(Q57046051)

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:30278800%20AND%20SRC:MED&resulttype=core&format=json

26 April 2020

title

Chymase inhibitors for the treatment of cardiac diseases: a patent review (2010-2018) (English)

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:30278800%20AND%20SRC:MED&resulttype=core&format=json

26 April 2020

author name string

Sarfaraz Ahmad

series ordinal

1

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:30278800%20AND%20SRC:MED&resulttype=core&format=json

26 April 2020

Carlos M Ferrario

series ordinal

2

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:30278800%20AND%20SRC:MED&resulttype=core&format=json

26 April 2020

language of work or name

English

0 references

publication date

10 October 2018

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:30278800%20AND%20SRC:MED&resulttype=core&format=json

Expert Opinion on Therapeutic Patents

26 April 2020

published in

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:30278800%20AND%20SRC:MED&resulttype=core&format=json

26 April 2020

volume

28

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:30278800%20AND%20SRC:MED&resulttype=core&format=json

26 April 2020

issue

11

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:30278800%20AND%20SRC:MED&resulttype=core&format=json

26 April 2020

page(s)

755-764

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:30278800%20AND%20SRC:MED&resulttype=core&format=json

Angiotensin-[1-7]: evidence for novel actions in the brain

26 April 2020

cites work

1 reference

12 December 2020

Multiple determinants for the high substrate specificity of an angiotensin II-forming chymase from the human heart

1 reference

12 December 2020

Angiotensin II-forming pathways in normal and failing human hearts

1 reference

12 December 2020

Identification of a highly specific chymase as the major angiotensin II-forming enzyme in the human heart

1 reference

12 December 2020

Angiotensin II receptors in normal and failing human hearts.

1 reference

12 December 2020

Cardiovascular effects of angiotensin-(1-7) injected into the dorsal medulla of rats

1 reference

12 December 2020

Characterization and mast cell origin of a chymotrypsin-like proteinase isolated from intestines of mice infected with Trichinella spiralis

1 reference

12 December 2020

Release of vasopressin from the rat hypothalamo-neurohypophysial system by angiotensin-(1-7) heptapeptide

1 reference

12 December 2020

Mast cells in rat gastrointestinal mucosa. I. Effects of fixation

1 reference

12 December 2020

Angiotensin I Conversion by Human and Rat Chymotryptic Proteinases

1 reference

12 December 2020

1 reference

12 December 2020

Cloning of the cDNA encoding a novel rat mast-cell proteinase, rMCP-3, and its expression in comparison with other rat mast-cell proteinases

1 reference

12 December 2020

The human cardiac mast cell: localization, isolation, phenotype, and functional characterization

1 reference

12 December 2020

Human heart mast cells: a definitive case of mast cell heterogeneity

1 reference

12 December 2020

Role of mast cells in atherosclerosis

1 reference

12 December 2020

Angiotensin II formation in the intact human heart. Predominance of the angiotensin-converting enzyme pathway

1 reference

12 December 2020

Cardiovascular actions of angiotensin(1-7)

1 reference

12 December 2020

A comparison of the properties and enzymatic activities of three angiotensin processing enzymes: angiotensin converting enzyme, prolyl endopeptidase and neutral endopeptidase 24.11.

1 reference

12 December 2020

Angiotensin II-forming activity in a reconstructed ancestral chymase

1 reference

12 December 2020

Transmural changes in mast cell density in rat heart after infarct induction in vivo.

1 reference

12 December 2020

Chymase in exocytosed rat mast cell granules effectively proteolyzes apolipoprotein AI-containing lipoproteins, so reducing the cholesterol efflux-inducing ability of serum and aortic intimal fluid

1 reference

12 December 2020

Angiotensin II formation in dog heart is mediated by different pathways in vivo and in vitro

1 reference

12 December 2020

Increased cardiac mast cell density and mediator release in patients with dilated cardiomyopathy

1 reference

12 December 2020

Compartmentalization of angiotensin II generation in the dog heart. Evidence for independent mechanisms in intravascular and interstitial spaces

1 reference

12 December 2020

1 reference

12 December 2020

Angiotensin II formation from ACE and chymase in human and animal hearts: methods and species considerations

1 reference

12 December 2020

Three-dimensional molecular modeling explains why catalytic function for angiotensin-I is different between human and rat chymases.

1 reference

12 December 2020

Peptidyl human heart chymase inhibitors. 1. Synthesis and inhibitory activity of difluoromethylene ketone derivatives bearing P' binding subsites

1 reference

12 December 2020

Peptidyl human heart chymase inhibitors. 2. Discovery of highly selective difluoromethylene ketone derivatives with Glu at P3 site

1 reference

12 December 2020

Symmetrical anhydride-type serine protease inhibitors: structure-activity relationship studies of human chymase inhibitors

1 reference

12 December 2020

Structure-activity relationship studies of chloromethyl ketone derivatives for selective human chymase inhibitors

1 reference

12 December 2020

Angiotensin II generation by mast cell alpha- and beta-chymases

1 reference

12 December 2020

A novel vascular smooth muscle chymase is upregulated in hypertensive rats

1 reference

12 December 2020

Dipeptidyl peptidase I is essential for activation of mast cell chymases, but not tryptases, in mice

1 reference

12 December 2020

Total synthesis of human chymase inhibitor methyllinderone and structure--activity relationships of its derivatives

1 reference

12 December 2020

An orally active chymase inhibitor, BCEAB, suppresses heart chymase activity in the hamster

1 reference

12 December 2020

Possible roles of cardiac chymase after myocardial infarction in hamster hearts

1 reference

12 December 2020

Oral administration of a specific chymase inhibitor, NK3201, inhibits vascular proliferation in grafted vein

1 reference

12 December 2020

The impact of tranilast on restenosis after coronary angioplasty: the Second Tranilast Restenosis Following Angioplasty Trial (TREAT-2).

1 reference

12 December 2020

Rat mast cell protease 4 is a beta-chymase with unusually stringent substrate recognition profile

1 reference

12 December 2020

Angiotensin-converting enzyme 2 is an essential regulator of heart function

1 reference

12 December 2020

Results of Prevention of REStenosis with Tranilast and its Outcomes (PRESTO) trial

1 reference

12 December 2020

Therapeutic potential of a specific chymase inhibitor in atopic dermatitis

1 reference

12 December 2020

A novel chymase inhibitor, 4-[1-([bis-(4-methyl-phenyl)-methyl]-carbamoyl)3-(2-ethoxy-benzyl)-4-oxo-azetidine-2-yloxy]-benzoic acid (BCEAB), suppressed cardiac fibrosis in cardiomyopathic hamsters

1 reference

12 December 2020

Cardiac mast cell- and chymase-mediated matrix metalloproteinase activity and left ventricular remodeling in mitral regurgitation in the dog.

1 reference

12 December 2020

Chymase inhibitor improves survival in hamsters with myocardial infarction

1 reference

12 December 2020

Chymase Inhibition Prevents Cardiac Fibrosis and Improves Diastolic Dysfunction in the Progression of Heart Failure

1 reference

12 December 2020

Will chymase inhibitors be the next major development for the treatment of cardiovascular disorders?

1 reference

12 December 2020

Application of a chymase inhibitor, NK3201, for prevention of vascular proliferation

1 reference

12 December 2020

A role for cardiac mast cells in the pathogenesis of hypertensive heart disease

1 reference

12 December 2020

Attenuation of adhesion formation after cardiac surgery with a chymase inhibitor in a hamster model

1 reference

12 December 2020

Vascular chymase: pathophysiological role and therapeutic potential of inhibition

1 reference

12 December 2020

Cardiac chymase: pathophysiological role and therapeutic potential of chymase inhibitors

1 reference

12 December 2020

Effect of mast cell chymase inhibitor on the development of scleroderma in tight-skin mice

1 reference

12 December 2020

Species differences in angiotensin II generation and degradation by mast cell chymases

1 reference

12 December 2020

Role of chymase-dependent angiotensin II formation in regulating blood pressure in spontaneously hypertensive rats

1 reference

12 December 2020

Pharmacologic inhibition of mast cell degranulation prevents left ventricular remodeling induced by chronic volume overload in rats

1 reference

12 December 2020

Nutritional mechanisms that influence cardiovascular disease.

1 reference

12 December 2020

Rapid lineage-specific diversification of the mast cell chymase locus during mammalian evolution

1 reference

12 December 2020

Pathological roles of angiotensin II produced by mast cell chymase and the effects of chymase inhibition in animal models

1 reference

12 December 2020

Isolation and identification of proangiotensin-12, a possible component of the renin-angiotensin system.

1 reference

12 December 2020

Role of angiotensin II in cardiovascular disease therapeutic implications of more than a century of research

1 reference

12 December 2020

Expression profile of novel members of the rat mast cell protease (rMCP)-2 and (rMCP)-8 families, and functional analyses of mouse mast cell protease (mMCP)-8

1 reference

12 December 2020

Discovery of potent, selective, orally active, nonpeptide inhibitors of human mast cell chymase

1 reference

12 December 2020

FcepsilonRI aggregation promotes survival of connective tissue-like mast cells but not mucosal-like mast cells.

1 reference

12 December 2020

Chymase and matrix metalloproteinase

1 reference

12 December 2020

Mast cell tryptases and chymases in inflammation and host defense

1 reference

12 December 2020

1 reference

12 December 2020

Oral chymase inhibitor SUN13834 ameliorates skin inflammation as well as pruritus in mouse model for atopic dermatitis

1 reference

12 December 2020

Cardiac mast cells mediate left ventricular fibrosis in the hypertensive rat heart.

1 reference

12 December 2020

Novel insights into the biological function of mast cell carboxypeptidase A.

1 reference

12 December 2020

New physiological concepts of the renin-angiotensin system from the investigation of precursors and products of angiotensin I metabolism

1 reference

12 December 2020

New approaches to blockade of the renin-angiotensin-aldosterone system: chymase as an important target to prevent organ damage

1 reference

12 December 2020

Mast cell chymase inhibition reduces atherosclerotic plaque progression and improves plaque stability in ApoE-/- mice.

1 reference

12 December 2020

Cardiac mast cells: the centrepiece in adverse myocardial remodelling

1 reference

12 December 2020

Biological implications of preformed mast cell mediators

1 reference

12 December 2020

Mast cells and metabolic syndrome

1 reference

12 December 2020

Uptake and metabolism of the novel peptide angiotensin-(1-12) by neonatal cardiac myocytes

1 reference

12 December 2020

Dynamic molecular and histopathological changes in the extracellular matrix and inflammation in the transition to heart failure in isolated volume overload

1 reference

12 December 2020

Pharmacokinetic/pharmacodynamic analyses of chymase inhibitor SUN13834 in NC/Nga mice and prediction of effective dosage for atopic dermatitis patients

1 reference

12 December 2020

Chymase inhibition reduces infarction and matrix metalloproteinase-9 activation and attenuates inflammation and fibrosis after acute myocardial ischemia/reperfusion.

1 reference

12 December 2020

Chymase-dependent generation of angiotensin II from angiotensin-(1-12) in human atrial tissue

1 reference

12 December 2020

Chymase inhibition as a pharmacological target: a role in inflammatory and functional gastrointestinal disorders?

1 reference

12 December 2020

Chymase mediates angiotensin-(1-12) metabolism in normal human hearts

1 reference

12 December 2020

New era of biologic therapeutics in atopic dermatitis

1 reference

12 December 2020

Discovery of potent, selective chymase inhibitors via fragment linking strategies

1 reference

12 December 2020

Big angiotensin-25: a novel glycosylated angiotensin-related peptide isolated from human urine

1 reference

12 December 2020

An evolving story of angiotensin-II-forming pathways in rodents and humans

1 reference

12 December 2020

Development of mast cells

1 reference

12 December 2020

Angiotensin-(1-12): a chymase-mediated cellular angiotensin II substrate

1 reference

12 December 2020

Chymase inhibition improves vascular dysfunction and survival in stroke-prone spontaneously hypertensive rats

1 reference

12 December 2020

Hypertension: renin-angiotensin-aldosterone system alterations

1 reference

12 December 2020

Effects of chymostatin, a chymase inhibitor, on blood pressure, plasma and tissue angiotensin II, renal haemodynamics and renal excretion in two models of hypertension in the rat.

1 reference

12 December 2020

Increased fibroblast chymase production mediates procollagen autophagic digestion in volume overload.

1 reference

12 December 2020

Primacy of cardiac chymase over angiotensin converting enzyme as an angiotensin-(1-12) metabolizing enzyme

1 reference

12 December 2020

Chymase-dependent production of angiotensin II: an old enzyme in old hearts.

1 reference

12 December 2020

Novel Cardiac Intracrine Mechanisms Based on Ang-(1-12)/Chymase Axis Require a Revision of Therapeutic Approaches in Human Heart Disease

1 reference

12 December 2020

Renin angiotensin aldosterone inhibition in the treatment of cardiovascular disease

1 reference

12 December 2020

Dual inhibition of cathepsin G and chymase reduces myocyte death and improves cardiac remodeling after myocardial ischemia reperfusion injury.

1 reference

12 December 2020

Serine protease inhibitors to treat inflammation: a patent review (2011-2016).

1 reference

12 December 2020

Increased Inflammation in Pericardial Fluid Persists 48 Hours After Cardiac Surgery

1 reference

12 December 2020

Multifunctional Role of Chymase in Acute and Chronic Tissue Injury and Remodeling

1 reference

12 December 2020

1 reference

12 December 2020

Pharmacokinetics, Safety, and Tolerability of the Novel Chymase Inhibitor BAY 1142524 in Healthy Male Volunteers

1 reference

12 December 2020

10.1080/13543776.2018.1531848

Identifiers

DOI

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:30278800%20AND%20SRC:MED&resulttype=core&format=json

26 April 2020

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:30278800%20AND%20SRC:MED&resulttype=core&format=json

26 April 2020

1 reference