(Q44827080)

English

Probing the role of crystallographically defined/predicted hinge-bending regions in the substrate-induced global conformational transition and catalytic activation of human phenylalanine hydroxylase by single-site mutagenesis

scientific article published in April 2004

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scholarly article

1 reference

Europe PubMed Central

6 December 2017

Probing the role of crystallographically defined/predicted hinge-bending regions in the substrate-induced global conformational transition and catalytic activation of human phenylalanine hydroxylase by single-site mutagenesis (English)

1 reference

Europe PubMed Central

6 December 2017

Torgeir Flatmark

4

object named as

Torgeir Flatmark

1 reference

Europe PubMed Central

6 December 2017

author name string

Anne Jorunn Stokka

1

1 reference

Europe PubMed Central

6 December 2017

Raquel Negrão Carvalho

2

1 reference

Europe PubMed Central

6 December 2017

João Filipe Barroso

3

1 reference

Europe PubMed Central

6 December 2017

language of work or name

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publication date

1 April 2004

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Europe PubMed Central

6 December 2017

Journal of Biological Chemistry

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Europe PubMed Central

6 December 2017

279

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Europe PubMed Central

6 December 2017

25

1 reference

Europe PubMed Central

6 December 2017

26571-26580

1 reference

Europe PubMed Central

6 December 2017

PAHdb 2003: what a locus-specific knowledgebase can do.

1 reference

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21 January 2018

Structural Insight into the Aromatic Amino Acid Hydroxylases and Their Disease-Related Mutant Forms

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M400879200

21 January 2018

Structure of tetrameric human phenylalanine hydroxylase and its implications for phenylketonuria

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M400879200

21 January 2018

Use of surface plasmon resonance for real-time measurements of the global conformational transition in human phenylalanine hydroxylase in response to substrate binding and catalytic activation

1 reference

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21 January 2018

Crystal structure of the ternary complex of the catalytic domain of human phenylalanine hydroxylase with tetrahydrobiopterin and 3-(2-thienyl)-L-alanine, and its implications for the mechanism of catalysis and substrate activation

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M400879200

21 January 2018

Substrate-induced conformational transition in human phenylalanine hydroxylase as studied by surface plasmon resonance analyses: the effect of terminal deletions, substrate analogues and phosphorylation

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M400879200

21 January 2018

Crystal structure and site-specific mutagenesis of pterin-bound human phenylalanine hydroxylase

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M400879200

21 January 2018

High resolution crystal structures of the catalytic domain of human phenylalanine hydroxylase in its catalytically active Fe(II) form and binary complex with tetrahydrobiopterin

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M400879200

21 January 2018

2.0A resolution crystal structures of the ternary complexes of human phenylalanine hydroxylase catalytic domain with tetrahydrobiopterin and 3-(2-thienyl)-L-alanine or L-norleucine...

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M400879200

21 January 2018

Crystal structure of the catalytic domain of human phenylalanine hydroxylase reveals the structural basis for phenylketonuria

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M400879200

21 January 2018

Structural basis of autoregulation of phenylalanine hydroxylase

1 reference

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21 January 2018

A comparison of kinetic and regulatory properties of the tetrameric and dimeric forms of wild-type and Thr427-->Pro mutant human phenylalanine hydroxylase: contribution of the flexible hinge region Asp425-Gln429 to the tetramerization and cooperativ

1 reference

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21 January 2018

Deamidations in recombinant human phenylalanine hydroxylase. Identification of labile asparagine residues and functional characterization of Asn --> Asp mutant forms

1 reference

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21 January 2018

Expression of recombinant human phenylalanine hydroxylase as fusion protein in Escherichia coli circumvents proteolytic degradation by host cell proteases. Isolation and characterization of the wild-type enzyme

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M400879200

21 January 2018

Deamidation of labile asparagine residues in the autoregulatory sequence of human phenylalanine hydroxylase.

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M400879200

21 January 2018

Phosphorylation and mutations of Ser(16) in human phenylalanine hydroxylase. Kinetic and structural effects

1 reference

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21 January 2018

Studies on the regulatory properties of the pterin cofactor and dopamine bound at the active site of human phenylalanine hydroxylase.

1 reference

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21 January 2018

Partial characterization and three-dimensional-structural localization of eight mutations in exon 7 of the human phenylalanine hydroxylase gene associated with phenylketonuria.

1 reference

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21 January 2018

Spectroscopic and kinetic studies of PKU-inducing mutants of phenylalanine hydroxylase: Arg158Gln and Glu280Lys

1 reference

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21 January 2018

Spectroscopic and kinetic properties of unphosphorylated rat hepatic phenylalanine hydroxylase expressed in Escherichia coli. Comparison of resting and activated states.

1 reference

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21 January 2018

The cooperative binding of phenylalanine to phenylalanine 4-monooxygenase studied by 1H-NMR paramagnetic relaxation. Changes in water accessibility to the iron at the active site upon substrate binding

1 reference

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21 January 2018

ON THE NATURE OF ALLOSTERIC TRANSITIONS: A PLAUSIBLE MODEL

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M400879200

21 January 2018

Activation of phenylalanine hydroxylase: effect of substitutions at Arg68 and Cys237.

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M400879200

21 January 2018

Essential role of the N-terminal autoregulatory sequence in the regulation of phenylalanine hydroxylase

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M400879200

21 January 2018

Mutagenesis of the regulatory domain of phenylalanine hydroxylase

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M400879200

21 January 2018

Structural characterization of the N-terminal autoregulatory sequence of phenylalanine hydroxylase

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M400879200

21 January 2018

Probing cofactor specificity in phenylalanine hydroxylase by molecular dynamics simulations

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M400879200

21 January 2018

Crystal structure of tyrosine hydroxylase at 2.3 A and its implications for inherited neurodegenerative diseases

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M400879200

21 January 2018

L-phenylalanine binding and domain organization in human phenylalanine hydroxylase: a differential scanning calorimetry study.

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M400879200

21 January 2018

Pterin-Dependent Amino Acid Hydroxylases

1 reference

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21 January 2018

Identifiers

10.1074/JBC.M400879200

1 reference

Europe PubMed Central

6 December 2017

1 reference

Europe PubMed Central

6 December 2017

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