(Q6155967)

English

Janus kinase 1

mammalian protein found in Homo sapiens

tyrosine-protein kinase JAK1
JAK1
JAK-1

In more languages

Statements

1 reference

16 January 2019

UniProt protein ID

tyrosine-protein kinase, non-receptor Jak1

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/P23458

Protein kinase-like domain superfamily

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/P23458

SH2 domain superfamily

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/P23458

FERM superfamily, second domain

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/P23458

Serine-threonine/tyrosine-protein kinase, catalytic domain, protein family

1 reference

based on heuristic

inferred from protein domain or family

SH2 domain, protein family

1 reference

based on heuristic

inferred from protein domain or family

Band 4.1 domain, protein family

1 reference

based on heuristic

inferred from protein domain or family

FERM central domain, protein family

1 reference

based on heuristic

inferred from protein domain or family

FERM domain, protein family

1 reference

based on heuristic

inferred from protein domain or family

Protein kinase domain, protein family

1 reference

based on heuristic

inferred from protein domain or family

Protein kinase, ATP binding site, protein family

1 reference

based on heuristic

inferred from protein domain or family

Tyrosine-protein kinase, catalytic domain, protein family

1 reference

based on heuristic

inferred from protein domain or family

Tyrosine-protein kinase, active site, protein family

1 reference

based on heuristic

inferred from protein domain or family

1 reference

16 January 2019

UniProt protein ID

1 reference

16 January 2019

UniProt protein ID

molecular function

transferase activity

determination method

1 reference

8 April 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P23458

determination method

nucleotide binding

determination method

1 reference

8 April 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P23458

determination method

protein kinase activity

determination method

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P23458

determination method

CCR5 chemokine receptor binding

determination method

1 reference

8 April 2019

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P23458

determination method

metal ion binding

determination method

1 reference

8 April 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P23458

determination method

kinase activity

determination method

1 reference

8 April 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P23458

determination method

protein binding

determination method

5 references

8 April 2019

Soluble and membrane-anchored forms of the human IFN-alpha/beta receptor

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P23458

determination method

8 April 2019

CHZ868, a Type II JAK2 Inhibitor, Reverses Type I JAK Inhibitor Persistence and Demonstrates Efficacy in Myeloproliferative Neoplasms.

IntAct protein interaction database

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P23458

determination method

8 April 2019

Structural snapshots of full-length Jak1, a transmembrane gp130/IL-6/IL-6Rα cytokine receptor complex, and the receptor-Jak1 holocomplex

IntAct protein interaction database

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P23458

determination method

8 April 2019

A quantitative protein interaction network for the ErbB receptors using protein microarrays

IntAct protein interaction database

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P23458

determination method

8 April 2019

UBP43 is a novel regulator of interferon signaling independent of its ISG15 isopeptidase activity

IntAct protein interaction database

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P23458

determination method

protein tyrosine kinase activity

determination method

7 references

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P23458

determination method

8 April 2019

Two novel protein-tyrosine kinases, each with a second phosphotransferase-related catalytic domain, define a new class of protein kinase

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P23458

determination method

8 April 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P23458

determination method

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P23458

determination method

8 April 2019

Hierarchy of protein tyrosine kinases in interleukin-2 (IL-2) signaling: activation of syk depends on Jak3; however, neither Syk nor Lck is required for IL-2-mediated STAT activation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P23458

determination method

8 April 2019

The protein tyrosine kinase JAK1 complements defects in interferon-alpha/beta and -gamma signal transduction

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P23458

determination method

8 April 2019

A protein tyrosine kinase in the interferon alpha/beta signaling pathway

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P23458

determination method

protein phosphatase binding

determination method

1 reference

8 April 2019

The T cell protein tyrosine phosphatase is a negative regulator of janus family kinases 1 and 3

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P23458

determination method

signaling receptor binding

determination method

1 reference

31 October 2017

http://www.ebi.ac.uk/QuickGO/annotations?protein=P23458&geneProductId=UniProtKB:P23458

determination method

determination method

2 references

ubiquitin protein ligase binding

determination method

1 reference

8 April 2019

Unanchored K48-linked polyubiquitin synthesized by the E3-ubiquitin ligase TRIM6 stimulates the interferon-IKKε kinase-mediated antiviral response

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P23458

determination method

non-membrane spanning protein tyrosine kinase activity

determination method

4 references

31 October 2017

http://www.ebi.ac.uk/QuickGO/annotations?protein=P23458&geneProductId=UniProtKB:P23458

determination method

31 October 2017

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?protein=P23458&geneProductId=UniProtKB:P23458

determination method

31 October 2017

http://www.ebi.ac.uk/QuickGO/annotations?protein=P23458&geneProductId=UniProtKB:P23458

determination method

31 October 2017

http://www.ebi.ac.uk/QuickGO/annotations?protein=P23458&geneProductId=UniProtKB:P23458

determination method

non-membrane spanning protein tyrosine kinase activity

determination method

growth hormone receptor binding

determination method

3 references

8 April 2019

The growth hormone receptor associates with Jak1, Jak2 and Tyk2 in human liver

British Heart Foundation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P23458

determination method

8 April 2019

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P23458

determination method

8 April 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P23458

determination method

determination method

1 reference

8 April 2019

The growth hormone receptor associates with Jak1, Jak2 and Tyk2 in human liver

British Heart Foundation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P23458

determination method

determination method

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P23458

determination method

determination method

2 references

determination method

1 reference

31 October 2017

Analysis of the myosin-II-responsive focal adhesion proteome reveals a role for β-Pix in negative regulation of focal adhesion maturation

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?protein=P23458&geneProductId=UniProtKB:P23458

determination method

extrinsic component of cytoplasmic side of plasma membrane

determination method

1 reference

31 October 2017

http://www.ebi.ac.uk/QuickGO/annotations?protein=P23458&geneProductId=UniProtKB:P23458

determination method

determination method

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P23458

determination method

endomembrane system

determination method

1 reference

8 April 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P23458

determination method

determination method

1 reference

8 April 2019

The growth hormone receptor associates with Jak1, Jak2 and Tyk2 in human liver

British Heart Foundation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P23458

determination method

determination method

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P23458

determination method

determination method

1 reference

8 April 2019

Analysis of the myosin-II-responsive focal adhesion proteome reveals a role for β-Pix in negative regulation of focal adhesion maturation

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P23458

determination method

biological process

cell differentiation

determination method

1 reference

31 October 2017

http://www.ebi.ac.uk/QuickGO/annotations?protein=P23458&geneProductId=UniProtKB:P23458

determination method

phosphorylation

determination method

1 reference

8 April 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P23458

determination method

transmembrane receptor protein tyrosine kinase signaling pathway

determination method

1 reference

31 October 2017

http://www.ebi.ac.uk/QuickGO/annotations?protein=P23458&geneProductId=UniProtKB:P23458

determination method

interferon-gamma-mediated signaling pathway

determination method

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P23458

determination method

response to antibiotic

determination method

1 reference

8 April 2019

The heat shock protein 90-CDC37 chaperone complex is required for signaling by types I and II interferons

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P23458

determination method

determination method

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P23458

determination method

positive regulation of sprouting angiogenesis

determination method

1 reference

8 April 2019

Members of the microRNA-17-92 cluster exhibit a cell-intrinsic antiangiogenic function in endothelial cells

British Heart Foundation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P23458

determination method

regulation of type I interferon-mediated signaling pathway

determination method

1 reference

31 October 2017

http://www.ebi.ac.uk/QuickGO/annotations?protein=P23458&geneProductId=UniProtKB:P23458

determination method

regulation of interferon-gamma-mediated signaling pathway

determination method

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P23458

determination method

regulation of cell population proliferation

determination method

1 reference

31 October 2017

http://www.ebi.ac.uk/QuickGO/annotations?protein=P23458&geneProductId=UniProtKB:P23458

determination method

type I interferon signaling pathway

determination method

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P23458

determination method

interleukin-2-mediated signaling pathway

determination method

1 reference

31 October 2017

The T cell protein tyrosine phosphatase is a negative regulator of janus family kinases 1 and 3

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?protein=P23458&geneProductId=UniProtKB:P23458

determination method

peptidyl-tyrosine autophosphorylation

determination method

1 reference

31 October 2017

http://www.ebi.ac.uk/QuickGO/annotations?protein=P23458&geneProductId=UniProtKB:P23458

determination method

protein autophosphorylation

determination method

1 reference

31 October 2017

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?protein=P23458&geneProductId=UniProtKB:P23458

determination method

determination method

1 reference

31 October 2017

http://www.ebi.ac.uk/QuickGO/annotations?protein=P23458&geneProductId=UniProtKB:P23458

determination method

innate immune response

determination method

1 reference

31 October 2017

http://www.ebi.ac.uk/QuickGO/annotations?protein=P23458&geneProductId=UniProtKB:P23458

determination method

interleukin-12-mediated signaling pathway

determination method

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P23458

determination method

interleukin-7-mediated signaling pathway

determination method

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P23458

determination method

interleukin-15-mediated signaling pathway

determination method

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P23458

determination method

interleukin-9-mediated signaling pathway

determination method

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P23458

determination method

regulation of molecular function

determination method

1 reference

31 October 2017

Gene Ontology Consortium

http://www.ebi.ac.uk/QuickGO/annotations?protein=P23458&geneProductId=UniProtKB:P23458

determination method

peptidyl-tyrosine phosphorylation

determination method

1 reference

8 April 2019

Gene Ontology Consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P23458

determination method

interleukin-21-mediated signaling pathway

determination method

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P23458

determination method

interleukin-6-mediated signaling pathway

determination method

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P23458

determination method

interleukin-27-mediated signaling pathway

determination method

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P23458

determination method

interleukin-35-mediated signaling pathway

determination method

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P23458

determination method

physically interacts with

1 reference

ClinicalTrials.gov ID

enzyme inhibitor

1 reference

IUPHAR/BPS Guide to PHARMACOLOGY

Guide to Pharmacology Ligand ID

language of work or name

17 August 2016

enzyme inhibitor

1 reference

IUPHAR/BPS Guide to PHARMACOLOGY

Guide to Pharmacology Ligand ID

language of work or name

17 August 2016

enzyme inhibitor

1 reference

IUPHAR/BPS Guide to PHARMACOLOGY

Guide to Pharmacology Ligand ID

language of work or name

17 August 2016

enzyme inhibitor

1 reference

IUPHAR/BPS Guide to PHARMACOLOGY

Guide to Pharmacology Ligand ID

language of work or name

17 August 2016

object has role

reaction inhibitor

1 reference

Open Targets Platform

14 August 2023

https://platform.opentargets.org/drug/CHEMBL3301607

object has role

reaction inhibitor

1 reference

Open Targets Platform

14 August 2023

https://platform.opentargets.org/drug/CHEMBL1078178

object has role

reaction inhibitor

1 reference

Open Targets Platform

14 August 2023

https://platform.opentargets.org/drug/CHEMBL3622821

object has role

reaction inhibitor

1 reference

Open Targets Platform

14 August 2023

https://platform.opentargets.org/drug/CHEMBL3137308

Gene Atlas image

PBB GE JAK1 201648 at fs.png
732 × 530; 11 KB

0 references

tyrosine-protein kinase, active site

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/P23458

protein kinase, ATP binding site

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/P23458

protein kinase domain

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/P23458

tyrosine-protein kinase, catalytic domain

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/P23458

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/P23458

serine-threonine/tyrosine-protein kinase, catalytic domain

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/P23458

Band 4.1 domain

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/P23458

FERM central domain

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/P23458

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/P23458

Identifiers

MeSH descriptor ID

subject named as

Janus Kinase 1

0 references

D12.776.476.393.100

0 references

D08.811.913.696.620.682.725.124.100

0 references

RefSeq protein ID

1 reference

16 November 2018

1 reference

16 November 2018

1 reference

16 November 2018

1 reference

16 November 2018

1 reference

16 November 2018

1 reference

16 November 2018

1 reference

16 November 2018

1 reference

16 November 2018

UniProt protein ID

1 reference

16 January 2019

UniProt protein ID

Ensembl protein ID

ENSP00000343204

1 reference

ensembl Release 96

Ensembl protein ID

ENSP00000343204

PDB structure ID

1 reference

UniProt protein ID

9 August 2016

language of work or name

1 reference

UniProt protein ID

9 August 2016

language of work or name

1 reference

UniProt protein ID

9 August 2016

language of work or name

1 reference

UniProt protein ID

9 August 2016

language of work or name

1 reference

UniProt protein ID

9 August 2016

language of work or name

1 reference

UniProt protein ID

9 August 2016

language of work or name

1 reference

UniProt protein ID

9 August 2016

language of work or name

1 reference

UniProt protein ID

9 August 2016

language of work or name

1 reference

UniProt protein ID

9 August 2016

language of work or name

1 reference

UniProt protein ID

9 August 2016

language of work or name

1 reference

UniProt protein ID

9 August 2016

language of work or name

1 reference

UniProt protein ID

9 August 2016

language of work or name

1 reference

UniProt protein ID

9 August 2016

language of work or name

1 reference

UniProt protein ID

9 August 2016

language of work or name

1 reference

UniProt protein ID

9 August 2016

language of work or name

1 reference

UniProt protein ID

9 August 2016

language of work or name

1 reference

UniProt protein ID

9 August 2016

language of work or name

1 reference

UniProt protein ID

9 August 2016

language of work or name

1 reference

UniProt protein ID

9 August 2016

language of work or name

1 reference

UniProt protein ID

9 August 2016

language of work or name

1 reference

based on heuristic

inferred by common MeSH mappings on source and on Wikidata

25 May 2023

Sitelinks

Wikipedia(0 entries)

Wikibooks(0 entries)

Wikinews(0 entries)

Wikiquote(0 entries)

Wikisource(0 entries)

Wikiversity(0 entries)

Wikivoyage(0 entries)

Wiktionary(0 entries)

Multilingual sites(0 entries)

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