(Q40370849)

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Glycogen synthase kinase 3beta modulates synphilin-1 ubiquitylation and cellular inclusion formation by SIAH: implications for proteasomal function and Lewy body formation.

scientific article published on 20 September 2005

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scholarly article

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7 January 2020

Glycogen synthase kinase 3beta modulates synphilin-1 ubiquitylation and cellular inclusion formation by SIAH: implications for proteasomal function and Lewy body formation (English)

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7 January 2020

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Simone Engelender

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7 January 2020

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Eyal Avraham

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7 January 2020

Raymonde Szargel

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7 January 2020

Allon Eyal

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7 January 2020

Ruth Rott

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20 September 2005

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7 January 2020

Journal of Biological Chemistry

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7 January 2020

280

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7 January 2020

52

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7 January 2020

42877-42886

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7 January 2020

Mutation in the alpha-synuclein gene identified in families with Parkinson's disease

1 reference

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21 January 2018

Ala30Pro mutation in the gene encoding alpha-synuclein in Parkinson's disease

1 reference

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21 January 2018

The new mutation, E46K, of alpha-synuclein causes Parkinson and Lewy body dementia

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M505608200

21 January 2018

Mutations in the parkin gene cause autosomal recessive juvenile parkinsonism

1 reference

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21 January 2018

The ubiquitin pathway in Parkinson's disease.

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M505608200

21 January 2018

Alpha-synuclein in Lewy bodies

1 reference

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21 January 2018

Inducible expression of mutant alpha-synuclein decreases proteasome activity and increases sensitivity to mitochondria-dependent apoptosis

1 reference

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21 January 2018

Aggregated and monomeric alpha-synuclein bind to the S6' proteasomal protein and inhibit proteasomal function

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M505608200

21 January 2018

Proteasomal inhibition by alpha-synuclein filaments and oligomers.

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M505608200

21 January 2018

Molecular Pathways of Neurodegeneration in Parkinson's Disease

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M505608200

21 January 2018

Proteasomal function is impaired in substantia nigra in Parkinson's disease

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M505608200

21 January 2018

Synphilin-1 associates with alpha-synuclein and promotes the formation of cytosolic inclusions

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M505608200

21 January 2018

Synphilin-1 is developmentally localized to synaptic terminals, and its association with synaptic vesicles is modulated by alpha-synuclein

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M505608200

21 January 2018

Synphilin-1 degradation by the ubiquitin-proteasome pathway and effects on cell survival

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M505608200

21 January 2018

Association of the cytoskeletal GTP-binding protein Sept4/H5 with cytoplasmic inclusions found in Parkinson's disease and other synucleinopathies

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M505608200

21 January 2018

BAG5 inhibits parkin and enhances dopaminergic neuron degeneration

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M505608200

21 January 2018

Ubiquitylation of synphilin-1 and alpha-synuclein by SIAH and its presence in cellular inclusions and Lewy bodies imply a role in Parkinson's disease

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M505608200

21 January 2018

Identification and functional characterization of a novel R621C mutation in the synphilin-1 gene in Parkinson's disease

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M505608200

21 January 2018

Aggresomes formed by alpha-synuclein and synphilin-1 are cytoprotective

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M505608200

21 January 2018

Optimized survival of hippocampal neurons in B27-supplemented Neurobasal, a new serum-free medium combination

1 reference

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21 January 2018

Pharmacological inhibitors of glycogen synthase kinase 3.

1 reference

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21 January 2018

The glamour and gloom of glycogen synthase kinase-3

1 reference

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21 January 2018

14-3-3 binds to and mediates phosphorylation of microtubule-associated tau protein by Ser9-phosphorylated glycogen synthase kinase 3beta in the brain

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M505608200

21 January 2018

14-3-3 proteins in Lewy bodies in Parkinson disease and diffuse Lewy body disease brains

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M505608200

21 January 2018

Siah-1 facilitates ubiquitination and degradation of synphilin-1

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M505608200

21 January 2018

Casein kinase II-mediated phosphorylation regulates alpha-synuclein/synphilin-1 interaction and inclusion body formation

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M505608200

21 January 2018

Impairment of the ubiquitin-proteasome system by protein aggregation

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M505608200

21 January 2018

Glycogen synthase kinase‐3β phosphorylates synphilin‐1 in vitro

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M505608200

21 January 2018

A trip to the ER: coping with stress

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M505608200

21 January 2018

An unfolded putative transmembrane polypeptide, which can lead to endoplasmic reticulum stress, is a substrate of Parkin

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M505608200

21 January 2018

Glycogen synthase kinase 3beta (GSK3beta) mediates 6-hydroxydopamine-induced neuronal death

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M505608200

21 January 2018

Central role of glycogen synthase kinase-3beta in endoplasmic reticulum stress-induced caspase-3 activation

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M505608200

21 January 2018

Tau phosphorylation, tangles, and neurodegeneration: the chicken or the egg?

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M505608200

21 January 2018

Proteasomal inhibition causes the formation of protein aggregates containing a wide range of proteins, including nitrated proteins

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M505608200

21 January 2018

From entropy to Duino

1 reference

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21 January 2018

Identifiers

10.1074/JBC.M505608200

1 reference

Europe PubMed Central

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:16174773%20AND%20SRC:MED&resulttype=core&format=json

7 January 2020

1 reference

Europe PubMed Central

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:16174773%20AND%20SRC:MED&resulttype=core&format=json

7 January 2020

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