Wikidata

(Q7660502)

English

spleen associated tyrosine kinase

mammalian protein found in Homo sapiens

  • SYK
  • tyrosine-protein kinase SYK
  • spleen tyrosine kinase
  • p72-Syk
  • syk kinase
In more languages

Statements

molecular function
protein binding
determination method
IPI
28 references
retrieved
9 May 2019
stated in
The protein-tyrosine kinase Syk interacts with the C-terminal region of tensin2
GOA
curator
UniProt
UniProt protein ID
P43405
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P43405
determination method
IPI
retrieved
9 May 2019
stated in
Coordinate interactions of Csk, Src, and Syk kinases with [alpha]IIb[beta]3 initiate integrin signaling to the cytoskeleton
GOA
curator
UniProt
UniProt protein ID
P43405
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P43405
determination method
IPI
retrieved
9 May 2019
stated in
A novel interaction between FlnA and Syk regulates platelet ITAM-mediated receptor signaling and function
GOA
curator
UniProt
UniProt protein ID
P43405
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P43405
determination method
IPI
retrieved
9 May 2019
stated in
Germinal centre protein HGAL promotes lymphoid hyperplasia and amyloidosis via BCR-mediated Syk activation
GOA
curator
UniProt
UniProt protein ID
P43405
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P43405
determination method
IPI
retrieved
9 May 2019
stated in
FCRL3, an autoimmune susceptibility gene, has inhibitory potential on B-cell receptor-mediated signaling.
GOA
curator
UniProt
UniProt protein ID
P43405
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P43405
determination method
IPI
retrieved
9 May 2019
stated in
A novel histidine tyrosine phosphatase, TULA-2, associates with Syk and negatively regulates GPVI signaling in platelets
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P43405
determination method
IPI
retrieved
9 May 2019
stated in
ABL2 suppresses FLT3-ITD-induced cell proliferation through negative regulation of AKT signaling.
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P43405
determination method
IPI
retrieved
9 May 2019
stated in
A quantitative protein interaction network for the ErbB receptors using protein microarrays
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P43405
determination method
IPI
retrieved
9 May 2019
stated in
A proteome-scale map of the human interactome network
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P43405
determination method
IPI
retrieved
9 May 2019
stated in
Next-generation sequencing to generate interactome datasets
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P43405
determination method
IPI
retrieved
9 May 2019
stated in
Identification of the site in the Syk protein tyrosine kinase that binds the SH2 domain of Lck
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P43405
determination method
IPI
retrieved
9 May 2019
stated in
CD22 associates with protein tyrosine phosphatase 1C, Syk, and phospholipase C-gamma(1) upon B cell activation
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P43405
determination method
IPI
retrieved
9 May 2019
stated in
SYK is a critical regulator of FLT3 in acute myeloid leukemia
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P43405
determination method
IPI
retrieved
9 May 2019
stated in
Syk is involved in NLRP3 inflammasome-mediated caspase-1 activation through adaptor ASC phosphorylation and enhanced oligomerization
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P43405
determination method
IPI
retrieved
9 May 2019
stated in
Phospholipase C-gamma1 interacts with conserved phosphotyrosyl residues in the linker region of Syk and is a substrate for Syk
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P43405
determination method
IPI
retrieved
9 May 2019
stated in
Tetraspanin CD37 directly mediates transduction of survival and apoptotic signals
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P43405
determination method
IPI
retrieved
9 May 2019
stated in
Phospho-tyrosine dependent protein-protein interaction network
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P43405
determination method
IPI
retrieved
9 May 2019
stated in
Involvement of p72syk kinase, p53/56lyn kinase and phosphatidyl inositol-3 kinase in signal transduction via the human B lymphocyte antigen CD22
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P43405
determination method
IPI
retrieved
9 May 2019
stated in
Glycoprotein VI is the collagen receptor in platelets which underlies tyrosine phosphorylation of the Fc receptor gamma-chain
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P43405
determination method
IPI
retrieved
9 May 2019
stated in
Structural basis for a novel intrapeptidyl H-bond and reverse binding of c-Cbl-TKB domain substrates
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P43405
determination method
IPI
retrieved
9 May 2019
stated in
Structural basis for Syk tyrosine kinase ubiquity in signal transduction pathways revealed by the crystal structure of its regulatory SH2 domains bound to a dually phosphorylated ITAM peptide
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P43405
determination method
IPI
retrieved
9 May 2019
stated in
Interaction of phosphorylated FcepsilonRIgamma immunoglobulin receptor tyrosine activation motif-based peptides with dual and single SH2 domains of p72syk. Assessment of binding parameters and real time binding kinetics
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P43405
determination method
IPI
retrieved
9 May 2019
stated in
Analysis of the interaction of ZAP-70 and syk protein-tyrosine kinases with the T-cell antigen receptor by plasmon resonance
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P43405
determination method
IPI
retrieved
9 May 2019
stated in
STAT3 is a substrate of SYK tyrosine kinase in B-lineage leukemia/lymphoma cells exposed to oxidative stress
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P43405
determination method
IPI
retrieved
9 May 2019
stated in
Molecular basis for a direct interaction between the Syk protein-tyrosine kinase and phosphoinositide 3-kinase
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P43405
determination method
IPI
retrieved
9 May 2019
stated in
Enhanced prediction of Src homology 2 (SH2) domain binding potentials using a fluorescence polarization-derived c-Met, c-Kit, ErbB, and androgen receptor interactome
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P43405
determination method
IPI
retrieved
9 May 2019
stated in
Genome-wide YFP fluorescence complementation screen identifies new regulators for telomere signaling in human cells
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P43405
determination method
IPI
retrieved
9 May 2019
stated in
Interactions among HCLS1, HAX1 and LEF-1 proteins are essential for G-CSF-triggered granulopoiesis
GOA
curator
British Heart Foundation
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P43405
determination method
IPI
protein tyrosine kinase activity
determination method
EXP
IEA
TAS
10 references
retrieved
17 October 2017
stated in
GOA
curator
Reactome
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=P43405&geneProductId=UniProtKB:P43405
determination method
TAS
retrieved
17 October 2017
stated in
GOA
curator
UniProt
UniProt protein ID
P43405
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=P43405&geneProductId=UniProtKB:P43405
determination method
IEA
retrieved
17 October 2017
stated in
GOA
curator
InterPro
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=P43405&geneProductId=UniProtKB:P43405
determination method
IEA
retrieved
17 October 2017
stated in
GOA
curator
Ensembl genome database project
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=P43405&geneProductId=UniProtKB:P43405
determination method
IEA
retrieved
17 October 2017
stated in
Kit- and Fc epsilonRI-induced differential phosphorylation of the transmembrane adaptor molecule NTAL/LAB/LAT2 allows flexibility in its scaffolding function in mast cells
GOA
curator
Reactome
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=P43405&geneProductId=UniProtKB:P43405
determination method
EXP
retrieved
17 October 2017
stated in
Phospholipase C-gamma1 interacts with conserved phosphotyrosyl residues in the linker region of Syk and is a substrate for Syk
GOA
curator
Reactome
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=P43405&geneProductId=UniProtKB:P43405
determination method
EXP
retrieved
17 October 2017
stated in
Activation of BTK by a phosphorylation mechanism initiated by SRC family kinases
GOA
curator
Reactome
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=P43405&geneProductId=UniProtKB:P43405
determination method
EXP
retrieved
17 October 2017
stated in
Purification and characterization of human Syk produced using a baculovirus expression system
GOA
curator
Reactome
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=P43405&geneProductId=UniProtKB:P43405
determination method
EXP
retrieved
17 October 2017
stated in
Molecular mechanism of the Syk activation switch
GOA
curator
Reactome
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=P43405&geneProductId=UniProtKB:P43405
determination method
EXP
retrieved
17 October 2017
stated in
Phospholipase Cγ2 (PLCγ2) is key component in Dectin-2 signaling pathway, mediating anti-fungal innate immune responses
GOA
curator
Reactome
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=P43405&geneProductId=UniProtKB:P43405
determination method
EXP
protein tyrosine kinase activity
determination method
EXP
IEA
NAS
TAS
11 references
retrieved
9 May 2019
stated in
GOA
curator
Reactome
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P43405
determination method
TAS
retrieved
9 May 2019
stated in
Roles of tau protein in health and disease
GOA
curator
ARUK-UCL
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P43405
determination method
NAS
retrieved
9 May 2019
stated in
GOA
curator
UniProt
UniProt protein ID
P43405
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P43405
determination method
IEA
retrieved
9 May 2019
stated in
GOA
curator
InterPro
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P43405
determination method
IEA
retrieved
9 May 2019
stated in
GOA
curator
Ensembl genome database project
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P43405
determination method
IEA
retrieved
9 May 2019
stated in
Phospholipase Cγ2 (PLCγ2) is key component in Dectin-2 signaling pathway, mediating anti-fungal innate immune responses
GOA
curator
Reactome
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P43405
determination method
EXP
retrieved
9 May 2019
stated in
Activation of BTK by a phosphorylation mechanism initiated by SRC family kinases
GOA
curator
Reactome
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P43405
determination method
EXP
retrieved
9 May 2019
stated in
Phospholipase C-gamma1 interacts with conserved phosphotyrosyl residues in the linker region of Syk and is a substrate for Syk
GOA
curator
Reactome
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P43405
determination method
EXP
retrieved
9 May 2019
stated in
Kit- and Fc epsilonRI-induced differential phosphorylation of the transmembrane adaptor molecule NTAL/LAB/LAT2 allows flexibility in its scaffolding function in mast cells
GOA
curator
Reactome
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P43405
determination method
EXP
retrieved
9 May 2019
stated in
Molecular mechanism of the Syk activation switch
GOA
curator
Reactome
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P43405
determination method
EXP
retrieved
9 May 2019
stated in
Purification and characterization of human Syk produced using a baculovirus expression system
GOA
curator
Reactome
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P43405
determination method
EXP
cell component
biological process
Gene Atlas image
PBB GE SYK 209269 s at fs.png
732 × 530; 11 KB
0 references

Identifiers

Freebase ID
/m/026n9cb
0 references
PDB structure ID
 
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