(Q38253281)

1 September 2017

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title

Chagas disease drug discovery: toward a new era. (English)

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1 September 2017

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Eric Chatelain

1

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1 September 2017

22 September 2014

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Journal of Biomolecular Screening

1 September 2017

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1 September 2017

20

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1 September 2017

1

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1 September 2017

22-35

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PubMed ID

25245987

on focus list of Wikimedia project

1 September 2017

ScienceSource

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cites work

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21 January 2018

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21 January 2018

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21 January 2018

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Chagas disease in Australia and New Zealand: risks and needs for public health interventions

21 January 2018

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Chagas disease in Spain: need for further public health measures

21 January 2018

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Global and regional mortality from 235 causes of death for 20 age groups in 1990 and 2010: a systematic analysis for the Global Burden of Disease Study 2010

21 January 2018

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Epidemiology of mortality related to Chagas' disease in Brazil, 1999-2007.

21 January 2018

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Neglected tropical diseases as hidden causes of cardiovascular disease

21 January 2018

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Neglected diseases and poverty in "The Other America": the greatest health disparity in the United States?

21 January 2018

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Innovation for the 'bottom 100 million': eliminating neglected tropical diseases in the Americas

21 January 2018

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Measuring the burden of neglected tropical diseases: the global burden of disease framework

21 January 2018

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Global economic burden of Chagas disease: a computational simulation model

21 January 2018

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Congenital and oral transmission of American trypanosomiasis: an overview of physiopathogenic aspects

21 January 2018

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Large urban outbreak of orally acquired acute Chagas disease at a school in Caracas, Venezuela

21 January 2018

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Chagas' disease as a foodborne illness

21 January 2018

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21 January 2018

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Chagas disease: recombinant Trypanosoma cruzi antigens for serological diagnosis

21 January 2018

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ELISA versus PCR for diagnosis of chronic Chagas disease: systematic review and meta-analysis.

21 January 2018

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Chronic phase of Chagas disease: why should it be treated? A comprehensive review

21 January 2018

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Mode of death on Chagas heart disease: comparison with other etiologies. a subanalysis of the REMADHE prospective trial

21 January 2018

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The life cycle of Trypanosoma cruzi revisited

21 January 2018

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Aspects of Trypanosoma cruzi stage differentiation

21 January 2018

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A genome-wide analysis of genetic diversity in Trypanosoma cruzi intergenic regions

21 January 2018

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A new consensus for Trypanosoma cruzi intraspecific nomenclature: second revision meeting recommends TcI to TcVI.

21 January 2018

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The revised Trypanosoma cruzi subspecific nomenclature: rationale, epidemiological relevance and research applications

21 January 2018

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Trypanosoma cruzi I diversity: towards the need of genetic subdivision?

21 January 2018

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Chagas disease: the challenge of polyparasitism?

21 January 2018

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Toxic side effects of drugs used to treat Chagas' disease (American trypanosomiasis)

21 January 2018

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Side effects of benznidazole as treatment in chronic Chagas disease: fears and realities

21 January 2018

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Current status of Chagas disease chemotherapy.

21 January 2018

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Chagas disease: pushing through the pipeline

21 January 2018

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https://api.crossref.org/works/10.1177%2F1087057114550585

Screening of Potential anti-Trypanosoma cruzi Candidates: In Vitro and In Vivo Studies

21 January 2018

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https://api.crossref.org/works/10.1177%2F1087057114550585

Novel ruthenium complexes as potential drugs for Chagas's disease: enzyme inhibition and in vitro/in vivo trypanocidal activity

21 January 2018

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Potential mechanism of the anti-trypanosomal activity of organoruthenium complexes with bioactive thiosemicarbazones

21 January 2018

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https://api.crossref.org/works/10.1177%2F1087057114550585

Advances in Chagas disease drug development: 2009-2010

21 January 2018

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Approaches for the development of new anti-Trypanosoma cruzi agents.

21 January 2018

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Report of the 2nd Chagas Drug Discovery Consortium meeting, held on 3 November 2010; Atlanta GA, USA.

21 January 2018

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Drugs for bad bugs: confronting the challenges of antibacterial discovery

21 January 2018

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Fexinidazole--a new oral nitroimidazole drug candidate entering clinical development for the treatment of sleeping sickness

21 January 2018

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Fexinidazole: a potential new drug candidate for Chagas disease

21 January 2018

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Antitrypanosomal activity of fexinidazole metabolites, potential new drug candidates for Chagas disease

21 January 2018

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Boron-based drugs as antiprotozoals

21 January 2018

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New, combined, and reduced dosing treatment protocols cure Trypanosoma cruzi infection in mice

21 January 2018

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Analogues of fenarimol are potent inhibitors of Trypanosoma cruzi and are efficacious in a murine model of Chagas disease

21 January 2018

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Selection and optimization of hits from a high-throughput phenotypic screen against Trypanosoma cruzi.

21 January 2018

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In vitro and in vivo experimental models for drug screening and development for Chagas disease

21 January 2018

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Rationale and design of a randomized placebo-controlled trial assessing the effects of etiologic treatment in Chagas' cardiomyopathy: the BENznidazole Evaluation For Interrupting Trypanosomiasis (BENEFIT).

21 January 2018

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The BENEFIT trial: testing the hypothesis that trypanocidal therapy is beneficial for patients with chronic Chagas heart disease

21 January 2018

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Randomized trial of posaconazole and benznidazole for chronic Chagas' disease.

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F1087057114550585

Antibody levels correlate with detection of Trypanosoma cruzi DNA by sensitive polymerase chain reaction assays in seropositive blood donors and possible resolution of infection over time

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F1087057114550585

Parasite persistence correlates with disease severity and localization in chronic Chagas' disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F1087057114550585

The Trypanosoma cruzi-host-cell interplay: location, invasion, retention

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F1087057114550585

Lack of association between blood-based detection of Trypanosoma cruzi DNA and cardiac involvement in a non-endemic area.

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F1087057114550585

International study to evaluate PCR methods for detection of Trypanosoma cruzi DNA in blood samples from Chagas disease patients

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F1087057114550585

Biological markers for evaluating therapeutic efficacy in Chagas disease, a systematic review.

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F1087057114550585

Pharmacokinetics, safety, and efficacy of posaconazole in patients with persistent febrile neutropenia or refractory invasive fungal infection

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F1087057114550585

Pharmacokinetics of SCH 56592, a new azole broad-spectrum antifungal agent, in mice, rats, rabbits, dogs, and cynomolgus monkeys

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F1087057114550585

Activities of the triazole derivative SCH 56592 (posaconazole) against drug-resistant strains of the protozoan parasite Trypanosoma (Schizotrypanum) cruzi in immunocompetent and immunosuppressed murine hosts

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F1087057114550585

Successful treatment with posaconazole of a patient with chronic Chagas disease and systemic lupus erythematosus

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F1087057114550585

Designing the next generation of medicines for malaria control and eradication

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F1087057114550585

Effects of ravuconazole treatment on parasite load and immune response in dogs experimentally infected with Trypanosoma cruzi.

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F1087057114550585

A comparative study of posaconazole and benznidazole in the prevention of heart damage and promotion of trypanocidal immune response in a murine model of Chagas disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F1087057114550585

Targeting Trypanosoma cruzi sterol 14α-demethylase (CYP51)

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F1087057114550585

Pharmacological Characterization, Structural Studies, and In Vivo Activities of Anti-Chagas Disease Lead Compounds Derived from Tipifarnib

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F1087057114550585

Complexes of Trypanosoma cruzi Sterol 14 -Demethylase (CYP51) with Two Pyridine-based Drug Candidates for Chagas Disease: STRUCTURAL BASIS FOR PATHOGEN SELECTIVITY

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F1087057114550585

In vitro and in vivo studies of the antiparasitic activity of sterol 14α-demethylase (CYP51) inhibitor VNI against drug-resistant strains of Trypanosoma cruzi.

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F1087057114550585

Experimental chemotherapy and approaches to drug discovery for Trypanosoma cruzi infection.

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F1087057114550585

Methodological advances in drug discovery for Chagas disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F1087057114550585

In vitro and in vivo high-throughput assays for the testing of anti-Trypanosoma cruzi compounds

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F1087057114550585

High-content imaging for automated determination of host-cell infection rate by the intracellular parasite Trypanosoma cruzi

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F1087057114550585

Image-based high-throughput drug screening targeting the intracellular stage of Trypanosoma cruzi, the agent of Chagas' disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F1087057114550585

Nitroheterocyclic compounds are more efficacious than CYP51 inhibitors against Trypanosoma cruzi: implications for Chagas disease drug discovery and development

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F1087057114550585

Improved method for in vitro secondary amastigogenesis of Trypanosoma cruzi: morphometrical and molecular analysis of intermediate developmental forms

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F1087057114550585

P. falciparum in vitro killing rates allow to discriminate between different antimalarial mode-of-action

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F1087057114550585

Discovery of novel orally bioavailable oxaborole 6-carboxamides that demonstrate cure in a murine model of late-stage central nervous system african trypanosomiasis

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F1087057114550585

Identification of three classes of heteroaromatic compounds with activity against intracellular Trypanosoma cruzi by chemical library screening

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F1087057114550585

Shotgun sequencing analysis of Trypanosoma cruzi I Sylvio X10/1 and comparison with T. cruzi VI CL Brener

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F1087057114550585

The expected outcome of the Trypanosoma cruzi proteomic map: a review of its potential biological applications for drug target discovery

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F1087057114550585

Benznidazole biotransformation and multiple targets in Trypanosoma cruzi revealed by metabolomics

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F1087057114550585

Selection of molecular targets for drug development against trypanosomatids

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F1087057114550585

Genetic profiling of the isoprenoid and sterol biosynthesis pathway genes of Trypanosoma cruzi

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F1087057114550585

Activity in vivo of anti-Trypanosoma cruzi compounds selected from a high throughput screening

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F1087057114550585

Bioluminescence imaging of chronic Trypanosoma cruzi infections reveals tissue-specific parasite dynamics and heart disease in the absence of locally persistent infection

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F1087057114550585

Serum biomarkers predictive of cure in Chagas disease patients after nifurtimox treatment

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F1087057114550585

21 January 2018

Identifiers

DOI

10.1177/1087057114550585

1 reference

1 September 2017

1 reference

PubMed ID

25245987