(Q37856294)

24 August 2017

1 reference

title

Tinkering outside the kinase ATP box: allosteric (type IV) and bivalent (type V) inhibitors of protein kinases (English)

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24 August 2017

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Kurt J Cox

1

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24 August 2017

Carolyn D Shomin

series ordinal

2

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24 August 2017

Indraneel Ghosh

series ordinal

3

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24 August 2017

language of work or name

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1 January 2011

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Future Medicinal Chemistry

24 August 2017

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24 August 2017

3

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24 August 2017

1

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24 August 2017

29-43

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The regulation of protein function by multisite phosphorylation--a 25 year update

24 August 2017

1 reference

https://api.crossref.org/works/10.4155%2FFMC.10.272

The regulation of protein phosphorylation

21 January 2018

1 reference

https://api.crossref.org/works/10.4155%2FFMC.10.272

Caspases and kinases in a death grip

21 January 2018

1 reference

https://api.crossref.org/works/10.4155%2FFMC.10.272

Cell cycle control and cancer

21 January 2018

1 reference

https://api.crossref.org/works/10.4155%2FFMC.10.272

Cell cycle kinases in cancer

21 January 2018

1 reference

https://api.crossref.org/works/10.4155%2FFMC.10.272

Targeting cancer with small molecule kinase inhibitors

21 January 2018

1 reference

https://api.crossref.org/works/10.4155%2FFMC.10.272

The (un)targeted cancer kinome

21 January 2018

1 reference

https://api.crossref.org/works/10.4155%2FFMC.10.272

Protein kinases--the major drug targets of the twenty-first century?

21 January 2018

1 reference

https://api.crossref.org/works/10.4155%2FFMC.10.272

Imatinib compared with interferon and low-dose cytarabine for newly diagnosed chronic-phase chronic myeloid leukemia

21 January 2018

1 reference

https://api.crossref.org/works/10.4155%2FFMC.10.272

The protein kinase complement of the human genome

21 January 2018

1 reference

https://api.crossref.org/works/10.4155%2FFMC.10.272

Exploiting chemical libraries, structure, and genomics in the search for kinase inhibitors

21 January 2018

1 reference

https://api.crossref.org/works/10.4155%2FFMC.10.272

The Sequence of the Human Genome

21 January 2018

1 reference

https://api.crossref.org/works/10.4155%2FFMC.10.272

The selectivity of protein kinase inhibitors: a further update

21 January 2018

1 reference

https://api.crossref.org/works/10.4155%2FFMC.10.272

A quantitative analysis of kinase inhibitor selectivity

21 January 2018

1 reference

https://api.crossref.org/works/10.4155%2FFMC.10.272

A coiled-coil enabled split-luciferase three-hybrid system: applied toward profiling inhibitors of protein kinases

21 January 2018

1 reference

https://api.crossref.org/works/10.4155%2FFMC.10.272

Features of selective kinase inhibitors

21 January 2018

1 reference

https://api.crossref.org/works/10.4155%2FFMC.10.272

Staurosporine, a potent inhibitor of phospholipid/Ca++dependent protein kinase

21 January 2018

1 reference

https://api.crossref.org/works/10.4155%2FFMC.10.272

Staurosporine, K-252 and UCN-01: potent but nonspecific inhibitors of protein kinases

21 January 2018

1 reference

https://api.crossref.org/works/10.4155%2FFMC.10.272

Chemical inhibitors of protein kinases

21 January 2018

1 reference

https://api.crossref.org/works/10.4155%2FFMC.10.272

Strategies for the design of potent and selective kinase inhibitors.

21 January 2018

1 reference

https://api.crossref.org/works/10.4155%2FFMC.10.272

Creating chemical diversity to target protein kinases

21 January 2018

1 reference

https://api.crossref.org/works/10.4155%2FFMC.10.272

A new paradigm for protein kinase inhibition: blocking phosphorylation without directly targeting ATP binding

21 January 2018

1 reference

https://api.crossref.org/works/10.4155%2FFMC.10.272

Allosteric modulation of kinases and GPCRs: design principles and structural diversity

21 January 2018

1 reference

https://api.crossref.org/works/10.4155%2FFMC.10.272

Structural mechanism for STI-571 inhibition of abelson tyrosine kinase

21 January 2018

1 reference

https://api.crossref.org/works/10.4155%2FFMC.10.272

Structure-based design of cyclin-dependent kinase inhibitors

21 January 2018

1 reference

https://api.crossref.org/works/10.4155%2FFMC.10.272

Inhibition of p38 MAP kinase by utilizing a novel allosteric binding site

21 January 2018

1 reference

https://api.crossref.org/works/10.4155%2FFMC.10.272

Rational design of inhibitors that bind to inactive kinase conformations

21 January 2018

1 reference

https://api.crossref.org/works/10.4155%2FFMC.10.272

A general strategy for creating "inactive-conformation" abl inhibitors

21 January 2018

1 reference

https://api.crossref.org/works/10.4155%2FFMC.10.272

Rapid synthesis of Abelson tyrosine kinase inhibitors using click chemistry

21 January 2018

1 reference

https://api.crossref.org/works/10.4155%2FFMC.10.272

A new screening assay for allosteric inhibitors of cSrc

21 January 2018

1 reference

https://api.crossref.org/works/10.4155%2FFMC.10.272

High-throughput screening to identify inhibitors which stabilize inactive kinase conformations in p38alpha

21 January 2018

1 reference

https://api.crossref.org/works/10.4155%2FFMC.10.272

Structures of human MAP kinase kinase 1 (MEK1) and MEK2 describe novel noncompetitive kinase inhibition.

21 January 2018

1 reference

https://api.crossref.org/works/10.4155%2FFMC.10.272

21 January 2018

1 reference

https://api.crossref.org/works/10.4155%2FFMC.10.272

Structural bioinformatics-based design of selective, irreversible kinase inhibitors

21 January 2018

1 reference

https://api.crossref.org/works/10.4155%2FFMC.10.272

ON012380, a putative BCR-ABL kinase inhibitor with a unique mechanism of action in imatinib-resistant cells

21 January 2018

1 reference

https://api.crossref.org/works/10.4155%2FFMC.10.272

Profiling small molecule inhibitors against helix-receptor interactions: the Bcl-2 family inhibitor BH3I-1 potently inhibits p53/hDM2.

21 January 2018

1 reference

https://api.crossref.org/works/10.4155%2FFMC.10.272

Reaching for high-hanging fruit in drug discovery at protein-protein interfaces

21 January 2018

1 reference

https://api.crossref.org/works/10.4155%2FFMC.10.272

The specificities of protein kinase inhibitors: an update

21 January 2018

1 reference

https://api.crossref.org/works/10.4155%2FFMC.10.272

A small molecule-kinase interaction map for clinical kinase inhibitors

21 January 2018

1 reference

https://api.crossref.org/works/10.4155%2FFMC.10.272

The conformational plasticity of protein kinases

21 January 2018

1 reference

https://api.crossref.org/works/10.4155%2FFMC.10.272

Development of thioquinazolinones, allosteric Chk1 kinase inhibitors

21 January 2018

1 reference

https://api.crossref.org/works/10.4155%2FFMC.10.272

Characterization of the CHK1 allosteric inhibitor binding site

21 January 2018

1 reference

https://api.crossref.org/works/10.4155%2FFMC.10.272

Identification and characterization of pleckstrin-homology-domain-dependent and isoenzyme-specific Akt inhibitors

21 January 2018

1 reference

https://api.crossref.org/works/10.4155%2FFMC.10.272

Discovery of 2,3,5-trisubstituted pyridine derivatives as potent Akt1 and Akt2 dual inhibitors

21 January 2018

1 reference

https://api.crossref.org/works/10.4155%2FFMC.10.272

Optimization of 2,3,5-trisubstituted pyridine derivatives as potent allosteric Akt1 and Akt2 inhibitors

21 January 2018

1 reference

https://api.crossref.org/works/10.4155%2FFMC.10.272

Intramolecular and intermolecular interactions of protein kinase B define its activation in vivo

21 January 2018

1 reference

https://api.crossref.org/works/10.4155%2FFMC.10.272

An isoform-selective, small-molecule inhibitor targets the autoregulatory mechanism of p21-activated kinase

21 January 2018

1 reference

https://api.crossref.org/works/10.4155%2FFMC.10.272

Structure of PAK1 in an autoinhibited conformation reveals a multistage activation switch

21 January 2018

1 reference

https://api.crossref.org/works/10.4155%2FFMC.10.272

An allosteric kinase inhibitor binds the p21-activated kinase autoregulatory domain covalently.

21 January 2018

1 reference

https://api.crossref.org/works/10.4155%2FFMC.10.272

Discovery of PDK1 kinase inhibitors with a novel mechanism of action by ultrahigh throughput screening

21 January 2018

1 reference

https://api.crossref.org/works/10.4155%2FFMC.10.272

Identification of a pocket in the PDK1 kinase domain that interacts with PIF and the C-terminal residues of PKA

21 January 2018

1 reference

https://api.crossref.org/works/10.4155%2FFMC.10.272

Allosteric inhibitors of Bcr-abl-dependent cell proliferation

21 January 2018

1 reference

https://api.crossref.org/works/10.4155%2FFMC.10.272

A myristoyl/phosphotyrosine switch regulates c-Abl

21 January 2018

1 reference

https://api.crossref.org/works/10.4155%2FFMC.10.272

Targeting Bcr–Abl by combining allosteric with ATP-binding-site inhibitors

21 January 2018

1 reference

https://api.crossref.org/works/10.4155%2FFMC.10.272

ON01910, a non-ATP-competitive small molecule inhibitor of Plk1, is a potent anticancer agent.

21 January 2018

1 reference

https://api.crossref.org/works/10.4155%2FFMC.10.272

A small molecule inhibits Akt through direct binding to Akt and preventing Akt membrane translocation

21 January 2018

1 reference

https://api.crossref.org/works/10.4155%2FFMC.10.272

Strategies for targeting protein-protein interactions with synthetic agents.

21 January 2018

1 reference

https://api.crossref.org/works/10.4155%2FFMC.10.272

The road less traveled: modulating signal transduction enzymes by inhibiting their protein-protein interactions

21 January 2018

1 reference

https://api.crossref.org/works/10.4155%2FFMC.10.272

Small-molecule inhibitors of protein-protein interactions: progressing towards the dream

21 January 2018

1 reference

https://api.crossref.org/works/10.4155%2FFMC.10.272

On the attribution and additivity of binding energies

21 January 2018

1 reference

https://api.crossref.org/works/10.4155%2FFMC.10.272

Bisubstrate inhibitors of protein kinases: from principle to practical applications

21 January 2018

1 reference

https://api.crossref.org/works/10.4155%2FFMC.10.272

Designing bisubstrate analog inhibitors for protein kinases

21 January 2018

1 reference

https://api.crossref.org/works/10.4155%2FFMC.10.272

Mechanism-based design of a protein kinase inhibitor

21 January 2018

1 reference

https://api.crossref.org/works/10.4155%2FFMC.10.272

Peptide and protein library screening defines optimal substrate motifs for AKT/PKB.

21 January 2018

1 reference

https://api.crossref.org/works/10.4155%2FFMC.10.272

Structural analysis of ARC-type inhibitor (ARC-1034) binding to protein kinase A catalytic subunit and rational design of bisubstrate analogue inhibitors of basophilic protein kinases

21 January 2018

1 reference

https://api.crossref.org/works/10.4155%2FFMC.10.272

Preparation of novel alkylated arginine derivatives suitable for click-cycloaddition chemistry and their incorporation into pseudosubstrate- and bisubstrate-based kinase inhibitors.

21 January 2018

1 reference

https://api.crossref.org/works/10.4155%2FFMC.10.272

Increasing the kinase specificity of k252a by protein surface recognition.

21 January 2018

1 reference

https://api.crossref.org/works/10.4155%2FFMC.10.272

Stepwise combinatorial evolution of Akt bisubstrate inhibitors.

21 January 2018

1 reference

https://api.crossref.org/works/10.4155%2FFMC.10.272

A highly potent and selective PKCalpha inhibitor generated via combinatorial modification of a peptide scaffold

21 January 2018

1 reference

https://api.crossref.org/works/10.4155%2FFMC.10.272

Acquisition of a "Group A"-selective Src kinase inhibitor via a global targeting strategy

21 January 2018

1 reference

https://api.crossref.org/works/10.4155%2FFMC.10.272

A chemical genetic method for generating bivalent inhibitors of protein kinases

21 January 2018

1 reference

https://api.crossref.org/works/10.4155%2FFMC.10.272

Tethering small molecules to a phage display library: discovery of a selective bivalent inhibitor of protein kinase A.

21 January 2018

1 reference

https://api.crossref.org/works/10.4155%2FFMC.10.272

Staurosporine tethered peptide ligands that target cAMP-dependent protein kinase (PKA): optimization and selectivity profiling

21 January 2018

1 reference

https://api.crossref.org/works/10.4155%2FFMC.10.272

A general and rapid cell-free approach for the interrogation of protein-protein, protein-DNA, and protein-RNA interactions and their antagonists utilizing split-protein reporters

21 January 2018

1 reference

https://api.crossref.org/works/10.4155%2FFMC.10.272

Multiple BCR-ABL kinase domain mutations confer polyclonal resistance to the tyrosine kinase inhibitor imatinib (STI571) in chronic phase and blast crisis chronic myeloid leukemia

21 January 2018

1 reference

https://api.crossref.org/works/10.4155%2FFMC.10.272

Activation of tyrosine kinases by mutation of the gatekeeper threonine

21 January 2018

1 reference

https://api.crossref.org/works/10.4155%2FFMC.10.272

21 January 2018

Identifiers

DOI

10.4155/FMC.10.272

1 reference

24 August 2017

1 reference