(Q40362917)

English

WOX1 is essential for tumor necrosis factor-, UV light-, staurosporine-, and p53-mediated cell death, and its tyrosine 33-phosphorylated form binds and stabilizes serine 46-phosphorylated p53.

scientific article published on 11 October 2005

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scholarly article

1 reference

Europe PubMed Central

19 September 2017

WOX1 is essential for tumor necrosis factor-, UV light-, staurosporine-, and p53-mediated cell death, and its tyrosine 33-phosphorylated form binds and stabilizes serine 46-phosphorylated p53. (English)

1 reference

Europe PubMed Central

19 September 2017

phosphorylation

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1 reference

based on heuristic

inferred from title

author name string

Nan-Shan Chang

1

1 reference

Europe PubMed Central

19 September 2017

Joan Doherty

2

1 reference

Europe PubMed Central

19 September 2017

Amy Ensign

3

1 reference

Europe PubMed Central

19 September 2017

Lori Schultz

4

1 reference

Europe PubMed Central

19 September 2017

Li-Jin Hsu

5

1 reference

Europe PubMed Central

19 September 2017

Qunying Hong

6

1 reference

Europe PubMed Central

19 September 2017

language of work or name

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publication date

11 October 2005

1 reference

Europe PubMed Central

19 September 2017

number of pages

9

1 reference

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inferred from page(s)

Journal of Biological Chemistry

1 reference

Europe PubMed Central

19 September 2017

280

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Europe PubMed Central

19 September 2017

52

1 reference

Europe PubMed Central

19 September 2017

43100-43108

1 reference

Europe PubMed Central

19 September 2017

Increased hyaluronidase levels in breast tumor metastases

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M505590200

21 January 2018

Hyaluronidase induction of a WW domain-containing oxidoreductase that enhances tumor necrosis factor cytotoxicity

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M505590200

21 January 2018

Transforming growth factor-beta1 blocks the enhancement of tumor necrosis factor cytotoxicity by hyaluronidase Hyal-2 in L929 fibroblasts

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M505590200

21 January 2018

Fragile and unstable chromosomes in cancer: causes and consequences

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M505590200

21 January 2018

Common chromosomal fragile site FRA16D sequence: identification of the FOR gene spanning FRA16D and homozygous deletions and translocation breakpoints in cancer cells

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M505590200

21 January 2018

Down-regulation of WW domain-containing oxidoreductase induces Tau phosphorylation in vitro. A potential role in Alzheimer's disease

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M505590200

21 January 2018

17beta-Estradiol upregulates and activates WOX1/WWOXv1 and WOX2/WWOXv2 in vitro: potential role in cancerous progression of breast and prostate to a premetastatic state in vivo

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M505590200

21 January 2018

WWOX: a candidate tumor suppressor gene involved in multiple tumor types

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M505590200

21 January 2018

Loss of WWOX expression in gastric carcinoma

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M505590200

21 January 2018

The tumor suppressor gene WWOX at FRA16D is involved in pancreatic carcinogenesis

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M505590200

21 January 2018

The fragile genes FHIT and WWOX are inactivated coordinately in invasive breast carcinoma

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M505590200

21 January 2018

Alterations of common chromosome fragile sites in hematopoietic malignancies

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M505590200

21 January 2018

WWOX protein expression varies among ovarian carcinoma histotypes and correlates with less favorable outcome

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M505590200

21 January 2018

Fragile genes as biomarkers: epigenetic control of WWOX and FHIT in lung, breast and bladder cancer

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M505590200

21 January 2018

Alternative transcripts of the candidate tumor suppressor gene, WWOX, are expressed at high levels in human breast tumors.

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M505590200

21 January 2018

WOX1 is essential for UVB irradiation-induced apoptosis and down-regulated via translational blockade in UVB-induced cutaneous squamous cell carcinoma in vivo

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M505590200

21 January 2018

JNK1 physically interacts with WW domain-containing oxidoreductase (WOX1) and inhibits WOX1-mediated apoptosis

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M505590200

21 January 2018

Functional association between Wwox tumor suppressor protein and p73, a p53 homolog

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M505590200

21 January 2018

Light-induced retinal damage involves tyrosine 33 phosphorylation, mitochondrial and nuclear translocation of WW domain-containing oxidoreductase in vivo

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M505590200

21 January 2018

The non-ankyrin C terminus of Ikappa Balpha physically interacts with p53 in vivo and dissociates in response to apoptotic stress, hypoxia, DNA damage, and transforming growth factor-beta 1-mediated growth suppression

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M505590200

21 January 2018

Phosphorylation of human p53 at serine 46 determines promoter selection and whether apoptosis is attenuated or amplified.

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M505590200

21 January 2018

p53AIP1, a potential mediator of p53-dependent apoptosis, and its regulation by Ser-46-phosphorylated p53

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M505590200

21 January 2018

Homeodomain-interacting protein kinase-2 phosphorylates p53 at Ser 46 and mediates apoptosis.

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M505590200

21 January 2018

Phosphorylation of p53 on key serines is dispensable for transcriptional activation and apoptosis

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M505590200

21 January 2018

Transfection of a dominant-negative mutant NF-kB inhibitor (IkBm) represses p53-dependent apoptosis in acute lymphoblastic leukemia cells: interaction of IkBm and p53

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M505590200

21 January 2018

WW domain-containing proteins, WWOX and YAP, compete for interaction with ErbB-4 and modulate its transcriptional function

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M505590200

21 January 2018

Physical and functional interactions between the Wwox tumor suppressor protein and the AP-2gamma transcription factor

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M505590200

21 January 2018

TIAF1 and p53 functionally interact in mediating apoptosis and silencing of TIAF1 abolishes nuclear translocation of serine 15-phosphorylated p53.

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M505590200

21 January 2018

Molecular interaction map of the p53 and Mdm2 logic elements, which control the Off-On switch of p53 in response to DNA damage

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M505590200

21 January 2018

Small molecule inhibitors of p53/MDM2 interaction

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M505590200

21 January 2018

MDM2 is a central node in the p53 pathway: 12 years and counting

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M505590200

21 January 2018

DNA-dependent protein kinase inhibitor (OK-1035) suppresses p21 expression in HCT116 cells containing wild-type p53 induced by adriamycin

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M505590200

21 January 2018

Discovery of a perinecrotic 60 kDa MDM2 isoform within glioma spheroids and glioblastoma biopsy material

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M505590200

21 January 2018

p76(MDM2) inhibits the ability of p90(MDM2) to destabilize p53.

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M505590200

21 January 2018

In vivo activation of the p53 pathway by small-molecule antagonists of MDM2

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M505590200

21 January 2018

Identification of a novel p53 functional domain that is necessary for efficient growth suppression

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M505590200

21 January 2018

Definition of the p53 functional domains necessary for inducing apoptosis

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M505590200

21 January 2018

Regulation and function of the p53-related proteins: same family, different rules

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M505590200

21 January 2018

Stabilization of wild-type p53 by hypoxia-inducible factor 1alpha

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M505590200

21 January 2018

NQO1 stabilizes p53 through a distinct pathway

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M505590200

21 January 2018

p53 Stabilization and accumulation induced by human vaccinia-related kinase 1

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M505590200

21 January 2018

PML regulates p53 stability by sequestering Mdm2 to the nucleolus

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M505590200

21 January 2018

Merlin neutralizes the inhibitory effect of Mdm2 on p53.

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M505590200

21 January 2018

PTEN tumor suppressor regulates p53 protein levels and activity through phosphatase-dependent and -independent mechanisms

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M505590200

21 January 2018

The prolyl isomerase Pin1 is a regulator of p53 in genotoxic response.

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M505590200

21 January 2018

A map of WW domain family interactions

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M505590200

21 January 2018

A Role for the Polyproline Domain of p53 in Its Regulation by Mdm2

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M505590200

21 January 2018

Identifiers

10.1074/JBC.M505590200

1 reference

Europe PubMed Central

19 September 2017

1 reference

Europe PubMed Central

19 September 2017

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