(Q699996)

Cystine-knot cytokine

1 reference

Transforming growth factor-beta, C-terminal domain, protein family

1 reference

based on heuristic

inferred from protein domain or family

TGF-beta, propeptide family

1 reference

based on heuristic

inferred from protein domain or family

Transforming growth factor beta, conserved site, protein family

1 reference

based on heuristic

inferred from protein domain or family

1 reference

13 November 2019

1 reference

13 November 2019

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P18075

transforming growth factor beta receptor binding

1 reference

8 April 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P18075

1 reference

8 April 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P18075

3 references

8 April 2019

Targeting of bone morphogenetic protein growth factor complexes to fibrillin

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P18075

8 April 2019

Bone morphogenetic proteins signal through the transforming growth factor-beta type III receptor

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P18075

8 April 2019

Endoglin is an accessory protein that interacts with the signaling receptor complex of multiple members of the transforming growth factor-beta superfamily

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P18075

1 reference

27 March 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=P18075&geneProductId=UniProtKB:P18075

3 references

27 March 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=P18075&geneProductId=UniProtKB:P18075

27 March 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=P18075&geneProductId=UniProtKB:P18075

27 March 2018

Expression and characterization of a human BMP-7 variant with improved biochemical properties

http://www.ebi.ac.uk/QuickGO/annotations?protein=P18075&geneProductId=UniProtKB:P18075

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P18075

4 references

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P18075

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P18075

8 April 2019

Expression and characterization of a human BMP-7 variant with improved biochemical properties

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P18075

8 April 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P18075

collagen-containing extracellular matrix

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P18075

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P18075

pattern specification process

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P18075

skeletal system development

1 reference

8 April 2019

OP-1 cDNA encodes an osteogenic protein in the TGF-beta family

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P18075

embryonic pattern specification

TAS

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P18075

anatomical structure formation involved in morphogenesis

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P18075

negative regulation of cell cycle

1 reference

8 April 2019

Altered growth responses of pulmonary artery smooth muscle cells from patients with primary pulmonary hypertension to transforming growth factor-beta(1) and bone morphogenetic proteins

HUGO Gene Nomenclature Committee

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P18075

Involvement of FGF and BMP family proteins and VEGF in early human kidney development

mesonephros development

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P18075

odontogenesis of dentin-containing tooth

IEP

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P18075

mesenchymal cell differentiation

1 reference

8 April 2019

Regulation of BMP7 expression during kidney development

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P18075

negative regulation of mitotic nuclear division

1 reference

8 April 2019

Antagonistic effects of bone morphogenetic protein-4 and -7 on renal mesangial cell proliferation induced by aldosterone through MAPK activation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P18075

animal organ morphogenesis

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P18075

metanephric mesenchyme morphogenesis

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P18075

Involvement of FGF and BMP family proteins and VEGF in early human kidney development

metanephros development

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P18075

cellular response to hypoxia

IEP

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P18075

regulation of pathway-restricted SMAD protein phosphorylation

1 reference

8 April 2019

Identification of receptors and signaling pathways for orphan bone morphogenetic protein/growth differentiation factor ligands based on genomic analyses

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P18075

regulation of removal of superoxide radicals

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P18075

steroid hormone mediated signaling pathway

1 reference

8 April 2019

Antagonistic effects of bone morphogenetic protein-4 and -7 on renal mesangial cell proliferation induced by aldosterone through MAPK activation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P18075

negative regulation of Notch signaling pathway

IMP

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P18075

negative regulation of cell population proliferation

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P18075

branching involved in salivary gland morphogenesis

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P18075

regulation of apoptotic process

1 reference

8 April 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P18075

SMAD protein signal transduction

1 reference

27 March 2018

Antagonistic effects of bone morphogenetic protein-4 and -7 on renal mesangial cell proliferation induced by aldosterone through MAPK activation

http://www.ebi.ac.uk/QuickGO/annotations?protein=P18075&geneProductId=UniProtKB:P18075

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P18075

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P18075

negative regulation of cell death

1 reference

8 April 2019

Evidence that bone morphogenetic protein 4 has multiple biological functions during kidney and urinary tract development

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P18075

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P18075

positive regulation of transcription, DNA-templated

3 references

8 April 2019

BMP-7 modulates hyaluronan-mediated proximal tubular cell-monocyte interaction

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P18075

8 April 2019

Myostatin Signals through a Transforming Growth Factor β-Like Signaling Pathway To Block Adipogenesis

HUGO Gene Nomenclature Committee

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P18075

8 April 2019

Identification of receptors and signaling pathways for orphan bone morphogenetic protein/growth differentiation factor ligands based on genomic analyses

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P18075

negative regulation of prostatic bud formation

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P18075

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P18075

cartilage development

1 reference

8 April 2019

embryonic limb morphogenesis

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P18075

negative regulation of MAP kinase activity

1 reference

8 April 2019

Antagonistic effects of bone morphogenetic protein-4 and -7 on renal mesangial cell proliferation induced by aldosterone through MAPK activation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P18075

embryonic camera-type eye morphogenesis

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P18075

positive regulation of neuron differentiation

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P18075

positive regulation of cell differentiation

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P18075

negative regulation of phosphorylation

1 reference

8 April 2019

Antagonistic effects of bone morphogenetic protein-4 and -7 on renal mesangial cell proliferation induced by aldosterone through MAPK activation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P18075

regulation of branching involved in prostate gland morphogenesis

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P18075

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P18075

nephrogenic mesenchyme morphogenesis

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P18075

positive regulation of heterotypic cell-cell adhesion

1 reference

8 April 2019

BMP-7 modulates hyaluronan-mediated proximal tubular cell-monocyte interaction

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P18075

epithelial cell differentiation

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P18075

response to vitamin D

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P18075

positive regulation of hyaluranon cable assembly

1 reference

8 April 2019

BMP-7 modulates hyaluronan-mediated proximal tubular cell-monocyte interaction

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P18075

positive regulation of bone mineralization

1 reference

8 April 2019

BMP-2/4 and BMP-6/7 differentially utilize cell surface receptors to induce osteoblastic differentiation of human bone marrow-derived mesenchymal stem cells

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P18075

1 reference

8 April 2019

Bone morphogenetic protein-5 (BMP-5) promotes dendritic growth in cultured sympathetic neurons

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P18075

negative regulation of neurogenesis

TAS

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P18075

regulation of phosphorylation

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P18075

Hemojuvelin regulates hepcidin expression via a selective subset of BMP ligands and receptors independently of neogenin

BMP signaling pathway

4 references

27 March 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=P18075&geneProductId=UniProtKB:P18075

27 March 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=P18075&geneProductId=UniProtKB:P18075

27 March 2018

Identification of receptors and signaling pathways for orphan bone morphogenetic protein/growth differentiation factor ligands based on genomic analyses

http://www.ebi.ac.uk/QuickGO/annotations?protein=P18075&geneProductId=UniProtKB:P18075

27 March 2018

BMP-2/4 and BMP-6/7 differentially utilize cell surface receptors to induce osteoblastic differentiation of human bone marrow-derived mesenchymal stem cells

http://www.ebi.ac.uk/QuickGO/annotations?protein=P18075&geneProductId=UniProtKB:P18075

positive regulation of osteoblast differentiation

1 reference

8 April 2019

BMP-2/4 and BMP-6/7 differentially utilize cell surface receptors to induce osteoblastic differentiation of human bone marrow-derived mesenchymal stem cells

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P18075

epithelial to mesenchymal transition

1 reference

8 April 2019

Epithelial-mesenchymal transition and its implications for fibrosis

HUGO Gene Nomenclature Committee

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P18075

negative regulation of transcription, DNA-templated

TAS

negative regulation of NF-kappaB transcription factor activity

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P18075

branching morphogenesis of an epithelial tube

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P18075

negative regulation of mesenchymal cell apoptotic process involved in nephron morphogenesis

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P18075

negative regulation of glomerular mesangial cell proliferation

1 reference

8 April 2019

Antagonistic effects of bone morphogenetic protein-4 and -7 on renal mesangial cell proliferation induced by aldosterone through MAPK activation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P18075

response to estradiol

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P18075

1 reference

8 April 2019

BMP-7 modulates hyaluronan-mediated proximal tubular cell-monocyte interaction

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P18075

metanephric mesenchymal cell proliferation involved in metanephros development

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P18075

positive regulation of cell death

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P18075

1 reference

27 March 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=P18075&geneProductId=UniProtKB:P18075

negative regulation of striated muscle cell apoptotic process

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P18075

positive regulation of pathway-restricted SMAD protein phosphorylation

5 references

27 March 2018

Bone morphogenetic protein-5 (BMP-5) promotes dendritic growth in cultured sympathetic neurons

http://www.ebi.ac.uk/QuickGO/annotations?protein=P18075&geneProductId=UniProtKB:P18075

27 March 2018

Antagonistic effects of bone morphogenetic protein-4 and -7 on renal mesangial cell proliferation induced by aldosterone through MAPK activation

http://www.ebi.ac.uk/QuickGO/annotations?protein=P18075&geneProductId=UniProtKB:P18075

27 March 2018

TGF-beta receptor-mediated signalling through Smad2, Smad3 and Smad4

http://www.ebi.ac.uk/QuickGO/annotations?protein=P18075&geneProductId=UniProtKB:P18075

27 March 2018

Identification of receptors and signaling pathways for orphan bone morphogenetic protein/growth differentiation factor ligands based on genomic analyses

http://www.ebi.ac.uk/QuickGO/annotations?protein=P18075&geneProductId=UniProtKB:P18075

27 March 2018

Endoglin phosphorylation by ALK2 contributes to the regulation of prostate cancer cell migration

http://www.ebi.ac.uk/QuickGO/annotations?protein=P18075&geneProductId=UniProtKB:P18075

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P18075

response to peptide hormone

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P18075

cellular response to BMP stimulus

1 reference

8 April 2019

Hemojuvelin regulates hepcidin expression via a selective subset of BMP ligands and receptors independently of neogenin

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P18075

positive regulation of dendrite development

IMP

1 reference

8 April 2019

Bone morphogenetic protein-5 (BMP-5) promotes dendritic growth in cultured sympathetic neurons

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P18075

salivary gland morphogenesis

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P18075

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P18075

multicellular organism development

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P18075

positive regulation of peptidyl-threonine phosphorylation

1 reference

8 April 2019

Endoglin phosphorylation by ALK2 contributes to the regulation of prostate cancer cell migration

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P18075

positive regulation of apoptotic process

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P18075

protein localization to nucleus

1 reference

8 April 2019

Antagonistic effects of bone morphogenetic protein-4 and -7 on renal mesangial cell proliferation induced by aldosterone through MAPK activation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P18075

embryonic skeletal joint morphogenesis

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P18075

camera-type eye morphogenesis

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P18075

positive regulation of transcription by RNA polymerase II

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P18075

positive regulation of epithelial to mesenchymal transition

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P18075

positive regulation of cardiac neural crest cell migration involved in outflow tract morphogenesis

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P18075

regulation of signaling receptor activity

1 reference

8 April 2019

Gene Ontology Consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P18075

positive regulation of gene expression

1 reference

8 April 2019

Bone morphogenetic protein 4 regulates microRNAs miR-494 and miR-126-5p in control of endothelial cell function in angiogenesis

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P18075

negative regulation of NIK/NF-kappaB signaling

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P18075

positive regulation of pathway-restricted SMAD protein phosphorylation

6 references

8 April 2019

Bone morphogenetic protein-5 (BMP-5) promotes dendritic growth in cultured sympathetic neurons

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P18075

8 April 2019

Antagonistic effects of bone morphogenetic protein-4 and -7 on renal mesangial cell proliferation induced by aldosterone through MAPK activation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P18075

8 April 2019

TGF-beta receptor-mediated signalling through Smad2, Smad3 and Smad4

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P18075

8 April 2019

Identification of receptors and signaling pathways for orphan bone morphogenetic protein/growth differentiation factor ligands based on genomic analyses

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P18075

8 April 2019

Endoglin phosphorylation by ALK2 contributes to the regulation of prostate cancer cell migration

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P18075

8 April 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P18075

Hemojuvelin regulates hepcidin expression via a selective subset of BMP ligands and receptors independently of neogenin

BMP signaling pathway

5 references

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P18075

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P18075

8 April 2019

Identification of receptors and signaling pathways for orphan bone morphogenetic protein/growth differentiation factor ligands based on genomic analyses

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P18075

8 April 2019

BMP-2/4 and BMP-6/7 differentially utilize cell surface receptors to induce osteoblastic differentiation of human bone marrow-derived mesenchymal stem cells

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P18075

8 April 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P18075

regulation of MAPK cascade

1 reference

8 April 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P18075

SMAD protein signal transduction

http://purl.uniprot.org/uniprot/P18075

1 reference

Transforming growth factor-beta, C-terminal

Identifiers.org

has part(s)

1 reference

TGF-beta, propeptide

1 reference

Transforming growth factor beta, conserved site

1 reference

Identifiers

1 reference

30 May 2020

1 reference

13 November 2019

1 reference

1 reference

1 reference

1 reference

1 reference

28 October 2013

1 reference

4 August 2016

1 reference

4 August 2016

1 reference

4 August 2016

1 reference

4 August 2016