(Q3820749)

English

Aquaporin 4

mammalian protein found in Homo sapiens

MIWC
mercurial-insensitive water channel
aquaporin-4
WCH4
aquaporin type4
AQP4

In more languages

Statements

1 reference

13 November 2019

UniProt protein ID

0 references

1 reference

13 November 2019

UniProt protein ID

1 reference

13 November 2019

UniProt protein ID

molecular function

water channel activity

determination method

3 references

1 January 2018

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P55087

determination method

1 January 2018

Identification of arylsulfonamides as Aquaporin 4 inhibitors

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P55087

determination method

1 January 2018

Novel variants in human Aquaporin-4 reduce cellular water permeability

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P55087

determination method

water transmembrane transporter activity

determination method

1 reference

1 January 2018

cDNA cloning, gene organization, and chromosomal localization of a human mercurial insensitive water channel. Evidence for distinct transcriptional units

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P55087

determination method

protein binding

determination method

1 reference

9 May 2019

Widespread macromolecular interaction perturbations in human genetic disorders

IntAct protein interaction database

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P55087

determination method

identical protein binding

determination method

1 reference

31 January 2018

Crystal structure of human aquaporin 4 at 1.8 A and its mechanism of conductance

IntAct protein interaction database

http://www.ebi.ac.uk/QuickGO/annotations?protein=P55087&geneProductId=UniProtKB:P55087

determination method

channel activity

determination method

1 reference

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P55087

determination method

water channel activity

determination method

24 references

10 September 2018

Aquaporin-1, nothing but a water channel.

http://www.ebi.ac.uk/QuickGO/annotations?protein=P55087&geneProductId=UniProtKB:P55087

determination method

10 September 2018

The subcellular localization of an aquaporin-2 tetramer depends on the stoichiometry of phosphorylated and nonphosphorylated monomers

http://www.ebi.ac.uk/QuickGO/annotations?protein=P55087&geneProductId=UniProtKB:P55087

determination method

10 September 2018

Water permeability and characterization of aquaporin-11.

http://www.ebi.ac.uk/QuickGO/annotations?protein=P55087&geneProductId=UniProtKB:P55087

determination method

10 September 2018

Aquaporin-6: An intracellular vesicle water channel protein in renal epithelia

http://www.ebi.ac.uk/QuickGO/annotations?protein=P55087&geneProductId=UniProtKB:P55087

determination method

10 September 2018

Purification and functional characterization of aquaporin-8.

http://www.ebi.ac.uk/QuickGO/annotations?protein=P55087&geneProductId=UniProtKB:P55087

determination method

10 September 2018

Mercury-sensitive residues and pore site in AQP3 water channel

http://www.ebi.ac.uk/QuickGO/annotations?protein=P55087&geneProductId=UniProtKB:P55087

determination method

10 September 2018

Functional characterization and localization of AQP3 in the human colon

http://www.ebi.ac.uk/QuickGO/annotations?protein=P55087&geneProductId=UniProtKB:P55087

determination method

10 September 2018

Novel variants in human Aquaporin-4 reduce cellular water permeability

http://www.ebi.ac.uk/QuickGO/annotations?protein=P55087&geneProductId=UniProtKB:P55087

determination method

10 September 2018

Functional impairment of lens aquaporin in two families with dominantly inherited cataracts

http://www.ebi.ac.uk/QuickGO/annotations?protein=P55087&geneProductId=UniProtKB:P55087

determination method

10 September 2018

Mechanism of selectivity in aquaporins and aquaglyceroporins.

http://www.ebi.ac.uk/QuickGO/annotations?protein=P55087&geneProductId=UniProtKB:P55087

determination method

10 September 2018

Appearance of water channels in Xenopus oocytes expressing red cell CHIP28 protein

http://www.ebi.ac.uk/QuickGO/annotations?protein=P55087&geneProductId=UniProtKB:P55087

determination method

10 September 2018

Functional characterization of human aquaporin 9 as a facilitative glycerol carrier.

http://www.ebi.ac.uk/QuickGO/annotations?protein=P55087&geneProductId=UniProtKB:P55087

determination method

10 September 2018

Functional characterization of a human aquaporin 0 mutation that leads to a congenital dominant lens cataract

http://www.ebi.ac.uk/QuickGO/annotations?protein=P55087&geneProductId=UniProtKB:P55087

determination method

10 September 2018

Molecular cloning and characterization of an aquaporin cDNA from salivary, lacrimal, and respiratory tissues

http://www.ebi.ac.uk/QuickGO/annotations?protein=P55087&geneProductId=UniProtKB:P55087

determination method

10 September 2018

Molecular cloning and expression of a novel human aquaporin from adipose tissue with glycerol permeability

http://www.ebi.ac.uk/QuickGO/annotations?protein=P55087&geneProductId=UniProtKB:P55087

determination method

10 September 2018

Bidirectional water fluxes and specificity for small hydrophilic molecules in aquaporins 0-5

http://www.ebi.ac.uk/QuickGO/annotations?protein=P55087&geneProductId=UniProtKB:P55087

determination method

10 September 2018

Roles of aquaporin-3 water channels in volume-regulatory water flow in a human epithelial cell line.

http://www.ebi.ac.uk/QuickGO/annotations?protein=P55087&geneProductId=UniProtKB:P55087

determination method

10 September 2018

Reconstitution of functional water channels in liposomes containing purified red cell CHIP28 protein

http://www.ebi.ac.uk/QuickGO/annotations?protein=P55087&geneProductId=UniProtKB:P55087

determination method

10 September 2018

Cloning and identification of a new member of water channel (AQP10) as an aquaglyceroporin

http://www.ebi.ac.uk/QuickGO/annotations?protein=P55087&geneProductId=UniProtKB:P55087

determination method

10 September 2018

Structural determinants of water permeation through aquaporin-1

http://www.ebi.ac.uk/QuickGO/annotations?protein=P55087&geneProductId=UniProtKB:P55087

determination method

10 September 2018

Cloning and functional expression of human aquaporin8 cDNA and analysis of its gene

http://www.ebi.ac.uk/QuickGO/annotations?protein=P55087&geneProductId=UniProtKB:P55087

determination method

10 September 2018

Cloning of a new aquaporin (AQP10) abundantly expressed in duodenum and jejunum

http://www.ebi.ac.uk/QuickGO/annotations?protein=P55087&geneProductId=UniProtKB:P55087

determination method

10 September 2018

Functional and molecular characterization of the human neutral solute channel aquaporin-9.

http://www.ebi.ac.uk/QuickGO/annotations?protein=P55087&geneProductId=UniProtKB:P55087

determination method

10 September 2018

Identification of arylsulfonamides as Aquaporin 4 inhibitors

http://www.ebi.ac.uk/QuickGO/annotations?protein=P55087&geneProductId=UniProtKB:P55087

determination method

water channel activity

determination method

5 references

9 May 2019

Crystal structure of human aquaporin 4 at 1.8 A and its mechanism of conductance

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P55087

determination method

9 May 2019

A water channel closely related to rat brain aquaporin 4 is expressed in acid- and pepsinogen-secretory cells of human stomach.

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P55087

determination method

9 May 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P55087

determination method

9 May 2019

Novel variants in human Aquaporin-4 reduce cellular water permeability

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P55087

determination method

9 May 2019

Identification of arylsulfonamides as Aquaporin 4 inhibitors

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P55087

determination method

determination method

1 reference

9 May 2019

Changes in skeletal muscle expression of AQP1 and AQP4 in dystrophinopathy and dysferlinopathy patients

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P55087

determination method

integral component of membrane

determination method

1 reference

10 September 2018

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?protein=P55087&geneProductId=UniProtKB:P55087

determination method

basolateral plasma membrane

determination method

1 reference

1 January 2018

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P55087

determination method

external side of plasma membrane

determination method

1 reference

9 May 2019

Human astrocytes express aquaporin-1 and aquaporin-4 in vitro and in vivo

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P55087

determination method

integral component of plasma membrane

determination method

1 reference

31 January 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=P55087&geneProductId=UniProtKB:P55087

determination method

plasma membrane

determination method

3 references

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P55087

determination method

8 April 2019

Fetal development of membrane water channel proteins aquaporin-1 and aquaporin-4 in the human brain

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P55087

determination method

8 April 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P55087

determination method

integral component of plasma membrane

determination method

1 reference

9 May 2019

A water channel closely related to rat brain aquaporin 4 is expressed in acid- and pepsinogen-secretory cells of human stomach.

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P55087

determination method

determination method

1 reference

8 April 2019

Supramolecular aggregation of aquaporin-4 is different in muscle and brain: correlation with tissue susceptibility in neuromyelitis optica.

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P55087

determination method

astrocyte end-foot

determination method

1 reference

9 May 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P55087

determination method

extracellular region

determination method

1 reference

9 May 2019

Gene Ontology Consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P55087

determination method

determination method

1 reference

9 May 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P55087

determination method

plasma membrane

determination method

4 references

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P55087

determination method

9 May 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P55087

determination method

9 May 2019

Fetal development of membrane water channel proteins aquaporin-1 and aquaporin-4 in the human brain

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P55087

determination method

9 May 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P55087

determination method

endosome membrane

determination method

1 reference

9 May 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P55087

determination method

basolateral plasma membrane

determination method

3 references

9 May 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P55087

determination method

9 May 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P55087

determination method

9 May 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P55087

determination method

cell projection

determination method

1 reference

9 May 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P55087

determination method

biological process

water transport

determination method

1 reference

1 January 2018

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P55087

determination method

ion transmembrane transport

determination method

1 reference

31 January 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=P55087&geneProductId=UniProtKB:P55087

determination method

renal water homeostasis

determination method

1 reference

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P55087

determination method

cellular response to interferon-gamma

determination method

1 reference

9 May 2019

Human astrocytes express aquaporin-1 and aquaporin-4 in vitro and in vivo

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P55087

determination method

transmembrane transport

determination method

1 reference

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P55087

determination method

water transport

determination method

3 references

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P55087

determination method

9 May 2019

Crystal structure of human aquaporin 4 at 1.8 A and its mechanism of conductance

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P55087

determination method

9 May 2019

A water channel closely related to rat brain aquaporin 4 is expressed in acid- and pepsinogen-secretory cells of human stomach.

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P55087

determination method

cellular water homeostasis

determination method

1 reference

9 May 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P55087

determination method

water homeostasis

determination method

1 reference

9 May 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P55087

determination method

protein homotetramerization

determination method

1 reference

9 May 2019

Crystal structure of human aquaporin 4 at 1.8 A and its mechanism of conductance

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P55087

determination method

cerebrospinal fluid circulation

determination method

1 reference

9 May 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P55087

determination method

Major intrinsic protein, conserved site

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/P55087

Identifiers

RefSeq protein ID

1 reference

30 May 2020

1 reference

30 May 2020

1 reference

30 May 2020

1 reference

30 May 2020

1 reference

30 May 2020

1 reference

30 May 2020

1 reference

30 May 2020

1 reference

30 May 2020

UniProt protein ID

1 reference

13 November 2019

UniProt protein ID

Ensembl protein ID

ENSP00000372654

1 reference

Ensembl Release 99

Ensembl protein ID

ENSP00000372654

ENSP00000393121

1 reference

Ensembl Release 99

Ensembl protein ID

ENSP00000393121

ENSP00000462597

1 reference

Ensembl Release 99

Ensembl protein ID

ENSP00000462597

ENSP00000372656

1 reference

Ensembl Release 99

Ensembl protein ID

ENSP00000372656

ENSP00000462075

1 reference

Ensembl Release 99

Ensembl protein ID

ENSP00000462075

ENSP00000500598

1 reference

Ensembl Release 99

Ensembl protein ID

ENSP00000500598

ENSP00000500720

1 reference

Ensembl Release 99

Ensembl protein ID

ENSP00000500720

PDB structure ID

1 reference

UniProt protein ID

9 August 2016

language of work or name

Transporter Classification Database ID

2 references

Transporter Classification database

13 March 2020

Transporter Classification database

29 April 2020

Sitelinks

Wikipedia(0 entries)

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Wikinews(0 entries)

Wikiquote(0 entries)

Wikisource(0 entries)

Wikiversity(0 entries)

Wikivoyage(0 entries)

Wiktionary(0 entries)

Multilingual sites(0 entries)

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