(Q4044985)

Neurogenic locus Notch 1

1 reference

Growth factor receptor cysteine-rich domain superfamily

1 reference

Ankyrin repeat-containing domain superfamily

1 reference

Putative uncharacterized transport proteins

1 reference

Transporter Classification Database ID

9.B.87.1.12

retrieved

2 October 2019

hierarchical database ID heuristic

Notch, NODP domain, protein family

1 reference

Notch proteins

1 reference

Notch, NOD domain, protein family

1 reference

Domain of unknown function DUF3454, notch, protein family

1 reference

Ankyrin repeat-containing domain, protein family

1 reference

EGF-like calcium-binding domain, protein family

1 reference

EGF-like domain, protein family

1 reference

EGF-like, conserved site, protein family

1 reference

EGF-like calcium-binding, conserved site, protein family

1 reference

Ankyrin repeat, protein family

1 reference

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P46531

1 reference

13 November 2019

1 reference

13 November 2019

1 reference

9 May 2019

DNA-binding transcription factor activity

1 reference

1 January 2018

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P46531

1 reference

1 January 2018

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P46531

1 reference

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P46531

1 reference

1 January 2018

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P46531

28 references

9 May 2019

The Notch coactivator, MAML1, functions as a novel coactivator for MEF2C-mediated transcription and is required for normal myogenesis

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P46531

9 May 2019

MAML1, a human homologue of Drosophila mastermind, is a transcriptional co-activator for NOTCH receptors

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P46531

9 May 2019

A human protein with sequence similarity to Drosophila mastermind coordinates the nuclear form of notch and a CSL protein to build a transcriptional activator complex on target promoters

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P46531

9 May 2019

Physical interaction of Delta1, Jagged1, and Jagged2 with Notch1 and Notch3 receptors

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P46531

9 May 2019

Structural basis for cooperativity in recruitment of MAML coactivators to Notch transcription complexes

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P46531

9 May 2019

SKIP, a CBF1-associated protein, interacts with the ankyrin repeat domain of NotchIC To facilitate NotchIC function

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P46531

9 May 2019

NACK is an integral component of the Notch transcriptional activation complex and is critical for development and tumorigenesis.

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P46531

9 May 2019

Structural basis for cooperativity in recruitment of MAML coactivators to Notch transcription complexes

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P46531

9 May 2019

Conformational Locking upon Cooperative Assembly of Notch Transcription Complexes

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P46531

9 May 2019

The CD46-Jagged1 interaction is critical for human TH1 immunity

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P46531

9 May 2019

Angiopoietin-like proteins stimulate HSPC development through interaction with notch receptor signaling

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P46531

9 May 2019

The prolyl-isomerase Pin1 is a Notch1 target that enhances Notch1 activation in cancer

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P46531

9 May 2019

Notch signaling mediates hypoxia-induced tumor cell migration and invasion

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P46531

9 May 2019

Proteomic analyses reveal distinct chromatin-associated and soluble transcription factor complexes

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P46531

9 May 2019

NOTCH1 nuclear interactome reveals key regulators of its transcriptional activity and oncogenic function.

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P46531

9 May 2019

Notch signaling contributes to proliferation and tumor formation of human T-cell leukemia virus type 1-associated adult T-cell leukemia.

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P46531

9 May 2019

Direct inhibition of the NOTCH transcription factor complex

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P46531

9 May 2019

Structural and mechanistic insights into cooperative assembly of dimeric Notch transcription complexes

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P46531

9 May 2019

Kaposi's sarcoma herpesvirus-encoded latency-associated nuclear antigen stabilizes intracellular activated Notch by targeting the Sel10 protein

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P46531

9 May 2019

Notch inhibits apoptosis by direct interference with XIAP ubiquitination and degradation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P46531

9 May 2019

Notch is a direct negative regulator of the DNA-damage response

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P46531

9 May 2019

A human interactome in three quantitative dimensions organized by stoichiometries and abundances

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P46531

9 May 2019

Notch1 augments NF-kappaB activity by facilitating its nuclear retention

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P46531

9 May 2019

Cyclin C is a haploinsufficient tumour suppressor

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P46531

9 May 2019

Ataxin-1 and Brother of ataxin-1 are components of the Notch signalling pathway

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P46531

9 May 2019

Cooperative assembly of higher-order Notch complexes functions as a switch to induce transcription

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P46531

9 May 2019

SKIP, a CBF1-associated protein, interacts with the ankyrin repeat domain of NotchIC To facilitate NotchIC function

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P46531

9 May 2019

A conserved face of the Jagged/Serrate DSL domain is involved in Notch trans-activation and cis-inhibition

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P46531

sequence-specific DNA binding

IPI

1 reference

1 January 2018

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P46531

protein heterodimerization activity

1 reference

1 January 2018

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P46531

chromatin DNA binding

1 reference

1 January 2018

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P46531

transmembrane signaling receptor activity

1 reference

1 January 2018

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P46531

signaling receptor activity

1 reference

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P46531

RNA polymerase II cis-regulatory region sequence-specific DNA binding

1 reference

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P46531

DNA-binding transcription activator activity, RNA polymerase II-specific

1 reference

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P46531

enzyme inhibitor activity

1 reference

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P46531

1 reference

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P46531

1 reference

1 January 2018

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P46531

1 reference

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P46531

1 reference

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P46531

1 reference

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P46531

4 references

9 May 2019

SKIP, a CBF1-associated protein, interacts with the ankyrin repeat domain of NotchIC To facilitate NotchIC function

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P46531

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P46531

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P46531

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P46531

1 reference

1 January 2018

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P46531

endoplasmic reticulum

1 reference

1 January 2018

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P46531

1 reference

1 January 2018

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P46531

1 reference

8 April 2019

Structural basis for endosomal trafficking of diverse transmembrane cargos by PX-FERM proteins

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P46531

1 reference

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P46531

MAML1-RBP-Jkappa- ICN1 complex

TAS

1 reference

9 May 2019

The Notch coactivator, MAML1, functions as a novel coactivator for MEF2C-mediated transcription and is required for normal myogenesis

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P46531

1 reference

1 January 2018

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P46531

endoplasmic reticulum membrane

1 reference

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P46531

1 reference

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P46531

1 reference

1 January 2018

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P46531

1 reference

1 January 2018

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P46531

1 reference

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P46531

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P46531

apical plasma membrane

1 reference

9 May 2019

4 references

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P46531

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P46531

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P46531

9 May 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P46531

1 reference

9 May 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P46531

1 reference

1 January 2018

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P46531

pulmonary valve morphogenesis

1 reference

24 April 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=P46531&geneProductId=UniProtKB:P46531

positive regulation of endothelial cell differentiation

1 reference

1 January 2018

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P46531

regulation of somitogenesis

1 reference

1 January 2018

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P46531

cell differentiation in spinal cord

1 reference

1 January 2018

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P46531

negative regulation of neuron differentiation

1 reference

1 January 2018

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P46531

distal tubule development

1 reference

1 January 2018

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P46531

regulation of transcription by RNA polymerase II

1 reference

1 January 2018

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P46531

oligodendrocyte differentiation

1 reference

1 January 2018

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P46531

negative regulation of stem cell differentiation

1 reference

9 May 2019

Notch signaling is required for maintaining stem-cell features of neuroprogenitor cells derived from human embryonic stem cells

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P46531

negative regulation of photoreceptor cell differentiation

1 reference

1 January 2018

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P46531

Notch signaling pathway involved in regulation of secondary heart field cardioblast proliferation

1 reference

1 January 2018

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P46531

humoral immune response

1 reference

1 January 2018

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P46531

foregut morphogenesis

1 reference

1 January 2018

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P46531

regulation of developmental process

1 reference

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P46531

animal organ regeneration

1 reference

1 January 2018

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P46531

1 reference

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P46531

1 reference

1 January 2018

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P46531

regulation of cardioblast proliferation

1 reference

1 January 2018

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P46531

hair follicle morphogenesis

1 reference

1 January 2018

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P46531

negative regulation of canonical Wnt signaling pathway

1 reference

1 January 2018

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P46531

regulation of neurogenesis

1 reference

1 January 2018

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P46531

negative regulation of cell population proliferation

3 references

1 January 2018

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P46531

1 January 2018

Notch signaling induces cell cycle arrest in small cell lung cancer cells

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P46531

1 January 2018

Integrin cytoplasmic domain-associated protein-1 attenuates sprouting angiogenesis

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P46531

collecting duct development

1 reference

1 January 2018

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P46531

positive regulation of neuroblast proliferation

1 reference

1 January 2018

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P46531

1 reference

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P46531

atrioventricular node development

1 reference

1 January 2018

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P46531

negative regulation of myoblast differentiation

1 reference

9 May 2019

SKIP, a CBF1-associated protein, interacts with the ankyrin repeat domain of NotchIC To facilitate NotchIC function

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P46531

1 reference

1 January 2018

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P46531

cellular response to follicle-stimulating hormone stimulus

1 reference

9 May 2019

Follicular stimulating hormone enhances Notch 1 expression in SK-OV-3 ovarian cancer cells

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P46531

1 reference

1 January 2018

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P46531

negative regulation of inner ear auditory receptor cell differentiation

1 reference

1 January 2018

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P46531

ventricular septum morphogenesis

1 reference

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P46531

negative regulation of cell differentiation

1 reference

1 January 2018

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P46531

response to muramyl dipeptide

1 reference

1 January 2018

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P46531

in utero embryonic development

1 reference

1 January 2018

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P46531

negative regulation of cell death

1 reference

1 January 2018

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P46531

transcription, DNA-templated

1 reference

5 June 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=P46531&geneProductId=UniProtKB:P46531

1 reference

9 May 2019

Identification of de novo mutations and rare variants in hypoplastic left heart syndrome

Developmental FunctionaL Annotation at Tufts

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P46531

prostate gland epithelium morphogenesis

1 reference

1 January 2018

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P46531

embryonic limb morphogenesis

1 reference

1 January 2018

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P46531

neural tube development

1 reference

1 January 2018

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P46531

epidermis development

1 reference

1 January 2018

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P46531

transcription initiation from RNA polymerase II promoter

1 reference

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P46531

negative regulation of cell-substrate adhesion

TAS

1 reference

9 May 2019

Increased Wnt signaling triggers oncogenic conversion of human breast epithelial cells by a Notch-dependent mechanism

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P46531

regulation of inner ear auditory receptor cell differentiation

1 reference

1 January 2018

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P46531

inflammatory response to antigenic stimulus

1 reference

1 January 2018

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P46531

positive regulation of epithelial cell proliferation

1 reference

1 January 2018

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P46531

cardiac right ventricle formation

1 reference

1 January 2018

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P46531

endocardial cushion development

1 reference

1 January 2018

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P46531

cell fate specification

1 reference

1 January 2018

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P46531

positive regulation of keratinocyte differentiation

1 reference

1 January 2018

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P46531

positive regulation of glial cell differentiation

1 reference

1 January 2018

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P46531

glomerular mesangial cell development

1 reference

1 January 2018

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P46531

sprouting angiogenesis

1 reference

1 January 2018

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P46531

glial cell differentiation

1 reference

1 January 2018

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P46531

negative regulation of transcription by RNA polymerase II

cardiac muscle cell proliferation

1 reference

1 January 2018

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P46531

secretory columnal luminar epithelial cell differentiation involved in prostate glandular acinus development

1 reference

1 January 2018

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P46531

neuronal stem cell population maintenance

1 reference

9 May 2019

Notch signaling is required for maintaining stem-cell features of neuroprogenitor cells derived from human embryonic stem cells

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P46531

negative regulation of cell migration involved in sprouting angiogenesis

IEP

1 reference

9 May 2019

Integrin cytoplasmic domain-associated protein-1 attenuates sprouting angiogenesis

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P46531

response to lipopolysaccharide

1 reference

1 January 2018

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P46531

compartment pattern specification

1 reference

1 January 2018

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P46531

1 reference

9 May 2019

TAN-1, the human homolog of the Drosophila Notch gene, is broken by chromosomal translocations in T lymphoblastic neoplasms

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P46531

NAS

neuron differentiation

1 reference

1 January 2018

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P46531

skeletal muscle cell differentiation

1 reference

1 January 2018

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P46531

regulation of gene expression

1 reference

1 January 2018

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P46531

positive regulation of viral genome replication

1 reference

1 January 2018

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P46531

regulation of epithelial cell proliferation involved in prostate gland development

1 reference

1 January 2018

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P46531

branching morphogenesis of an epithelial tube

1 reference

1 January 2018

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P46531

negative regulation of anoikis

1 reference

9 May 2019

Jagged1-mediated Notch activation induces epithelial-to-mesenchymal transition through Slug-induced repression of E-cadherin

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P46531

Notch signaling involved in heart development

3 references

1 January 2018

Novel NOTCH1 mutations in patients with bicuspid aortic valve disease and thoracic aortic aneurysms

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P46531

1 January 2018

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P46531

1 January 2018

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P46531

apoptotic process involved in embryonic digit morphogenesis

1 reference

1 January 2018

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P46531

regulation of cell migration

1 reference

1 January 2018

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P46531

1 reference

1 January 2018

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P46531

1 reference

1 January 2018

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P46531

somatic stem cell division

1 reference

1 January 2018

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P46531

negative regulation of endothelial cell chemotaxis

1 reference

9 May 2019

Integrin cytoplasmic domain-associated protein-1 attenuates sprouting angiogenesis

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P46531

keratinocyte differentiation

1 reference

1 January 2018

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P46531

auditory receptor cell fate commitment

1 reference

1 January 2018

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P46531

response to corticosteroid

1 reference

1 January 2018

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P46531

1 reference

9 May 2019

Integrin cytoplasmic domain-associated protein-1 attenuates sprouting angiogenesis

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P46531

astrocyte differentiation

1 reference

1 January 2018

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P46531

negative regulation of calcium ion-dependent exocytosis

1 reference

1 January 2018

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P46531

1 reference

1 January 2018

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P46531

regulation of cell population proliferation

1 reference

1 January 2018

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P46531

positive regulation of cell population proliferation

3 references

1 January 2018

Follicular stimulating hormone enhances Notch 1 expression in SK-OV-3 ovarian cancer cells

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P46531

1 January 2018

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P46531

1 January 2018

Notch activation promotes cell proliferation and the formation of neural stem cell-like colonies in human glioma cells

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P46531

positive regulation of apoptotic process

1 reference

1 January 2018

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P46531

mitral valve formation

1 reference

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P46531

1 reference

1 January 2018

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P46531

forebrain development

1 reference

1 January 2018

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P46531

cellular response to vascular endothelial growth factor stimulus

1 reference

9 May 2019

Integrin cytoplasmic domain-associated protein-1 attenuates sprouting angiogenesis

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P46531

neuron fate commitment

1 reference

1 January 2018

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P46531

regulation of epithelial cell proliferation

1 reference

1 January 2018

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P46531

regulation of Notch signaling pathway

1 reference

1 January 2018

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P46531

left/right axis specification

1 reference

1 January 2018

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P46531

positive regulation of transcription by RNA polymerase II

4 references

1 January 2018

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P46531

1 January 2018

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P46531

1 January 2018

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P46531

1 January 2018

Integrin cytoplasmic domain-associated protein-1 attenuates sprouting angiogenesis

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P46531

embryonic hindlimb morphogenesis

1 reference

1 January 2018

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P46531

positive regulation of aorta morphogenesis

1 reference

1 January 2018

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P46531

venous blood vessel morphogenesis

1 reference

1 January 2018

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P46531

SKIP, a CBF1-associated protein, interacts with the ankyrin repeat domain of NotchIC To facilitate NotchIC function

Notch signaling pathway

6 references

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P46531

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P46531

8 April 2019

Notch signaling is required for maintaining stem-cell features of neuroprogenitor cells derived from human embryonic stem cells

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P46531

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P46531

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P46531

8 April 2019

Notch signaling induces cell cycle arrest in small cell lung cancer cells

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P46531

negative regulation of gene expression

1 reference

9 May 2019

Notch signaling induces cell cycle arrest in small cell lung cancer cells

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P46531

negative regulation of growth rate

1 reference

9 May 2019

Notch signaling induces cell cycle arrest in small cell lung cancer cells

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P46531

positive regulation of Ras protein signal transduction

1 reference

9 May 2019

Notch signaling induces cell cycle arrest in small cell lung cancer cells

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P46531

positive regulation of ERK1 and ERK2 cascade

1 reference

9 May 2019

Notch signaling induces cell cycle arrest in small cell lung cancer cells

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P46531

positive regulation of transcription of Notch receptor target

outflow tract morphogenesis

1 reference

9 May 2019

NOTCH1 mutations in individuals with left ventricular outflow tract malformations reduce ligand-induced signaling

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P46531

aortic valve morphogenesis

6 references

1 January 2018

NOTCH1 missense alleles associated with left ventricular outflow tract defects exhibit impaired receptor processing and defective EMT.

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P46531

1 January 2018

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P46531

1 January 2018

Novel NOTCH1 mutations in patients with bicuspid aortic valve disease and thoracic aortic aneurysms

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P46531

1 January 2018

NOTCH1 mutations in individuals with left ventricular outflow tract malformations reduce ligand-induced signaling

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P46531

1 January 2018

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P46531

1 January 2018

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P46531

coronary sinus valve morphogenesis

1 reference

1 January 2018

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P46531

pulmonary valve morphogenesis

homeostasis of number of cells within a tissue

1 reference

1 January 2018

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P46531

epithelial to mesenchymal transition

1 reference

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P46531

1 reference

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P46531

endocardium development

1 reference

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P46531

endocardium morphogenesis

1 reference

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P46531

coronary vein morphogenesis

1 reference

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P46531

aortic valve morphogenesis

5 references

9 May 2019

NOTCH1 missense alleles associated with left ventricular outflow tract defects exhibit impaired receptor processing and defective EMT.

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P46531

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P46531

9 May 2019

NOTCH1 mutations in individuals with left ventricular outflow tract malformations reduce ligand-induced signaling

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P46531

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P46531

9 May 2019

Novel NOTCH1 mutations in patients with bicuspid aortic valve disease and thoracic aortic aneurysms

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P46531

atrioventricular valve morphogenesis

1 reference

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P46531

epithelial to mesenchymal transition involved in endocardial cushion formation

1 reference

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P46531

endocardial cushion morphogenesis

1 reference

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P46531

cardiac chamber formation

1 reference

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P46531

cardiac ventricle morphogenesis

1 reference

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P46531

cardiac atrium morphogenesis

1 reference

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P46531

cardiac right atrium morphogenesis

1 reference

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P46531

cardiac left ventricle morphogenesis

1 reference

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P46531

ventricular trabecula myocardium morphogenesis

1 reference

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P46531

growth involved in heart morphogenesis

1 reference

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P46531

negative regulation of cell proliferation involved in heart valve morphogenesis

1 reference

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P46531

cell migration involved in endocardial cushion formation

1 reference

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P46531

negative regulation of extracellular matrix constituent secretion

1 reference

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P46531

pericardium morphogenesis

1 reference

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P46531

determination of left/right symmetry

1 reference

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P46531

positive regulation of cell population proliferation

negative regulation of cardiac muscle hypertrophy

1 reference

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P46531

positive regulation of gene expression

1 reference

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P46531

positive regulation of epithelial to mesenchymal transition

1 reference

9 May 2019

Jagged1-mediated Notch activation induces epithelial-to-mesenchymal transition through Slug-induced repression of E-cadherin

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P46531

negative regulation of myotube differentiation

1 reference

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P46531

mesenchymal cell development

1 reference

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P46531

negative regulation of ossification

1 reference

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P46531

positive regulation of cell migration

1 reference

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P46531

positive regulation of BMP signaling pathway

1 reference

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P46531

negative regulation of BMP signaling pathway

1 reference

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P46531

negative regulation of catalytic activity

1 reference

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P46531

negative regulation of osteoblast differentiation

1 reference

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P46531

positive regulation of Notch signaling pathway

1 reference

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P46531

negative regulation of transcription, DNA-templated

TAS

1 reference

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P46531

positive regulation of transcription, DNA-templated

1 reference

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P46531

positive regulation of transcription by RNA polymerase II

3 references

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P46531

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P46531

9 May 2019

Integrin cytoplasmic domain-associated protein-1 attenuates sprouting angiogenesis

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P46531

positive regulation of receptor signaling pathway via JAK-STAT

1 reference

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P46531

positive regulation of astrocyte differentiation

1 reference

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P46531

negative regulation of oligodendrocyte differentiation

1 reference

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P46531

negative regulation of neurogenesis

1 reference

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P46531

cardiac muscle tissue morphogenesis

1 reference

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P46531

positive regulation of cardiac muscle cell proliferation

1 reference

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P46531

negative regulation of glial cell proliferation

1 reference

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P46531

cardiac epithelial to mesenchymal transition

1 reference

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P46531

cardiac septum morphogenesis

1 reference

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P46531

arterial endothelial cell differentiation

1 reference

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P46531

venous endothelial cell differentiation

1 reference

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P46531

cardiac vascular smooth muscle cell development

1 reference

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P46531

endocardial cell differentiation

1 reference

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P46531

vasculogenesis involved in coronary vascular morphogenesis

1 reference

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P46531

coronary artery morphogenesis

1 reference

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P46531

heart trabecula morphogenesis

1 reference

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P46531

positive regulation of transcription from RNA polymerase II promoter in response to hypoxia

1 reference

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P46531

positive regulation of cardiac epithelial to mesenchymal transition

1 reference

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P46531

negative regulation of biomineral tissue development

1 reference

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P46531

negative regulation of cold-induced thermogenesis

1 reference

9 May 2019

Inhibition of Notch signaling promotes browning of white adipose tissue and ameliorates obesity

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P46531

regulation of extracellular matrix assembly

1 reference

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P46531

positive regulation of apoptotic process involved in morphogenesis

1 reference

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P46531

negative regulation of pro-B cell differentiation

1 reference

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P46531

SKIP, a CBF1-associated protein, interacts with the ankyrin repeat domain of NotchIC To facilitate NotchIC function

Notch signaling pathway

7 references

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P46531

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P46531

9 May 2019

Notch signaling is required for maintaining stem-cell features of neuroprogenitor cells derived from human embryonic stem cells

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P46531

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P46531

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P46531

9 May 2019

Notch signaling induces cell cycle arrest in small cell lung cancer cells

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P46531

9 May 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P46531

EGF-type aspartate/asparagine hydroxylation site

IBA

Gene Atlas image

PBB GE NOTCH1 218902 at fs.png
732 × 530; 11 KB

0 references

has part(s)

1 reference

Notch domain

1 reference

EGF-like calcium-binding, conserved site

1 reference

Notch, NODP domain

1 reference

ankyrin repeat-containing domain

1 reference

Notch, NOD domain

1 reference

EGF-like, conserved site

1 reference

Domain of unknown function DUF3454, notch

1 reference

ankyrin repeat

1 reference

EGF-like calcium-binding domain

1 reference

EGF-like domain

1 reference

Identifiers

MeSH descriptor ID

D051881

subject named as

Receptor, Notch1

0 references

MeSH tree code

D12.776.543.750.725.500

0 references

0 references

1 reference

30 May 2020

1 reference

30 May 2020

1 reference

13 November 2019

1 reference

1 reference

9 August 2016

1 reference

9 August 2016

1 reference

9 August 2016

1 reference

9 August 2016

1 reference

9 August 2016

1 reference

9 August 2016

1 reference

9 August 2016

1 reference

9 August 2016

1 reference

9 August 2016

1 reference

9 August 2016

1 reference

9 August 2016

1 reference

9 August 2016

1 reference

9 August 2016

1 reference

9 August 2016

1 reference

9 August 2016

1 reference

9 August 2016

1 reference

9 August 2016

1 reference

9 August 2016

1 reference

9 August 2016

Transporter Classification Database ID

English

9.B.87.1.12

2 references

Transporter Classification database

retrieved

13 March 2020

Transporter Classification database

29 April 2020

1 reference

inferred by common MeSH mappings on source and on Wikidata