Wikidata

(Q7670160)

English

transforming growth factor beta receptor 1

mammalian protein found in Homo sapiens

  • TGFBR1
  • TGF-beta receptor type-1
  • activin A receptor type II-like protein kinase of 53kD
  • ALK-5
  • serine/threonine-protein kinase receptor R4
  • TbetaR-I
  • transforming growth factor beta receptor I
  • SKR4
  • TGF-beta type I receptor
  • activin receptor-like kinase 5
  • mutant transforming growth factor beta receptor I
  • activin A receptor type II-like kinase, 53kDa
  • ALK5
  • TGF-beta receptor type I
  • transforming growth factor-beta receptor type I
  • Receptor, Transforming Growth Factor-beta Type I
In more languages

Statements

molecular function
transforming growth factor beta-activated receptor activity
determination method
IC
IDA
IEA
IMP
6 references
retrieved
24 April 2018
stated in
Transforming growth factor beta engages TACE and ErbB3 to activate phosphatidylinositol-3 kinase/Akt in ErbB2-overexpressing breast cancer and desensitizes cells to trastuzumab
GOA
curator
British Heart Foundation
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=P36897&geneProductId=UniProtKB:P36897
determination method
IMP
retrieved
24 April 2018
stated in
TGF beta signals through a heteromeric protein kinase receptor complex
GOA
curator
British Heart Foundation
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=P36897&geneProductId=UniProtKB:P36897
determination method
IMP
retrieved
24 April 2018
stated in
GOA
curator
Ensembl genome database project
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=P36897&geneProductId=UniProtKB:P36897
determination method
IEA
retrieved
24 April 2018
stated in
SB-431542 and Gleevec inhibit transforming growth factor-beta-induced proliferation of human osteosarcoma cells
GOA
curator
HUGO Gene Nomenclature Committee
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=P36897&geneProductId=UniProtKB:P36897
determination method
IDA
retrieved
24 April 2018
stated in
Extracellular and cytoplasmic domains of endoglin interact with the transforming growth factor-beta receptors I and II
GOA
curator
British Heart Foundation
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=P36897&geneProductId=UniProtKB:P36897
determination method
IDA
retrieved
24 April 2018
stated in
Endoglin is a component of the transforming growth factor-beta receptor system in human endothelial cells
GOA
curator
British Heart Foundation
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=P36897&geneProductId=UniProtKB:P36897
determination method
IC
protein binding
determination method
IPI
22 references
retrieved
8 April 2019
stated in
Syntenin regulates TGF-β1-induced Smad activation and the epithelial-to-mesenchymal transition by inhibiting caveolin-mediated TGF-β type I receptor internalization
GOA
curator
UniProt
UniProt protein ID
P36897
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P36897
determination method
IPI
retrieved
8 April 2019
stated in
Potentiation of Smad-mediated transcriptional activation by the RNA-binding protein RBPMS
GOA
curator
UniProt
UniProt protein ID
P36897
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P36897
determination method
IPI
retrieved
8 April 2019
stated in
Regulation of the polarity protein Par6 by TGFbeta receptors controls epithelial cell plasticity
GOA
curator
UniProt
UniProt protein ID
P36897
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P36897
determination method
IPI
retrieved
8 April 2019
stated in
APPL proteins promote TGFβ-induced nuclear transport of the TGFβ type I receptor intracellular domain
GOA
curator
UniProt
UniProt protein ID
P36897
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P36897
determination method
IPI
retrieved
8 April 2019
stated in
USP15 stabilizes TGF-β receptor I and promotes oncogenesis through the activation of TGF-β signaling in glioblastoma
GOA
curator
UniProt
UniProt protein ID
P36897
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P36897
determination method
IPI
retrieved
8 April 2019
stated in
Transforming growth factor-beta receptor-associated protein 1 is a Smad4 chaperone
GOA
curator
UniProt
UniProt protein ID
P36897
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P36897
determination method
IPI
retrieved
8 April 2019
stated in
The type I TGF-beta receptor engages TRAF6 to activate TAK1 in a receptor kinase-independent manner
GOA
curator
UniProt
UniProt protein ID
P36897
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P36897
determination method
IPI
retrieved
8 April 2019
stated in
HCV NS3 protease enhances liver fibrosis via binding to and activating TGF-β type I receptor
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P36897
determination method
IPI
retrieved
8 April 2019
stated in
Critical role of endoglin in tumor cell plasticity of Ewing sarcoma and melanoma
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P36897
determination method
IPI
retrieved
8 April 2019
stated in
Crystal structure of the cytoplasmic domain of the type I TGF beta receptor in complex with FKBP12
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P36897
determination method
IPI
retrieved
8 April 2019
stated in
The mammalian-membrane two-hybrid assay (MaMTH) for probing membrane-protein interactions in human cells
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P36897
determination method
IPI
retrieved
8 April 2019
stated in
14-3-3zeta Cooperates with ErbB2 to promote ductal carcinoma in situ progression to invasive breast cancer by inducing epithelial-mesenchymal transition
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P36897
determination method
IPI
retrieved
8 April 2019
stated in
Interaction and functional interplay between endoglin and ALK-1, two components of the endothelial transforming growth factor-beta receptor complex
GOA
curator
HUGO Gene Nomenclature Committee
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P36897
determination method
IPI
retrieved
8 April 2019
stated in
Activation of signalling by the activin receptor complex
GOA
curator
HUGO Gene Nomenclature Committee
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P36897
determination method
IPI
retrieved
8 April 2019
stated in
Sorting nexin 6, a novel SNX, interacts with the transforming growth factor-beta family of receptor serine-threonine kinases
GOA
curator
HUGO Gene Nomenclature Committee
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P36897
determination method
IPI
retrieved
8 April 2019
stated in
Activin receptor-like kinase (ALK)1 is an antagonistic mediator of lateral TGFbeta/ALK5 signaling
GOA
curator
HUGO Gene Nomenclature Committee
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P36897
determination method
IPI
retrieved
8 April 2019
stated in
Myostatin Signals through a Transforming Growth Factor β-Like Signaling Pathway To Block Adipogenesis
GOA
curator
British Heart Foundation
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P36897
determination method
IPI
retrieved
8 April 2019
stated in
Transforming growth factor beta engages TACE and ErbB3 to activate phosphatidylinositol-3 kinase/Akt in ErbB2-overexpressing breast cancer and desensitizes cells to trastuzumab
GOA
curator
British Heart Foundation
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P36897
determination method
IPI
retrieved
8 April 2019
stated in
S-endoglin expression is induced in senescent endothelial cells and contributes to vascular pathology
GOA
curator
British Heart Foundation
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P36897
determination method
IPI
retrieved
8 April 2019
stated in
Cooperative assembly of TGF-beta superfamily signaling complexes is mediated by two disparate mechanisms and distinct modes of receptor binding
GOA
curator
British Heart Foundation
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P36897
determination method
IPI
retrieved
8 April 2019
stated in
Extracellular and cytoplasmic domains of endoglin interact with the transforming growth factor-beta receptors I and II
GOA
curator
British Heart Foundation
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P36897
determination method
IPI
retrieved
8 April 2019
stated in
HCV NS3 protease enhances liver fibrosis via binding to and activating TGF-β type I receptor
GOA
curator
AgBase
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P36897
determination method
IPI
SMAD binding
determination method
IDA
IEA
IPI
5 references
retrieved
24 April 2018
stated in
TGF-beta receptor-mediated signalling through Smad2, Smad3 and Smad4
GOA
curator
British Heart Foundation
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=P36897&geneProductId=UniProtKB:P36897
determination method
IPI
retrieved
24 April 2018
stated in
MADR2 is a substrate of the TGFbeta receptor and its phosphorylation is required for nuclear accumulation and signaling
GOA
curator
British Heart Foundation
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=P36897&geneProductId=UniProtKB:P36897
determination method
IPI
retrieved
24 April 2018
stated in
GOA
curator
Ensembl genome database project
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=P36897&geneProductId=UniProtKB:P36897
determination method
IEA
retrieved
24 April 2018
stated in
SB-431542 is a potent and specific inhibitor of transforming growth factor-beta superfamily type I activin receptor-like kinase (ALK) receptors ALK4, ALK5, and ALK7
GOA
curator
HUGO Gene Nomenclature Committee
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=P36897&geneProductId=UniProtKB:P36897
determination method
IDA
retrieved
24 April 2018
stated in
Transforming growth factor beta engages TACE and ErbB3 to activate phosphatidylinositol-3 kinase/Akt in ErbB2-overexpressing breast cancer and desensitizes cells to trastuzumab
GOA
curator
British Heart Foundation
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=P36897&geneProductId=UniProtKB:P36897
determination method
IDA
transforming growth factor beta binding
determination method
IDA
ISS
IEA
IMP
IPI
6 references
retrieved
24 April 2018
stated in
GOA
curator
AgBase
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=P36897&geneProductId=UniProtKB:P36897
determination method
ISS
retrieved
24 April 2018
stated in
Endoglin is a component of the transforming growth factor-beta receptor system in human endothelial cells
GOA
curator
British Heart Foundation
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=P36897&geneProductId=UniProtKB:P36897
determination method
IPI
retrieved
24 April 2018
stated in
TGF beta signals through a heteromeric protein kinase receptor complex
GOA
curator
British Heart Foundation
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=P36897&geneProductId=UniProtKB:P36897
determination method
IMP
retrieved
24 April 2018
stated in
GOA
curator
Ensembl genome database project
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=P36897&geneProductId=UniProtKB:P36897
determination method
IEA
retrieved
24 April 2018
stated in
SB-431542 and Gleevec inhibit transforming growth factor-beta-induced proliferation of human osteosarcoma cells
GOA
curator
HUGO Gene Nomenclature Committee
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=P36897&geneProductId=UniProtKB:P36897
determination method
IDA
retrieved
24 April 2018
stated in
Type III TGF-beta receptor-independent signalling of TGF-beta2 via TbetaRII-B, an alternatively spliced TGF-beta type II receptor
GOA
curator
British Heart Foundation
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=P36897&geneProductId=UniProtKB:P36897
determination method
IDA
transforming growth factor beta-activated receptor activity
determination method
IBA
IC
IDA
IEA
IMP
7 references
retrieved
8 April 2019
stated in
Transforming growth factor beta engages TACE and ErbB3 to activate phosphatidylinositol-3 kinase/Akt in ErbB2-overexpressing breast cancer and desensitizes cells to trastuzumab
GOA
curator
British Heart Foundation
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P36897
determination method
IMP
retrieved
8 April 2019
stated in
TGF beta signals through a heteromeric protein kinase receptor complex
GOA
curator
British Heart Foundation
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P36897
determination method
IMP
retrieved
8 April 2019
stated in
GOA
curator
Ensembl genome database project
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P36897
determination method
IEA
retrieved
8 April 2019
stated in
SB-431542 and Gleevec inhibit transforming growth factor-beta-induced proliferation of human osteosarcoma cells
GOA
curator
HUGO Gene Nomenclature Committee
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P36897
determination method
IDA
retrieved
8 April 2019
stated in
Extracellular and cytoplasmic domains of endoglin interact with the transforming growth factor-beta receptors I and II
GOA
curator
British Heart Foundation
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P36897
determination method
IDA
retrieved
8 April 2019
stated in
Endoglin is a component of the transforming growth factor-beta receptor system in human endothelial cells
GOA
curator
British Heart Foundation
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P36897
determination method
IC
retrieved
8 April 2019
stated in
Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium
GOA
curator
GO Central
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P36897
determination method
IBA
SMAD binding
determination method
IBA
IDA
IEA
IPI
6 references
retrieved
8 April 2019
stated in
TGF-beta receptor-mediated signalling through Smad2, Smad3 and Smad4
GOA
curator
British Heart Foundation
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P36897
determination method
IPI
retrieved
8 April 2019
stated in
MADR2 is a substrate of the TGFbeta receptor and its phosphorylation is required for nuclear accumulation and signaling
GOA
curator
British Heart Foundation
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P36897
determination method
IPI
retrieved
8 April 2019
stated in
GOA
curator
Ensembl genome database project
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P36897
determination method
IEA
retrieved
8 April 2019
stated in
SB-431542 is a potent and specific inhibitor of transforming growth factor-beta superfamily type I activin receptor-like kinase (ALK) receptors ALK4, ALK5, and ALK7
GOA
curator
HUGO Gene Nomenclature Committee
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P36897
determination method
IDA
retrieved
8 April 2019
stated in
Transforming growth factor beta engages TACE and ErbB3 to activate phosphatidylinositol-3 kinase/Akt in ErbB2-overexpressing breast cancer and desensitizes cells to trastuzumab
GOA
curator
British Heart Foundation
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P36897
determination method
IDA
retrieved
8 April 2019
stated in
Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium
GOA
curator
GO Central
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P36897
determination method
IBA
cell component
biological process
transforming growth factor beta receptor signaling pathway
determination method
IC
ISS
IEA
IDA
IMP
TAS
8 references
retrieved
24 April 2018
stated in
GOA
curator
Reactome
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=P36897&geneProductId=UniProtKB:P36897
determination method
TAS
retrieved
24 April 2018
stated in
GOA
curator
British Heart Foundation
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=P36897&geneProductId=UniProtKB:P36897
determination method
ISS
retrieved
24 April 2018
stated in
GOA
curator
AgBase
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=P36897&geneProductId=UniProtKB:P36897
determination method
ISS
retrieved
24 April 2018
stated in
TGF beta signals through a heteromeric protein kinase receptor complex
GOA
curator
British Heart Foundation
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=P36897&geneProductId=UniProtKB:P36897
determination method
IMP
retrieved
24 April 2018
stated in
GOA
curator
Ensembl genome database project
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=P36897&geneProductId=UniProtKB:P36897
determination method
IEA
retrieved
24 April 2018
stated in
Dual role of the Smad4/DPC4 tumor suppressor in TGFbeta-inducible transcriptional complexes
GOA
curator
British Heart Foundation
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=P36897&geneProductId=UniProtKB:P36897
determination method
IDA
retrieved
24 April 2018
stated in
Type III TGF-beta receptor-independent signalling of TGF-beta2 via TbetaRII-B, an alternatively spliced TGF-beta type II receptor
GOA
curator
British Heart Foundation
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=P36897&geneProductId=UniProtKB:P36897
determination method
IDA
retrieved
24 April 2018
stated in
Endoglin is a component of the transforming growth factor-beta receptor system in human endothelial cells
GOA
curator
British Heart Foundation
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=P36897&geneProductId=UniProtKB:P36897
determination method
IC
transforming growth factor beta receptor signaling pathway
determination method
IBA
IC
IDA
IEA
IMP
ISS
TAS
8 references
retrieved
8 April 2019
stated in
GOA
curator
Reactome
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P36897
determination method
TAS
retrieved
8 April 2019
stated in
GOA
curator
British Heart Foundation
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P36897
determination method
ISS
retrieved
8 April 2019
stated in
TGF beta signals through a heteromeric protein kinase receptor complex
GOA
curator
British Heart Foundation
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P36897
determination method
IMP
retrieved
8 April 2019
stated in
GOA
curator
Ensembl genome database project
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P36897
determination method
IEA
retrieved
8 April 2019
stated in
Type III TGF-beta receptor-independent signalling of TGF-beta2 via TbetaRII-B, an alternatively spliced TGF-beta type II receptor
GOA
curator
British Heart Foundation
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P36897
determination method
IDA
retrieved
8 April 2019
stated in
Dual role of the Smad4/DPC4 tumor suppressor in TGFbeta-inducible transcriptional complexes
GOA
curator
British Heart Foundation
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P36897
determination method
IDA
retrieved
8 April 2019
stated in
Endoglin is a component of the transforming growth factor-beta receptor system in human endothelial cells
GOA
curator
British Heart Foundation
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P36897
determination method
IC
retrieved
8 April 2019
stated in
Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium
GOA
curator
GO Central
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P36897
determination method
IBA

Identifiers

MeSH descriptor ID
D000077293
subject named as
Receptor, Transforming Growth Factor-beta Type I
0 references
PDB structure ID
 
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