(Q424709)

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/P42898

Eukaryotic-type methylenetetrahydrofolate reductase

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/P42898

image

MTHFR active site.jpg
939 × 649; 149 KB

0 references

1 reference

13 November 2019

1 reference

13 November 2019

methylenetetrahydrofolate reductase (NAD(P)H) activity

10 references

27 February 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=P42898&geneProductId=UniProtKB:P42898

27 February 2018

A candidate genetic risk factor for vascular disease: a common mutation in methylenetetrahydrofolate reductase

http://www.ebi.ac.uk/QuickGO/annotations?protein=P42898&geneProductId=UniProtKB:P42898

27 February 2018

Insights into severe 5,10-methylenetetrahydrofolate reductase deficiency: molecular genetic and enzymatic characterization of 76 patients

http://www.ebi.ac.uk/QuickGO/annotations?protein=P42898&geneProductId=UniProtKB:P42898

27 February 2018

Characterization of mutations in severe methylenetetrahydrofolate reductase deficiency reveals an FAD-responsive mutation

http://www.ebi.ac.uk/QuickGO/annotations?protein=P42898&geneProductId=UniProtKB:P42898

27 February 2018

Functional characterization of human methylenetetrahydrofolate reductase in Saccharomyces cerevisiae

http://www.ebi.ac.uk/QuickGO/annotations?protein=P42898&geneProductId=UniProtKB:P42898

27 February 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=P42898&geneProductId=UniProtKB:P42898

27 February 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=P42898&geneProductId=UniProtKB:P42898

27 February 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=P42898&geneProductId=UniProtKB:P42898

27 February 2018

Characterization of mutations in severe methylenetetrahydrofolate reductase deficiency reveals an FAD-responsive mutation

http://www.ebi.ac.uk/QuickGO/annotations?protein=P42898&geneProductId=UniProtKB:P42898

27 February 2018

MTHFR promotes heterochromatin maintenance

http://www.ebi.ac.uk/QuickGO/annotations?protein=P42898&geneProductId=UniProtKB:P42898

modified amino acid binding

1 reference

27 February 2018

Novel associations of CPS1, MUT, NOX4, and DPEP1 with plasma homocysteine in a healthy population: a genome-wide evaluation of 13 974 participants in the Women's Genome Health Study

http://www.ebi.ac.uk/QuickGO/annotations?protein=P42898&geneProductId=UniProtKB:P42898

1 reference

27 February 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=P42898&geneProductId=UniProtKB:P42898

1 reference

27 February 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=P42898&geneProductId=UniProtKB:P42898

http://www.ebi.ac.uk/QuickGO/annotations?protein=P42898&geneProductId=UniProtKB:P42898

oxidoreductase activity

1 reference

27 February 2018

protein-containing complex binding

1 reference

27 February 2018

MTHFR promotes heterochromatin maintenance

http://www.ebi.ac.uk/QuickGO/annotations?protein=P42898&geneProductId=UniProtKB:P42898

1 reference

27 February 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=P42898&geneProductId=UniProtKB:P42898

biological process

response to amino acid

1 reference

27 February 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=P42898&geneProductId=UniProtKB:P42898

response to interleukin-1

1 reference

27 February 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=P42898&geneProductId=UniProtKB:P42898

1 reference

27 February 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=P42898&geneProductId=UniProtKB:P42898

cellular amino acid metabolic process

1 reference

27 February 2018

A candidate genetic risk factor for vascular disease: a common mutation in methylenetetrahydrofolate reductase

http://www.ebi.ac.uk/QuickGO/annotations?protein=P42898&geneProductId=UniProtKB:P42898

tetrahydrofolate interconversion

TAS

5 references

27 February 2018

Insights into severe 5,10-methylenetetrahydrofolate reductase deficiency: molecular genetic and enzymatic characterization of 76 patients

http://www.ebi.ac.uk/QuickGO/annotations?protein=P42898&geneProductId=UniProtKB:P42898

27 February 2018

Characterization of mutations in severe methylenetetrahydrofolate reductase deficiency reveals an FAD-responsive mutation

http://www.ebi.ac.uk/QuickGO/annotations?protein=P42898&geneProductId=UniProtKB:P42898

27 February 2018

Functional characterization of human methylenetetrahydrofolate reductase in Saccharomyces cerevisiae

http://www.ebi.ac.uk/QuickGO/annotations?protein=P42898&geneProductId=UniProtKB:P42898

27 February 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=P42898&geneProductId=UniProtKB:P42898

27 February 2018

Characterization of mutations in severe methylenetetrahydrofolate reductase deficiency reveals an FAD-responsive mutation

http://www.ebi.ac.uk/QuickGO/annotations?protein=P42898&geneProductId=UniProtKB:P42898

S-adenosylmethionine metabolic process

1 reference

27 February 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=P42898&geneProductId=UniProtKB:P42898

1 reference

27 February 2018

A candidate genetic risk factor for vascular disease: a common mutation in methylenetetrahydrofolate reductase

http://www.ebi.ac.uk/QuickGO/annotations?protein=P42898&geneProductId=UniProtKB:P42898

tetrahydrofolate metabolic process

TAS

1 reference

27 February 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=P42898&geneProductId=UniProtKB:P42898

regulation of histone methylation

1 reference

27 February 2018

MTHFR promotes heterochromatin maintenance

http://www.ebi.ac.uk/QuickGO/annotations?protein=P42898&geneProductId=UniProtKB:P42898

response to vitamin B2

1 reference

27 February 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=P42898&geneProductId=UniProtKB:P42898

folic acid metabolic process

1 reference

27 February 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=P42898&geneProductId=UniProtKB:P42898

homocysteine metabolic process

TAS

response to folic acid

1 reference

27 February 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=P42898&geneProductId=UniProtKB:P42898

1 reference

27 February 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=P42898&geneProductId=UniProtKB:P42898

http://purl.uniprot.org/uniprot/P42898

Gene Atlas image

PBB GE MTHFR 206800 at fs.png
732 × 530; 11 KB

0 references

exact match

1 reference

https://docs.openalex.org/download-snapshot/snapshot-data-format

Identifiers.org

Identifiers

MeSH descriptor ID

D042965

subject named as

Methylenetetrahydrofolate Reductase (NADPH2)

0 references

0 references

0 references

1 reference

30 May 2020

1 reference

30 May 2020

1 reference

30 May 2020

1 reference

30 May 2020

1 reference

30 May 2020

1 reference

30 May 2020

1 reference

30 May 2020

1 reference

30 May 2020

1 reference

30 May 2020

1 reference

13 November 2019

1 reference

1 reference

1 reference

1 reference

1 reference

1 reference

1 reference

1 reference

1 reference

1 reference

1 reference

1 reference

1 reference

28 October 2013

Microsoft Academic ID

0 references

0 references

1 reference

26 January 2022

UMLS CUI

C0066357

1 reference

based on heuristic

inferred by common MeSH mappings on source and on Wikidata