(Q37417486)

20 August 2017

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title

Death receptor signal transducers: nodes of coordination in immune signaling networks (English)

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20 August 2017

Nicholas S Wilson

1

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20 August 2017

Vishva Dixit

series ordinal

2

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20 August 2017

Avi Ashkenazi

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3

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20 August 2017

language of work or name

English

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publication date

19 March 2009

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20 August 2017

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20 August 2017

10

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20 August 2017

4

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20 August 2017

348-355

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The CD95 Receptor: Apoptosis Revisited

20 August 2017

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12 December 2020

Tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) contributes to interferon gamma-dependent natural killer cell protection from tumor metastasis

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12 December 2020

The generation of protective memory-like CD8+ T cells during homeostatic proliferation requires CD4+ T cells

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12 December 2020

Palmitoylation of CD95 facilitates formation of SDS-stable receptor aggregates that initiate apoptosis signaling

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12 December 2020

TIPE2, a negative regulator of innate and adaptive immunity that maintains immune homeostasis

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12 December 2020

Inhibitor of apoptosis protein cIAP2 is essential for lipopolysaccharide-induced macrophage survival

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12 December 2020

A Fas-associated death domain protein/caspase-8-signaling axis promotes S-phase entry and maintains S6 kinase activity in T cells responding to IL-2.

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12 December 2020

Molecular cloning and characterization of mouse caspase-8

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12 December 2020

CD4+ T-cell help controls CD8+ T-cell memory via TRAIL-mediated activation-induced cell death.

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12 December 2020

Developmental pathways that generate natural-killer-cell diversity in mice and humans

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12 December 2020

Monocyte-mediated tumoricidal activity via the tumor necrosis factor-related cytokine, TRAIL.

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12 December 2020

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12 December 2020

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12 December 2020

B-cell receptor and Fas-mediated signals for life and death

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12 December 2020

Normal thymocyte negative selection in TRAIL-deficient mice

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12 December 2020

CARP-2 is an endosome-associated ubiquitin ligase for RIP and regulates TNF-induced NF-kappaB activation

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12 December 2020

Cellular FLICE-inhibitory protein splice variants inhibit different steps of caspase-8 activation at the CD95 death-inducing signaling complex

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12 December 2020

The caspase-8 inhibitor FLIP promotes activation of NF-kappaB and Erk signaling pathways

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12 December 2020

Critical link between TRAIL and CCL20 for the activation of TH2 cells and the expression of allergic airway disease

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12 December 2020

The c-FLIP-NH2 terminus (p22-FLIP) induces NF-kappaB activation.

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12 December 2020

CD95 stimulation results in the formation of a novel death effector domain protein-containing complex

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12 December 2020

The CD95(APO-1/Fas) DISC and beyond

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12 December 2020

Activation of caspases-8 and -10 by FLIP(L).

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12 December 2020

IAP antagonists target cIAP1 to induce TNFalpha-dependent apoptosis

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12 December 2020

A New TRADDition in intracellular antiviral signaling

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12 December 2020

Phosphatidylinositol 3-kinase/Akt activity regulates c-FLIP expression in tumor cells

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12 December 2020

Function of TRADD in tumor necrosis factor receptor 1 signaling and in TRIF-dependent inflammatory responses

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12 December 2020

NK cell TRAIL eliminates immature dendritic cells in vivo and limits dendritic cell vaccination efficacy

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12 December 2020

Evolutionary struggles between NK cells and viruses

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12 December 2020

Potential role for IL-7 in Fas-mediated T cell apoptosis during HIV infection.

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12 December 2020

De-ubiquitination and ubiquitin ligase domains of A20 downregulate NF-kappaB signalling

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12 December 2020

RIP1 is an essential mediator of Toll-like receptor 3-induced NF-kappa B activation

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12 December 2020

The E3 ubiquitin ligase Itch in T cell activation, differentiation, and tolerance

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12 December 2020

In vivo natural killer cell activities revealed by natural killer cell-deficient mice

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12 December 2020

The suicide in the thymus, a twisted trail

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12 December 2020

TNF regulates thymocyte production by apoptosis and proliferation of the triple negative (CD3-CD4-CD8-) subset

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12 December 2020

Involvement of cellular death in TRAIL/DR5-dependent suppression induced by CD4(+)CD25(+) regulatory T cells

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12 December 2020

Mathematical modeling identified c-FLIP as an apoptotic switch in death receptor induced apoptosis.

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12 December 2020

Molecular cloning and functional analysis of the mouse homologue of the KILLER/DR5 tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) death receptor.

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12 December 2020

A Function of Fas-Associated Death Domain Protein in Cell Cycle Progression Localized to a Single Amino Acid at Its C-Terminal Region

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12 December 2020

Innate immunity gone awry: linking microbial infections to chronic inflammation and cancer

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12 December 2020

The function of TRADD in signaling through tumor necrosis factor receptor 1 and TRIF-dependent Toll-like receptors

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12 December 2020

Identification and functional characterization of DR6, a novel death domain-containing TNF receptor

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12 December 2020

Natural killer cell developmental pathways: a question of balance.

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12 December 2020

MAP kinase kinase kinases and innate immunity

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12 December 2020

NEMO recognition of ubiquitinated Bcl10 is required for T cell receptor-mediated NF-kappaB activation

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12 December 2020

Antigen-mediated T cell expansion regulated by parallel pathways of death

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12 December 2020

p53-dependent impairment of T-cell proliferation in FADD dominant-negative transgenic mice

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12 December 2020

Apoptosis by death factor

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12 December 2020

Monocyte and macrophage heterogeneity

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12 December 2020

Targeting the extrinsic apoptosis pathway in cancer

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12 December 2020

Fas ligand costimulates the in vivo proliferation of CD8+ T cells

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12 December 2020

Roles of caspase-8 and caspase-10 in innate immune responses to double-stranded RNA

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12 December 2020

Human dendritic cells mediate cellular apoptosis via tumor necrosis factor-related apoptosis-inducing ligand (TRAIL)

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12 December 2020

Mutational analyses of c-FLIPR, the only murine short FLIP isoform, reveal requirements for DISC recruitment

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12 December 2020

Both cIAP1 and cIAP2 regulate TNFalpha-mediated NF-kappaB activation

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12 December 2020

TRAIL-R as a negative regulator of innate immune cell responses.

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12 December 2020

The TNF and TNF receptor superfamilies: integrating mammalian biology

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12 December 2020

Cellular FLIP (long form) regulates CD8+ T cell activation through caspase-8-dependent NF-kappa B activation

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12 December 2020

Competitive control of independent programs of tumor necrosis factor receptor-induced cell death by TRADD and RIP1

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12 December 2020

Multistep pathogenesis of autoimmune disease.

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12 December 2020

Essential role for caspase 8 in T-cell homeostasis and T-cell-mediated immunity

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12 December 2020

Life and death in peripheral T cells

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12 December 2020

c-FLIP protects mature T lymphocytes from TCR-mediated killing

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12 December 2020

Tumor necrosis factor: an apoptosis JuNKie?

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12 December 2020

TRAIL-R deficiency in mice promotes susceptibility to chronic inflammation and tumorigenesis

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12 December 2020

Cutting Edge: CpG DNA inhibits dendritic cell apoptosis by up-regulating cellular inhibitor of apoptosis proteins through the phosphatidylinositide-3'-OH kinase pathway.

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12 December 2020

N-terminal fragment of c-FLIP(L) processed by caspase 8 specifically interacts with TRAF2 and induces activation of the NF-kappaB signaling pathway

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12 December 2020

Ubiquitination of RIP1 regulates an NF-kappaB-independent cell-death switch in TNF signaling

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12 December 2020

Conditional Fas-associated death domain protein (FADD): GFP knockout mice reveal FADD is dispensable in thymic development but essential in peripheral T cell homeostasis

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12 December 2020

cIAP1 and cIAP2 facilitate cancer cell survival by functioning as E3 ligases that promote RIP1 ubiquitination

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12 December 2020

Role of adaptor TRIF in the MyD88-independent toll-like receptor signaling pathway

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12 December 2020

Regulation of antiviral responses by a direct and specific interaction between TRAF3 and Cardif

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12 December 2020

The long form of FLIP is an activator of caspase-8 at the Fas death-inducing signaling complex

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12 December 2020

Role of tumor necrosis factor-related apoptosis-inducing ligand in immune response to influenza virus infection in mice

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12 December 2020

A dominant interfering mutant of FADD/MORT1 enhances deletion of autoreactive thymocytes and inhibits proliferation of mature T lymphocytes

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12 December 2020

TNF-dependent recruitment of the protein kinase RIP to the TNF receptor-1 signaling complex

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12 December 2020

Autoimmune lymphoproliferative syndrome

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12 December 2020

The caspase 8 inhibitor c-FLIP(L) modulates T-cell receptor-induced proliferation but not activation-induced cell death of lymphocytes

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12 December 2020

Pleiotropic defects in lymphocyte activation caused by caspase-8 mutations lead to human immunodeficiency

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12 December 2020

The regulation of CD95 (Fas) ligand expression in primary T cells: induction of promoter activation in CD95LP-Luc transgenic mice

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12 December 2020

Targeting death and decoy receptors of the tumour-necrosis factor superfamily

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12 December 2020

TRAIL deficiency does not rescue impaired CD8+ T cell memory generated in the absence of CD4+ T cell help

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12 December 2020

TRAF6 and MEKK1 play a pivotal role in the RIG-I-like helicase antiviral pathway

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12 December 2020

Caspase-8 and c-FLIPL associate in lipid rafts with NF-kappaB adaptors during T cell activation.

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12 December 2020

A new class of reverse signaling costimulators belongs to the TNF family

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12 December 2020

c-IAP1 and c-IAP2 are critical mediators of tumor necrosis factor alpha (TNFalpha)-induced NF-kappaB activation

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12 December 2020

Defective thymocyte apoptosis and accelerated autoimmune diseases in TRAIL-/- mice

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12 December 2020

Selective modulation of protein kinase C-theta during T-cell activation

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12 December 2020

Fas and Fas ligand in gut and liver

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12 December 2020

Spatial differences in active caspase-8 defines its role in T-cell activation versus cell death

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12 December 2020

Regulation of TNFR1 and CD95 signalling by receptor compartmentalization

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12 December 2020

Induction of TNF receptor I-mediated apoptosis via two sequential signaling complexes

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12 December 2020

Up-regulation of c-FLIP short by NFAT contributes to apoptosis resistance of short-term activated T cells

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12 December 2020

RIP1, a kinase on the crossroads of a cell's decision to live or die

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12 December 2020

Rapid up-regulation of c-FLIP expression by BCR signaling through the PI3K/Akt pathway inhibits simultaneously induced Fas-mediated apoptosis in murine B lymphocytes

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12 December 2020

Fas-mediated cytotoxicity by freshly isolated natural killer cells

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12 December 2020

Distinct signaling pathways in TRAIL- versus tumor necrosis factor-induced apoptosis

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12 December 2020

Fas ligation on macrophages enhances IL-1R1-Toll-like receptor 4 signaling and promotes chronic inflammation

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12 December 2020

Apoptosis induced by the toll-like receptor adaptor TRIF is dependent on its receptor interacting protein homotypic interaction motif

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12 December 2020

Deficiency of Bim in dendritic cells contributes to overactivation of lymphocytes and autoimmunity.

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12 December 2020

Cellular FLICE-inhibitory protein is required for T cell survival and cycling

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12 December 2020

Involvement of tumor necrosis factor-related apoptosis-inducing ligand in surveillance of tumor metastasis by liver natural killer cells

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12 December 2020

Requirement for caspase-8 in NF-kappaB activation by antigen receptor.

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12 December 2020

Fas-mediated apoptosis and activation-induced T-cell proliferation are defective in mice lacking FADD/Mort1

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12 December 2020

Steady-state and inflammatory dendritic-cell development

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12 December 2020

Activated human NK and CD8+ T cells express both TNF-related apoptosis-inducing ligand (TRAIL) and TRAIL receptors but are resistant to TRAIL-mediated cytotoxicity

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12 December 2020

Priming of T cells to Fas-mediated proliferative signals by interleukin-7

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12 December 2020

TRAIL identifies immature natural killer cells in newborn mice and adult mouse liver

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12 December 2020

Cell-autonomous Fas (CD95)/Fas-ligand interaction mediates activation-induced apoptosis in T-cell hybridomas.

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12 December 2020

FLICE-inhibitory protein expression during macrophage differentiation confers resistance to fas-mediated apoptosis

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12 December 2020

TNF-alpha induces two distinct caspase-8 activation pathways

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12 December 2020

The TRAIL apoptotic pathway in cancer onset, progression and therapy

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12 December 2020

Toll/IL-1 receptor domain-containing adaptor inducing IFN-beta (TRIF) associates with TNF receptor-associated factor 6 and TANK-binding kinase 1, and activates two distinct transcription factors, NF-kappa B and IFN-regulatory factor-3...

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12 December 2020

Antiviral response by natural killer cells through TRAIL gene induction by IFN-alpha/beta

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12 December 2020

Critical role of TRAF3 in the Toll-like receptor-dependent and -independent antiviral response

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12 December 2020

Death-receptor O-glycosylation controls tumor-cell sensitivity to the proapoptotic ligand Apo2L/TRAIL.

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12 December 2020

Cell cycle effects by C-FADD depend on its C-terminal phosphorylation site.

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12 December 2020

Elimination of antigen-presenting cells and autoreactive T cells by Fas contributes to prevention of autoimmunity

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12 December 2020

Tumor necrosis factor-related apoptosis-inducing ligand-mediated apoptosis is an important endogenous mechanism for resistance to liver metastases in murine renal cancer

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12 December 2020

TRADD Protein Is an Essential Component of the RIG-like Helicase Antiviral Pathway

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12 December 2020

The long isoform of cellular FLIP is essential for T lymphocyte proliferation through an NF-kappaB-independent pathway

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12 December 2020

Beyond tumor necrosis factor receptor: TRADD signaling in toll-like receptors.

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12 December 2020

New insights into NF-kappaB regulation and function

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12 December 2020

Phosphorylation and ubiquitination of the IkappaB kinase complex by two distinct signaling pathways

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12 December 2020

High endothelial venules of the lymph nodes express Fas ligand.

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12 December 2020

IL-15 as a mediator of CD4+ help for CD8+ T cell longevity and avoidance of TRAIL-mediated apoptosis

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12 December 2020

The E3 ubiquitin ligase itch couples JNK activation to TNFalpha-induced cell death by inducing c-FLIP(L) turnover

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12 December 2020

RIP: a novel protein containing a death domain that interacts with Fas/APO-1 (CD95) in yeast and causes cell death

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12 December 2020

Molecular determinants of kinase pathway activation by Apo2 ligand/tumor necrosis factor-related apoptosis-inducing ligand

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12 December 2020

The paracaspase MALT1 controls caspase-8 activation during lymphocyte proliferation

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12 December 2020

Ligand-independent redistribution of Fas (CD95) into lipid rafts mediates clonotypic T cell death.

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12 December 2020

Rip1 mediates the Trif-dependent toll-like receptor 3- and 4-induced NF-{kappa}B activation but does not contribute to interferon regulatory factor 3 activation

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12 December 2020

(Un)expected roles of c-IAPs in apoptotic and NFkappaB signaling pathways

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12 December 2020

Selective knockdown of the long variant of cellular FLICE inhibitory protein augments death receptor-mediated caspase-8 activation and apoptosis.

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12 December 2020

The Fas-associated death domain protein is required in apoptosis and TLR-induced proliferative responses in B cells

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12 December 2020

Shared principles in NF-kappaB signaling

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12 December 2020

Stimulation of Toll-like receptor 3 and 4 induces interleukin-1beta maturation by caspase-8.

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12 December 2020

Death receptors: signaling and modulation

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12 December 2020

cFLIP regulation of lymphocyte activation and development

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12 December 2020

Genetic disorders of programmed cell death in the immune system

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12 December 2020

Identifiers

DOI

10.1038/NI.1714

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20 August 2017

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