schnurri gene acts in the Dpp/TGF beta signaling pathway and encodes a transcription factor homologous to the human MBP family

31 March 2020

1 reference

Schnurri is required for Drosophila Dpp signaling and encodes a zinc finger protein similar to the mammalian transcription factor PRDII-BF1.

31 March 2020

1 reference

Conversion of an extracellular Dpp/BMP morphogen gradient into an inverse transcriptional gradient.

31 March 2020

1 reference

Nuclear interpretation of Dpp signaling in Drosophila

31 March 2020

1 reference

Regulation of spalt expression in the Drosophila wing blade in response to the Decapentaplegic signaling pathway

31 March 2020

1 reference

Multiple sequence alignment with the Clustal series of programs

31 March 2020

1 reference

Growth differentiation factor 11 signals through the transforming growth factor-beta receptor ALK5 to regionalize the anterior-posterior axis

31 March 2020

1 reference

inferred from DOI database lookup

7 January 2021

based on heuristic

Identifiers

DOI

10.1038/NRM2297

1 reference

PubMed ID

18000526

Dimensions Publication ID

4 August 2017

0 references

1 reference

PubMed ID

18000526