Wikidata

(Q7670161)

English

Transforming growth factor beta receptor 2

mammalian protein found in Homo sapiens

  • transforming growth factor, beta receptor II alpha
  • transforming growth factor, beta receptor II beta
  • transforming growth factor beta receptor II
  • transforming growth factor, beta receptor II epsilon
  • transforming growth factor beta receptor type IIC
  • TGF-beta receptor type II
  • tbetaR-II
  • TGF-beta receptor type IIB
  • TGF-beta receptor type-2
  • transforming growth factor, beta receptor II delta
  • transforming growth factor, beta receptor II gamma
  • transforming growth factor, beta receptor II (70/80kDa)
  • Transforming growth factor-beta receptor type II
  • TGF-beta type II receptor
  • TGFBR2
In more languages

Statements

molecular function
transforming growth factor beta-activated receptor activity
determination method
IC
IDA
IEA
IMP
5 references
retrieved
24 April 2018
stated in
TGF beta signals through a heteromeric protein kinase receptor complex
GOA
curator
British Heart Foundation
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=P37173&geneProductId=UniProtKB:P37173
determination method
IMP
retrieved
24 April 2018
stated in
GOA
curator
Ensembl genome database project
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=P37173&geneProductId=UniProtKB:P37173
determination method
IEA
retrieved
24 April 2018
stated in
The soluble exoplasmic domain of the type II transforming growth factor (TGF)-beta receptor. A heterogeneously glycosylated protein with high affinity and selectivity for TGF-beta ligands
GOA
curator
British Heart Foundation
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=P37173&geneProductId=UniProtKB:P37173
determination method
IDA
retrieved
24 April 2018
stated in
Activation of a TGF-beta-specific multistep gene expression program in mature macrophages requires glucocorticoid-mediated surface expression of TGF-beta receptor II
GOA
curator
British Heart Foundation
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=P37173&geneProductId=UniProtKB:P37173
determination method
IDA
retrieved
24 April 2018
stated in
Endoglin is a component of the transforming growth factor-beta receptor system in human endothelial cells
GOA
curator
British Heart Foundation
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=P37173&geneProductId=UniProtKB:P37173
determination method
IC
protein binding
determination method
IPI
20 references
retrieved
8 April 2019
stated in
Identification of human activin and TGF beta type I receptors that form heteromeric kinase complexes with type II receptors
GOA
curator
UniProt
UniProt protein ID
P37173
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P37173
determination method
IPI
retrieved
8 April 2019
stated in
SARA, a FYVE domain protein that recruits Smad2 to the TGFbeta receptor
GOA
curator
UniProt
UniProt protein ID
P37173
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P37173
determination method
IPI
retrieved
8 April 2019
stated in
Transforming growth factor-beta receptor-associated protein 1 is a Smad4 chaperone
GOA
curator
UniProt
UniProt protein ID
P37173
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P37173
determination method
IPI
retrieved
8 April 2019
stated in
Interaction of transforming growth factor beta receptors with apolipoprotein J/clusterin
GOA
curator
UniProt
UniProt protein ID
P37173
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P37173
determination method
IPI
retrieved
8 April 2019
stated in
SCUBE3 is an endogenous TGF-β receptor ligand and regulates the epithelial-mesenchymal transition in lung cancer
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P37173
determination method
IPI
retrieved
8 April 2019
stated in
TGF-β signalling is mediated by two autonomously functioning TβRI:TβRII pairs
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P37173
determination method
IPI
retrieved
8 April 2019
stated in
Critical role of endoglin in tumor cell plasticity of Ewing sarcoma and melanoma
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P37173
determination method
IPI
retrieved
8 April 2019
stated in
TGF-beta-induced apoptosis is mediated by the adapter protein Daxx that facilitates JNK activation
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P37173
determination method
IPI
retrieved
8 April 2019
stated in
Emilin1 links TGF-beta maturation to blood pressure homeostasis
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P37173
determination method
IPI
retrieved
8 April 2019
stated in
MED12 controls the response to multiple cancer drugs through regulation of TGF-β receptor signaling
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P37173
determination method
IPI
retrieved
8 April 2019
stated in
Crystal structure of the human TbetaR2 ectodomain--TGF-beta3 complex
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P37173
determination method
IPI
retrieved
8 April 2019
stated in
DIP2 disco-interacting protein 2 homolog A (Drosophila) is a candidate receptor for follistatin-related protein/follistatin-like 1--analysis of their binding with TGF-β superfamily proteins
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P37173
determination method
IPI
retrieved
8 April 2019
stated in
WFIKKN1 and WFIKKN2 bind growth factors TGFβ1, BMP2 and BMP4 but do not inhibit their signalling activity
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P37173
determination method
IPI
retrieved
8 April 2019
stated in
Interaction and functional interplay between endoglin and ALK-1, two components of the endothelial transforming growth factor-beta receptor complex
GOA
curator
HUGO Gene Nomenclature Committee
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P37173
determination method
IPI
retrieved
8 April 2019
stated in
Activation of signalling by the activin receptor complex
GOA
curator
HUGO Gene Nomenclature Committee
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P37173
determination method
IPI
retrieved
8 April 2019
stated in
Sorting nexin 6, a novel SNX, interacts with the transforming growth factor-beta family of receptor serine-threonine kinases
GOA
curator
HUGO Gene Nomenclature Committee
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P37173
determination method
IPI
retrieved
8 April 2019
stated in
Extracellular and cytoplasmic domains of endoglin interact with the transforming growth factor-beta receptors I and II
GOA
curator
British Heart Foundation
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P37173
determination method
IPI
retrieved
8 April 2019
stated in
Cooperative assembly of TGF-beta superfamily signaling complexes is mediated by two disparate mechanisms and distinct modes of receptor binding
GOA
curator
British Heart Foundation
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P37173
determination method
IPI
retrieved
8 April 2019
stated in
The soluble exoplasmic domain of the type II transforming growth factor (TGF)-beta receptor. A heterogeneously glycosylated protein with high affinity and selectivity for TGF-beta ligands
GOA
curator
British Heart Foundation
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P37173
determination method
IPI
retrieved
8 April 2019
stated in
HCV NS3 protease enhances liver fibrosis via binding to and activating TGF-β type I receptor
GOA
curator
AgBase
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P37173
determination method
IPI
transforming growth factor beta binding
determination method
IDA
IEA
IPI
7 references
retrieved
8 April 2019
stated in
Endoglin is a component of the transforming growth factor-beta receptor system in human endothelial cells
GOA
curator
British Heart Foundation
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P37173
determination method
IPI
retrieved
8 April 2019
stated in
TGF beta signals through a heteromeric protein kinase receptor complex
GOA
curator
British Heart Foundation
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P37173
determination method
IPI
retrieved
8 April 2019
stated in
The soluble exoplasmic domain of the type II transforming growth factor (TGF)-beta receptor. A heterogeneously glycosylated protein with high affinity and selectivity for TGF-beta ligands
GOA
curator
British Heart Foundation
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P37173
determination method
IPI
retrieved
8 April 2019
stated in
GOA
curator
Ensembl genome database project
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P37173
determination method
IEA
retrieved
8 April 2019
stated in
Cooperative assembly of TGF-beta superfamily signaling complexes is mediated by two disparate mechanisms and distinct modes of receptor binding
GOA
curator
British Heart Foundation
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P37173
determination method
IDA
retrieved
8 April 2019
stated in
Activation of a TGF-beta-specific multistep gene expression program in mature macrophages requires glucocorticoid-mediated surface expression of TGF-beta receptor II
GOA
curator
British Heart Foundation
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P37173
determination method
IDA
retrieved
8 April 2019
stated in
The soluble exoplasmic domain of the type II transforming growth factor (TGF)-beta receptor. A heterogeneously glycosylated protein with high affinity and selectivity for TGF-beta ligands
GOA
curator
British Heart Foundation
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P37173
determination method
IDA
transforming growth factor beta-activated receptor activity
determination method
IBA
IC
IDA
IEA
IMP
6 references
retrieved
8 April 2019
stated in
TGF beta signals through a heteromeric protein kinase receptor complex
GOA
curator
British Heart Foundation
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P37173
determination method
IMP
retrieved
8 April 2019
stated in
GOA
curator
Ensembl genome database project
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P37173
determination method
IEA
retrieved
8 April 2019
stated in
Activation of a TGF-beta-specific multistep gene expression program in mature macrophages requires glucocorticoid-mediated surface expression of TGF-beta receptor II
GOA
curator
British Heart Foundation
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P37173
determination method
IDA
retrieved
8 April 2019
stated in
The soluble exoplasmic domain of the type II transforming growth factor (TGF)-beta receptor. A heterogeneously glycosylated protein with high affinity and selectivity for TGF-beta ligands
GOA
curator
British Heart Foundation
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P37173
determination method
IDA
retrieved
8 April 2019
stated in
Endoglin is a component of the transforming growth factor-beta receptor system in human endothelial cells
GOA
curator
British Heart Foundation
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P37173
determination method
IC
retrieved
8 April 2019
stated in
Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium
GOA
curator
GO Central
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P37173
determination method
IBA
cell component
biological process
transforming growth factor beta receptor signaling pathway
determination method
IC
IDA
TAS
IMP
IEA
7 references
retrieved
24 April 2018
stated in
GOA
curator
Reactome
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=P37173&geneProductId=UniProtKB:P37173
determination method
TAS
retrieved
24 April 2018
stated in
TGF beta signals through a heteromeric protein kinase receptor complex
GOA
curator
British Heart Foundation
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=P37173&geneProductId=UniProtKB:P37173
determination method
IMP
retrieved
24 April 2018
stated in
Type III TGF-beta receptor-independent signalling of TGF-beta2 via TbetaRII-B, an alternatively spliced TGF-beta type II receptor
GOA
curator
British Heart Foundation
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=P37173&geneProductId=UniProtKB:P37173
determination method
IMP
retrieved
24 April 2018
stated in
GOA
curator
InterPro
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=P37173&geneProductId=UniProtKB:P37173
determination method
IEA
retrieved
24 April 2018
stated in
GOA
curator
Ensembl genome database project
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=P37173&geneProductId=UniProtKB:P37173
determination method
IEA
retrieved
24 April 2018
stated in
Activation of a TGF-beta-specific multistep gene expression program in mature macrophages requires glucocorticoid-mediated surface expression of TGF-beta receptor II
GOA
curator
British Heart Foundation
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=P37173&geneProductId=UniProtKB:P37173
determination method
IDA
retrieved
24 April 2018
stated in
Endoglin is a component of the transforming growth factor-beta receptor system in human endothelial cells
GOA
curator
British Heart Foundation
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=P37173&geneProductId=UniProtKB:P37173
determination method
IC
transforming growth factor beta receptor signaling pathway
determination method
IBA
IC
IDA
IEA
IMP
TAS
7 references
retrieved
8 April 2019
stated in
GOA
curator
Reactome
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P37173
determination method
TAS
retrieved
8 April 2019
stated in
TGF beta signals through a heteromeric protein kinase receptor complex
GOA
curator
British Heart Foundation
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P37173
determination method
IMP
retrieved
8 April 2019
stated in
GOA
curator
InterPro
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P37173
determination method
IEA
retrieved
8 April 2019
stated in
GOA
curator
Ensembl genome database project
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P37173
determination method
IEA
retrieved
8 April 2019
stated in
Activation of a TGF-beta-specific multistep gene expression program in mature macrophages requires glucocorticoid-mediated surface expression of TGF-beta receptor II
GOA
curator
British Heart Foundation
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P37173
determination method
IDA
retrieved
8 April 2019
stated in
Endoglin is a component of the transforming growth factor-beta receptor system in human endothelial cells
GOA
curator
British Heart Foundation
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P37173
determination method
IC
retrieved
8 April 2019
stated in
Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium
GOA
curator
GO Central
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P37173
determination method
IBA
Gene Atlas image
PBB GE TGFBR2 208944 at fs.png
732 × 530; 11 KB
0 references

Identifiers

 
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