(Q50495797)

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:27460023%20AND%20SRC:MED&resulttype=core&format=json

19 March 2020

review article

1 reference

title

Considerations on inhibition approaches for proinflammatory functions of ADAM proteases (English)

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:27460023%20AND%20SRC:MED&resulttype=core&format=json

19 March 2020

1

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:27460023%20AND%20SRC:MED&resulttype=core&format=json

19 March 2020

Andreas Ludwig

series ordinal

2

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:27460023%20AND%20SRC:MED&resulttype=core&format=json

19 March 2020

author name string

Daniela Dreymueller

series ordinal

1

1 reference

http://europepmc.org/abstract/MED/27460023

14 March 2018

Andreas Ludwig

series ordinal

2

1 reference

http://europepmc.org/abstract/MED/27460023

14 March 2018

publication date

26 July 2016

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:27460023%20AND%20SRC:MED&resulttype=core&format=json

19 March 2020

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:27460023%20AND%20SRC:MED&resulttype=core&format=json

19 March 2020

volume

28

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:27460023%20AND%20SRC:MED&resulttype=core&format=json

19 March 2020

issue

4

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:27460023%20AND%20SRC:MED&resulttype=core&format=json

19 March 2020

page(s)

354-361

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:27460023%20AND%20SRC:MED&resulttype=core&format=json

ADAM17: a molecular switch to control inflammation and tissue regeneration

19 March 2020

cites work

1 reference

https://api.crossref.org/works/10.1080%2F09537104.2016.1203396

The "A Disintegrin And Metalloproteases" ADAM10 and ADAM17: novel drug targets with therapeutic potential?

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F09537104.2016.1203396

ADAM-family metalloproteinases in lung inflammation: potential therapeutic targets

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F09537104.2016.1203396

The role of ADAM-mediated shedding in vascular biology.

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F09537104.2016.1203396

A metalloproteinase disintegrin that releases tumour-necrosis factor-alpha from cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F09537104.2016.1203396

ADAM10 regulates endothelial permeability and T-Cell transmigration by proteolysis of vascular endothelial cadherin.

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F09537104.2016.1203396

Regulated release and functional modulation of junctional adhesion molecule A by disintegrin metalloproteinases.

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F09537104.2016.1203396

Controlled shedding of platelet glycoprotein (GP)VI and GPIb-IX-V by ADAM family metalloproteinases.

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F09537104.2016.1203396

Evidence for a role of ADAM17 (TACE) in the regulation of platelet glycoprotein V

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F09537104.2016.1203396

Leukocytes require ADAM10 but not ADAM17 for their migration and inflammatory recruitment into the alveolar space

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F09537104.2016.1203396

The metalloprotease-disintegrin ADAM8 is essential for the development of experimental asthma

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F09537104.2016.1203396

The disintegrin/metalloprotease ADAM 10 is essential for Notch signalling but not for alpha-secretase activity in fibroblasts

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F09537104.2016.1203396

ADAM10 is the physiologically relevant, constitutive alpha-secretase of the amyloid precursor protein in primary neurons

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F09537104.2016.1203396

Distinct roles for ADAM10 and ADAM17 in ectodomain shedding of six EGFR ligands

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F09537104.2016.1203396

The disintegrin/metalloproteinase Adam10 is essential for epidermal integrity and Notch-mediated signaling

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F09537104.2016.1203396

Critical role of the disintegrin metalloprotease ADAM17 for intestinal inflammation and regeneration in mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F09537104.2016.1203396

Targeting the sheddase activity of ADAM17 by an anti-ADAM17 antibody D1(A12) inhibits head and neck squamous cell carcinoma cell proliferation and motility via blockage of bradykinin induced HERs transactivation

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F09537104.2016.1203396

The ADAMs family of proteases: new biomarkers and therapeutic targets for cancer?

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F09537104.2016.1203396

ADAM10 regulates Notch function in intestinal stem cells of mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F09537104.2016.1203396

Deficiency of TNFalpha converting enzyme (TACE/ADAM17) causes a lean, hypermetabolic phenotype in mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F09537104.2016.1203396

Conditional inactivation of TACE by a Sox9 promoter leads to osteoporosis and increased granulopoiesis via dysregulation of IL-17 and G-CSF.

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F09537104.2016.1203396

Pathological neovascularization is reduced by inactivation of ADAM17 in endothelial cells but not in pericytes.

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F09537104.2016.1203396

Lung endothelial ADAM17 regulates the acute inflammatory response to lipopolysaccharide

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F09537104.2016.1203396

ADAM Proteases and Gastrointestinal Function

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F09537104.2016.1203396

Loss of ADAM17-Mediated Tumor Necrosis Factor Alpha Signaling in Intestinal Cells Attenuates Mucosal Atrophy in a Mouse Model of Parenteral Nutrition

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F09537104.2016.1203396

Differentially regulated GPVI ectodomain shedding by multiple platelet-expressed proteinases.

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F09537104.2016.1203396

Role of metalloproteinases in platelet function.

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F09537104.2016.1203396

Inflammatory skin and bowel disease linked to ADAM17 deletion

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F09537104.2016.1203396

The disintegrin/metalloproteinase ADAM10 is essential for the establishment of the brain cortex

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F09537104.2016.1203396

A disintegrin-metalloproteinase prevents amyloid plaque formation and hippocampal defects in an Alzheimer disease mouse model

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F09537104.2016.1203396

Deletion of Adam10 in endothelial cells leads to defects in organ-specific vascular structures

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F09537104.2016.1203396

A potential new target for asthma therapy: a disintegrin and metalloprotease 10 (ADAM10) involvement in murine experimental asthma

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F09537104.2016.1203396

ADAM10 is essential for Notch2-dependent marginal zone B cell development and CD23 cleavage in vivo

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F09537104.2016.1203396

Myeloid A disintegrin and metalloproteinase domain 10 deficiency modulates atherosclerotic plaque composition by shifting the balance from inflammation toward fibrosis.

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F09537104.2016.1203396

Genetic requirement for ADAM10 in severe Staphylococcus aureus skin infection

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F09537104.2016.1203396

A Staphylococcus aureus pore-forming toxin subverts the activity of ADAM10 to cause lethal infection in mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F09537104.2016.1203396

Pioglitazone improves glucose metabolism and modulates skeletal muscle TIMP-3-TACE dyad in type 2 diabetes mellitus: a randomised, double-blind, placebo-controlled, mechanistic study

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F09537104.2016.1203396

Short-term TNFα shedding is independent of cytoplasmic phosphorylation or furin cleavage of ADAM17.

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F09537104.2016.1203396

Tumor necrosis factor signaling requires iRhom2 to promote trafficking and activation of TACE

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F09537104.2016.1203396

iRhom2 controls the substrate selectivity of stimulated ADAM17-dependent ectodomain shedding.

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F09537104.2016.1203396

iRhoms 1 and 2 are essential upstream regulators of ADAM17-dependent EGFR signaling

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F09537104.2016.1203396

TspanC8 tetraspanins differentially regulate the cleavage of ADAM10 substrates, Notch activation and ADAM10 membrane compartmentalization.

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F09537104.2016.1203396

TspanC8 Tetraspanins and A Disintegrin and Metalloprotease 10 (ADAM10) Interact via Their Extracellular Regions: EVIDENCE FOR DISTINCT BINDING MECHANISMS FOR DIFFERENT TspanC8 PROTEINS.

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F09537104.2016.1203396

Membrane-proximal domain of a disintegrin and metalloprotease-17 represents the putative molecular switch of its shedding activity operated by protein-disulfide isomerase

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F09537104.2016.1203396

Thiol isomerases negatively regulate the cellular shedding activity of ADAM17.

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F09537104.2016.1203396

ADAM17 is regulated by a rapid and reversible mechanism that controls access to its catalytic site

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F09537104.2016.1203396

Development of a 'mouse and human cross-reactive' affinity-matured exosite inhibitory human antibody specific to TACE (ADAM17) for cancer immunotherapy.

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F09537104.2016.1203396

Targeting ADAM-17 with an inhibitory monoclonal antibody has antitumour effects in triple-negative breast cancer cells.

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F09537104.2016.1203396

Antibodies binding the ADAM10 substrate recognition domain inhibit Eph function

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F09537104.2016.1203396

ADAM8 as a drug target in pancreatic cancer.

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F09537104.2016.1203396

Crystal structure of the catalytic domain of human tumor necrosis factor-alpha-converting enzyme

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F09537104.2016.1203396

Fluorescent substrates useful as high-throughput screening tools for ADAM9.

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F09537104.2016.1203396

Metalloproteinase inhibitors for the disintegrin-like metalloproteinases ADAM10 and ADAM17 that differentially block constitutive and phorbol ester-inducible shedding of cell surface molecules.

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F09537104.2016.1203396

Phase II trial of temozolomide plus marimastat for recurrent anaplastic gliomas: a relationship among efficacy, joint toxicity and anticonvulsant status.

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F09537104.2016.1203396

Broad-spectrum matrix metalloproteinase inhibitor marimastat-induced musculoskeletal side effects in rats

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F09537104.2016.1203396

Synergistic inhibition with a dual epidermal growth factor receptor/HER-2/neu tyrosine kinase inhibitor and a disintegrin and metalloprotease inhibitor

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F09537104.2016.1203396

TACE/ADAM-17: a component of the epidermal growth factor receptor axis and a promising therapeutic target in colorectal cancer

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F09537104.2016.1203396

Pharmacokinetics and pharmacodynamics of DPC 333 ((2R)-2-((3R)-3-amino-3{4-[2-methyl-4-quinolinyl) methoxy] phenyl}-2-oxopyrrolidinyl)-N-hydroxy-4-methylpentanamide)), a potent and selective inhibitor of tumor necrosis factor alpha-converting enzyme

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F09537104.2016.1203396

Fluorescent substrates for the proteinases ADAM17, ADAM10, ADAM8, and ADAM12 useful for high-throughput inhibitor screening.

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F09537104.2016.1203396

Drug insight: tumor necrosis factor-converting enzyme as a pharmaceutical target for rheumatoid arthritis

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F09537104.2016.1203396

Amino-terminal TACE prodomain attenuates TNFR2 cleavage independently of the cysteine switch.

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F09537104.2016.1203396

The regulation of TACE catalytic function by its prodomain

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F09537104.2016.1203396

The study of the inhibition of the recombinant TACE prodomain to endotoxemia in mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F09537104.2016.1203396

The ADAM10 prodomain is a specific inhibitor of ADAM10 proteolytic activity and inhibits cellular shedding events.

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F09537104.2016.1203396

Targeting autocrine HB-EGF signaling with specific ADAM12 inhibition using recombinant ADAM12 prodomain

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F09537104.2016.1203396

SAR Studies of Exosite-Binding Substrate-Selective Inhibitors of A Disintegrin And Metalloprotease 17 (ADAM17) and Application as Selective in Vitro Probes.

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F09537104.2016.1203396

Discovery of novel inhibitors of a disintegrin and metalloprotease 17 (ADAM17) using glycosylated and non-glycosylated substrates.

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F09537104.2016.1203396

A systematic study of modulation of ADAM-mediated ectodomain shedding by site-specific O-glycosylation.

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F09537104.2016.1203396

Activity of ADAM17 (a disintegrin and metalloprotease 17) is regulated by its noncatalytic domains and secondary structure of its substrates

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F09537104.2016.1203396

Structural determinants of the ADAM inhibition by TIMP-3: crystal structure of the TACE-N-TIMP-3 complex

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F09537104.2016.1203396

Intravitreal injection of TIMP3 or the EGFR inhibitor erlotinib offers protection from oxygen-induced retinopathy in mice.

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F09537104.2016.1203396

The C-terminal domains of TACE weaken the inhibitory action of N-TIMP-3

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F09537104.2016.1203396

Total conversion of tissue inhibitor of metalloproteinase (TIMP) for specific metalloproteinase targeting: fine-tuning TIMP-4 for optimal inhibition of tumor necrosis factor-{alpha}-converting enzyme

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F09537104.2016.1203396

Tailoring tissue inhibitor of metalloproteinases-3 to overcome the weakening effects of the cysteine-rich domains of tumour necrosis factor-alpha converting enzyme.

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F09537104.2016.1203396

RECK modulates Notch signaling during cortical neurogenesis by regulating ADAM10 activity.

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F09537104.2016.1203396

RECK inhibits stemness gene expression and tumorigenicity of gastric cancer cells by suppressing ADAM-mediated Notch1 activation

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F09537104.2016.1203396

Development of a polymeric matrix metalloproteinase inhibitor as a bioactive stent coating material for prevention of restenosis.

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F09537104.2016.1203396

Membrane-bound FRET probe visualizes MMP12 activity in pulmonary inflammation.

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F09537104.2016.1203396

Pathologic shear triggers shedding of vascular receptors: a novel mechanism for down-regulation of platelet glycoprotein VI in stenosed coronary vessels

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F09537104.2016.1203396

10.1080/09537104.2016.1203396

21 January 2018

Identifiers

DOI

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:27460023%20AND%20SRC:MED&resulttype=core&format=json

release_4nmv3tmpyvgo5dgksshpqgfd64

19 March 2020

Fatcat ID

1 reference

Fatcat

https://api.fatcat.wiki/v0/release/4nmv3tmpyvgo5dgksshpqgfd64

mapped directly with Wikidata item

24 November 2022

based on heuristic

1 reference