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(Q77509624)

English

Hypericin

Hypericin is an anthraquinone derivative that is naturally found in the yellow flower of Hypericum perforatum (St. John's wort) with antidepressant, potential antiviral, antineoplastic and immunostimulating activities

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Statements

mass
504.0845174719998 dalton
1 reference
based on heuristic
inferred from InChI
chemical formula
C₃₀H₁₆O₈
0 references
canonical SMILES
CC1=CC(=O)C2=C(C3=C(C=C(C4=C3C5=C2C1=C6C(=CC(=O)C7=C(C8=C(C=C(C4=C8C5=C67)O)O)O)C)O)O)O
0 references
found in taxon
Hypericum perforatum
73 references
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High performance liquid chromatography/electrospray mass spectrometry of Hypericum perforatum extracts
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Hypericin and Pseudohypericin in Cell Cultures of VariousHypericumSpecies and Chemotypes
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Characterisation of extracts of Hypericum perforatum L. using an on-line HPLC system with UV/visible and fluorescence detection prior to and after photochemical conversion of the effluent
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Hypericum perforatum--chemical profiling and quantitative results of St. John's Wort products by an improved high-performance liquid chromatography method
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Improved procedure for the quality control of Hypericum perforatum L.
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Quantitative analysis of the active components and the by-products of eight dry extracts of Hypericum perforatum L. (St John's Wort).
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Fast high-performance liquid chromatographic analysis of naphthodianthrones and phloroglucinols from Hypericum perforatum extracts
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Sedative activity in mice of a hydroalcohol extract ofHypericum perforatum L.
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Quantitative evaluation of some species of St. John's wort for their level of hypericins by the HPLC method
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On the nature of ?soluble? hypericin inHypericum species
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HPLC-DAD and TLC-Densitometry for quantification of hypericin inHypericum perforatum L. Extracts
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High-performance liquid chromatographic determination of the biologically active principle hypericin in phytotherapeutic vegetable extracts and alcoholic beverages
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Hypericin content variation in Hypericum perforatum in Australia
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Induction of hypericins in Hypericum perforatum in response to chromium
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Extracts of St. John's wort and various constituents affect beta-adrenergic binding in rat frontal cortex
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Comparative evaluation of St. John's wort from different Italian regions
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Evaluation of major active components in St. John's Wort dietary supplements by high-performance liquid chromatography with photodiode array detection and electrospray mass spectrometric confirmation
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Quantitative determination of biologically active constituents in medicinal plant crude extracts by thin-layer chromatography—densitometry
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Identification by high-performance liquid chromatography–diode array detection–mass spectrometry and quantification by high-performance liquid chromatography–UV absorbance detection of active constituents of Hypericum perforatum
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Pressurized liquid extraction of medicinal plants
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Step by step removal of hyperforin and hypericin: activity profile of different Hypericum preparations in behavioral models
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Jasmonic acid-induced hypericin production in cell suspension cultures of Hypericum perforatum L. (St. John's wort).
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Stimulation of the production of hypericins by mannan in Hypericum perforatum shoot cultures
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The content of hypericins and phloroglucinols in Hypericum perforatum L. seedlings at early stage of development
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Hypericin and pseudohypericin in some Hypericum species
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Hypericum perforatum L. - chemotype without rutin from Italy
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Determination of hypericin and pseudohypericin in pharmaceutical preparations by liquid chromatography with fluorescence detection
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High performance liquid chromatographic analysis of St. John's wort with photodiode array detection.
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Determination of naphthodianthrones in plant extracts from Hypericum perforatum L. by liquid chromatography-electrospray mass spectrometry
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Evaluation of chemical stability of St. John's wort commercial extract and some preparations
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Development of a simple, rapid and reproducible HPLC assay for the simultaneous determination of hypericins and stabilized hyperforin in commercial St. John's wort preparations
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Separation of hypericins and hyperforins in extracts of Hypericum perforatum L. using non-aqueous capillary electrophoresis with reversed electro-osmotic flow
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Influence of nitrogen on the production of hypericins by St. John’s wort
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Differential effects of light and nitrogen on production of hypericins and leaf glands in Hypericum perforatum
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Comparison of German St. John's wort products according to hyperforin and total hypericin content.
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Pseudohypericin and hypericin in St. John's wort extracts. Breakdown of pseudohypericin
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High-Performance Liquid Chromatography On-Line Coupled to High-Field NMR and Mass Spectrometry for Structure Elucidation of Constituents ofHypericum perforatumL.
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Biochemical activities of extracts from Hypericum perforatum L. 5th communication: dopamine-beta-hydroxylase-product quantification by HPLC and inhibition by hypericins and flavonoids.
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Quantitative changes of dianthrones, hyperforin and flavonoids content in the flower ontogenesis of Hypericum perforatum
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Effect of light on hypericins contents in fresh flowering top parts and in an extract of St. John's Wort (Hypericum perforatum).
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Phenolic compounds from Hypericum perforatum
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Hypericum perforatum subspecies angustifolium shows a protective activity on the consequences of unavoidable stress exposure at lower doses than Hypericum perforatum perforatum.
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Effect of acute drought stress and time of harvest on phytochemistry and dry weight of St. John's wort leaves and flowers
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Solubilized hypericin and pseudohypericin from Hypericum perforatum exert antidepressant activity in the forced swimming test
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Significance of genetic and environmental aspects in the field cultivation of Hypericum perforatum
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Production of hypericin, pseudohypericin and flavonoids in cell cultures of various Hypericum species and their chemotypes
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Effects of Visible and Ultraviolet Light on the Production of Hypericins and Flavonoids in Cell Cultures ofHypericum perforatum
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Quantitative phytochemical analyses of six hypericum species growing in slovenia
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Analysis and stability of Hyperici oleum
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Initiation of Shoot Organ Cultures ofHypericum perforatumand Formation of Hypericin Derivatives
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Hyperforin, possibly the major non-nitrogenous secondary metabolite of Hypericum perforatum L
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Antidepressant activity of hypericum perforatum and hyperforin: the neglected possibility
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Effects of a methanolic extract and a hyperforin-enriched CO2 extract of St. John's Wort (Hypericum perforatum) on intracerebral field potentials in the freely moving rat (Tele-Stereo-EEG).
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Note Variations in Hypericin Concentrations in Hypericum perforatum L. and Commercial Products
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Factors affecting growth of cell suspension cultures of hypericum perforatum L. (St. John's wort) and production of hypericin
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Determination of Major Constituents in St. John's Wort Under Different Extraction Conditions
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Comparative chemical composition and variability of biological activity of methanolic extracts from Hypericum perforatum L.
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RAPID ISOCRATIC HPLC ANALYSIS OF HYPERICINS
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THE DEVELOPMENT AND EVALUATION OF AN HPLC-DAD METHOD FOR THE ANALYSIS OF THE PHENOLIC FRACTIONS FROMIN VIVOANDIN VITROBIOMASS OFHYPERICUMSPECIES
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Determining hyperforin and hypericin content in eight brands of St. John's wort.
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Simultaneous Determination of the Predominant Hyperforins and Hypericins in St. John's Wort (Hypericum perforatum L.) by Liquid Chromatography
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Determination of St. John's Wort Components in Dietary Supplements and Functional Foods by Liquid Chromatography
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In vitro and in vivo activation of hypericin with the incoherent light source PDT 1200 SOA (520-750 nm) and with solar simulated radiation (290-2500 nm).
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Regional differences in hypericin and pseudohypericin concentrations and five morphological traits among Hypericum perforatum plants in the northwestern United States
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The spectral properties of Hypericum perforatum leaves: the implications for its photoactivated defences
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Pharmaceutical quality of hypericum extracts
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Pharmacokinetics of Hypericin and Pseudohypericin after Oral Intake of the Hypericum Perforatum Extract LI 160 in Healthy Volunteers
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Ontogenetic Variation Regarding Hypericin and Hyperforin Levels in Four Accessions ofHypericum perforatumL.
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Variation in Hypericins from Wild Populations of Hypericum perforatum L. in the Pacific Northwest of the U.S.A1
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The analysis of the kinetics of extraction of resinoids and hypericines from the amber, Hypericum perforatum L
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Hypericin content of Nova Scotia biotypes of Hypericum perforatum L.
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Catalytic inhibition of human DNA topoisomerase IIalpha by hypericin, a naphthodianthrone from St. John's wort (Hypericum perforatum).
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Cytotoxic activity of Hypericum perforatum L. on K562 erythroleukemic cells: differential effects between methanolic extract and hypericin

Identifiers

 
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