(Q7671477)

Transient receptor potential cation channel subfamily M member 2

1 reference

transient receptor potential channel

1 reference

Transporter Classification Database ID

1.A.4.5.5

hierarchical database ID heuristic

2 October 2019

based on heuristic

NUDIX hydrolase domain, protein family

1 reference

based on heuristic

inferred from protein domain or family

Ion transport domain, protein family

1 reference

based on heuristic

inferred from protein domain or family

1 reference

13 November 2019

1 reference

13 November 2019

sodium channel activity

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O94759

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O94759

1 reference

16 July 2018

Four Ca2+ ions activate TRPM2 channels by binding in deep crevices near the pore but intracellularly of the gate

http://www.ebi.ac.uk/QuickGO/annotations?protein=O94759&geneProductId=UniProtKB:O94759

calcium-release channel activity

1 reference

8 April 2019

Reciprocal regulation of actin cytoskeleton remodelling and cell migration by Ca2+ and Zn2+: role of TRPM2 channels

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O94759

1 reference

8 April 2019

The proposed channel-enzyme transient receptor potential melastatin 2 does not possess ADP ribose hydrolase activity

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O94759

ligand-gated calcium channel activity

6 references

8 April 2019

ADP-Ribose Activates the TRPM2 Channel from the Sea Anemone Nematostella vectensis Independently of the NUDT9H Domain

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O94759

8 April 2019

Four Ca2+ ions activate TRPM2 channels by binding in deep crevices near the pore but intracellularly of the gate

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O94759

8 April 2019

Modulation of activation and inactivation by Ca2+ and 2-APB in the pore of an archetypal TRPM channel from Nematostella vectensis

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O94759

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O94759

8 April 2019

Structure of a TRPM2 channel in complex with Ca2+ explains unique gating regulation.

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O94759

8 April 2019

Functional characterisation of a TRPM2 orthologue from the sea anemone Nematostella vectensis in human cells

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O94759

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O94759

ADP-ribose diphosphatase activity

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O94759

mono-ADP-D-ribose binding

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O94759

2 references

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O94759

integral component of plasma membrane

3 references

16 July 2018

Molecular cloning of a novel putative Ca2+ channel protein (TRPC7) highly expressed in brain

http://www.ebi.ac.uk/QuickGO/annotations?protein=O94759&geneProductId=UniProtKB:O94759

16 July 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=O94759&geneProductId=UniProtKB:O94759

16 July 2018

Four Ca2+ ions activate TRPM2 channels by binding in deep crevices near the pore but intracellularly of the gate

http://www.ebi.ac.uk/QuickGO/annotations?protein=O94759&geneProductId=UniProtKB:O94759

cytoplasmic vesicle membrane

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O94759

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O94759

specific granule membrane

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O94759

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O94759

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O94759

tertiary granule membrane

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O94759

ficolin-1-rich granule membrane

TAS

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O94759

3 references

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O94759

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O94759

8 April 2019

ADP-Ribose Activates the TRPM2 Channel from the Sea Anemone Nematostella vectensis Independently of the NUDT9H Domain

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O94759

integral component of plasma membrane

4 references

8 April 2019

Molecular cloning of a novel putative Ca2+ channel protein (TRPC7) highly expressed in brain

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O94759

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O94759

8 April 2019

Four Ca2+ ions activate TRPM2 channels by binding in deep crevices near the pore but intracellularly of the gate

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O94759

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O94759

sodium ion transmembrane transport

biological process

1 reference

8 April 2019

Gene Ontology Consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O94759

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O94759

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O94759

response to oxidative stress

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O94759

ion transmembrane transport

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O94759

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O94759

transmembrane transport

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O94759

temperature homeostasis

1 reference

8 April 2019

dendritic cell chemotaxis

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O94759

response to purine-containing compound

1 reference

8 April 2019

Four Ca2+ ions activate TRPM2 channels by binding in deep crevices near the pore but intracellularly of the gate

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O94759

calcium-mediated signaling using intracellular calcium source

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O94759

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O94759

neutrophil degranulation

1 reference

8 April 2019

regulation of filopodium assembly

TAS

1 reference

8 April 2019

Reciprocal regulation of actin cytoskeleton remodelling and cell migration by Ca2+ and Zn2+: role of TRPM2 channels

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O94759

cellular response to hydrogen peroxide

1 reference

8 April 2019

Reciprocal regulation of actin cytoskeleton remodelling and cell migration by Ca2+ and Zn2+: role of TRPM2 channels

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O94759

cellular response to calcium ion

1 reference

8 April 2019

Four Ca2+ ions activate TRPM2 channels by binding in deep crevices near the pore but intracellularly of the gate

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O94759

cellular response to purine-containing compound

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O94759

cellular response to temperature stimulus

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O94759

zinc ion transmembrane transport

1 reference

8 April 2019

Reciprocal regulation of actin cytoskeleton remodelling and cell migration by Ca2+ and Zn2+: role of TRPM2 channels

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O94759

dendritic cell differentiation

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O94759

calcium ion transmembrane import into cytosol

regulation of actin cytoskeleton reorganization

1 reference

8 April 2019

Reciprocal regulation of actin cytoskeleton remodelling and cell migration by Ca2+ and Zn2+: role of TRPM2 channels

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O94759

calcium ion import across plasma membrane

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O94759

protein homotetramerization

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O94759

calcium ion transmembrane transport

7 references

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O94759

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O94759

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O94759

8 April 2019

ADP-Ribose Activates the TRPM2 Channel from the Sea Anemone Nematostella vectensis Independently of the NUDT9H Domain

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O94759

8 April 2019

Modulation of activation and inactivation by Ca2+ and 2-APB in the pore of an archetypal TRPM channel from Nematostella vectensis

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O94759

8 April 2019

Structure of a TRPM2 channel in complex with Ca2+ explains unique gating regulation.

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O94759

8 April 2019

Functional characterisation of a TRPM2 orthologue from the sea anemone Nematostella vectensis in human cells

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O94759

physically interacts with

cyclic ADP-ribose

1 reference

2445

17 August 2016

1 reference

2448

17 August 2016

1 reference

2450

17 August 2016

1 reference

2391

English

2-aminoethoxydiphenylborate

17 August 2016

has use

channel blocker

1 reference

2433

17 August 2016

1 reference

2330

17 August 2016

1 reference

2446

17 August 2016

1 reference

2447

17 August 2016

1 reference

2449

17 August 2016

1 reference

2346

17 August 2016

1 reference

NUDIX hydrolase domain

1 reference

Transporter Classification Database ID

Identifiers

1 reference

30 May 2020

1 reference

30 May 2020

1 reference

30 May 2020

1 reference

30 May 2020

1 reference

30 May 2020

1 reference

30 May 2020

1 reference

30 May 2020

1 reference

30 May 2020

1 reference

13 November 2019

1 reference

1 reference

1 reference

1 reference

1 reference

1 reference

1.A.4.5.5

2 references

Transporter Classification database

13 March 2020

Transporter Classification database