(Q14865240)

English

Interleukin 6

mammalian protein found in Mus musculus

B-cell hybridoma growth factor
Il6
interleukin HP-1
interleukin-6

In more languages

Statements

1 reference

25 May 2022

UniProt protein ID

1 reference

19 January 2017

UniProt protein ID

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/P08505

four-helical cytokine-like, core

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/P08505

Interleukin-6/GCSF/MGF, conserved site, protein family

1 reference

based on heuristic

inferred from protein domain or family

1 reference

25 May 2022

UniProt protein ID

1 reference

25 May 2022

UniProt protein ID

molecular function

cytokine activity

determination method

8 references

9 May 2019

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P08505

determination method

9 May 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P08505

determination method

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P08505

determination method

9 May 2019

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P08505

determination method

9 May 2019

Intracellular interleukin-1 receptor 2 binding prevents cleavage and activity of interleukin-1α, controlling necrosis-induced sterile inflammation

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P08505

determination method

9 May 2019

Interplay between IFN-gamma and IL-6 signaling governs neutrophil trafficking and apoptosis during acute inflammation

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P08505

determination method

9 May 2019

Induction of endogenous retroviral gene product (SU) as an acute-phase protein by IL-6 in murine hepatocytes

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P08505

determination method

9 May 2019

A role of SMAD4 in iron metabolism through the positive regulation of hepcidin expression

British Heart Foundation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P08505

determination method

interleukin-6 receptor binding

determination method

4 references

9 May 2019

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P08505

determination method

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P08505

determination method

9 May 2019

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P08505

determination method

9 May 2019

Expression of the murine interleukin 6 receptor in hepatoma cells: the intracytoplasmic domain is not required for interleukin 6 signal transduction

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P08505

determination method

protein binding

determination method

1 reference

9 May 2019

Conservation of structure and function between human and murine IL-16

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P08505

determination method

external side of plasma membrane

determination method

1 reference

9 May 2019

Interleukin-6 signaling and embryonic mouse submandibular salivary gland morphogenesis

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P08505

determination method

extracellular space

determination method

25 references

9 May 2019

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P08505

determination method

9 May 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P08505

determination method

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P08505

determination method

9 May 2019

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P08505

determination method

9 May 2019

Role of adaptor TRIF in the MyD88-independent toll-like receptor signaling pathway

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P08505

determination method

9 May 2019

Pellino3 ubiquitinates RIP2 and mediates Nod2-induced signaling and protective effects in colitis

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P08505

determination method

9 May 2019

MyD88-, but not Nod1- and/or Nod2-deficient mice, show increased susceptibility to polymicrobial sepsis due to impaired local inflammatory response

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P08505

determination method

9 May 2019

Endocrine regulation of energy metabolism by the skeleton

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P08505

determination method

9 May 2019

An extraribosomal function of ribosomal protein L13a in macrophages resolves inflammation

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P08505

determination method

9 May 2019

Nod2-dependent regulation of innate and adaptive immunity in the intestinal tract

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P08505

determination method

9 May 2019

Fc epsilon RI gamma-ITAM is differentially required for mast cell function in vivo

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P08505

determination method

9 May 2019

Differential roles of TLR2 and TLR4 in recognition of gram-negative and gram-positive bacterial cell wall components

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P08505

determination method

9 May 2019

Intracellular interleukin-1 receptor 2 binding prevents cleavage and activity of interleukin-1α, controlling necrosis-induced sterile inflammation

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P08505

determination method

9 May 2019

Insect baculoviruses strongly potentiate adaptive immune responses by inducing type I IFN

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P08505

determination method

9 May 2019

The role of interleukin 1 receptor-associated kinase-4 (IRAK-4) kinase activity in IRAK-4-mediated signaling

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P08505

determination method

9 May 2019

Altered cytokine production in mice lacking P2X(7) receptors

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P08505

determination method

9 May 2019

CD25+CD4+ cells contribute to Th2 polarization during helminth infection by suppressing Th1 response development

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P08505

determination method

9 May 2019

Allergic dysregulation and hyperimmunoglobulinemia E in Foxp3 mutant mice

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P08505

determination method

9 May 2019

Accessory protein-like is essential for IL-18-mediated signaling

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P08505

determination method

9 May 2019

Negative regulation of Toll-like-receptor signaling by IRF-4.

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P08505

determination method

9 May 2019

Interleukin-1, interleukin-6, and tumor necrosis factor alpha are produced in the mouse uterus during the estrous cycle and are induced by estrogen and progesterone

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P08505

determination method

9 May 2019

The cytosolic sensors Nod1 and Nod2 are critical for bacterial recognition and host defense after exposure to Toll-like receptor ligands

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P08505

determination method

9 May 2019

RICK/Rip2/CARDIAK mediates signalling for receptors of the innate and adaptive immune systems

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P08505

determination method

9 May 2019

Critical role of NOD2 in regulating the immune response to Staphylococcus aureus

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P08505

determination method

9 May 2019

Adenosine receptors in regulation of dendritic cell differentiation and function

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P08505

determination method

interleukin-6 receptor complex

determination method

1 reference

9 May 2019

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P08505

determination method

biological process

response to yeast

determination method

1 reference

9 May 2019

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P08505

determination method

response to amino acid

determination method

1 reference

9 May 2019

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P08505

determination method

muscle cell cellular homeostasis

determination method

1 reference

9 May 2019

Interleukin-6 and cachexia in ApcMin/+ mice

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P08505

determination method

response to heat

determination method

1 reference

9 May 2019

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P08505

determination method

endocrine pancreas development

determination method

1 reference

9 May 2019

Interleukin-6 regulates pancreatic alpha-cell mass expansion

British Heart Foundation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P08505

determination method

regulation of apoptotic process

determination method

1 reference

9 May 2019

Interleukin-6 signaling and embryonic mouse submandibular salivary gland morphogenesis

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P08505

determination method

response to cytokine

determination method

1 reference

9 May 2019

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P08505

determination method

glucose homeostasis

determination method

1 reference

9 May 2019

NCOA5 haploinsufficiency results in glucose intolerance and subsequent hepatocellular carcinoma

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P08505

determination method

response to antibiotic

determination method

1 reference

9 May 2019

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P08505

determination method

myeloid cell homeostasis

determination method

1 reference

9 May 2019

Distinct roles for hepcidin and interleukin-6 in the recovery from anemia in mice injected with heat-killed Brucella abortus

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P08505

determination method

response to mechanical stimulus

determination method

1 reference

9 May 2019

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P08505

determination method

response to insulin

determination method

1 reference

9 May 2019

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P08505

determination method

glucagon secretion

determination method

1 reference

9 May 2019

Interleukin-6 regulates pancreatic alpha-cell mass expansion

British Heart Foundation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P08505

determination method

response to nutrient levels

determination method

1 reference

9 May 2019

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P08505

determination method

response to caffeine

determination method

1 reference

9 May 2019

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P08505

determination method

negative regulation of hormone secretion

determination method

1 reference

9 May 2019

Inhibition of growth hormone-releasing factor production in mouse placenta by cytokines using gp130 as a signal transducer

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P08505

determination method

T cell activation

determination method

1 reference

9 May 2019

Enforced expression of GATA3 allows differentiation of IL-17-producing cells, but constrains Th17-mediated pathology

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P08505

determination method

cellular response to hepatocyte growth factor stimulus

determination method

1 reference

9 May 2019

Hepatocyte growth factor modulates interleukin-6 production in bone marrow derived macrophages: implications for inflammatory mediated diseases

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P08505

determination method

determination method

1 reference

9 May 2019

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P08505

determination method

response to electrical stimulus

determination method

1 reference

9 May 2019

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P08505

determination method

cellular response to dexamethasone stimulus

determination method

1 reference

9 May 2019

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P08505

determination method

response to calcium ion

determination method

1 reference

9 May 2019

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P08505

determination method

response to lipopolysaccharide

determination method

1 reference

9 May 2019

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P08505

determination method

acute-phase response

determination method

1 reference

9 May 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P08505

determination method

immune response

determination method

1 reference

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P08505

determination method

defense response to protozoan

determination method

1 reference

9 May 2019

Immunomodulatory effects associated with a live vaccine against Leishmania major containing CpG oligodeoxynucleotides

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P08505

determination method

response to bacterium

determination method

1 reference

9 May 2019

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P08505

determination method

response to organic cyclic compound

determination method

1 reference

9 May 2019

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P08505

determination method

epithelial cell proliferation involved in salivary gland morphogenesis

determination method

1 reference

9 May 2019

Interleukin-6 signaling and embryonic mouse submandibular salivary gland morphogenesis

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P08505

determination method

determination method

1 reference

9 May 2019

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P08505

determination method

positive regulation of cell proliferation in bone marrow

determination method

1 reference

9 May 2019

Parathyroid hormone mediates hematopoietic cell expansion through interleukin-6

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P08505

determination method

T-helper 17 cell lineage commitment

determination method

1 reference

8 April 2019

The orphan nuclear receptor RORgammat directs the differentiation program of proinflammatory IL-17+ T helper cells

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P08505

determination method

positive regulation of gene expression

determination method

3 references

9 May 2019

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P08505

determination method

9 May 2019

NF-kappa B and C/EBP transcription factor families synergistically function in mouse serum amyloid A gene expression induced by inflammatory cytokines

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P08505

determination method

9 May 2019

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P08505

determination method

regulation of cell population proliferation

determination method

1 reference

9 May 2019

Interleukin-6 and cachexia in ApcMin/+ mice

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P08505

determination method

bone remodeling

determination method

1 reference

9 May 2019

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P08505

determination method

positive regulation of T-helper 2 cell differentiation

determination method

1 reference

9 May 2019

Inhibition of Th2 differentiation and GATA-3 expression by BCL-6

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P08505

determination method

response to auditory stimulus

determination method

1 reference

9 May 2019

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P08505

determination method

response to cold

determination method

1 reference

9 May 2019

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P08505

determination method

cellular response to lipopolysaccharide

determination method

5 references

9 May 2019

SASH1 is a scaffold molecule in endothelial TLR4 signaling

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P08505

determination method

9 May 2019

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P08505

determination method

9 May 2019

Glucocorticoids target suppressor of cytokine signaling 1 (SOCS1) and type 1 interferons to regulate Toll-like receptor-induced STAT1 activation

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P08505

determination method

9 May 2019

Critical role of AZI2 in GM-CSF-induced dendritic cell differentiation

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P08505

determination method

9 May 2019

Phosphoinositide 3-kinase-dependent inhibition of dendritic cell interleukin-12 production by Giardia lamblia

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P08505

determination method

cellular response to estradiol stimulus

determination method

1 reference

9 May 2019

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P08505

determination method

acute inflammatory response

determination method

1 reference

9 May 2019

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P08505

determination method

cellular response to prolactin

determination method

1 reference

9 May 2019

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P08505

determination method

positive regulation of T-helper 2 cell cytokine production

determination method

1 reference

9 May 2019

Interleukin-6 deficiency increases inflammatory bone destruction

British Heart Foundation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P08505

determination method

negative regulation of interleukin-1-mediated signaling pathway

determination method

1 reference

9 May 2019

Interleukin-6 deficiency increases inflammatory bone destruction

British Heart Foundation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P08505

determination method

cellular response to cytokine stimulus

determination method

1 reference

9 May 2019

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P08505

determination method

cellular response to nutrient levels

determination method

1 reference

9 May 2019

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P08505

determination method

negative regulation of bone resorption

determination method

1 reference

9 May 2019

Interleukin-6 deficiency increases inflammatory bone destruction

British Heart Foundation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P08505

determination method

lymphocyte costimulation

determination method

1 reference

9 May 2019

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P08505

determination method

regulation of signaling receptor activity

determination method

1 reference

8 April 2019

Gene Ontology Consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P08505

determination method

neutrophil apoptotic process

determination method

3 references

9 May 2019

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P08505

determination method

9 May 2019

Interplay between IFN-gamma and IL-6 signaling governs neutrophil trafficking and apoptosis during acute inflammation

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P08505

determination method

9 May 2019

Interplay between IFN-gamma and IL-6 signaling governs neutrophil trafficking and apoptosis during acute inflammation

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P08505

determination method

hepatic immune response

determination method

1 reference

9 May 2019

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P08505

determination method

positive regulation of acute inflammatory response

determination method

1 reference

9 May 2019

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P08505

determination method

inflammatory response

determination method

1 reference

9 May 2019

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P08505

determination method

positive regulation of cell population proliferation

determination method

1 reference

9 May 2019

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P08505

determination method

regulation of vascular endothelial growth factor production

determination method

1 reference

9 May 2019

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P08505

determination method

cytokine-mediated signaling pathway

determination method

1 reference

9 May 2019

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P08505

determination method

neuron projection development

determination method

1 reference

9 May 2019

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P08505

determination method

positive regulation of chemokine production

determination method

1 reference

9 May 2019

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P08505

determination method

positive regulation of interleukin-6 production

determination method

1 reference

9 May 2019

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P08505

determination method

negative regulation of collagen biosynthetic process

determination method

1 reference

9 May 2019

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P08505

determination method

positive regulation of peptidyl-serine phosphorylation

determination method

1 reference

9 May 2019

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P08505

determination method

positive regulation of T cell proliferation

determination method

1 reference

9 May 2019

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P08505

determination method

positive regulation of tyrosine phosphorylation of STAT protein

determination method

1 reference

9 May 2019

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P08505

determination method

positive regulation of apoptotic process

determination method

1 reference

9 May 2019

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P08505

determination method

negative regulation of apoptotic process

determination method

1 reference

9 May 2019

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P08505

determination method

positive regulation of MAPK cascade

determination method

1 reference

9 May 2019

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P08505

determination method

positive regulation of translation

determination method

1 reference

9 May 2019

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P08505

determination method

positive regulation of transcription by RNA polymerase II

determination method

3 references

9 May 2019

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P08505

determination method

9 May 2019

IL-1 family members and STAT activators induce cytokine production by Th2, Th17, and Th1 cells

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P08505

determination method

9 May 2019

A role of SMAD4 in iron metabolism through the positive regulation of hepcidin expression

British Heart Foundation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P08505

determination method

positive regulation of smooth muscle cell proliferation

determination method

1 reference

9 May 2019

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P08505

determination method

positive regulation of peptidyl-tyrosine phosphorylation

determination method

1 reference

9 May 2019

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P08505

determination method

positive regulation of B cell activation

determination method

1 reference

9 May 2019

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P08505

determination method

positive regulation of DNA-binding transcription factor activity

determination method

1 reference

9 May 2019

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P08505

determination method

response to glucocorticoid

determination method

1 reference

9 May 2019

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P08505

determination method

defense response to virus

determination method

1 reference

9 May 2019

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P08505

determination method

interleukin-6-mediated signaling pathway

determination method

3 references

9 May 2019

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P08505

determination method

9 May 2019

Expression of the murine interleukin 6 receptor in hepatoma cells: the intracytoplasmic domain is not required for interleukin 6 signal transduction

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P08505

determination method

9 May 2019

A role of SMAD4 in iron metabolism through the positive regulation of hepcidin expression

British Heart Foundation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P08505

determination method

positive regulation of glial cell proliferation

determination method

1 reference

9 May 2019

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P08505

determination method

positive regulation of gliogenesis

determination method

1 reference

9 May 2019

miR-155 Is Essential for Inflammation-Induced Hippocampal Neurogenic Dysfunction

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P08505

determination method

positive regulation of epithelial to mesenchymal transition

determination method

1 reference

9 May 2019

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P08505

determination method

positive regulation of extracellular matrix disassembly

determination method

1 reference

9 May 2019

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P08505

determination method

positive regulation of vascular endothelial growth factor production

determination method

1 reference

9 May 2019

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P08505

determination method

positive regulation of osteoblast differentiation

determination method

1 reference

9 May 2019

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P08505

determination method

positive regulation of apoptotic DNA fragmentation

determination method

1 reference

9 May 2019

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P08505

determination method

Interleukin-6/GCSF/MGF, conserved site

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/P08505

Identifiers

RefSeq protein ID

1 reference

20 March 2022

1 reference

20 March 2022

UniProt protein ID

1 reference

25 May 2022

UniProt protein ID

Ensembl protein ID

ENSMUSP00000026845

1 reference

ensembl Release 106

Ensembl protein ID

ENSMUSP00000026845

ENSMUSP00000143157

1 reference

ensembl Release 106

Ensembl protein ID

ENSMUSP00000143157

ENSMUSP00000143293

1 reference

ensembl Release 106

Ensembl protein ID

ENSMUSP00000143293

ENSMUSP00000143544

1 reference

ensembl Release 106

Ensembl protein ID

ENSMUSP00000143544

PDB structure ID

1 reference

UniProt protein ID

9 August 2016

language of work or name

Sitelinks

Wikipedia(0 entries)

Wikibooks(0 entries)

Wikinews(0 entries)

Wikiquote(0 entries)

Wikisource(0 entries)

Wikiversity(0 entries)

Wikivoyage(0 entries)

Wiktionary(0 entries)

Multilingual sites(0 entries)

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