(Q40173852)

18 September 2017

The rapid activation of protein synthesis by growth hormone requires signaling through mTOR. (English)

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18 September 2017

2

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18 September 2017

Amanda A Hayashi

1

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18 September 2017

6 February 2007

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American Journal of Physiology - Endocrinology and Metabolism

18 September 2017

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18 September 2017

292

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18 September 2017

6

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18 September 2017

E1647-55

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PD 098059 is a specific inhibitor of the activation of mitogen-activated protein kinase kinase in vitro and in vivo

18 September 2017

1 reference

https://api.crossref.org/works/10.1152%2FAJPENDO.00674.2006

Rapid activation of MAP kinase and S6 kinase by growth hormone in 3T3-F442A preadipocytes

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPENDO.00674.2006

Growth hormone activates mitogen-activated protein kinase and S6 kinase and promotes intracellular tyrosine phosphorylation in 3T3-F442A preadipocytes

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPENDO.00674.2006

Wortmannin is a potent phosphatidylinositol 3-kinase inhibitor: the role of phosphatidylinositol 3,4,5-trisphosphate in neutrophil responses.

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPENDO.00674.2006

Identification of JAK2 as a growth hormone receptor-associated tyrosine kinase

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPENDO.00674.2006

Quantitative phosphorylation profiling of the ERK/p90 ribosomal S6 kinase-signaling cassette and its targets, the tuberous sclerosis tumor suppressors.

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPENDO.00674.2006

Akt/mTOR pathway is a crucial regulator of skeletal muscle hypertrophy and can prevent muscle atrophy in vivo

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPENDO.00674.2006

Regulation of peptide-chain elongation in mammalian cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPENDO.00674.2006

A novel mTOR-regulated phosphorylation site in elongation factor 2 kinase modulates the activity of the kinase and its binding to calmodulin

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPENDO.00674.2006

Translational control of protein synthesis in muscle and liver of growth hormone-treated pigs

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPENDO.00674.2006

Functional properties of phosphorylated elongation factor 2

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPENDO.00674.2006

Signalling pathway of GH.

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPENDO.00674.2006

Both rapamycin-sensitive and -insensitive pathways are involved in the phosphorylation of the initiation factor-4E-binding protein (4E-BP1) in response to insulin in rat epididymal fat-cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPENDO.00674.2006

Mammalian cell size is controlled by mTOR and its downstream targets S6K1 and 4EBP1/eIF4E

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPENDO.00674.2006

eIF4 initiation factors: effectors of mRNA recruitment to ribosomes and regulators of translation

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPENDO.00674.2006

The TSC1-2 tumor suppressor controls insulin-PI3K signaling via regulation of IRS proteins

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPENDO.00674.2006

The role of STAT proteins in growth hormone signaling

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPENDO.00674.2006

TSC2 is phosphorylated and inhibited by Akt and suppresses mTOR signalling

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPENDO.00674.2006

A novel method to identify protein kinase substrates: eEF2 kinase is phosphorylated and inhibited by SAPK4/p38delta

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPENDO.00674.2006

Phosphorylation and functional inactivation of TSC2 by Erk implications for tuberous sclerosis and cancer pathogenesis

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPENDO.00674.2006

The translation initiation factor eIF-4E binds to a common motif shared by the translation factor eIF-4 gamma and the translational repressors 4E-binding proteins

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPENDO.00674.2006

Rheb fills a GAP between TSC and TOR.

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPENDO.00674.2006

United at last: the tuberous sclerosis complex gene products connect the phosphoinositide 3-kinase/Akt pathway to mammalian target of rapamycin (mTOR) signalling

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPENDO.00674.2006

Identification of the tuberous sclerosis complex-2 tumor suppressor gene product tuberin as a target of the phosphoinositide 3-kinase/akt pathway

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPENDO.00674.2006

Ribosome biogenesis and cell growth: mTOR coordinates transcription by all three classes of nuclear RNA polymerases

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPENDO.00674.2006

Drosophila S6 kinase: a regulator of cell size

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPENDO.00674.2006

mTOR function in skeletal muscle hypertrophy: increased ribosomal RNA via cell cycle regulators

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPENDO.00674.2006

Activation of protein synthesis in cardiomyocytes by the hypertrophic agent phenylephrine requires the activation of ERK and involves phosphorylation of tuberous sclerosis complex 2 (TSC2)

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPENDO.00674.2006

Tumor-promoting phorbol esters and activated Ras inactivate the tuberous sclerosis tumor suppressor complex via p90 ribosomal S6 kinase

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPENDO.00674.2006

In vivo analysis of growth hormone receptor signaling domains and their associated transcripts

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPENDO.00674.2006

Ribosomal protein S6 phosphorylation: from protein synthesis to cell size.

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPENDO.00674.2006

Ribosomal protein S6 phosphorylation is a determinant of cell size and glucose homeostasis

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPENDO.00674.2006

Growing roles for the mTOR pathway

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPENDO.00674.2006

Disruption of the p70(s6k)/p85(s6k) gene reveals a small mouse phenotype and a new functional S6 kinase

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPENDO.00674.2006

Inactivation of the tuberous sclerosis complex-1 and -2 gene products occurs by phosphoinositide 3-kinase/Akt-dependent and -independent phosphorylation of tuberin

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPENDO.00674.2006

Absence of S6K1 protects against age- and diet-induced obesity while enhancing insulin sensitivity

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPENDO.00674.2006

Signaling molecules involved in coupling growth hormone receptor to mitogen-activated protein kinase activation

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPENDO.00674.2006

Regulation of the phosphorylation of elongation factor 2 by MEK-dependent signalling in adult rat cardiomyocytes

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPENDO.00674.2006

Ras/Erk signaling is essential for activation of protein synthesis by Gq protein-coupled receptor agonists in adult cardiomyocytes

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPENDO.00674.2006

Distinct signaling events downstream of mTOR cooperate to mediate the effects of amino acids and insulin on initiation factor 4E-binding proteins

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPENDO.00674.2006

The C terminus of initiation factor 4E-binding protein 1 contains multiple regulatory features that influence its function and phosphorylation

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPENDO.00674.2006

Regulation of elongation factor 2 kinase by p90(RSK1) and p70 S6 kinase.

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPENDO.00674.2006

The mTOR pathway in the control of protein synthesis

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPENDO.00674.2006

Wortmannin inhibits the effects of insulin and serum on the activities of glycogen synthase kinase-3 and mitogen-activated protein kinase

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPENDO.00674.2006

TOR signaling in growth and metabolism

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPENDO.00674.2006

10.1152/AJPENDO.00674.2006

21 January 2018

Identifiers

DOI

1 reference

18 September 2017

1 reference

PubMed ID

17284572